AUCTORES
Globalize your Research
Review Article | DOI: https://doi.org/10.31579/2643-6612/046
Technical Director Elephant Dental (1977-2004), Special Professor Digital Dentistry University of Amsterdam (2004-2014).
*Corresponding Author: Jef van der Zel, Technical Director Elephant Dental (1977-2004), Special Professor Digital Dentistry University of Amsterdam (2004-2014).
Citation: Van der Zel JM, (2025), Fifty Years Full Ceramic in Dentistry (1973-2023), J Dentistry and Oral Maxillofacial Surgery, 7(1); DOI:10.31579/2643-6612/046
Copyright: © 2025, Van der Zel JM. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 06 January 2025 | Accepted: 16 January 2025 | Published: 27 January 2025
Keywords: CAD/CAM; dental porcelain; zirconia; lithium disilicate; digital veneering; artificial intelligence; histo-anatomic structure; biomimetic veneering; porcelain chipping; fuzzy logic
A summary of the development of full ceramic dental restorations over the last 50 years is challenging, especially because of the variety of the fabrication processes, that were as essential for on their quality and function as the constitution of the ceramics themselves. The contribution of the developments and innovations in full-ceramics in the advancement of biocompatibility and aesthetics cannot be underestimated. The development from the first full-ceramic restorations in feldspathic porcelain in 1973 to the veneered or monolithic zirconia restorations of today, would not have been possible without the development of dental CAD/CAM and laboratory and intraoral scanning. Some major innovations, of which some did not survive and others survived until this day, have been the trigger for amazing achievements in the field of full ceramic dental restorations.
The technology for creating full ceramic restorations in dentistry has significantly advanced since 1973. In the past, full ceramic restorations were limited to materials like feldspathic porcelain, which had limited strength and durability. However, with the development of new materials and manufacturing techniques, full ceramic restorations have become a popular choice for dental restorations due to their excellent aesthetics and biocompatibility.
One of the most significant advances in full ceramic restoration technology was the development of computer-aided design and computer-aided manufacturing (CAD/CAM) around the 90s. These systems allow for precise processing of a range of new ceramic dental materials for the production of full-ceramic restorations. Additionally, CAD/CAM systems have reduced the time required to create a restoration, making the process more efficient. The introduction of lithiumdisilicate and zirconia were two main steps in the further development of full-ceramic restorations. Chipping problems of porcelain veneered on zirconia was a problem with most porcelains on the market except some porcelains with an adequate crack stopping mechanism. However, the chipping problem has slowed down some developments such as digital veneering. However, now that present zirconia porcelains have less sensitivity to chipping digital veneering can again become a new opportunity.
The first all-ceramic crowns were introduced in 1973 by John W McLean, and since then, there have been many advancements in ceramic materials used for dental restorations. These advancements have led to improved strength and durability of ceramic crowns, making them a popular choice for dental restorations [1].
In 1985 the technique of producing porcelain veneers, onlays and inlays became popular and has proven to give good esthetic and functional results [2]. The technique for producing inlays, onlays and veneers consist of casting a refractory model of the impression of the preparation, burnout of the model and condensing the porcelain against the refractory model, building-up the contour of the restoration, firing the porcelain and removing the refractory. [3]. Bonding to tooth structure was achieved using an adhesive composite cement technique. At first, metal-ceramic was still the number one veneering material. In the 1990s, low-fusing hydrothermal porcelains in combination with a rich yellow gold alloy came onto the market (Carrara® System) [4,5]. Press ceramic, lithiumdisilicate the increase of leucite crystal phases in feldspathic porcelains raises the coefficient of thermal expansion and strength, but also increased the resistance to slow crack propagation. High leucite-containing ceramics Empress®1 by Ivoclar, optimal pressable glass (OPC) by Jeneric and Volumia®Press by Elephant were introduced in the late 1980s and were the first pressable ceramic materials. Although the initial steps for fabrication for Empress, Volumia and OPC were similar to Dicor® and Cerestore® in which the restoration was formed in wax, a heated leucite-reinforced ceramic ingot was pressed into the refractory mold using a specially designed pressing furnace, whereas the Dicor® crown was created using centrifugal casting. This process of pressing ceramic ingots became very popular due to the esthetics and ease of use in the laboratory. Despite the increase in strength of leucite-reinforced pressed glass-ceramics, fracture was still possible when used in the posterior region. In 1998 Ivoclar introduced IPS Empress II, which was a lithiumdisilicate ceramic material used as a single- and multiple-unit framework indicated for the anterior region. The framework was layered with a veneering ceramic specially designed for the lithium disilicate. In 1991 the first pressed ceramic came onto the market and the success story of press technology began. This heralded the age of “metal-free” restorations. A lot happened in material development in 1998. The all-ceramic system IPS e.max is considered a pioneering innovation in the field of dental ceramics after the innovations in the 1990s [6]. It came onto the market in 2005 and has set new standards in terms of optical and mechanical properties.
A modular, comprehensive all-ceramic system was now available for the first time, which combines high-strength and highly aesthetic materials for press and CAD/CAM technology and thus makes all indications available, from single teeth to long-span bridges. The selection of the translucency level depended on the clinical requirements of the respective patient case and the desired processing technique. Restorations with IPS e.max have been clinically proven a million times over [7,8]. No wonder then that the IPS e.max system and with it the lithiumdisilicate glass-ceramic have been extremely successful to this day. Incidentally, after almost 25 years of pressable ceramics, it is now possible for the first time to press multicolored press blanks into highly aesthetic monolithic restorations. The first generation of lithium disilicate enabled new indications and expanded applications for pressed ceramics.
At the same time, an innovative crystal was developed. Due to its structure, the fluorapatite crystal enabled a perfect reproduction of natural tooth substance, coupled with a brightness that had not been achieved before. The fluorapatite glass ceramics still deliver aesthetics almost like nature. Parallel to the metal ceramics, the first pressed ceramics established themselves - initially for single-tooth restorations.
Lithium disilicate re-emerged in 2006 as a pressable ingot and partially crystalized milling block (Cerec® for chairside and inLab® milling units for laboratories). The flexural strength of the material was found to be more than 170% higher than any of the currently used leucite-reinforced ceramics. The ceramic material can be milled or waxed, and then pressed to full contour and subsequently stained. Another option allows for cutting the crown back, followed with layering with different specially designed apatite ceramic glass. The layering ceramic has the same basic components as natural tooth enamel. CAD/CAM milling of a ceramic framework (zirconiumoxide), a full-contoured crown (lithium disilicate at chairside or in the laboratory), or an implant abutment has opened the market for digitized restorative dentistry.
The first commercially available CAD/CAM system was Cerec® processing of dental ceramics chairside had already begun in the mid-1980s enabling the delivery of inlays and onlays in one visit [9]. Early forms of digital imaging included both an intraoral imaging system integrated with the Cerec® system.
In the mid1990s Nobel Biocare introduced the Procera® AllCeram core, which was the first full-ceramic CAD/CAM substructure. On this white core of 99.9% alumina a low expansion feldspathic ceramic was layered for aesthetics. Basically, the gypsum die was copied by a touch probe and reproduction-milled with an enlargement factor in presintered alumina to the inner surface with a coping of uniform 0,6 mm thick, then sintered to final density.
The most important step that changed laboratory work dramatically in the direction of digital was the development of the first laser line laboratory scanner for full gypsum models in 2000 [11,12].
The first system that made use of contact-less scanning was CICERO® (Figure 1), whereby an shaded alumina based substructure was digitally veneered with a dentin and incisal porcelain layer by CAD/CAM, introduced, together with the laser line laboratory scanner (Figure 2) and the first laboratory CAD software with static and dynamic occlusal correction [13-15]. This pioneering CAD/CAM method of complete single crown fabrication consists of optically digitizing a gypsum die, designing the crown layer buildup, and subsequently pressing, sintering, and milling consecutive layers. The coping was applied as a fine-grained alumina-glass composite which was applied on a milled refractory die by a robot operated slip-casting process, and sintered to full density. Slip-casting alumina on a gypsum model and after pre-sintering infused by a low melting glass was some years later introduced by Vita with the introduction of the In-Ceram® system. Both systems achieved a 85% alumina by volume. These pioneering CAD/CAM systems have accelerated the development of new materials [15], laboratory triangulation scanning, as well as advancements in digital radiography [16] in the fabrication of full ceramic restorations.
Figure 1: CICERO®: Digitally veneered alumina coping [11].
Figure 2: CICERO®: First laser-line laboratory scanner [12].
Zirconia
One of the achievements of computer-aided dentistry is that it has enabled the introduction of high-strength zirconia ceramics in dental prosthetics in 2000, which will most likely be the decisive step towards metal-free all-ceramic restorations without restrictions [17,18]. The development of new CAD software like Cyrtina®CAD, 3Shape, Exocadspurred a whole new generation of ceramic substructures consisting of zirconia. Several manufacturers (Lava, 3M ESPE; Procera Forte, Nobel Biocare; and Cercon, DENTSLY) introduced crown-and-bridge frameworks milled from blocks of presintered yttrium-stabilized zirconium dioxide blocks. The oversized milled frame-works were then sintered for 11 hours at 1500°C providing excellent fit with 900 MPa to 1300 MPa of flexural strength. Other manufacturers (Everest, KaVo, DC-Zirkon, Precident DCS) milled fully sintered zirconium dioxide blocks (because it removed the shrinkage factor), which one study found to have a superior marginal fit. Both fabrication methods provide a framework with sufficient flexural strength, allowing them to be used for multi-unit posterior bridges. The recent evolution in CAD/CAM technologies is breathtaking, enabling clinicians and dental technicians to fabricate indirect restorations in the laboratory or at the chair in the dental office from a variety of ceramic materials, from resin matrix ceramics to silica-based and highly strong ceramics such as lithiumdisilicate and zirconia. Extensive world-wide research provided long-term scientific support and are used extensively with an increased understanding of optical, physical and biological material properties. This pertains not only to material properties and fabrication parameters, but also more clinical applications such as cementation and resin bonding protocols, which are critical to the success and survival of ceramic restorations. Until recently, aesthetics were one of the most important motives for choosing ceramics, but now the fabric-friendliness of the metal-free ceramics has also been added. The patient has spoken out for biocompatibility. The paradigm that ceramic must always be prepared and modeled differently from metal ceramics has been eliminated with the advent of zirconia. Until recently, aesthetics were the main reason for choosing ceramics. The tissue-friendliness of metal-free ceramics has become an additional criterion. The public has expressed their preference for biocompatibility. With the introduction of zirconia, the paradigm that ceramics required a different approach to preparation
and modeling than metal-ceramics was a thing of the past. One of the advantages of CAD/CAM is that it made the use of zirconia possible. With the exception of zirconia, the existing ceramic systems lack reliable potential for the different indications for bridges without size limitations. Ever greater demands are being placed on the aesthetics of the teeth. CAD/CAM plays a key role in the introduction of all-ceramic restorations, such as base structures made of sintered ceramics. For aesthetics the focus is not only on computer-aided milled inlays, onlays and veneers made of natural-colored porcelain, but also on the application of different layers of enamel porcelain on base structures to improve the aesthetics of zirconia. Research is mainly focused on the strength of the bond between zirconia and enamel porcelain and the strength and stresses of the whole structure in terms of the difference in thermal expansion coefficient. The first dental multi-layered zirconia appeared on the market around 2010. Multi-layered zirconia is a popular material used in dental restorations due to its high strength and esthetic properties. Esthetic properties that mimic the natural look of teeth, allowing for a more seamless and natural-looking restoration. It has a high resistance to wear and chipping, ensuring a long-lasting restoration and has become a popular choice for dental restorations due to its combination of strength, esthetics, and biocompatibility. The multi-layer KATANA™ Zirconia Block is made up of four layers of zirconium in varying color nuances, so that restorations with natural tooth colors can be fabricated in practice. This excludes a time-consuming and complicated process of staining the restoration (Figure 3).
Figure 3: KATANATM multi-layered zirconia block.
Porcelain chipping on zirconia In a literature review by Sailer et al. [19], for bridges on implants, conventionally veneered zirconia should not be considered a material selection of the first priority, due to the pronounced risk of breakage in bridges and porcelain chipping. Thanks to developments in veneering ceramics for zirconia and the use of strength control in the CAD-design of zirconia substructures, these problems no longer occur [20]. Ceramic veneering materials have differences in their thermal expansion, firing temperature and structure, which effect their longer-term chipping behavior when fired on zirconia. Because chipping is a fatigue phenomenon, the presence of an effective crack-stopping mechanism is crucial for its prevention. Conventional porcelains are homogenous and show a linear crack growth behavior, which makes them sensitive to chipping. Most conventional porcelains used for veneering zirconia were single component glass-ceramics, without any crack-stopping mechanisms. In 1990 the first low melting CARRARA® porcelain was developed to veneer an alloy with a rich gold color (Figure 4).
Figure 4: CARRARA® low melting veneering porcelain.
A similar low melting Sakura® porcelain was developed for zirconia that has three components, differing in melting point creating internal micro-stresses and a non-linear crack growth that effectively act as crack-stopper. The three glass phases, crystal content and expansion behavior, result in a low overall melting point of 865oC, compared to 960oC of previous porcelains. The lowest melting component improves wetting of the zirconia surface during firing, resulting in an high bond strength [21]. The small multi-directional internal micro-stresses caused by the three different components results in an effective mechanism that prevents chipping of the porcelain on zirconia [22]. This new generation porcelains, have a low melting hydrolyzing component that will in contact with saliva exchange sodium for water molecules which creates a surface with an hardness equal to natural enamel. These hydrothermal porcelains will wear at the same rate and mode as natural teeth and will not cause chewing force concentrations after a period of time. De Kler et al. [23] found by finite element analysis that the highest stress at three different thermal expansion differences of zirconia and porcelain that the highest stress after cooling down is not at the interface, but about 0.1-0.2 mm from the interface in the porcelain. Chipping is therefore mainly a matter of how sensitive the porcelain material itself is for crack propagation under fatigue loading. Extensive fatigue testing by Rosentritt et al. [24] revealed the chip resistance of these new porcelains. A number of 199 restorations were followed in a controlled clinical study over six years and the occurrence of chipping compared with studies on restorations where conventional porcelain and design of the zirconia sub-structure was used. The conclusion was that with the new porcelain and cognitive design and manufacturing, esthetic restorations are produced, that do not show any chipping.
Delamination and chipping have been major complications of veneering of zirconia-based all-ceramic restorations [19]. The absence of crack stopping in most porcelains was the cause for the blocking further developments such as digital veneering. Some digital veneering techniques were tested on zirconia frameworks and the veneering ceramic shapes were fabricated by CAD/CAM. Digital veneering can also be motivated by the expectation of negative effects due to the high hardness of monolithic zirconia as opposed to that of glass ceramics. Three different digital veneering techniques were tested: the Lava DVS Digital Veneering System (3M ESPE), the Rapid Layer Technology (Vita Zahnfabrik), and the CAD-on technique (Ivoclar Vivadent) [25,26]. Anatomical framework design and digital veneering using lithium disilicate and fusion porcelain might decrease the risk of chipping and delamination of veneering ceramic on zirconia-supported all-ceramic restorations. However, this result is mainly supported by in vitro studies.
Esthetic prosthetic restorations, with natural reflection, color from within and color gradients influenced by the internal dentinal core anatomy can best be accomplished by veneered zirconia, rather than with crowns of color and structure graded monolithic zirconia. In order to mimic the optical and esthetic appearance of the restoration it is important to copy the histo-anatomic build-up of the teeth of the patient [28-30]. This means that the three-dimensional shape of the dentine core, as defined by the dentin-enamel boundary (DEB), and the particular surface of the dentine core, are important parameters to reach this objective. The DEB and the outer surface of the restoration determine most of how the restoration will look like. In order to make naturally looking layered restorations, the copying of the histo-anatomical structure of the inner teeth is a prerequisite. This information forms the basis for the production of prosthetic mimetic restorations. The PRIMERO® system (Figure 5) consists of placement of a zirconia substructure in a standard Vita dentine shade on a die milled in a refractory transferblock in which the die and crown contour below the equatorial line is milled. A transparent incisal porcelain in paste form was pressed onto the zirconia substructure and, after drying, milled in calculated oversize and sintered. The color gradients in the resulting restoration are created by the variation of in thickness of the incisal porcelain, that follows the biomimetic design of the dentin contour in the Cyrtina®CAD software (Figure 6).
Figure 5: PRIMERO® biomimetic veneering of zirconia with incisal porcelain.
Figure 6: Design of zirconia substructure with resulting biomimetic veneered front teeth.
Korenhof [27] discovered that the dentin-enamel boundary (DEB) shows a certain amount of “primitiveness”, more than the enamel surface. The outer and inner surface boundaries are connected by a relation. Therefore, changing the enamel-outer surface in the CAD software automatically leads to a change of the dentin-enamel boundary. This data mining system of dentin geometries was used to produce a set of interpretable fuzzy rules that led to the 2HueTM color system for the production of the color resulting from a certain incisal build-up. The fuzzy system obtained has the special characteristic whereby the rule antecedents correspond to thickness of the enamel layer to the colors of the well-known Vita commercial shade guide. Additionally, the rule consequents directly correspond with the expected CIELAB values for each Vita shade, thanks to a modification of the system's inference structure. Finally, the values of the CIELAB coordinates have been associated with Vita shades by evaluating their respective membership functions, thereby approximating which Vita shades are to be expected for each final shade [31]. A thorough understanding of the histo-anatomic structures and dynamic light interaction of the natural dentition provides dental practitioners with the ultimate strategic advantage with regard to optical integration of the final restoration [29].
Future developments
The first application of artificial intelligence in CAD software was the integration of functional occlusion using virtual articulation in complete dental prosthetic rehabilitation [29]. It is likely that artificial intelligence in CAD software will play a greater part in the future. A first example is the mimicking of the color and shade distribution from intra-oral scanning as demonstrated by the 2HueTM software model for digital veneering in the CyrtinaCAD® software, whereby the enamel thickness is derived by the geometry of the dentin zirconia core by the subtracting the enamel porcelain thickness from the outer element contour.
In these times of scarcity and durable use of materials, the recycling of zirconia blocks after milling might start to play a role. In the 2HueTM build-up pressed and not presintered blocks in 16 dentin colors are used, that can be sorted and ground to be re-used again. When tested no deterioration of properties was detected, except that the homogeneity by back-mixing improved.
The production of zirconia substructures by additive manufacturing technology [32] by 3D printing is a durable alternative to address durability and the drawbacks of subtractive manufacturing in the CAM step of the dental digital workflow. Even though additive manufacturing has yet to be developed, it enables the production of ceramic parts with complex geometries, high precision, and low cost.
Full ceramic restorations have become increasingly popular in dentistry due to their superior aesthetics and biocompatibility. In terms of durability and longevity, studies have shown that full ceramic restorations can be just as durable as traditional metal-based restorations, if not more so. In summary, the technology for creating full ceramic restorations in dentistry has advanced significantly over time, with the development of CAD/CAM systems and new materials. These advancements have improved the accuracy, efficiency, and durability of full ceramic restorations, making them an excellent option for dental patients. With biomimetic digital veneering restorations with a zirconia substructure with dentin shape and a milled layer of chip-resistant translucent enamel porcelain can be produced. For the computer-generated layer build-up, special dentin contour shape libraries – especially the anatomy of the dentin core - are designed with precise spatial definitions and determine the natural aesthetics of the restoration. The exemplary 2HueTM tooth shade model for these restorations is based on research into the effect of the thickness of the transparent enamel on the degree of transfer of the color of the internal dentine zirconia core. These advanced cognitive designed CAD/CAM restorations could give a new impulse to new innovations.
Pioneering efforts in the production of full ceramic systems could only fabricate inlays and onlays or copings or single crowns. Now there seems to be no more limitation in the types of full-ceramic restorations that can be produced, ranging from simple inlays to digitally designed and manufactured complete rehabilitations in full ceramic on implants.
This means that the patient can be provided with ceramic restorations quickly and comfortably, and sometimes in one appointment. The latter can easily compete with the handmade equivalents with the latest production technology in aesthetics.
With the advent of restorations milled out of multi horizontally layered zirconia that mimic the color gradient in the restoration in a monolithic restoration rather than a veneered restoration, is now standard in CAD/CAM restorations [33]. The preliminary lab studies present different additive manufacturing technologies for processing zirconia for different clinical applications mainly in restorative and implant dentistry.
It is pretentious to say that with layered zirconia we have come to the end of developments in the area of full-ceramics and is also against human nature. Now that the porcelain chipping problem has been solved, possibilities for digital veneering or aesthetics by CAD can be explored. Cognitive design can follow a histo-anatomic structure of the dentin-enamel junction, to mimic the build-up of the teeth of the patient. New applications of artificial intelligence in dental CAD software could for example lead to new innovations in digital veneering.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
