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case report | DOI: https://doi.org/10.31579/2690-1897/213
1Department of Thoracic Surgery, Guilan University of Medical Sciences, Rasht, Iran
2Department of Pulmonology, Guilan University of Medical Sciences, Rasht, Iran
3Department of Rdiooncology , Guilan University of Medical Sciences, Rasht, Iran
4Department of pathology, Guilan University of Medical Sciences, Rasht, Iran
5Department of Radiology, Guilan University of Medical Sciences, Rasht, Iran
6Inflammatory Lung Diseases Research Center, Department of Internal Medicine, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
7Department of physiology, Razi Clinical Research Development Center, Guilan University of Medical Sciences, Rasht, Iran
*Corresponding Author: Manouchehr Aghajanzadeh, Department of Thoracic Surgery, Guilan University of Medical Sciences, Rasht, Iran.
Citation: Manouchehr Aghajanzadeh, Alreza Gafernejad, Hamidi Saidi Saidi, Ali Talebi, Mahmode Khyabani, et al, (2024), Unusual Presentation of a Posterior Mediastinal Schwannoma Associated with Chest Pain, Cough, Hemoptysis and Dyspnia, J, Surgical Case Reports and Images, 7(8); DOI:10.31579/2690-1897/213
Copyright: © 2024, Manouchehr Aghajanzadeh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 22 August 2024 | Accepted: 29 August 2024 | Published: 06 September 2024
Keywords: parenchyma preserving; hepatotomy; lesionectomy; metastatectomy; deep-seated liver lesions
Neurogenic tumors (NT) are the most common of posterior mediastinal tumors an 80% of all posterior mediastinal tumors are (NT). They originate from the spinal cord, sympathetic ganglia, or peripheral nerve roots. A schwannoma is a slow-growing, encapsulated, and benign neurogenic tumor. Fewer than 9% of schwannomas are located in the mediastinum. Posterior mediastinal schwannomas originate from neural crest cells and typically from the intercostal nerves. Mediastinal schwannomas are often asymptomatic but may present with unusual symptoms as cough or dyspnea and hemoptysis because of pulmonary invovovement. Although a definitive diagnosis is made by histopathology and immunohistochemical analysis and electron microscopy can be used to help ite final diagnosis. We present a case of a benign posterior mediastinal schwannoma which present in CXR and computed tomography (CT) imaging as a cystic lesion in a 58-year-old woman who admitted to our hospital with back pain,cough,hemomptsis and dyspnea.
Several mediastinal classification systems have been discussed, which historically were based on no anatomic divisions on the lateral chest radiographs [1,2,3]. One of the classification systems includes perivascular (anterior), visceral (middle), and paravertebral (posterior) compartments [2,3]. Localization of a mediastinal lesion can help to better diagnosis and treatment. The paravertebral compartment is bound superiorly by the thoracic inlet, inferiorly by the diaphragm, anteriorly by the posterior boundary by pricardium, and posterior by lateral margin of the transverse processes and inner surface the chest wall [2,3]. Organs contains of posterior mediastinum include of descending aorta, esophagus, thoracic duct, and valgus nerve. Neurogenic tumors of posterior mediastinum originate from the neural crest as peripheral, sympathetic, or paraganglionic elements, tumors of lymphatic, vascular, and mesenchymal origin may also occur [1,2,3]. Posterior mediastinal masses and lesion according to their origin and morphology can divide as neurogenic, esophageal, cystic lesion, extramedullary hematopoiesis, or lymphoma. 80% of posterior mediastinal masses are Neurogenic tumors [3,4,22]. There are two broad categories of neurogenic neoplasms: peripheral nerve sheath tumors such as schwannoma or neurofibroma which present as round or dumbbell lesions and the sympathetic ganglion neoplasms such as ganglioneuroma, ganglioneuroblastoma and neuroblastoma which present as elongated masses involving 3 or more vertebral levels [2,3]. Other less common neoplasms in the differential include lymphoma, bone tumors, and metastases [2,3,4,5,6]. No neoplastic entities include spinal infections, cystic lesions (meningocele and neurenteric cyst), pancreatic pseudocyst and extramedullary hematopoiesis lesion, sympathetic ganglia. A schwannoma is a slow-growing, encapsulated, and benign neurogenic tumor. Fewer than 9% of schwannomas are located in the mediastinum. Posterior mediastinal schwannomas originate from neural crest cells and typically originate from the intercostal nerves [3,4,7,22]. Mediastinal schwannomas are often asymptomatic but may present with cough or dyspnea, hemoptysis and pain [2,3,4,5]. Although a definitive diagnosis is by histopathology, immunohistochemical analysis and electron microscopy can be used for difinitive diagnosis [2,3,4,8,9,10]. Surgical resection is the primary treatment of choice in most neurogenic tumors, including the schwannoma [2,3,4,5,22]. A minimally invasive resection can use for resection [7,8,9,10,11]. The histology of mediastinal schwannoma is similar to that in other locations, presenting as an encapsulated tumors composed of spindle cells with typical variability in cellularity [11,12,13]. We present a case of a benign posterior mediastinal cystic schwannoma which present with cough, dyspnea,hemoptsis and chest pain and discovered by CXR and (CT-scan) in a 58-year-old woman and resect with right side posterolateral thoracotomy without any complications.
A 58-year-old woman was refered to our hospital with a history of recurrent right side chest wall pain, cough, night sweating, hemoptysis and dyspnea for 4-6 weeks. A physical examination revealed respiratory sounds were decreased on the middle right side of chest. His complete blood count, erythrocyte sedimentation rate, CRP blood urea nitrogen (BUN) level, and creatinine level were normal and liver function tests (AST, ALT, AKP and bilirubin) and anti-hydatid tests were normal. Poster anterior (PA) and lateral chest radiographs were performed. The PA chest radiograph (Figure 1) showed a well-defined 10- to 14-cm right paracardiac cystic mass located in the right middle zone of chest. The CT-scan showed a large well –defined hypo dense cystic mass measuring 112 mm is seen in superior segment of RUL.Sub segmental atelectasis also seen in right lung caused compressing. Left lung was normal. Figure 2(a,b,c,d,e,f,g,h,i) .
In the CT –scan there was no invasion of the chest wall and others intrathoracic structures. CT images show no enlargement of lymph nodes and pleural effusion but lung parachymal was involved. The testes for hydatid cyst were negative .Ultrasonography of abdomen was normal . A classic right posterolateral thoracotomy in six intercostal space was performed. Around of cystic lesion was walling off with wet sponge with normal Saline (Fig 3). In the aspiration of the lesion there was a hemorrhagic dense viscous fluid. The cystic mass was completely removed without complications and free margin. On the operation time, macroscopic examination show hemorrhagic dense viscous fluid and debris was observed in the center of the lesion (Fig 4) Microscopic examination showed an encapsulated mesenchymal neoplasm composed of short fasciles of bland looking spindle cell which are diffusely positive for S100 and GEAP on immunohistochemically diagnosis was a schwannoma tumor. The patient was discharged on the 6 th postoperative day. The patient did not recurrence after 8 months of follow-up
Figure 1: CXR show right side lung cyst
Figure A,B Fig C,D Fig E,F,G
Figure 2: CT -scan A,B,C,D,E,F,G show solid cystic lesion
Figure 3: A,B,C,D show walling of aroun cystic lesion for prevention of spillagechstic fluid and debris of cystic masses
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Figure 4: A,B,C pathology Microscopic examination showed an encapsulated mesenchymal neoplasm composed of short fasciles of bland looking spindle cell which are diffusely positive for S100 and GEAP on immunohistochemically diagnosis was a schwannoma tumor.
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Figure 6: CXR 8 month postoperative
The anterior border of the posterior mediastinum is pericardium and trachea, posterior border and lateral border is inner chest wall and the spine colom (2,3) Organs contains of posterior mediastinum include of descending aorta, esophagus, thoracic duct, and vagus nerve1,2,3 14). neurogenic tumors of posterior mediastinum originate from the neural crest as peripheral, sympathetic, or paraganglionic elements. tumors of lymphatic, vascular, and mesenchymal origin may also occur [1,2,3,4]. Posterior mediastinal masses and lesion according to their origin and morphology can divide as neurogenic, esophageal, cystic, extramedullary hematopoiesis, or lymphoma. 80% of posterior mediastinal masses are Neurogenic tumors 4. about 10- 20% of (2,3,4,7,8,22). Lesions are malignant[3,4]. neurofibroma, schwannoma, neurogenic sarcoma originate from peripheral nerve roots. ganglioneuroma, ganglioneuroblastoma, and neuroblastoma originated from aorticosympathetic paraganglia and paravertebral paraganglioma or from sympathetic ganglia in the Posterior mediastinum or rarely, meningocele or meningomyelocele origenited from the intrathoracic spinal canal (1,2,3,4,5,9,10). Among mediastinal neurogenic tumors, schwannomas and neurofibromas arise from peripheral nerves and are more common in adults, whereas ganglioneuromas and neuroblastomas arise from sympathetic ganglia and are more common in children [3,4,5,6,7,11,12]. The most common pediatric mediastinal neurogenic tumors are the ganglioneuroma and neuroblastoma (2,3,4,5). While the ganglioneuroma is a benign tumor, the neuroblastoma is highly malignant [2,3]. In the adult population, the neurofibroma and schwannoma are most common, with the schwannoma being the most common posterior mediastinal neurogenic neoplasm [2,3,4,6,8,9]. Schwannomas are often asymptomatic and incidentally detected during imaging. Schwannomas are mostly solid tumors, some of which may contain cystic degenerations or hemorrhages as our case. Rarely they present as a completely cystic lesion [8,9,10,11]. Schwannomas originating from the nerve roots are located in the paravertebral area, and in the anterior vertebral corpus and neural foramen. PA and lateral chest x-rays are usually the first test performed, as our case [2,3,4,5,15,16,22]. but a CT scan with intravenous contrast is the most valuable test for mediastinal lesions. In this case after CXR we used CT-scan [2,3,4,5,8], Posterior mediastinum masses usually compress the lung and produce Symptoms may occur due to the compression of adjacent mediastinal structures, such as the airway, esophagus, heart, and great vessels [2,3,5,15,16]. Although they are rarely malignant, they may cause respiratory symptoms, such as stridor, dyspnea, hemoptysis, and cough, or gastrointestinal symptoms, such as dysphagia, in the case of invasion to local structures [3,4,5,18].4. Our case present with cough, dyspnea, chest pain and hemopetsis. Symptoms of posterior mediastinum neurogenic tumors include compression of the airway, esophagus, heart, and great veins. Malignant tumors of this area can of invasion into the tracheobronchial tree, spinal canal, lungs, esophagus, superior vena cava, pleura, and chest wall, these invasion can produce cough, stridor, dyspnea, hemoptysis, dysphagia, pleural effusion, and superior vena cava syndrome and hoarseness, neuropathic pain, diaphragmatic paralysis, or Horner’s syndrome and Paraneoplastic syndromes.in our case presentation was due to compressions to adjacent organs involvement [2,3,4,5,9,18,19]. The initial workup of a posterior mediastinal mass involves radiographic evaluation, with the majority of asymptomatic masses discovered incidentally on posteroanterior (PA) and lateral radiographs(2,3,4,14). Additional radiologic findings include enlargement of the neural foramina (creating a dumbbell shaped lesion), scalloping of posterior vertebral bodies, erosion of the ribs, pleural effusion, and scoliosis. Disruption of the azygoesophageal recess is a nonspecific finding seen in both middle and posterior mediastinal masses [3,16,17) Posterior masses generally have sharp margins due to their interface with the lung, CT imaging of the mass is useful in determining the exact location and its relationship to adjacent structures and may aid in differentiating tissue densities between cystic, vascular, and solid masses [2,3,4,6,7]. Due to high contrast resolution and multiplanar capability, MRI is the preferred modality of imaging as it provides better evaluation regarding the nature and extent of intraspinal involvement towards the neural and vertebral foramen [3,17]. The limitations of MRI compared to CT are the limited radiographic evaluation of calcifications and poorer spatial resolution [2,3,4,16,17] therefore, while an MRI is preferable it is not always necessary, we do not MRI in our case [2,3,21]. Recent studies have offered ultrasound guided FNA as a viable diagnostic modality for accessible mediastinal lesions [2,3,23] allowing for formal diagnosis without the potential complications from more invasive procedures such as CT-guided biopsy, mediastinoscopy, or video-assisted thoracoscopic surgery which offer no benefit in the management of these tumors [2,3]. Because of suspicion of hydatid cyst our radiologist team do not use FNA [23.24], hydatid cyst in IRAN are endemic [22]. PET scans have shown the ability to distinguish between malignant peripheral nerve sheath tumors and neurofibromas with high accuracy but are not as helpful in distinguishing between benign and malignant peripheral nerve sheath tumors [2,3,16,17] Primary treatment of schwannoma and most neurogenic tumors are Surgical resection [2,3,4,5,19]. schwannomas mayoriginate from the vagus, phrenic, or any part of the intercostal nerve and removed of tumor should be removed by a saving the Involved nerve [2,3,18.19], Radiation therapy may be used postoperatively to control residual disease in malignant schwannomas, but its benefit is unknown [2,3,4,5]. No known chemotherapeutic regimens are effective against these tumors [3,5,6,7]. Since serologic markers are absent and characteristic imaging abnormalities are variable, tissue pathology and immunohistochemistry are required for a diagnosis [11,12,13]. Schwannomas are composed of spindle cells with twisted nuclei, amphophilic cytoplasm, and rare mitoses [2,3.11,12,13]. Patients with neurofibromatosis are likely to display a variant form called plexiform schwannoma [12,13]. Another variant, the melanocytic schwannoma, has a pronounced brownish cytoplasmic pigment and malignant potential [11,12,13]. The malignant schwannoma, the most dangerous variant, is a soft gray-pinkish tumor with central necrosis and microscopically consists of sheets of pleomorphic spindle cells with numerous mitotic figures and necrotic areas [3,11,12,13]. Malignant schwannomas may also exhibit a variety of cellular components such as clusters of epithelial cells; mucin-secreting glands; and even mesenchymal features such as bone, cartilage, or skeletal muscle [3,10,11,12,13]. Patients who undergo resection of a benign schwannoma are generally followed up to monitor wound healing and resumption of daily activities. Routine follow-up of patients who undergo curative resection of a malignant neoplasm has not demonstrated a survival benefit in randomized controlled trials due to the variety and infrequency of malignant mediastinal tumors [2,3,12,15,16)]. Overall, patients with benign schwannoma have excellent survival following complete resection, whereas those with malignant tumors have a poorer prognosis [2,3,5,22,23,24].
The authors wish to thank Roya Moghadam, Chraghalizadeh Executive Assistant in the Department of Thoracic Nursing at the Arya private hospital. for her and his skillful expertise in preparation of the figures for publication
We acknowledge the great work of our medical officer Dr Ahmad Reshad Wajed, and our histotechnologists; Mohammad Ibrahim Wali Zada, Esmatullah Ramzi, and Adil Muhammedi.
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Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
