AUCTORES
Globalize your Research
Chat with us
Research Article | DOI: https://doi.org/10.31579/2768-2757/094
Institute of Physiology named academician Abdulla Garayev, Ministry of Science and Education of the Republic of Azerbaijan,
*Corresponding Author: Ibragimov A. Sh, General Surgery Department, Ain Taya Hospital, 16029, Algiers, Algeria.
Citation: Ibragimova J.M., Mukhtarov M.M., Gurbanova G.A., Bayramova S.D., Ibragimov A. Sh, et al., (2023), Thiol Homeostasis in The Crystalline Eye and Influence on It Irradiation by Decimeter Electromagnetic Radiation (Experiments on Rats), Journal of Clinical Surgery and Research, 4(6); DOI:10.31579/2768-2757/094
Copyright: © 2023, Ibragimov A. Sh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 05 September 2023 | Accepted: 25 September 2023 | Published: 02 October 2023
Keywords: electromagnetic radiation; eye lens; thiols; cataract
Electromagnetic radiation (EMR) in the microwave range, even at non-thermal intensity, causes significant biochemical and physiological changes in living organisms, which are supposed to be associated with their possible oxidative effect. This work is devoted to the study of the mechanism of realization of the EMR effect in the eye lens at the level of redox state elements, based on the fact that this organ is the most suitable model: it functions semiautonomously and has a well-organized system of antioxidant protection. The transparency of the lens is maintained by preserving the redox balance, in which the homeostasis of thiol compounds of protein and non-protein nature plays an important role. Our experiments were performed on rats using 460 MHz EMR for exposure at non-thermal intensities (power flux density between 10 and 30 µW/cm2). It has been shown that chronic exposure to EMR for up to two weeks caused changes in the redox state of the lens, which manifested in changes in the level of lipid peroxidation processes and the content of thiols of various natures. The substructures of the lens (cortical and nuclear regions) reacted to EMR exposure in different ways. Depending on the EMR intensity, pro- and antioxidant characters were revealed in their reactions. The dynamics of the oxidative reaction of lens substructures were also different under high- and low-intensity exposure. The character of the kinetics of changes in the products of oxidative reactions (malondialdehyde and lipid hydroperoxides) and reducing agents (non-protein and protein SH groups) in the lens of the irradiated organism suggested the role of the enzymatic thiolation-dethiolation system to preserve the redox balance in the substructures of the lens. In addition, the results on changes (kinetics) in the content of various protein SH-groups, i.e., hidden inside the protein molecule and exposed on its surface, during EMR exposure, as well as the data available in the literature, allow us to put forward suggestions about the supramolecular mechanism of homeostasis regulation, in particular, thiol homeostasis regulation in such high-protein structures as the lens, which can be realized by aggregation-disaggregation of protein molecules (crystallins in the case of the lens). Our results can serve as a basis for developing a new non-invasive approach to cataract prevention using low-intensity microwave radiation.
The data available in the literature indicate that the lens can be a good, convenient model for studying the oxidative action of an external factor, in particular, nonionizing EMR [5, 6, 7]. It is already known that ensuring the transparency of the lens is associated with the balance of its redox state. A high level of endogenous thiols, especially glutathione, plays a vital role in maintaining the reduced state of lens proteins [8, 9]. Along with this, to maintain the function of the lens, two systems of internal repair (glutaredoxin and thioredoxin systems) are constantly working, which deiolate mixed disulfides of the protein-non-protein thiol type or protein-protein disulfides formed during oxidative stress [10, 11]. We have previously shown that exposure UHF EMR in rats modifies the activity of lipid peroxidation (LPO) in the lens [12, 13]. Since the LPO level is closely related to antioxidant protection in tissues, including the content of endogenous reduced thiols, the latter are predominantly oxidized by lipid peroxidation products, thereby protecting other functional groups and molecules from oxidation. The redox shift state of the lens (in one direction or another), which can occur under the action of low-energy radiation, can serve as a change in the conditions for the development of free radical pathologies, in particular, a pre-cataract state [14, 15]. Based on these data, we set a goal – to find out how changes in LPO processes (caused by exposure to non-ionizing electromagnetic radiation) in the lens of the eye are related to changes in the content of thiols.
The experiments were carried out on 3- month-old male rats which were irradiated using a “Volna-2” generator (460 MHz). The technique of the experiment was described in more detail in the article by Abbasova and Gadzhiev [16]. Experiments with low-intensity and relatively high-intensity irradiation were carried out at a power flux density of 10 and 30 μW/cm2 . The values of the specific absorption rate (SAR) of electromagnetic energy averaged over the entire animal body were estimated as 5 and 15 mW/kg for two intensity modes, respectively. For each specific exposure, the rats were divided into three groups of six rats each, i.e., one control group (falsely irradiated) and two experimental groups, accordingly, low intensity and relatively high-intensity exposed. Experimental groups were exposed to EMR 20 min daily for 1, 3, 5, 7, 10, and 14 days. After an appropriate radiation load, the lenses of the control and experimental groups were isolated for studies in compliance with the rules of working with experimental animals. To determine the content of thiols in lens homogenates, a modified Sedlak-Lindsay method based on the Ellman reaction was used [17]. Concentrations of readily available (RA) (the sum of low molecular weight thiols and superficially located protein thiols) and hidden (masked in the protein structure) thiols in the cortex and nucleus of the lens, which were then recalculated by 1 mg of protein (nmol/mg protein). Statistical data analysis was performed using the SPSS software package for Windows version 22.0. The differences between the control and experimental measurements were examined using the t-test for paired samples.
We studied the content of readily available (RA) (the sum of low molecular weight thiols and superficially located protein thiol groups, which can also be called cytoplasmic) and hidden (masked in the protein structure) thiol groups in the cortex and nucleus of the lens of rats during chronic irradiation for a period of up to 14 days. Changes in the content of cytoplasmic thiols in the cortex and nucleus of the lens at different exposures to high-intensity irradiation are shown in Figs.1 and 2.
Figure 1: Changes in the content of readily available thiols in the lens substructures of rats exposed to high intensity irradiation with EMR 460 MHz
Figure 2: Changes in the content of hidden thiols in the lens substructures of rats exposed to high intensity irradiation with EMR 460 MHz.
Note: The average concentration of readily available thiols for the control group was 473±31 nmol/mg protein in the nucleus and 464±39 nmol/mg protein in the cortex. The average value of concentration for hidden intramolecular protein thiols in the control group, calculated from the difference between the total number of thiols and readily available thiols, was 565±126 nmol/mg protein in the nucleus and 296±100 nmol/mg protein in the cortex. Dotted lines indicate the general trend of changes in different substructures and were carried out using linear approximation of experimental points.
The changes in the content of cytoplasmic thiols in the cortex and nucleus of the lens at different exposures are demonstrated in the Fig. for relatively highintensity irradiation. The level of RA-thiols in the lens cortex, which has fallen after 1st day of irradiation, gradually increased, reached the control level on days 7-8, and increased by ~60% over the control by further irradiation; in the nucleus, on the contrary, the level of thiols that has increased after 1st day of irradiation gradually falls to the control level on days 8-9 with a further decrease in with respect to control by ~30% (see in Fig.1). Such a nature of changes in the content of RA-thiols was correlated with changes in the LPO process in the same tissues. The dynamics of changes in the content of hidden thiols in the cortex and nucleus of the lens under relatively high-intensity irradiation were opposite to the changes in RA-thiols (Fig.2). With a linear approximation of the time dependence of the experimental data, it can be seen that the initial decrease in the level of hidden thiols by 80% in the nucleus was replaced by a gradual increase until it was restored to control at the end of irradiation. In the lens cortex, at the beginning of exposure to EMR,
there was also a decrease in the level of hidden thiols (initially by ~20%), which developed further with the continuation of irradiation, and by the end of exposure reached ~60% lower level than the control. An important result was that the assessment of the total amount of thiols, both for the cortex and for the nucleus, showed a stable level during the entire irradiation period, which was about 20% lower than the control level. Exposure to irradiation at low intensity led to a pattern of changes in thiols of various types in the cortex and the nucleus of the lens, in general, opposite to the picture with highintensity irradiation (the data has not given here). The decrease in the number of readily available thiols in the lens cortex was compensated with an increase in hidden protein thiols under low-intensity irradiation. In the nucleus, the nature of changes in easily accessible and hidden thiols was the same as in the cortex, but these changes were more moderate. Experimental studies were carried out in several stages. First of all, the parameters of the amplitude of the evoked potential (EP) of individual components (total, positive, negative) were recorded in all studied structures in intact animals. Then, in accordance with Noel's methodology, an experimental model of retinal dystrophy was created by injecting MIAA into the ear vein of animals. Experimental retinal dystrophy of a moderate degree was formed within 28-30 days. 30 days after injection EP was recorded again and a corresponding decrease in the amplitude parameters of EP in each structure was observed. The decrease was 40-50% in CS and LGB, and 20-25% in the VC compared to the control. Then curcumin was added to animal food for 30 days. After that, the EP parameters were recorded again. From the results obtained, it became known that the amplitude parameters of EP in all structures after taking curcumin partially increased. However, the positive effect of curcumin on the amplitude parameters of EP in CS and LGB structures was much less than in VC (Fig.1 and 2).
In the lens cortex, at the beginning of exposure to EMR, there was also a decrease in the level of hidden thiols (initially by ~20%), which developed further with the continuation of irradiation, and by the end of exposure reached ~60% lower level than the control. An important result was that the assessment of the total amount of thiols, both for the cortex and for the nucleus, showed a stable level during the entire irradiation period, which was about 20% lower than the control level. Exposure to irradiation at low intensity led to a pattern of changes in thiols of various types in the cortex and the nucleus of the lens, in general, opposite to the picture with highintensity irradiation (the data has not given here). The decrease in the number of readily available thiols in the lens cortex was compensated with an increase in hidden protein thiols under low-intensity irradiation. In the nucleus, the nature of changes in easily accessible and hidden thiols was the same as in the cortex, but these changes were more moderate.
The results of the total exposure of organisms to relatively high- and low-intensity EMR revealed shifts in the redox state in the lens, respectively, in the direction of oxidation and in the direction of reduction. And, apparently, one of the ways to realize the shift of the redox balance is the transition between different types of thiols. The level of LPO can be considered an indicator of the redox state of the tissue [6]. Because the rate of accumulation of its products depends on the balance between the speed of this process and the antioxidant ability of the medium to destroy its products. The increase in LPO indicates a shift in the redox state towards greater oxidation of the cellular environment; this occurred under high-intensity irradiation. A decrease in the rate of LPO, as it occurs with low-intensity irradiation in the lens, indicates a shift towards lower oxidation, i.e. greater reduction. Just as with high oxidation of the tissue environment, when we talk about oxidative stress, with high recovery of the environment, for some time they began to talk about reductive (restorative) stress. References to reports on the phenomenon of reductive stress in relation to other tissues (liver, muscles) can be found in the article by Clanton et al. [18]. Apparently, there are systems of protection against reductive stress in the cells, which are able to mask the excess of reductive agents, and various thiols. With low-intensity irradiation in the lens, we are faced with just such a situation [12]. With a reduced level of LPO, open protein thiols pass into a disguised (hidden) state when they are unable to restore oxidized LPO products. Thus, there is a transition from one type of thiol to another under the influence of highintensity irradiation. Such transformation of protein thiols in tissues, in particular, in the lens under the action of oxidative factors is discussed in the literature and the regulation of these processes by thiolation and dethiolation reactions using certain enzymes is an important subject in the study of the lens [19]. Based on our results and literature data, we can discuss the development of a new noninvasive non-drug method of cataract prevention by exposure to low-intensity decimeter EMR to change two factors, namely redox shift and protein aggregation leading to loss of lens transparency [20, 21]. The transition of protein thiols from one state to another under the influence of a physical factor allows us to put forward speculation suggestion about a supramolecular mechanism for regulating homeostasis (in particular, thiol homeostasis) in such high-protein structure as the lens, which can be realized by aggregationdisaggregation of protein molecules - crystallins. There is a certain threshold size of protein aggregates (molecular weight - about 107Da), above which such aggregates, with sufficient concentration, cause significant scattering of light falling on the lens, which manifests itself in the loss of transparency of the latter. It can be assumed that the proteins of the lens at the physiological norm are represented by their small aggregates within those limits that do not affect transparency. At the same time, these aggregated molecules hide their SH groups. Under the action of oxidative-damaging factors, with the development of oxidative stress, perhaps at some certain stage of this development, the path of antioxidant protection implemented by disaggregation of the supramolecular protein structure, comes into effect, as a result of which previously hidden SH-groups can act as additional reducing agents. When the threat of oxidative damage to cellular structures or lens enzymes disappears, protein molecules can form high-molecular aggregates again without compromising the transparency of this visual structure.
It has been established that shifts in the redox state are detected in the substructures of the lens (in its nuclear and cortical parts) as a result of irradiation of the body with non-ionizing EMR of a certain intensity. The data obtained indicate that one of the ways to realize the shift of the redox balance in the lens is most likely the transition between different forms of protein SH groups. A suggestion is put forward about the supramolecular mechanism of regulation of thiol homeostasis in the eye lens, which allows via aggregation-disaggregation of SH containing protein molecules of crystallins to protect themselves from oxidative-damaging factors.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
