AUCTORES
Globalize your Research
Research Article | DOI: https://doi.org/10.31579/2641-0419/465
1Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, ul. Żelaznej Bramy 10, 00-136 Warsaw, Poland.
2Department of Clinical Biochemistry, The Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730 Warsaw, Poland.
*Corresponding Author: Piotr Łojko, Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, ul. Żelaznej Bramy 10, 00-136 Warsaw, Poland
Citation: Piotr Łojko, Aldona W. Rucińska, (2025), The Pivotal Role of the NT-proBNP Biomarker in Diagnosing Cardiac Dysfunction post- COVID-19, A Systematic Review and Meta-Analyses, J Clinical Cardiology and Cardiovascular Interventions, 8(7); DOI: 10.31579/2641-0419/465
Copyright: © 2025, Piotr Łojko. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 21 March 2025 | Accepted: 09 April 2025 | Published: 14 May 2025
Keywords: NT-proBNP; covid-19; cardiac dysfunction
NT-proBNP plays a key role in the diagnosis and monitoring of cardiac dysfunction in patients after COVID-19. Its use in clinical practice allows for early detection of complications, assessment of their severity and monitoring of treatment effectiveness. An increase in NT-proBNP levels, especially in patients with a severe course of COVID-19, requires a detailed cardiological evaluation, including imaging tests such as echocardiography or magnetic resonance imaging. Due to the increasing number of patients with cardiac complications after COVID-19, NT-proBNP is becoming an increasingly important diagnostic tool that helps doctors make therapeutic decisions and improve patient prognosis.
The SARS-CoV-2 virus affects the heart, even in patients who have been infected asymptomatically or with mild symptoms. In the face of a global pandemic that has affected millions of people worldwide, understanding the long-term effects of SARS-CoV-2 infection on the cardiovascular system has become a priority. NT-proBNP, previously known mainly in the context of heart failure diagnostics, has proven to be a valuable tool in detecting and monitoring cardiovascular complications associated with COVID-19 [1,2]. In this context, biomarkers such as NT-proBNP have become crucial for early detection and monitoring of potential heart damage. Their role in the care of patients after COVID-19 cannot be overestimated, especially in light of the increasing number of cases of the so-called "long COVID". NT-proBNP (N-terminal fragment of B-type natriuretic propeptide) has gained new, crucial importance as a biomarker in the diagnosis of heart dysfunction after COVID-19. NT-proBNP is produced by the breakdown of the prohormone BNP (brain natriuretic peptide), which is secreted by cardiomyocytes in response to increased stress on the heart wall. This process is key to understanding the role of NT-proBNP as a biomarker of heart dysfunction. When the heart is overloaded, whether due to increased blood pressure, excess fluid, or direct damage to the heart muscle, cardiomyocytes respond by increasing the production of proBNP. This prohormone is then split into two parts: the active hormone BNP and the inactive fragment NT-proBNP [3,4]. While BNP has physiological effects, helping to regulate blood pressure and fluid volume, NT-proBNP has no biological function. However, due to its longer half-life in the blood, NT-proBNP has become the preferred marker for diagnostic purposes. In the case of heart dysfunction after COVID-19, NT-proBNP levels can increase significantly, signaling heart muscle overload or damage. This increase may be due to the direct effect of the virus on heart cells, the body's inflammatory response, hypoxia associated with respiratory failure, or other pathophysiological mechanisms associated with SARS-CoV-2 infection [5,6]. The effect of SARS virus -CoV-2 on the human organism is closely linked to the membrane receptortore - converting enzyme 2 angiotensin (ACE2) and the renin-angiotensin-aldosterone (RAA) system. ransmembrane serin peptidase type 2 (TMPRSS2) assists in the active binding of viral envelope proteins to the host cell [7]. Expression of the ACE2 receptor has been demonstrated in many organs but the lungs are the main entry gateway for the SARS virus -CoV-2.4 In addition, membrane receptors for ACE2 are present in the vascular endothelium, myocytes and other organs, including the kidneys, increasing the likelihood of multi-organ damage[8]. ACE2 expression decreases with the moment the virus attaches. This leads to a local increase in angiotensin II (Ang II), which is a major subloss of ACE2, thus promoting stimulation of the RAA system. The exact mechanism of damage to the myocardium and vasculature (with particular-emphasis on the endothelium) by SARS virus -CoV-2 is under investigation [9]. A number of papers have observed an association between the cardiovascular system and cardiovascular disease, myocardial damage and death in patients with COVID-19. In a Chinese study of patients with COVID-19, 27% had elevated TnT levels, which showed myocardial damage [10,11]. In this group, mortality was significantly higher than in patients with normal TnT levels . It was noted that patients with underlying cardiovascular disease but with normal TnT levels during the course of the disease had a more favorable prognosis compared to patients with elevated TnT levels. The dynamic escalation of NT-proBNP and increased incidence of malignant arrhythmias over the course of the disease in patients with elevated TnT levels demonstrate that myocardial damage played a greater role in the fatal outcome of COVID-19 than the presence of underlying cardiovascular disease alone. Increased NT-proBNP levels and malignant arrhythmias were significantly more frequent in patients with elevated TnT levels, and NT-proBNP significantly correlated with TnT levels, suggesting that those with myocardial damage had cardiac dysfunction.
2.1.Selection criteria
Two independent reviewers (Piotr Łojko and Aldona Wierzbicka-Rucińska) analyzed all titles and abstracts, excluding minor studies. Studies that met the following conditions were qualified for analysis: (1) types of studies: retrospective, prospective, cross-sectional, observational, in which cardiac biomarkers (including NT-proBNP, CK, CK-MB, TnI, Myo or, LDH) were evaluated or the patient suffered acute cardiac injury due to COVID-19; (2) patient characteristics: patients should be diagnosed with COVID-19 and divided into moderate, severe or critical cases according to the protocol for diagnosis of new coronavirus-induced. Exclusion criteria were as follows: (1) types of studies: case reports, reviews, editorials, conference abstracts and discussion summaries, (2) patient characteristics: patients with a specific condition, such as oncological diseases.
2.2.Search strategy
This review was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) [7]. The scope of this systematic review was limited to clinical trials conducted in humans in the last 6 years (2019–2025). Six databases were selected for the literature search: Ebsco, Embase, Cochrane, Pub Med, Scopus, and Web of Science. The search and selection process was performed by two reviewers working independently and in parallel. Searches included a combination of MeSH terms and keywords, using quotation marks and field tags with BOOLEAN operators. Not all databases had the same query options (for example, selecting a clinical trial), so steps and phrases were created. Five primary exclusion steps were defined for all databases: (1) keywords (“NT-proBNP biomarker as cardiac dysfunction following COVID-19” OR “NT-proBNP and Covid 19” * OR NT-proBNP biomarker *); publication type (article); (4) language (English); (5) source type (journal). For nonmedical databases, the search was performed in the following areas: title, abstract, keywords (Scopus–Core Collection), topic (Web of Science–Medline), and Ebsco (all). The last search was performed in February 2025. Results from each database were exported to files with the appropriate CSV or Excel extension, and abstracts were created for each database containing publication information, including abstracts. The initial search yielded 23 studies. After removing publications and reviews in a language other than English and removing duplicates, 23 records were selected for abstract review. We did not exclude any publications according to the exclusion criteria, and the full text of 23 eligible studies was included—only studies involving human participants. Articles that reported genetic, pharmacological, or simulation studies were excluded from the review. Three independent reviewers reviewed the abstracts, and articles that did not meet the inclusion criteria were excluded through discussion. The literature search process is shown in Figure 1.
Figure 1: Identification of study via database.
Prisma flow diagram representing the screening strategy and selection process for research articles. Process of selecting eligible studies. We used the Jadad scale [8,9] to assess the quality and reliability of the study results in the selected clinical trials. According to the scale assumptions, attention was paid to three main categories: randomization (0 points for quasi-RCTs; 1 point if randomization was declared but without a detailed description of the generation of random numbers; 2 points if a valid method of generating random numbers was described), double-blind (0 points if blinding was not mentioned; 1 point if blinding was mentioned but efficacy was not described; 2 points if the study used a robust method, such as placebo, to ensure double-blindness), and withdrawals and abandonments (0 points if withdrawals were not described despite a smaller number of patients analyzed compared to those recruited). The Jadad scale classified scores of 0–2 as indicating low quality clinical trials, 3 as moderate quality, and 4–5 as high quality clinical trials.
NT-proBNP as a diagnostic tool in COVID-19 The studies by Caro-Codón et al. (2021) have significantly contributed to understanding the role of NT-proBNP as a diagnostic tool in the context of COVID-19[10]. They have shown that NT-proBNP is an extremely sensitive marker of myocardial damage in patients with COVID-19, even in cases where standard cardiological tests do not show visible abnormalities. Of particular importance is the fact that NT-proBNP can detect subclinical cardiac dysfunction. This means that this marker can signal heart problems before clear clinical symptoms or changes visible in imaging
studies appear. This property of NT-proBNP is extremely valuable in the context of COVID-19, where heart damage can develop slowly and initially asymptomatically. In addition, these studies have shown that NT-proBNP levels correlate with the severity of COVID-19 and the risk of cardiovascular complications. Patients with higher levels of NT-proBNP during the acute phase of the disease were more likely to develop serious complications, including heart failure, arrhythmia, and even death. COVID-19 can affect the heart through various mechanisms, and NT-proBNP plays a key role in detecting and monitoring these changes. The main mechanisms by which COVID-19 affects the cardiovascular system include:
NT-proBNP in monitoring heart dysfunction after COVID-19 The research by Sánchez-Marteles and colleagues (2024) has significantly advanced our understanding of the role of NT-proBNP in the long-term monitoring of patients after COVID-19 [11]. They showed that NT-proBNP is not only a valuable tool in the acute phase of the disease, but also during the convalescence period and long-term follow-up. Regular NT-proBNP measurements can help identify patients with progressive heart dysfunction, even in the absence of clear clinical symptoms [12,13]. This is particularly important in the context of “long COVID”, where cardiovascular complications can develop slowly and initially asymptomatically. These studies also showed that NT-proBNP levels can be a predictor of long-term outcomes in patients after COVID-19. Patients whose NT-proBNP levels remained elevated for a longer period after recovery from the acute phase of COVID-19 had a higher risk of developing chronic heart diseases, including heart failure. In addition, monitoring NT-proBNP can help assess the effectiveness of treatment. A decrease in NT-proBNP levels over time may indicate an improvement in heart function and the effectiveness of the applied therapy [14,15].
NT-proBNP Index:
An Improved Diagnostic Tool introduced an innovative concept of the NT-proBNP index, which significantly improved the diagnostic accuracy of this biomarker [16,17]. This index takes into account not only the absolute level of NT-proBNP but also the patient's age and gender, which allows for a more precise assessment of the risk of cardiac dysfunction after COVID-19. This concept is based on the observation that the normal level of NT-proBNP may vary with age and gender. For example, older patients and women tend to have higher NT-proBNP levels even in health [18, 19] and trails are summarized in the meta‐analysis, and their characteristics are presented in table 1.
| Study | Data | Study design | Region and Country | Diagnostic criteria | n | predicting 30-day mortality. |
| 4 | 2020/01–2020/02 | retrospective, observational study | Beijing, China | coronary artery disease | 85 | 31% |
| 6 | 1991/02- 1993/02 | prospective observational study | The Danish | patients with symptoms or signs of coronary artery disease | 1078 | 1,5-4% |
| 8 | January 1 to January 28, 2020 | single-center case | Wuhan, China | novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) | 138 | 4,3% |
| 15 | March 1st to April 20th, 2020 | observational study | Madrid, Spain | myocardial injury | 918 | 1,57–4,04 |
| 16 | February 27 to April 7, 2020 | single-center prospective study | Barcelona, Spain, | patients were diagnosed with COVID-19 | 923 | 7,4% |
| 17 | 2008-2012 | multi-center prospective study | USA | Patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) | 2690 | 1-1,7% |
| 18 | January 20, 2020, to February 10, 2020 | single-center prospective study | Wuhan, China | patients with COVID-19 | 416 | 3,41% |
| 20 | 1987- 2013 | trial-level analysis of 16 phase III chronic HF trials | USA, Europe | heart failure (HF) | 48844 | 5% |
| 21 | 2003-2013 | observational study | Sweden | Patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) | 9136 | 0,63-1,5% |
| 23 | 2020-2022 | retrospective analysis | China | patients diagnosed with COVID-19 | 2917 | 3,90% |
Table 1: The characteristics of the included studies
The NT-proBNP index takes into account these differences, allowing for a more personalized interpretation of the results. The NT-proBNP index is calculated by dividing the measured NT-proBNP level by the upper limit of the normal range for a given age and gender. An index value above 1 suggests an increased risk of cardiac dysfunction, with higher values indicating a higher risk. Studies have shown that NT-proBNP is a better predictor of clinical outcomes than absolute NT-proBNP values alone, especially in older patients. It can help identify high-risk patients who may require more intensive monitoring and treatment [20,21]. Challenges in Interpreting NT-proBNP Results Despite its diagnostic value, the use of NT-proBNP in the assessment of cardiac dysfunction after COVID-19 is associated with certain challenges that must be considered when interpreting results:
1. Nonspecificity of the marker: NT-proBNP levels may increase not only in heart disease but also in other conditions such as renal failure, hyperthyroidism, and chronic obstructive pulmonary disease. Therefore, it is important to interpret NT-proBNP results in the context of the patient's complete clinical picture.
2. Influence of age and gender: As mentioned earlier, the normal range of NT-proBNP levels may vary by age and gender. Older patients and women tend to have higher NT-proBNP levels, which must be considered when interpreting results.
3. Differences in measurement methods: Different laboratories may use different methods to measure NT-proBNP, which may lead to some discrepancies in results. It is important to consider the measurement method when comparing results.
4. Influence of other factors: Factors such as obesity, anemia, or the use of certain medications may affect NT-proBNP levels. This should be kept in mind when interpreting results.
5. Dynamics of change: A single NT-proBNP measurement may not be sufficient for a complete risk assessment. It is important to monitor changes in NT-proBNP levels over time.
Analysis of biomarkers (markers of myocardial damage, inflammation and prothrombotic status) in SARS-CoV-2 infected patients with pre-existing cardio-vascular disease is currently the subject of research and discussion. However, the importance of myocardial damage, defined as cardiac troponin levels above the 99th percentile of the normal range, regardless of new electrocardiographic and echocardiographic abnormalities, during SARS-CoV-2 infection is emphasized. Elevated troponin levels (myocardial damage) and a positive correlation between hs-TnI levels and mortality. was observed in elderly patients and burden of cardiovascular disease, such as hypertension (59.8% vs. 23.4%), diabetes (24.4% vs. 12.0%), ischemic heart disease (29.3% vs. 6.0%), cerebrovascular disease (15.9% vs. 2.7%) and heart failure (14.6% vs. 1.5%) [30]. Patients with cardiovascular disease and other comorbidities are at greater risk of myocardial damage during COVID-19. In patients with cardiovascular disease, including hypertension, coronary artery disease and cardiomyopathy, viral disease can further damage myocardial cells through several mechanisms, including direct damage by the virus, systemic inflammatory reactions, destabilization of the coronary plaque and increased hypoxia [31].
Although the exact pathophysiological mechanism underlying COVID-19-induced myocardial damage is not fully understood, it draws attention to the possibility of direct damage to cardiomyocytes by SARS-CoV-2 virus. Viral particles spread through the respiratory mucosa and simultaneously infect other cells, which can trigger a cytokine storm and a range of immune responses. Highlighted that in patients with COVID-19, an imbalance of T helper 1 and T helper 1 responses caused a cytokine storm that can contribute to myocardial damage. The release of inflammatory cytokines after infection can result in reduced coronary blood flow, reduced oxygen supply, coronary plaque destabilization and microthrombogenesis [32,33]. NT-proBNP peptide has been recognized as an effective biomarker not only for diagnosis and risk stratification, but also for treatment optimization and prognostic evaluation in patients regardless of HF classification. Higher levels of NT-proBNP in patients on admission were associated with a worse prognosis, while lower levels of NT-proBNP reflected relatively better myocardial health. As NT-proBNP is released by the myocardium, it is thought to affect the activation of the renin-angiotensin-aldosterone system (RAAS) and sympathetic nervous system. Studies have shown that NT-proBNP levels were strongly correlated with left ventricular dimensions, volumes and functions, and were seen as useful tools for identifying actual cardiac hemodynamic conditions.
The role of NT-proBNP in the diagnosis and monitoring of cardiac complications after COVID-19 is still evolving. Further research in this area may contribute to: Establishing optimal cut-off points for different patient groups: Further studies are needed to determine the optimal NT-proBNP thresholds for different age and gender groups in the context of COVID-19. Developing algorithms combining NT-proBNP with other biomarkers: Combining NT-proBNP with other markers, such as troponin or CRP, may increase diagnostic and prognostic accuracy. Creating personalized strategies for monitoring patients after COVID-19. Studies may help develop individual monitoring protocols based on NT-proBNP levels and other risk factors. Better understanding of the long-term effects of COVID-19 on the heart. Long-term studies using NT-proBNP may help understand how COVID-19 affects the heart in the long term. Development of new therapies: Understanding the role of NT-proBNP may lead to the development of new strategies for the treatment of cardiac complications after COVID-19.
NT-proBNP has proven to be an extremely valuable diagnostic tool in the assessment of cardiac dysfunction after COVID-19. Its use allows for early detection of cardiac complications, optimization of treatment strategies and monitoring of patients in the long term after infection. Key advantages of using NT-proBNP in the context of COVID-19 include: Early detection of subclinical cardiac damage. Ability to predict the severity of COVID-19 and the risk of complications. Help in monitoring disease progression and treatment efficacy. Ability to identify patients requiring long-term cardiac care. Further research on this biomarker may contribute to a better understanding and treatment of cardiac complications associated with COVID-19, which may have great public health implications in the post-pandemic era. As our knowledge of the long-term effects of COVID-19 increases, the role of NT-proBNP as a key tool in the care of patients after COVID-19 will likely become increasingly important.
None declared
Conceptualization PŁ, AWR.; methodology PŁ, AWR,: validation, PŁ, AWR ; formal analysis, P.S and AWR. writing—original draft preparation, PŁ, AWR supervision, PŁ, AWR All authors have read and agreed to the published version of the manuscript.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
