AUCTORES
Globalize your Research
Research Article | DOI: https://doi.org/10.31579/2690-4861/891
Department of Transfusion Research, Dongguan Blood Center, Guangdong 523000, China.
*Corresponding Author: He Ziyi, Department of Transfusion Research, Dongguan Blood Center, Guangdong 523000, China.
Citation: He Ziyi, Hu Yingming, Bei Menghui, Jie Xiaomei, (2025), The Role of Mitogen-Activated Protein Kinase Kinase (MEK) in Hepatocellular Carcinoma, International Journal of Clinical Case Reports and Reviews, 30(1); DOI:10.31579/2690-4861/891
Copyright: © 2025, He Ziyi. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 18 June 2025 | Accepted: 16 July 2025 | Published: 22 September 2025
Keywords: institutional-normative factors, social norms covid-19, personal protective behaviour, mazandaran province
The mitogen-activated protein kinase kinase (MEK) pathway is a key regulator of cell proliferation, survival, and differentiation, and its dysregulation is closely linked to hepatocellular carcinoma (HCC) development. This retrospective study aimed to investigate the expression of MEK in HCC, its association with clinicopathological features, and prognostic significance. A total of 260 HCC patients who underwent surgical resection at our institution from 2016 - 2021 were included. MEK expression in tumor and adjacent non-tumor tissues was detected by immunohistochemistry. High MEK expression in tumor tissues was significantly associated with larger tumor size (p = 0.003), higher histological grade (p = 0.01), microvascular invasion (p = 0.001), and elevated alpha-fetoprotein (AFP) levels (p = 0.005). Multivariate Cox regression analysis identified high MEK expression as an independent predictor of poor overall survival (hazard ratio [HR] = 2.2, 95% confidence interval [CI]: 1.4 - 3.5, p < 0.001) and recurrence-free survival (HR = 2.1, 95% CI: 1.3 - 3.3, p = 0.002). These findings highlight the critical role of MEK in HCC progression and suggest its potential as a prognostic biomarker and therapeutic target.
With the rapid development of blood transfusion technology, automatic blood group analyzer based on MGT has been widely used in blood group serological detection, almost replacing the traditional blood group serological technology such as saline method, polybrene method and antiglobulin method. MGT has high sensitivity and specificity in crossmatching [1], and compared with polybrene method, MGT can significantly improve the detection rate of unexpected antibodies [2]. Wang Wenting et al reported[3] that 164,838 cases of cross-matching blood by MGT were negative, and 35 cases of positive blood were detected by cross-matching by saline method and polybrene method. The reason was analyzed that the laboratory over-relied on a single MGT for cross-matching and missed the detection of saline-reactive antibodies, but the report did not find unexpected anti-E missed during cross-matching by MGT. There were no reports of anti-E missed by the MGT when searching the literature on the "China National Knowledge Network", but there were more reports of anti-E detected by the MGT after the missed detection by the polybrene method [4], and the detection rate of anti-E by the MGT (37 cases) was higher than that by the polybrene method (20 cases) [5]. In the routine work of our laboratory, we found that there are two serological reaction characteristics of anti-E from human sources, one is missed by MGT and detected by polybrene method, and the other is detected by MGT and polybrene method. We speculated that there might be two kinds of anti-E immunoglobulins with high and low charges, and designed low ion and strong ion reaction system to verify the experiment, as reported below.
1.1 General Information Case 1: The patient was a 77-year-old female with 3 pregnancies and 2 pregnancies and a history of transfusion. She developed fever and adverse transfusion reactions during transfusion of white suspended RBC. She was clinically diagnosed with hemorrhagic anemia, RBC:1.47×1012/L, Hb 47g/L, hematocrit 14.8%, blood group:O, RhD(+), and applied for transfusion of washed RBC. Case 2: A 32-year-old female patient with 4 pregnancies and 2 births, unknown transfusion history, clinically diagnosed hemolytic anemia, applied for infusion of washed RBC 4U.
1.2 Specific identification: Anti-E by MGT or polybrene method, unexpected antibodies were identified as anti-E, no autoantibodies or other unexpected antibodies, no lipids, no hemolysis.
1.3 Instruments and reagents: Diana microcolumn gel card incubator and special centrifuge, KA-2200 Kubota centrifuge. MGT provided by Diana Company; Polybrene reagents, screening cells, Pannel cells, monoclonal anti-A, anti-B blood group reagents, monoclonal anti-E are provided by Shanghai Blood Biomedicine Co., LTD. Pannel cell 2 was produced in Hungary (Lot: 732209); IgG monoclonal anti-D,IgG monoclonal anti-AB, and anti-globulin reagents are manufactured by DIAGNOSTICS SCOTLAND. ABO reverse reagent for RBC was made by our laboratory.
1.2 Methods
1.2.1 Blood group ABO/RhD blood group was performed using the saline test.
1.2.2 Screening and identification of unexpected antibodies The routine method is to first detect IgM unexpected antibodies by saline method, and then to screen IgG unexpected antibodies by MGT. If the unexpected antibodies are positive, Pannel cells are used for antibody specific identification. MGT and Polybrene method were used for screening and identification of IgG unexpected antibodies.
1.2.3 Cross-matching: Primary and secondary cross matching, the saline test method was used, and then the MGT and the Polybrene method were used for cross-matching.
1.2.4 Comparison between low ion reaction system and high ion reaction system
RhE positive RBC were selected, washed with 0.9%NaCl for 3 times, hematocrit was taken and Liss solution was used to prepare 4% and 1% RBC suspensions as low ion salt suspension RBC, and 0.9% NaCl was used to prepare 4% and 1% RBC suspensions as high ion salt suspension RBC. Human anti-E was diluted 1:4 with Liss solution and 0.9%NaCl, respectively. The suspended RBC and diluted human anti-E were detected by MGT and Polybrene method.
2.1 Blood group identification ABO group: O, RhD(+).
2.2 Unexpected Antibody screening The sample 1 was negative in saline medium and MGT, and strongly positive "3+" in Polybrene method. Sample 2 did not agglutinate in saline medium, and the agglutination strength of cells screened by MGT was "2+", which was significantly higher than that by Polybrene method (see Table 1).
| Methods | Samples 1 | Samples 2 | ||||||
| O1 | O2 | O3 | Control | O1 | O2 | O3 | Control | |
| saline medium | - | - | - | - | - | - | - | - |
| MGT | - | - | - | - | 2+ | - | 2+ | - |
| Polybrene | 3+ | - | 3+ | - | ± | - | ± | - |
Table 1: Results of unexpected antibody screening by three serological methods
2.3 Unexpected Antibody identification In sample 1, unexpected antibody identification was performed by MGT, and cells Ⅰ to X were negative (see Figure 1); Unexpected antibody identification was performed by Polybrene method, and cells II, IV and IX were positive (see Figure 2), and the reaction pattern was completely consistent with that of anti-E. The anti-E in sample 1 was missed by MGT. Sample 2 was unexpectedly identified by MGT. Cells II, VI, VII, Ⅷ and X of the Pannel cells were positive (see Figure 3). Cells I - X of the Pannel cells were negative by Polybrene method. The RBC E antigen of the two patients was identified by monoclonal anti-E, and the presence of anti-E in the plasma of the patients was determined with titers of 1:8 and 1:4, respectively.
Figure 1: Unexpected antibody identification by MGT
Figure 2: Unexpected antibody identification by Polybrene method
Figure 3: Results of unexpected antibody identification in sample 2
2.4 Cross matching O, RhD(+)Ec (-) RBC were selected for cross matching, and there was no agglutination or hemolysis in saline medium,
MGT and polybrene method. RBC from Rh Ec(+) simulated donors were selected to exhibit agglutination reaction on the main cross-matching with the polybrene (see Table 2).
| ABO | Rh | Sample 1 main cross matching | Sample 2 main cross matching | |||||
| N.S | MGT | Polybrene | N.S | MGT | Polybrene | |||
| Donor 1 | O | D (+),Ec（-） | - | - | - | - | - | - |
| Donor 2 | O | D (+),Ec（-） | - | - | - | - | - | - |
| Simulated donor | O | D(+),Ec（+） | - | - | 3+ | - | 2+ | ± |
Table 2: Results of cross-matching between donor and simulated donor
2.5 Comparison between Liss liquid (low ion) and 0.9% NaCl (strong ion) reaction system. The concentration of 4% Liss liquid suspended RBC and 0.9% NaCl suspended RBC were reacted with 1:4 diluted plasma containing anti-E, respectively. Sample 1 was negative by MGT and positive by polybrene method. Sample 2 was positive by MGT and stronger than polybrene method, especially negative in 0.9% saline medium after dilution (see Table 3).
| Reaction system | Sample 1 | Sample 2 | ||
| MGT | Polybrene | MGT | Polybrene | |
| 0.9% NaCl suspended red blood cells + human anti-E serum | - | 2+ | 2+ | + |
| Liss liquid suspension Red Blood cells +Liss diluted plasma (1:4) | - | 2+s | 3+ | 1+ |
| 0.9% NaCl suspended red blood cells +0.9% NaCl diluted plasma (1:4) | - | +s | 1+ | - |
Table 3: Comparison of Liss liquid (low ion) and 0.9% NaCl (strong ion) reaction system detection
The commonly methods for detecting IgG antibodiesinclude polybere method, antiglobulin method, MGT and enzyme medium method. The saline method is mainly used to detect IgM antibodies, which is an indispensable step in cross-matching. This method can find IgM unexpected antibodies, Group errors or determine whether hemolysis occurs, but cannot detect IgG unexpected antibodies. The process of polybere method is quick, simple and manual operation, but it is not sensitive to the antibodies of Kell group system, and K antigen in Chinese is almost 100% negative, so this method is widely used in primary medical institutions. Antiglobulin method is recognized as the "gold standard", but its operation time is long, there are many steps, many influencing factors, and it needs manual operation. Based on the gel filtration technology and the specific reaction principle of immunochemical antigen and antibody, the MGT controls the size of the gel gap by adjusting the concentration of the gel, so that the gap can only allow free RBC to pass through, so that free RBC and agglutinated RBC can be separated. This method has high sensitivity, simple operation, clear, and easy automation. And there is no need to worry about the false negative caused by the neutralization of anti-globulin antibodies, so this method has been widely used, and even will completely replace the saline method, polybere method and other methods.
Unexpected antibodies are a major cause of cross mismatch, most commonly in the Rh system. It was reported that the cross mismatch caused by unexpected antibodies accounted for 80.9% of the total cross mismatch [6], among which 25.9% (14/54) was caused by anti-E in the Rh group system [7], and there were more reports of hemolytic transfusion reactions caused by anti-E [8-13]. It is generally believed that the sensitivity of MGT to detect unexpected antibodies is higher than that of the ploybere method, but there are few reports of missing anti-E detection by MGT in China. Wang Wenting et al. [3] reported that 164,838 cases of cross-matching blood with MGT were detected by MGT, and no missed anti-E was found, and 35 cases of missed antibodies were all IgM unexpected antibodies. The anti-E found in this study was missed in antibody screening and antibody identification by MGT, but showed obvious positive reaction by polybere method. There was no positive reaction when Ec (+) RBC were cross-matched by MGT, but there was agglutination reaction when the main side was cross-matched by polybere method. In this case, if only the MGT is used for cross-matching, the RBC of E (+) may be mistakenly sent to the clinic, which may lead to delayed hemolytic transfusion adverse reactions. It has been reported that the sensitivity and specificity of polybere method used in cross-matching and screening of incomplete antibodies are 1-250 times higher than other media [14,15]. Polybere is more sensitive in the determination of most antibodies (such as Rh system antibodies, Kidd system) than enzymatic method and traditional antiglobulin method [16]. The anti-E sensitivity of sample 1 was better than that of the MGT. On the contrary, the reaction strength of sample 2 was stronger than that of the MGT. When the original plasma was diluted to 1:4, the polybere rule was missed. It is speculated that the amount of charge carried by the anti-E immunoglobulins produced by different individuals in the RBC is different, thus affecting the affinity between the anti-E immunoglobulins and the corresponding antigens. In the strong ionic medium, the anti-E immunoglobulins carrying more negative charges have a strong charge rejection effect on the RBC, so the antigen-antibody reaction cannot be well completed in the low ionic medium. The amount of charge of immunoglobulin is reduced, the rejection is weakened, but it is more prone to antigen-antibody reaction, which shows a positive reaction in the polybere method, and a negative reaction in the MGT. However, the charge repulsion of RBC with low charge of anti-E immunoglobulins and corresponding antigen is weak, and they are more sensitive in MGT. Experiments confirmed that the amount of charge carried by anti-E immunoglobulin and RBC was reduced in the low-ion solution system, and the decrease of charge repulsion made it easier for the RBC antigen and immunoglobulin antibody to bind to the immune antigen and antibody, showing the enhanced reaction in the low-ion salt solution, which also explained the reason for the missed detection by MGT method in the high-ion reaction system. In this report, it is speculated that there are two types of anti-E immunoglobulins derived from human sources, one of which carries a high negative charge, such as the anti-E derived from sample 1, and the other carries a weak negative charge, such as sample 2. The detection sensitivity of MGT is higher than that of polybere, which is consistent with most literature reports that such antibodies are easily missed by polybere [4,5]. Therefore, there is no single method that can detect all antibodies at the same time, and cross-matching methods with different sensitivity and specificity should be selected for different patients or antibodies[17]. At present, there is a lack of direct evidence for this speculation, such as detecting the amount of charge carried by immunoglobulins.
In summary, this study confirmed that there are two types of human anti-E, one missed by MGT and the other missed by polybere method. It is speculated that these two types of human immunoglobulins have the same immune reactivity, but the amount of charge they carry is different. Different media may have differences in different blood group systems or different specific antibodies, and a single method may cause unexpected antibody missed detection. It is advisable to use more than two media methods, and take advantage of the advantages of the two methods, such as low-ion medium micro-gel method, to better ensure the safety of clinic.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
