AUCTORES
Globalize your Research
Research Article | DOI: https://doi.org/10.31579/2578-8965/028
Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
*Corresponding Author: Hend S Saleh, Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt: E-mail: drhendsaleh@yahoo.com
Citation: Hend S Saleh, Hala E Sherif and Eman M Mahfouz. (2019) Single Dose of Methotrexate Therapy Followed By Suction Curettage for Management of Cesarean Scar Pregnancy. Obstetrics Gynecology and Reproductive Sciences, 3(1): DOI: 10.31579/2578-8965/028
Copyright: © 2019. Hend S Saleh. This is an open-access article distributed under the termsof the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Received: 06 November 2019 | Accepted: 16 November 2019 | Published: 02 December 2019
Keywords: ectopic pregnancy; cesarean section; scar; curettage ; MTX treatment
Objective
Implantation of the pregnancy in a cesarean scar is a rare condition named ; Cesarean scar pregnancy (CSP). Maternal complications can be prevented with the early diagnosis and an appropriate management .It is a Prospective clinical study to evaluate the efficacy and success rate of single dose use of methotrexate (MTX) followed by dilation and suction (D&S) regimen in management of women with cesarean scar pregnancy (CSP).
Methods
50mg of MTX in the form of a single dose Intramuscular injection then cervical dilatation and suction aspiration with a Karman cannula(D&S) under guidance of ultrasound after 48 preeceeded by vaginal misoprostol 2 tablet (200 mg) 4 hours ago.
Results
The mean gestational age at diagnosis was (8.5±1.6 ) and The mean level of serum b-human chorionic gonadotropin was (7424±2.560 ) and The mean gestational age of pregnancy was (8.5±1.6 ) .88.7% is the successive rate without complication need intervention, 2 (5.7%) patients needed intrauterine Foley's catheter for 24 hours as a mechanical hemostasis . 2 (5.7 %) had laparotomy with wedge resection of the gestational sac lesion and successful repair of the uterine defect and one (2.8 %)underwent subtotal hysterectomy.
Conclusion: Systemic single dose MTX injection followed by D&S is an effective and harmless management for CSP. Nevertheless more studies are required to prove the efficiency, safety, and reproductive outcome of variant modalities in treatment of CSP.
Increase the incidence caesarean delivery lead to attendance of one serious complication which is Cesarean scar pregnancy (CSP) is a uncommon form of ectopic pregnancy in which the gestational sac is imbedded in a cesarean scar of the lower uterine segment.[ 1]CSP is a risky condition, probably leading to immense bleeding uterine rupture,and life-threatening complications[2].The accurate incidence of CSP is unidentified. It is presently valued at 1:1800-2200 pregnancies. It exemplifies 6.1% of whole ectopic pregnancies with a history of at least one previous caesarean Section [ ,3 ]
The etiology and pathophysiology of CSP is still unidentified , may be related to an standing scar defect or microscopic dehiscent tract created between the previous cesarean scar tissue and the endometrial canal [4]. In the early days of pregnancy the blastocyst invades the myometrium via a microscopic abrasion present in the cesarean scar linked to a preceding uterine trauma such as cesarean section, metroplasty, myomectomy, and may be the manual elimination of the placenta. Some authors revealed its potential association to intrauterine Device and pelvic Inflammatory disease [5]. The most common symptom is painless vaginal bleeding that may be massive. There is no definite clinical sign of CSP.
Clinical history, serial serum human chorionic gonadotropin (HCG) measurements and transvaginal ultrasound examination, mainly in pregnant woman with a previous cesarean delivery early in pregnancy are necessary for early diagnosis and termination of that pregnancy .[6] Also magnetic resonance imaging (MRI), and endoscopic modalities may be helpful for diagnosis and the management of(CSP). It is frequently required for cases in which the TVUS is not definite or did not obviously prove urinary bladder Envelopment [ 7] To decrease the threat of a false diagnosis and improve its accuracy, a collective ultrasound ( TVS, TAS, color flow Doppler, and three-dimensional TVS ) should be suggested [ 8]The modalities of treatment are whichever medical , surgical or combined .There is no agreement on the favorite mode of management. Medical protocol Includes systemic ( single or repeated doses) or local administration of methotrexate (MTX),potassium chloride, trichosanthis, or mifepristone.[ 9] Surgical options; embrace uterine curettage, hysteroscopy resection, laparotomy or laparoscopic resection for patients are wishing to reserve fertility .[10] Selection of mode of termination depends on features like size of pregnancy, the hemodynamic Prominence of the patient, presence or absence of scar rupture, levels of hCG, and craving for upcoming fertility . [11] MTX is an antimetabolite drug used broadly in treatment of ectopic pregnancies. Systemic route is the least invasive management and has been commonly used for stable patients. Fertility preservation and reducing the requirement to surgery are the main advantages of its use. However, its use alone needs an extended time to follow-up both beta-hCG to return to normal and gestational mass to resolve [12] some studies proved that CSP responded well to the single dose of Systemic MTX 50 mg/m2
When HCG level is lower than 5000 mIU/ml. [13] others found that single-dose, systemic MTX was not sufficient, so they had to achieve multiple doses of MTX with its drawbacks. [14] Others found that combination of single dose of systemic Methotrexate followed by D&S can avoid these needless laparotomy and preserve fertility in most women with CSP. [15] our aim of the work, to evaluate the efficacy and safety of single dose of of Systemic MTX 50 mg/m2 followed by D&S in cases of Cesarean scar pregnancy (CSP) .
This is a prospective clinical study was done on 35 pregnant females with a diagnosis of CSP between 6 and 11weeks were admitted to our department from January 2017 to July 2019.
Gestational age was considered built on last menstrual period and accustomed according to the ultrasound dating.They were managed by MTX injection followed by D&S (combined therapy group) .All enrolled Women were hemodynamically stable,, had no internal bleeding, or ruptured CSP, the gestational sac ±8 weeks and had no contraindications to MTX, like elevated liver neutropenia or disturbed renal function tests. The diagnosis of CSP was proved according to the following criteria;
- Positive serum b-hCG levels,
- History of lower uterine segment cesarean delivery
-Gratification of the following ultrasonography conditions;
a) Visualized endometrium with an empty uterine cavity
b) A pure observable empty cervical canal;
C) A gestational sac with or without cardiac activity positioned anteriorly at the level of the the lower uterine segment with cesarean scar,{ internal os } inside a evident myometrial fault between the bladder and the sac on sagittal view of the uterus .
d) Negative ‘‘sliding organs sign,’’ which was demarcated as the failure to dislodge the gestational sac from its place at the level of the internal os using mild pressure smeared by the transvaginal probe.
e) Suggestion of functional placental circulation / trophoblastic on color flow Doppler examination [16] A written informed consent was taken from all participants. Our study was approved by the institutional research ethical committee of zagazig University according the standards of Helsinki Declaration .Full informations and counseling about nature of management and its hazards were given to the patients. All patients were managed by ;50mg of MTX in the form of a single dose Intramuscular injection then cervical dilatation and suction aspiration with a Karman cannula (D&S) under guidance of ultrasound after 48 preceded by vaginal misoprostol 2 tablet (200 mg) 4 hours ago. Positive outcomes were:
● decreasing serum b-hCG levels up to normal level.
● Vanishing CSP mass,
● evading the foremost complications like; rupture of uterine scar, hemorrhage, Conversion to laparoscopic surgery or laparotomy, or hysterectomy.Statistical analyses were done with SPSS for Windows (version 16.0; SPSS, Chicago, IL). Data were analyzed for normal distribution with the Kolmogorov-Smirnov test and for homogeneity of variance with Levene test. The variables did not meet homogeneity of variance and normality and were analyzed using Mann-WhitneyU test.
The demographic criteria of patients were presented in Table 1. Mean age, parity and gravity of patients was (32.1±3.5 years), 2.1±0.5 and 3.4±1.7 respectively. At ultrasound scan, Wholly 35 women had an empty uterine cavity with the gestational placed at the site of scar, nearby the bladder. All women had a history of previous cesarean section .The mean gestational age at diagnosis 8.5±1.6 (wks). The mean Levels of HCG were documented before starting the management 7424±2.560 (mIU/mL). The mean of myometrial thickness between the sac and the bladder wall under ultrasonic investigation was 2.6±0.89 mm.All females had a history of previous uterine surgery. The mean number of previous cesarean sections was 3.6±0.72, from the 35 women, 8(22.5%) had three, 18 (51.4%) had two, 6 (17.1%) had one, 2 (5.7%) had had four and 1 (2.8%) had five CDs.
At the time of diagnosis, 50% of the females were complaining from mild vaginal bleeding, and remaining were diagnosed with routine antenatal ultrasound examination without complaint.
Values are presented as mean ± SD, No. (Percentage %)
Post dilatation and suction (D&S), two cases had plentiful vaginal bleeding which was controlled with a Foley's catheter put intrauterine for 24 hours as a mechanical hemostasis. Three patients need laparotomic hysterotomy two of them can managed by wedge resection of the gestational sac lesion and successful repair of the uterine defect. Only one, had profuse intraoperative bleeding and big defect in the uterus at the scar area, which was cotrolled by urgent subtotal hysterectomy, Salpingectomy, with conservation of the ovaries. No more complications postoperatively were observed either at the 1-week or 1-month follow-up
Systemic administration of MTX is a standard management for tubal and cervical pregnancy (17). In the Current study we found that a single dose of 50 mg IM MTX followed by D&S had a high cure rate , In patients with CSPs . In study of Hua Wang, etal 2008 , who compared the efficacy of methotrexate (MTX) regimen only or MTX regimen followed by dilation
curettage (D&C). in women with cesarean scar pregnancy (CSP) , they found that Both regimens could treat most of CSP patients efficaciously, but the combined one caused a shorter period of treatment and designated a more satisfactory effect.[18] In the current study, 88.6%
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
