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Research Article | DOI: https://doi.org/10.31579/2690-8794/281
1Escola Bahiana de Medicina e Saúde Pública. Discente no Departamento de Medicina, Salvador, BA, Brazil.
2Escola Bahiana de Medicina e Saúde Pública. Mestre, Professor Assistente de Neurologia, Salvador, BA, Brazil.
*Corresponding Author: Ayssa Carneiro Castor de Vasconcelos, 1Escola Bahiana de Medicina e Saúde Pública. Discente no Departamento de Medicina, Salvador, BA, Brazil.
Citation: Ayssa Carneiro Castor de Vasconcelos, Calil Darzé Neto, (2025), Prevalence of mood and/or anxiety disorders in patients with essential tremor: an integrative review, Clinical Medical Reviews and Reports, 7(7); DOI:10.31579/2690-8794/281
Copyright: © 2025, Ayssa Carneiro Castor de Vasconcelos. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 29 August 2025 | Accepted: 15 September 2025 | Published: 30 September 2025
Keywords: essential tremor; mood disorders; anxiety; prevalence
Introduction: Essential tremor is a highly prevalent movement disorder worldwide. Characterized by tremors in the upper limbs, it can also affect other regions of the body and often compromises patients' ability to perform daily activities. The disease has a strong relationship with family history, commonly appearing between the second and sixth decades of life, and its prevalence is proportional to the population's age. While its pathophysiology is not entirely understood, several hypotheses exist, such as the neurodegenerative, GABAergic, and central oscillatory network hypotheses. Treatment options for this condition include pharmacological or surgical approaches. Although it was long considered a monosymptomatic disease, it is now known that essential tremor is correlated with psychiatric symptoms. These symptoms may arise from the condition's underlying pathophysiology or from the social stigma experienced by individuals due to the tremor, leading to anxiety and depression. Thus, studying the prevalence of these symptoms in this population is essential. Objectives: To describe the prevalence of mood and anxiety disorders in patients with essential tremor. Methods: A literature review was conducted using the databases PubMed, EMBASE, LILACS, Scielo and Pepsic. Cross-sectional studies, cohort studies, and clinical trials were included. Studies were excluded if the patients were not diagnosed with essential tremor according to the Movement Disorder Society criteria or if mood and anxiety disorders were not diagnosed according to the DSM-IV criteria. Results: Initially, 1,288 articles were identified, of which 4 met the eligibility criteria for this review. A significant association was found between the studied variables, with the prevalence of depression ranging from 15% to 27% and anxiety ranging from 16% to 42% in patients. Conclusion: The prevalence of mood and/or anxiety disorders in patients with essential tremor is higher than in healthy individuals.
Essential Tremor is one of the most common movement disorders, with an estimated prevalence of about 1% in the general population [1]. It has a clinical diagnosis, defined as bilateral tremor of the upper limbs lasting at least three years, which may or may not involve other parts of the body, such as the head, vocal cords, and, less frequently, the lower limbs [2]. This condition can develop at any stage of an individual's life; however, it has peaks of onset around the ages of 20 and 60 years old. It often occurs in individuals with a family history of the disorder [1].
Studies on the pathophysiology of Essential Tremor consistently show a relationship between this condition and alterations in the cerebellar-thalamic-cortical circuit of affected individuals, and Purkinje cells are significant components in this dynamic, as they are involved in degenerative processes associated with the disease's development [1,3].
Essential Tremor typically has an insidious onset, worsening progressively over the years and its intensity may increase with stress and decrease with the use of small amounts of alcohol [1,2]. Treatment for this condition can be pharmacological or surgical. Propranolol and primidone are the first-line medications aiming to reduce tremor severity. Surgical treatment involves deep brain stimulation or thalamotomy [4].
On the other hand, Essential Tremor, which for a long time was considered to be a purely motor disease, has shown, through studies, a pattern with a varied spectrum of non-motor symptoms such as depression and anxiety [3,5,6], which may be due primarily to the neurodegenerative nature of the disease [7], and/or due to situations secondary to the embarrassment and shame experienced by patients as a result of tremor on occasions of social contact [8].
Thus, given the evidence in the literature demonstrating the presence of neuropsychiatric symptoms in patients with Essential Tremor, along with the lack of integrative reviews on this topic, this study aims to analyze the prevalence of mood and anxiety disorders in the described population.
Study design
The present paper is an Integrative Review of the literature on scientific bases, in which the prevalence of mood and anxiety disorders in people with essential tremor will be described.
Search strategies
This review was conducted on November 9, 2023. Data collection was carried out in the electronic databases PubMed, Embase, LILACS, Scielo and PsychInfo by searching the combination of health descriptors and synonyms, evidenced by the Descriptors in Health Sciences (DeCS), Medical Subject Headings (MeSH) and Emtree, with the inclusion of works in English, Portuguese, Spanish and French. The terms to be searched, following a POT strategy as a guide for the integrative review, will be related to the population of interest (Essential Tremor) and related to the outcome (Mood Disorders OR Anxiety).
The search strategies and selection of studies followed the PRISMA protocol (Preferred Reporting Items for Systematic Reviews and Meta-Analyses).
Inclusion and exclusion criteria
We included Articles published from 1998 onwards that fit the design of cross-sectional studies, cohort studies, or clinical trials, considering only the baseline data in the latter two. Male and female patients aged 16 years or older diagnosed with essential tremor by medical evaluation according to the 1998 Moviment Disorder Society criteria were included. These patients may come from the community or specialized centers. The endpoints, mood and anxiety disorders, should be diagnosed according to DSM-IV criteria onwards. Were excluded articles containing patients who, upon further analysis, were not diagnosed with essential tremor based on medical evaluation using the Movement Disorder Society (MDS) criteria, or whose prevalence data were not clearly defined or extractable.
Evaluation of the methodological quality of the selected articles
To assess the risk of bias, the critical tool for use in systematic reviews, JBI (Joanna Briggs Institute), was used for cross-sectional studies, in addition to cohort studies and randomized clinical trials, since only the baseline (cross-sectional) of the latter two will be used. Assessment of the risk of bias was not included as an exclusion criterion for the articles, but was useful for analyzing heterogeneity and studying subgroups.
Results
Identification and selection of studies
After an initial search of the PubMed, EMBASE, Scielo, LILACS and PsycINFO databases, 1288 articles were found, of which 1200 were excluded. Of these, 206 were duplicates, and 994 articles were excluded because they did not fit the study design or did not address the studied topic. A total of 88 articles remained for full-text reading, of which 84 were excluded for not meeting the eligibility criteria or for impossibility to extract the necessary data for the study.
Figure 1: Flowchart of article selection (according to PRISMA)
Characteristics of the included studies
The general characteristics, including study designs and the diagnostic criteria for essential tremor, mood disorders, and anxiety disorders present in the selected journals, are listed in alphabetical order of author, year and country in Table 1.
All four included articles were published in English and the studies were conducted in Turkey [17], Latvia [19], Serbia [18] and Italy [20]. The studied populations consisted entirely of adults and elderly individuals, with sample sizes ranging from 37 to 63 patients. Three of the articles included patients followed up or investigated in Neurology departments and/or specialized centers for moviment disorders as the authors described [17,19,20], while one alticle did not describe the study location [18].
The data was extracted from one clinical trial and three cross-sectional studies, totaling a sample of 190 patients. Major Depressive Disorder and Anxiety disorder were the main psychiatric conditions observed in the articles, being the topics studied in the review. Additionally, two of the articles also highlighted the presence of other psychiatric comorbidities. (17, 19) All the studies used the 1998 Movement Disorders Society criteria for diagnosing essential tremor, and one of them described the additional use of the Fahn, Tolosa, Marin Tremor Rating Scale [19].
Regarding mood and anxiety disorders, all authors used DSM-IV criteria onwards, with the aid of scales to screen for psychiatric symptoms, such as the Symptom Check List (SCL-90R), General Symptom Index (GSI), Structural Clinical Interview-Nonpatient (SCID-NP), Depression Anxiety Stress Scale (DASS), Beck Depression Inventory – 2nd Edition (BDI II), Social Interaction Anxiety Scale (SIAS), Social Phobia Scale (SPS), State-Trait Anxiety Inventory form Y (STAI test), Structured Clinical Interview (SCID-I and SCID-II), Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS), Mini Mental State Examination (MMSE), and Millon Clinical Multiaxial Inventory III (MCMI III).
As far as the quality of the studies is concerned, none of them completed the items proposed by the checklist of the JBI (Joanna Briggs Institute) critical tool for use in systematic reviews. The articles with the lowest risk of bias were those by Fabbrini et al. (2021) [20], followed by Smeltere et al. (2017), conducted in Latvia [19].
Author, Year, Country | Study design |
Study location | Diagnostic Criteria for Essential Tremor | Diagnostic Criteria for Mood Disorders and Anxiety Disorders | Relationship between essential tremor and mood and/or anxiety disorders |
| Fabbrini et al. (2021). Itália. |
Cross-sectional study | Outpatient clinic at the Department of Neurology and Psychiatry, “Sapienza” University of Rome |
1998 Movement Disorders Society diagnostic criteria
| DSM IV/ Structured Clinical Interview (SCID-I e SCID-II) |
The prevalence of mood and anxiety disorders secondary to essential tremor was analyzed |
Günal et al. (2001). Turquia |
Clinical trial | Movement disorder outpatient clinic of a University Hospital | 1998 Movement Disorders Society diagnostic criteria
|
DSM IV/ Symptom Check List (SCL-90R), General Symptom Index (GSI) e Structural clinical interview-nonpatient (SCID-NP) |
The psychiatric evaluation of the patients was frequently pathological; however, there was not enough data to estimate whether the pathologies were secondary to essential tremor |
Smeltere et al. (2017). Letônia | Cross-sectional study | Neurology Outpatient Center at Pauls Stradiņš Clinical University Hospital and the Consulting Room for Parkinson’s Disease and Other Movement Disorders at Health Center 4 | 1998 Movement Disorders Society diagnostic criteria | DSM V/ Depression Anxiety Stress Scale (DASS), Beck Depression Inventory – 2ª edição (BDI II), Social Interaction Anxiety Scale (SIAS), Social Phobia Scale (SPS), State-Trait Anxiety Inventory form Y (STAI test) | Mood and anxiety disorders were analyzed as personality traits and secondary to essential tremor |
Tomic et al. (2012). Sérvia. |
Cross-sectional study | Not described | 1998 Movement Disorders Society diagnostic criteria
| DSM IV/ Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS), Mini Mental State Examination (MMSE), Millon Clinical Multiaxial Inventory III (MCMI III) | The prevalence of mood and anxiety disorders secondary to essential tremor and as pre-motor symptoms was analyzed |
Table 1: Characteristics of studies included in this review
Prevalence of Mood Disorders, Anxiety Disorders and characteristics of the study population
The most commonly described psychiatric disorders in the articles were mood and anxiety disorders, with the former varying between 15% and 27%
of patients, and the latter between 16% and 42%. Gunal et al. also identified conditions such as dysthymia and social phobia in a percentage of the studied population. Additionally, Smeltere et al. also reported the presence of social phobia in a considerable percentage of their population sample. Furthermore, their study compared anxiety symptoms as a personality trait or secondary to essential tremor, with the anxiety state secondary to the disease prevailing over anxiety as a personality trait in 37.5% of patients (19, 20).
Regarding the demographic characteristics of the participants in the selected studies, Günal et al. [17] conducted the study with patients of both sexes, including 32 men and 18 women, with a mean age of 52.2 years (range: 18–75 years). In this study, the average disease duration was 6.2 years (range: 3–25 years) [17].
Smeltere et al. [19] recruited 40 patients, 26 of whom were female. The mean age of the participants was 52.05 years with a standard deviation of ±20.18. The author did not describe the duration of essential tremor or the age of onset [19].
Fabbrini et al. [20] conducted the study with 37 patients, 21 of whom were male, with a mean age of 66.5 years and a standard deviation of ±9.9. The author also reported the age of onset of the tremor, which was 48.9 years with a standard deviation of ±16, and the mean disease duration, which was 17.7 years with a standard deviation of ±15.3 [20].
Tomic et al. [18] selected 63 patients, but it was not possible to extract sex-specific data. The mean age of the participants was 66.5 years with a standard deviation of ±14.9, and the mean disease duration was 16.3 years, with a standard deviation of ±13.8 [18].
None of the studies described the race/color of the participants, and only Fabbrini et al. [20] reported the educational level of the patients, which averaged 13.8 years of schooling with a standard deviation of ±4.2 [20]. Regarding the tremor location in patients, only Günal et al. [17] reported these data in the study, noting that all 50 patients exhibited hand tremors, with 5 patients also presenting head tremors and 3 with voice tremors [17].
Table 2 describes the psychiatric disorders reported in the studies reviewed and the characteristics of the population sample.
| Author, Year, Country | Sex (male/female) | Age (years) summarized | Educational level of the population | Race/ ethnicity | Age of essential tremor onset (years) | Location of essential tremor | Frequency of mood disorder | Frequency of anxiety disorders |
| Fabbrini et al. (2021). Itália. | 37 patients: 21 men and 16 women | Mean age 66.5 ± 9.9 | Years of education 13.8 ± 4.2 | Not reported | Age of tremor onset: 48.9 ± 16 Mean disease duration: 17.7 ± 15.3 | Not reported | 10 patients (27%) | 6 patients (16%) |
| Günal et al. (2001). Turquia | 50 patients: 32 men, 18 women | Mean age 52.2 (18-75) | Not reported | Not reported | Mean disease duration of 6.2 years (3-25) | Tremor nas mãos – 50 pacientes
Tremor adicional na cabeça – 5
Tremor adicional na voz – 3 pacientes | Episodes of Major Depressive Disorder in the past – 19 patients (38%) Dysthymia – 6 patients (16%) Social Phobia – 9 patients (18%) | Anxiety disorder – 21 patients (42%)
|
| Smeltere et al. (2017). Letônia. | 40 patients - 26 women (65%), 14 men (35%)
| Mean age 52.05 (standard deviation ± 20.18) | Not reported | Not reported | Not reported | Not reported | Major Depressive Disorder - 15%
| Disease-related anxiety prevailed in 37.5% of the patients |
| Tomic et al. (2012). Sérvia. | 63 patients – sex distinction not described | Mean age 66.5 + - 14.9 | Not reported | Not reported | Mean disease duration 16.3 ± 13.8 | Not reported | 23,3% | 33,3%
|
Table 2: Characteristics of the studies regarding the patient sample
In this integrative review, the prevalence of depression, the main mood disorder assessed, ranged from 15% to 27% of patients. Regarding anxiety disorders, the range was 16% to 42%. All studies included in this work used the 1998 Movement Disorders Society criteria for the diagnosis of essential tremor, although the scales used to measure tremor severity varied among authors. Similarly, all studies used DSM-IV or (DSM-)V criteria to diagnose mood and anxiety disorders, despite differences in the scales used to screen psychiatric symptoms and assess their severity. Anxiety and depression rates were higher in the essential tremor population compared to control groups, raising some hypotheses for this finding, such as the involvement of brain regions responsible for emotional control due to the disease [3,8], tremor in social situations causing discomfort and embarrassment in the individual, and the psychological burden of living with a chronic condition.
Fabbrini et al. identified a significant number of psychiatric disorders in patients with essential tremor especially depression [20]. In this study, it was
reported that anxiety and/or depression started after the onset of the motor symptom in 65% of the cases, a finding that converges with another study which points to the presence of greater psychological stress in patients with chronic diseases, showing that these individuals are 1.5 and 1.8 times more likely to report depression and anxiety, respectively, when compared to a healthy population. This may be because patients have to deal with the challenges and particularities that their illness imposes on them [21]. Drawing a parallel with the present study, essential tremor, as a chronic disease, has manifestations that patients have to live with and deal with, directly impacting on their routine and may predispose them to the development of psychiatric symptoms [22].
The authors also showed a relationship between an increased frequency of mood disorders and the presence of a family history of essential tremor in the patients in the study, suggesting that depression may be part of the clinical spectrum of essential tremor, at least in cases of a positive family history. However, this higher prevalence may occur because these patients, due to their family history, have a greater knowledge of the disease and, consequently, a greater inclination to develop psychiatric disorders in the face of the situation experienced [20].
Smeltere et al. also found non-motor symptoms in their study population. The Beck Depression Inventory revealed that 79.49% of essential tremor patients presented depressive symptoms at varying levels of severity, with 15% meeting criteria for major depressive disorder [19]. Similarly, Günal et al. identified psychopathology in 76% of essential tremor patients, with 38% reporting past major depressive episodes. However, after psychiatric evaluation, the author concluded that these individuals did not meet the criteria for the reported pathology and were diagnosed with dysthymia per DSM-IV criteria [17], characterized by chronically depressed mood lasting most of the day for at least two years, with symptom-free intervals not exceeding two months [23]. Tomic et al. found a prevalence of 47.8% for psychiatric manifestations in essential tremor patients, with 23.3% corresponding to depression [18].
Regarding anxiety disorders, these were measured using different instruments, which may explain the variation in the percentages found, which ranged from 16 to 42%, or even more than double depending on the study evaluated. Although there are no studies comparing all the scales used in the studies included in this review, it is possible to infer that this difference is due to the variation in sensitivity between them to identify anxiety, as well as the experience of the evaluator and the way the questions were applied. With the Social Interaction Anxiety Scale and Social Phobia Scale, used in the study conducted by Smeltere et al., the authors pointed out that patients with essential tremor tend to exhibit anxious symptoms, since they have shown to be more concerned about tremor when they are being seen by other people and nervous when they have to speak in front of them or in a position of authority, as well as distress in social interactions [19].
Additionally, these authors correlated the severity of tremor with the manifestation of social phobia, supporting the hypothesis that the emotional state can imply changes in the intensity of tremor and vice-versa. Consequently, Smeltere et al. put forward the hypothesis that social phobia plays a role in influencing tremor in patients as a factor that can increase its amplitude [19]. This hypothesis is corroborated by another study, in which treatment for anxiety combined with anti-tremor medication showed the best results, with a 29.2% reduction in the intensity of the motor symptom [17].
In addition to this hypothesis, the study carried out by Tomic et al. found that 25% of patients with essential tremor and psychiatric symptoms had psychiatric manifestations before their motor symptoms, most of which were depression and anxiety [18]. Based on this, the authors suggested that these psychiatric symptoms may be part of the clinical spectrum of essential tremor as premotor manifestations, suggesting that this disease is not monosymptomatic [18].
These findings are not unanimous. Fabbrini et al. noted that anxiety frequency was similar between essential tremor patients and controls without tremor. However, they emphasized that these results are inconclusive due to the limited statistical power of the sample [20]. Furthermore, these authors found no relationship between essential tremor duration or severity and the development of psychiatric disorders. While highlighting that 65% of patients developed these disorders after the onset of tremor, the age of onset for depressive and anxious symptoms was similar between essential tremor patients and controls. This led the authors to conclude that these disorders might not be part of the clinical spectrum of essential tremor but rather a non-specific consequence of the chronic neurological condition [20]. Gunal et al. also underscored this ambiguity, stating that while psychiatric evaluations often reveal abnormalities in these patients, it remains unclear whether these are secondary to the tremor [17].
Given this ambiguous context and the lack of an assertive body of evidence to indicate whether psychiatric alterations are part of the clinical picture of essential tremor, or are associated with it, or occur independently, being related to sociodemographic, geographical and/or genetic factors, other studies not selected in this systematic review sought to answer this question.
One of these studies, carried out on Egyptian patients with essential tremor, analyzed the presence of non-motor symptoms in two groups: one group aged over 45 and the other under 45. As a result, it was found that, when compared to their respective comparison groups (without essential tremor), the younger patients had a significant tendency to develop depression, while those in the older group had higher rates of already diagnosed depression [22]. This finding seems to indicate that depression has a higher incidence in patients with essential tremor and may also be directly proportional to advancing age, since there is a tendency for motor symptoms to worsen as the disease progresses.
The study by Huang et al. found that anxiety is present more frequently in female patients with essential tremor. This condition is known to be a risk factor for the development of anxiety symptoms [5]. This is due to genetic differences between the genders, psychosocial and cultural factors. Similarly, a Chinese study also pointed out that women are more likely to develop social anxiety and added that this may be due to hormonal effects and the habit of caring more about their personal image in public, leading to greater embarrassment in the face of tremor [24]. Therefore, these studies seem to indicate that the phenomenon of anxiety disorders follows, in patients with tremors, what is observed in the general population.
Additional factors, such as geographic location, may also influence mood and anxiety disorder prevalence. Dingwei et al. highlighted that depression rates in the United States were significantly lower compared to studies in China and Spain, potentially due to cultural, socioeconomic, and environmental differences [25]. Similarly, Smeltere et al. noted higher depression prevalence in Latvia compared to Spain, likely influenced by historical, sociopolitical, economic, and comorbid factors [19].
Finally, Smeltere et al. pointed out that psychiatric conditions such as depression and anxiety are poorly recognized in routine consultations with patients with movement disorders, since no tests are carried out to look for them. They therefore suggested adapting the clinical interview to a neuropsychiatric approach in order to better track these symptoms associated with tremor [19]. This research should be carried out given that the association between essential tremor and higher rates of depression and anxiety is notorious, since both the impairment of the cerebello-thalamo-cortical circuit in the pathophysiology of the disease and the neurodegenerative theory can also lead to an impairment of regions of the brain corresponding to emotional regulation and, consequently, the emergence of psychiatric symptoms [3,8]. In addition, the social component involving the embarrassment and discomfort caused by tremor in front of other people and the impact on patients' quality of life can contribute to the development of depression and anxiety.
It is concluded that the prevalence of mood disorders and/or anxiety in patients with essential tremor is high and statistically significant, exceeding that observed in healthy populations. This finding underscores a meaningful relationship between these conditions, highlighting the need to systematically evaluate psychiatric symptoms during consultations with patients experiencing movement disorders. Such an approach can ensure more comprehensive and effective treatment, addressing both motor and non-motor aspects of the disease.
However, further studies are needed to clarify the nature of this relationship. It is essential to determine whether mood and anxiety disorders are secondary to essential tremor, part of its clinical spectrum, or associated with independent factors. New research with larger samples and standardized methods could help answer these questions and improve the clinical management of these patients.
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Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
