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Research Article | DOI: https://doi.org/10.31579/2767-7370/018
1 Medical Microbiology and Clinical Immunology Department, Faculty of Medicine and Health Sciences, Sana’a University, Republic of Yemen.
*Corresponding Author: Hassan A. Al-Shamahy. Medical Microbiology and Clinical Immunology Department, Faculty of Medicine and Health Sciences, Sana’a University, Republic of Yemen.
Citation: Monya Abdullah Yahya El-Zine, Abdulrahman M Alhadi, Abdulrahman A. IshaK, and Hassan A. Al-Shamahy, Prevalence of Different Types of Leukemia and Associated Factors among Children in Children's Cancer Units at Al-Kuwait Hospital, Sana'a City: A Cross-Sectional Study, J. New Medical Innovations and Research, 2(4): DOI: 10.31579/2767-7370/018
Copyright: © 2021 Hassan A. Al-Shamahy. This is an open-access article distributed under the terms of The Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 26 April 2021 | Accepted: 14 May 2021 | Published: 27 May 2021
Keywords: childhood; leukemia; cancer; haematological disorders, pediatric cancer, cure rate, Yemen
Introduction: Leukemia is a heterogeneous group of hematological disorders that is made up of several diverse and biologically distinct subgroups. Leukemia is the 11th and10th most common cause of cancer morbidity and mortality worldwide, respectively. There are insufficient data on the prevalence and associated factors of leukemia in Yemen, particularly in the study area.
Aims: This cross-sectional study aims to determine the prevalence of different types of leukemia and associated factors among children with leukemia in the pediatric cancer units of Al-Kuwait Hospital, Sana'a City.
Materials and Methods: A cross-sectional study was conducted on children with leukemia who were treated selectively in the pediatric leukemia units of Kuwait University Hospital in Sana'a. Group diagnostics and histopathological diagnoses were formed in line with the French, American and British classifications of leukemia in children in the pediatric leukemia units, over a period of 5 years. Factors associated with become infected with leukemia that were studied included ages, gender, and regarding outcomes. The association of death and recovery with different age groups and leukemia types was also studied through rates and calculation of OR, CI, chi-square test and p values through probability tables.
Results: 244 leukemia patients were diagnosed, treated and followed; there was association of leukemia with younger age group; 50% were in the age group 1-5 years and with mean ± SD age= 6.44 ± 3.7 years. There was significant association with male gender (66.7%). There was non-significant association between high mortality and the 6-10 year age group [(8/78; 10.2%), with OR = 2.6, p = 0.060, and with the AML [(4/38; 10.5%), OR = 2.1)]. Considering, the cure rates association with ages, roughly there were similar cure rates occurred in the different age groups. Also, there was high cure rate in the JCM (2/3; 66%), with OR = 2.9. And with the CML (7/11; 63.6%; OR = 2.60.
Conclusion: In the current study an association between leukemia and younger age group, with males was found. An association between high mortality and the 6-10 year age group, with AML was found. Also, there was no association between ages and cure rate but a high cure rate occurred with JCM and CML.
Leukemia is the most common type of cancer in childhood, accounting for 25 percent of all cancers that occur before the age of 20. There are two main types of childhood leukemia - acute lymphocytic leukemia (ALL), which accounts for about three quarters of leukemia, and acute myeloid leukemia (AML) accounting for most of the rest of the leukemia cases [1-3]. ALL is a disease that affects about three quarters of leukemia. The hematopoietic tissue in the bone marrow is characterized by the overproduction of immature lymphocytes [3]. ALL occurs at all ages, from birth to adulthood, but the incidence peaks between 2 and 6 years of age. In the United States, there is a majority of white and male children and young adults with ALL. Improvements in treatment have led to remarkable gains in survival, estimated at 79 percent at 5 years. Acute myeloid leukemia is a cancer of the myeloid white blood cell line that occurs at all ages from childhood [1-4]. The prognosis for AML is poorer than for ALL, with a 5-year survival rate of 41 percent [1,2]. The precise cause of leukemia has not been yet determined. Nevertheless a lot of factors, mainly genetics, genetic mutations, epigenetic lesions, ionizing radiation, other chemical and occupational factors, curative factors, smoking and some viral agents, have been involved in the development of leukemia [3-8]. Commonly two types of classification systems are used for leukemia: the Franco-American and British classification system (FAB), which relies on morphology and cytochemical staining to identify specific types of leukemia, and the World Health Organization (WHO) that reviews classification information, cytomorphology, cell chemistry, immune profiling, cytogenetics and clinical features to identify and classify clinically significant disease entities [9, 10]. Lymphoma malignancies correspond to a heterogeneous group of illnesses separated into four classes established on tumor cell maturity and disease distribution such as ALL, CLL, lymphoma malignancies, plasma cell tumors and hairy cell leukemia [11].
Globally Leukemia involved 200,676 males and 151,289 females with ASR 5.6 and 3.6, respectively. There were 46,449 males and 35,880 females diagnosed in 2012 with leukemia in Europe. In Australia, Asia and the USA about 233,451 residents were diagnosed with leukemia by 2017. In contrast, in Africa by 2012, it has a rate of incidence equal to 23,928 cases, ASR 3.0 per 100,000 [12-14]. Leukemia was the most common type of cancer among children (including 29% of 3,707 cancer cases in children, and acute leukemia counting 89% (91% of which were ALL and 9% AML) of all cases of leukemia in children [15].
In developing countries, the influence of leukemia is massive attributable to premature death of children, loss of parents, failure of productivity due to disability, and high medical costs affecting the social, economic and health well-being of the population [16-18]. While leukemia is treated very well in the developed world, there is little evidence of the current state of the disease in Yemen in general and in the study area in particular. On the other hand, in Yemen as is the case in most Arab countries, there are few specialized epidemiological records devoted to this area, and for this reason it is important to encourage, update, build and continue to present studies on childhood leukemia with the goal of achieving greater impact on public health, with early diagnosis and appropriate treatment aimed at enhancing survival and minimizing potential consequences [19]. According to the limited Yemeni Cancer Studies, the most common types of cancer among Yemeni children and adults were leukemia (33.1%), lymphoma (31.5%), central nervous system tumors (7.2%), and bone tumors (5.2%) [20-22]. This cross-sectional study aims to determine the prevalence of different types of leukemia and the associated factors among children with leukemia in the pediatric cancer units of Al-Kuwait Hospital, Sana'a City.
Patient’s inclusion
A cross-sectional study was conducted on children with leukemia who were treated selectively in the pediatric leukemia units of Al-Kuwait University Hospital in Sana'a. Group diagnostics and histopathological diagnoses were formed in line with the French, American and British classifications of leukemia [9,10] in children in the pediatric leukemia units, over a period of 5 years from January 1, 2014 to December 31, 2018. Factors associated with become infected with leukemia that were studied included ages, gender, and outcomes including induction therapy, consolidation, maintenance therapy, relapse, cure and died. The association of death and recovery with different age groups and leukemia types was also studied through rates and calculation of OR, CI, X2 and p values through probability tables.
Statistical analysis
Data were recorded using appropriate descriptive statistics (including frequency, mean, and standard deviation). The odds ratio (OR) was used to determine the strength of the association between two events, such as leukemia, age, gender, and residence. Also determine the association between death, age, and type of leukemia. In addition to calculating the relationship between cure, age of patients, and types of leukemia. The two events in the current study were independent if and only if OR was equal to 1.
Ethical approval
Ethical approval was obtained from the Medical Research & Ethics Committee of the Faculty of Medicine and Health Sciences, Sana'a University. All data, including patient identification were kept confidential.
Table 1 shows the age and gender distribution of children with childhood leukemia in Sana'a, Yemen. The mean ± SD age of all cases was 6.44 ± 3.7 years. Most of the cases were in the age group 1-5 years (50%), followed by the age group 6-10 years (32.1%), while only 17.9% of the cases were in the age group 11-15 years (disease decreases with increasing age). As for gender, most of the cases were males (66.7%), while the percentage of females was 33.3% (male to female ratio = 2-1).
Age groups | Male | Female | Total | |||
No | % | No | % | No | % | |
1-5 years | 75 | *46.3 | 47 | 24.1 | 122 | *50 |
6-10 years | 57 | 41 | 21 | 25.9 | 78 | 32.1 |
11-15 years | 30 | 18.5 | 14 | 16.7 | 44 | 17.9 |
Total | 162 | *66.7 | 82 | 33.3 | 244 | 100 |
Mean age | 6.7 years | 5.8 years | *6.44 years | |||
SD | 3.6 years | 3.7 years | 3.7 years | |||
Median | 6 years | 1 years | 6 years | |||
Mode | 3 years | 3 years | 3 years | |||
Min | 1 year | 1 year | 1 year | |||
Max | 15 years | 14 years | 15 years | |||
Residency | ||||||
Urban | 51 | 31.5 | 25 | 30.5 | 76 | 31.1 |
Rural | 111 | 68.5 | 57 | 69.5 | 168 | 68.9* |
Table 1: Age and gender distribution of children with childhood leukemia in Sana'a, Yemen.
Table 2 shows leukemia outcomes among children suffering from childhood leukemia in Sana'a, Yemen. The cure rate was 40.7% while the death rate was 15 cases (6.2%), all of them male (male mortality rate = 9.3%). The relapse rate was 2%. The rest of the cases were in maintenance therapy (31.5%), induction therapy (15.4%), and consolidation (post-remission therapy) for 4.3% of cases.
Outcomes | Male | Female | Total | |||
No | % | No | % | No | % | |
Induction therapy | 24 | 14.8 | 13 | 16. | 40 | 15.4 |
Consolidation (post-remission therapy) | 9 | 5.6 | 2 | 2.4 | 11 | 4.3 |
Maintenance therapy | 48 | 29.6 | 29 | 35.3 | 77 | 31.5 |
Relapse | 2 | 0.9 | 3 | 3.7 | 5 | 2 |
*Cure | 64 | 39.8 | 35 | 42.6 | 99 | 40.7 |
Died | 15 | 9.3 | 0 | 0 | 15 | 6.2 |
Total | 162 | 66.4 | 82 | 33.6 | 244 | 100 |
* Cure = 5-year survival rate = percentage of children who live at least 5 years after a diagnosis of leukemia.
Table 2: Leukemia outcomes among children suffering from childhood leukemia in Sana'a, Yemen.
Table 3shows the age-group association of death among children with childhood leukemia in Sana'a, Yemen. The highest mortality occurred in the 6-10 year age group (8/78; 10.2%), with an associated OR = 2.6, CI = 1-7.4, X2 = 3.4, p = 0.06. However, the low mortality rate was 3.3% in the 1-5 year group, without association (OR = 0.34, p = 0.06). Also in the 11--15 year-old group, the death rate was 6.8% roughly similar to the overall death rate (6.1%).
Age groups | Death n= 15 | OR | CI | X2 | P | |
No | % | |||||
1-5 years n=122 | 4 | 3.3 | 0.34 | 0.1-1.1 | 3.4 | 0.06 |
6-10 years n=78 | 8 | 10.2 | 2.6 | 1-7.4 | 3.4 | 0.06 |
11-15 years n=44 | 3 | 6.8 | 1.1 | 0.3-4.2 | 0.04 | 0.87 |
Total n=244 | 15 | 6.1 |
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Table 3: The association of death with age groups among children suffering from childhood leukemia in Sana'a, Yemen.
Table 4 shows the type of leukemia association of death among children with childhood leukemia in Sana'a, Yemen. Acute lymphoblastic leukemia was the most common, accounting for 78.7% of the total, while the other types were less common, with acute myelogenous leukemia count of 15.6%, chronic myelogenous leukemia at 4.5% and Juvenile myelomonocytic leukemia only at 1.2. %. The highest mortality occurred in the AML (4/38; 10.5%), with an associated OR = 2.1, CI = 0.6 – 6.9, X2 = 1.5, p = 0.22. However, the mortality rate was 5.7% in the ALL patients, without association (OR = 0.72, p = 0.6).There was no death occurred in CML and JCM cases (0%).
Leukemia types | Death n= 15 | OR | CI | X2 | P | |
No | % | |||||
ALL n=192 (78.7%) | 11 | 5.7 | 0.72 | 0.2-2.3 | 0.27 | 0.6 |
AML n=38 (15.6%) | 4 | 10.5 | 2.1 | 0.6-6.9 | 1.5 | 0.22 |
CML n=11 (4.5%) | 0 | 0 | 0.0 | undefined | 0.75 | 0.8 |
JCM n=3 (1.2%) | 0 | 0 | 0.0 | undefined | 0.19 | 0.65 |
Total n=244 | 15 | 6.1 |
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OR less than 1 there is no association.
Table 4: The prevalence and association of death with type of leukemia among children suffering from childhood leukemia in Sana'a, Yemen.
Table 5 shows the age-group association of cure among children with childhood leukemia in Sana'a, Yemen. The cure rates were roughly similar in the different age groups. It is ranged from 38.5% in 1-5 year group to 43.2% in 11-15 year group.
Age groups | Cure n= 99 | OR | CI | X2 | P | |
No | % | |||||
1-5 years n=122 | 47 | 38.5 | 0.8 | 0.5-1.4 | 0.4 | 0.5 |
6-10 years n=78 | 33 | 42.3 | 1.1 | 0.6-1.9 | 0.14 | 0.7 |
11-15 years n=44 | 19 | 43.2 | 1.1 | 0.5-2.2 | 0.15 | 0.69 |
Total n=244 | 99 | 40.6 |
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Table 5: The association of cure with age groups among children suffering from childhood leukemia in Sana'a, Yemen
Table 6 shows the type of leukemia association of cure among children with childhood leukemia in Sana'a, Yemen. The highest cure rate occurred in the JCM (2/3; 66%), with an associated OR = 2.9, CI = 0.2 – 33, X2 = 0.8, p = 0.3. The second high cure rate occurred in the CML (7/11; 63.6%), with an associated OR = 2.6, CI = 0.7 – 9.4, X2 = 2.5, p = 0.11. However, the cure rate was 23.6% in the AML patients, without association (OR = 0.4, p = 0.02). The cure rate was 42.2% in the ALL patients, with association (OR = 1.4, p = 0.3).
Leukemia types | cure n= 99 | OR | CI | X2 | P | |
No | % | |||||
ALL n=192 | 81 | 42.2 | 1.4 | 0.7-2.6 | 0.9 | 0.3 |
AML n=38 | 9 | 23.6 | 0.4 | 0.18-0.88 | 5.3 | 0.02 |
CML n=11 | 7 | 63.6 | 2.6 | 0.7-9.4 | 2.5 | 0.11 |
JCM n=3 | 2 | 66 | 2.9 | 0.2-33 | 0.8 | 0.3 |
Total n=244 | 99 | 40.6 |
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Table 6: The association of cure with type of leukemia among children suffering from childhood leukemia in Sana'a, Yemen
Information of the prevalence of leukemia in a population may envisage pathogenic hypotheses for disease control and aid in the effective management of leukemia and other malignant tumors. In developing countries, and especially in Yemen, there is little information about the burden and patterns of hematological malignancies, especially leukemia. In the current study, with regard to gender, most of the cases were male (66.7%) while the percentage of females was 33.3% (male to female ratio = 2:1). This finding differs from that reported in Africa where the ratio of males to females is roughly equal, although females dominate slightly (1: 1.06) [23], but similar to that reported from the United States where the American Cancer Society estimates for leukemia in 2021, about 5,690 new cases, 3,000 in males and 2,690 in females [24]. The current results of different leukemia prevalence rates among gender are in line with the facts that the prevalence of leukemia must be varies according to gender due to the biological factors as hormones and chromosomes [11, 15, 25, 26].
Leukemia may appear at all ages, from newborns to the elderly, but the distinctive forms have different age distributions [27]. In the current study, the mean age of ± SD for all cases was 6.44 ± 3.7 years and most of the cases were in the age group 1-5 years (50%), followed by the age group 6-10 years (32.1%), while only 17.9% of the cases were in the age group 11-15 years (Table 1). This is similar to what has been reported elsewhere for pediatric leukemia where the mean age ± SD of pediatric leukemia cases was 6.0 years with a peak incidence at 6-10 years [2,12,14]. This differs from the leukemia hypothesis with age in which older children may develop leukemia more frequently than younger children due to advancing age, as many environmental exposures to carcinogens, irradiation, and malignant mutations due to clonal expansion occur more often [28, 29]. However, most of the younger children in the current study could be explained by the fact that prenatal and early life exposure is thought to be important determinants of childhood leukemia [19]. Several mechanisms have been identified through which external and internal factors can influence the risk of developing leukemia in children. Exposure to a carcinogen or toxic substance early in a female's life may cause permanent damage. Since no new oocytes are formed after birth and their maturation begins during pregnancy, the exposure that occurs during this critical time can be of great importance. During pregnancy, exposure to agents such as ionizing radiation may act directly while others may act indirectly by transporting the placenta [19]. On the other hand, offspring may be exposed after birth to environmental exposure, either directly or indirectly [30]. Since most of the children are from rural areas, they may have been exposed to various environmental exposures during their stay with their parents who are farmers.
Environmental factors, even though not well articulated, influence the chance of developing leukemia. In this study, the highest proportion of 68.9% out of the total of 244 patients diagnosed with leukemia was observed.
Among rural residents (p < 0.05). In Yemen, rural residents’ lifestyle is based on agricultural activities such as farming and plantations agriculture; especially gat, fruits and vegetables plantation are the major practice around the study area, thus this may lead to the repeated use of chemicals such as pesticides, herbicides, and fertilizers for agricultural activities which will result in genetic mutations conferring leukemia [31].
Leukemia types were determined using the FAB classification method [10,11], Wright-stained morphological examination, and cytochemical staining with Sudan black B staining to differentiate the cell lineage [10,11]. In this study, acute lymphocytic leukemia was the most common, accounting for 78.7% of the total, while the other types were less common, with acute myelogenous leukemia count of 15.6%, chronic myeloid leukemia 4.5%, and juvenile myeloid leukemia at only 1.2%. These results were consistent with results from Ethiopia, Nepal, and Pakistan [22,32], while it was contradictory with a study from Albania [33]. In the current study, the highest mortality occurred in the 6-10 year age group (8/78; 10.2%). However, the low mortality rate was 3.3% in the1-5 year group, without correlation. These results are consistent with the American Cancer Society's fact that most cases of leukemia occur in young children, but most deaths occur in older children. Very young children may perform better than older children due to differences in the nature of leukemia in children, differences in treatment; often young children's bodies can handle aggressive treatment better than older children; or a combination of these [24]. The highest mortality occurred in AML (4/38; 10.5%), cure rate was 23.6%. However, the mortality rate was 5.7% in ALL patients, with cure rate = 42.2%. These results are in line with findings by the Leukemia and Lymphoma Society of the USA where the 5-year survival rate for children and adolescents under the age of 15 years diagnosed with ALL was 91.8% in the United States between 2007 and 2013 [34]. While the survival rate for children under 15 years of age with AML was only 66.4% for the same period [34].
ALL is the most common type of leukemia in Sana'a city; and males and young children are affected the most by leukemia. In the current study there was an association between leukemia and younger age group, with males. An association between high mortality and the 6-10 year age group, with AML was found. Also, there was no association between ages and cure rate but a high cure rate occurred with JCM and CML.
"No conflict of interest associated with this work”.
Author's Contribution
The first author presented the data and the first, second and the third authors analyzed the data and wrote, revised and edited the paper.
Thanks to the Pediatric Leukemia Unit at Kuwait Hospital, specifically to Dr. Abdulrahman Al-Hadi, a human doctor who spends his life, knowledge and time for children who suffer from this malignant disease.
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Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
