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Research Article | DOI: https://doi.org/10.31579/2641-0419/483
1Instituto Cardiovascular de Puebla. Unidad de Hemodinámica e Intervencionismo Coronario complejo e Investigación. Puebla Pue. México.
2Hospital Universitario Lucus Augusti (HULA). Unidad de Hemodinámica e Intervencionismo Coronario. Lugo. España.
*Corresponding Author: Raymundo Ocaranza-Sánchez, Instituto Cardiovascular de Puebla. Unidad de Hemodinámica e Intervencionismo Coronario complejo e Investigación. Puebla Pue. México.
Citation: Raymundo Ocaranza-Sánchez, Fernández-Candelario BE, Rodrigo A. Calderón, Abellás Sequeiros RA, Carlos De la Fuente-Macip, et al, (2025), Preliminary Assessment of a Dedicated Bifurcation Stent Using a Modified Technique in True Coronary Bifurcation Lesions: A Dual-Centre Registry, J Clinical Cardiology and Cardiovascular Interventions, 8(10); DOI: 10.31579/2641-0419/483
Copyright: © 2025, Raymundo Ocaranza-Sánchez. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 22 May 2025 | Accepted: 17 June 2025 | Published: 01 July 2025
Keywords: bifurcation pci; biomime branch™; dedicated bifurcation stent; coronary artery disease
Background/Aim: Bifurcation lesions present challenges in percutaneous coronary intervention (PCI), increasing the risk of side branch (SB) occlusion and restenosis. The Biomime Branch™, a sirolimus-eluting dedicated bifurcation stent with an ultra-thin strut design and Flexi Connector Technology, aims to optimize SB access and procedural outcomes.
Aim: To evaluate the feasibility, safety, and procedural success of the Biomime Branch™ stent using a modified implantation technique in a dual-center registry.
Materials and Methods: Eighty patients with Medina 1-1-1 bifurcation lesions underwent PCI with a sirolimus-eluting dedicated bifurcation stent with an ultra-thin strut design and Flexi Connector Technology between April 2023 and December 2024. The primary endpoint was procedural success, defined as ≤30% residual stenosis in both branches without major adverse cardiac events (MACE) at discharge.
Results: The mean age was 69.8 ± 11 years; 77.5% were male. Hypertension (68.7%) and dyslipidemia (70%) were common. The left anterior descending artery (LAD) was the most treated vessel (63.7%). Pre-dilatation and final kissing balloon inflation were performed in 98.7% of cases. Procedural success was 98.7%, with minimal complications.
Conclusions: The Biomime Branch™ stent demonstrated high procedural success and safety in true bifurcation lesions. Its novel design ensures SB access and vessel patency, providing a promising alternative to conventional two-stent techniques. Long-term follow-up is warranted.
Bifurcation lesions accounting for approximately 15% to 20% of all lesions treated with PCI [1]. Despite significant advancements in stent technology, the treatment of bifurcation lesions remains a major challenge for interventional cardiologists. Procedural complexities contribute to an increased risk of periprocedural myocardial infarction (MI), stent thrombosis, long-term restenosis, and higher healthcare costs. [2] [3]
Over the years, various strategies have been proposed, to optimize bifurcation PCI. [4][7] The conservative (provisional) approach where the main branch (MB) is treated first, and the side branch (SB) is only intervened upon, if necessary, remains the current standard of care. [8] [2][3]
[11][14] However, this strategy has several limitations, including the risk of SB ostial jailing by MB stent struts, which can complicate rewiring and the advancement of a balloon or stent into the SB. Additional concerns include the potential distortion of the MB stent during SB dilation, the inability to ensure complete SB ostial coverage, and the influence of operator expertise on procedural success.[7] Furthermore, previous studies assessing bifurcation PCI have been hindered by selection bias, small sample sizes, and heterogeneous techniques, limiting the ability to draw definitive conclusions.[2][21]
Dedicated bifurcation stents have emerged as a potential solution to overcome the challenges associated with the provisional approach. Recent small non-randomised studies have reported promising initial outcomes with these devices. [15][19] Dedicated bifurcation stents can be broadly classified into two categories. [22] The first group comprises stents designed to maintain or facilitate SB access after MB stenting, eliminating the need for recrossing MB stent struts (e.g., Petal, former AST stent, Multi-link Frontier/Pathfinder, Invatec Twin-Rail, Nile Croco/Pax, Antares, Stentys . These devices allow for the placement of a second stent in the SB when required. The second group consists of stents that generally necessitate the deployment of an additional stent in the bifurcation (e.g., Axxess Plus, Sideguard, Tryton. The Tryton and Sideguard stents are implanted in the SB first, requiring recrossing into the SB after MB stenting for final kissing balloon inflation (FKBI).
A recent innovation in this field is the Biomime Branch™, a next-generation sirolimus-eluting coronary stent system featuring an ultra-thin 65 µm strut thickness and a novel hybrid design. These characteristics position Biomime Branch™ as a promising addition to the growing family of dedicated bifurcation stents, though further clinical trials are required to determine its long-term efficacy and safety.
To evaluate the feasibility, safety, and procedural success of implanting the dedicated bifurcation stent Biomime Branch™ using a modified technique. This modification, developed and refined by a single experienced operator, is assessed across two centres, one in Europe and one in America to determine its effectiveness in optimising stent deployment, improving procedural outcomes, and enhancing long-term vessel patency in complex bifurcation lesions.
Study Population
Patients were recruited from two different university hospital centres: one in the north of Spain (Lugo) and the other in central Mexico (Puebla), from April 2023 to December 2024. These patients were referred for diagnostic coronary angiography due to evidence of ischaemic heart disease diagnosed by non-invasive studies.
Following the diagnostic coronary angiography, coronary bifurcation lesions were identified. Patients with “true bifurcation” lesions classified as Medina 1-1-1, with MB ≥2.25 mm and ≤4.5 mm and SB of ≥ 2.25 mm, and for whom percutaneous coronary intervention (PCI) with a two-stent technique was planned, were included in the registry. The exclusion criteria was that the SB was not affected. The registry was approved by the ethics committee of both participating hospitals.
Study Device
The dedicated bifurcation stent Biomime Branch™ (Meril Lifesciences) consists of a proximal MB anchoring segment and a distal tapered SB segment with ultra-thin 65 µm strut thickness, connected by an advanced Flexi Connector Technology that ensures continuous SB access and protection. The Step-Up Balloon System allows for the simultaneous deployment of both segments, reducing procedural time and minimising the complexity associated with multiple hardware usage. Following Biomime Branch™ implantation, the MB segment can be stented as part of a standard PCI procedure, allowing seamless vessel integration [20]. All patients underwent bifurcation PCI using the Bio mime Branch™ dedicated bifurcation stent from Meril Lifesciences. The implantation technique was modified by the primary operator, incorporating two additional key steps essential for successful stent deployment. All procedures were performed by the same experienced operator at both participating centers. Figure 1.
Figure 1: Step-by-step illustration of Biomime Branch™ stent implantation in a bifurcation lesion. Panels A–B: guidewire placement and lesion preparation.C: stent positioning using four radiopaque markers. D–E: modified technique with NC balloon inflation in the side branch to facilitate main vessel wiring.F–G: stent and wire recrossing. H: final kissing balloon inflation.
Endpoint And Definitions
The primary objective of this registry was to evaluate the feasibility and success rate of device implantation and the angiographic procedural success; defined as 30% residual diameter stenosis in both branches by quantitative coronary angiography [QCA] using the assigned device and without MACE at discharge. Statistical analysis was carried out using IBM SPSS Statistics, version 21 (IBM Corp., Armonk, NY, USA). Given the retrospective and observational nature of the study, data are reported as absolute numbers and corresponding percentages. [20]
Demographic and Clinical Characteristics
80 patients were included in the study, all presenting with Medina 1-1-1 bifurcation lesions (“true bifurcation”), and all undergoing PCI with complete revascularization. With a mean age of 69.8 ± 11 years. The majority of the population was male (77.5%), while females accounted for 22.5%.
Regarding clinical variables, hypertension was present in 68.7% of the patients, making it the most common comorbidity in this cohort. Dyslipidemia was also prevalent, affecting 70% of the patients. Diabetes mellitus was observed in 38.7%, reflecting a considerable burden of metabolic disease. Obesity was present in 35% of the patients, further indicating the presence of risk factors associated with cardiovascular disease. A history of smoking was reported in 51.2% of patients, highlighting a significant lifestyle-related risk factor.
Previous stroke and chronic obstructive pulmonary disease (COPD) were observed in 2.5% and 3.7% of cases, respectively, indicating a relatively low prevalence of cerebrovascular and pulmonary disease within the cohort. Chronic kidney failure was noted in 16.5% of patients, representing a relevant comorbidity that could influence procedural outcomes. Atrial fibrillation was present in 6.2% of patients, demonstrating a moderate prevalence of arrhythmic complications. Furthermore, 20% of patients had a history of ischemic heart disease, while 12.5% had undergone previous revascularization, indicating that a subset of the cohort had already undergone prior cardiovascular interventions.
Study Size and Inclusion Criteria
The study did not employ a formal sample size calculation, as it was based on a prospective registry. All consecutive patients who were referred for coronary angiography with a diagnosis of ischaemic heart disease and who were found to have Medina 1-1-1 bifurcation lesions during diagnostic coronary angiography were included. Patients meeting these criteria and undergoing percutaneous coronary intervention (PCI) with complete revascularisation were prospectively enrolled. The inclusion of patients followed a standardised institutional protocol and reflects real-world clinical practice.
Data Collection Methodology
No standardised questionnaire was used for data collection. Clinical and demographic parameters were obtained directly from electronic medical records and procedural reports. All data were extracted by trained personnel following a predefined data abstraction protocol to ensure consistency and accuracy across all cases. Table 1
| AGE | 69.8 +11 | |
| Frequency | % | |
| GENDER | ||
| Female | 18 | 22.5 |
| Male | 62 | 77.5 |
| CLINICAL VARIABLES | ||
| Hypertension | 55 | 68.7 |
| Dyslipidemia | 56 | 70 |
| Diabetes Mellitus | 31 | 38.7 |
| Obesity | 28 | 35 |
| Smoker | 41 | 51.2 |
| Previous Stroke | 2 | 2.5 |
| Previous COPD | 3 | 3.7 |
| Chronic Kidney Failure | 13 | 16.5 |
| Atrial Fibrillation | 5 | 6.2 |
| Previous Ischemic Heart Disease | 16 | 20 |
| Previous Revascularization | 10 | 12.5 |
Table 1: Demographics and clinical variables, data are reported as absolute numbers and corresponding percentages.
Angiographic and Procedural Data
The most commonly affected main vessel was the left anterior descending artery (LAD) in 63.7% of cases, which is consistent with its dominant role in myocardial perfusion. The left main artery (LM) was affected in 21.3% of cases, indicating complex coronary pathology in a considerable number of patients. The circumflex artery (Cx) was involved in 13.8% of cases, while the right coronary artery (CD) was the least affected, with only 1.3% of cases.
Regarding side branches, the diagonal artery was the most frequently involved, with 61.3% of cases, followed by the circumflex artery (18.8%), LAD (6.3%), obtuse marginal (OM) (12.5%), and posterolateral (PL) (1.2%). This distribution highlights the frequent involvement of side branches in bifurcation lesions and the need for complex percutaneous coronary intervention (PCI) strategies.
Calcification was observed in 46.8% of patients, with 25.3% presenting severe calcification, 12.7% moderate, and 8.9% mild. The high prevalence of moderate to severe calcification suggests that many cases required advanced plaque modification techniques before stent implantation.
Vessel tortuosity was present in 31.6% of cases, with 11.4
The findings of this study reinforce the feasibility, safety, and efficacy of the Bio mime Branch™ dedicated bifurcation stent in the treatment of true bifurcation lesions. The modified implantation technique, systematically applied by a single experienced operator across two centers, resulted in a high procedural success rate (98.7%) with minimal intraprocedural complications. This underscores the potential of this next-generation stent system to simplify complex bifurcation PCI while maintaining excellent immediate angiographic outcomes.
Bifurcation lesions have long posed a significant challenge in interventional cardiology, given their inherent procedural complexities and the associated risks of side branch (SB) compromise, malposition, and restenosis. The conventional provisional approach, while widely adopted, has notable limitations, particularly in cases of Medina 1-1-1 lesions where SB protection is crucial. The present study demonstrates that the Bio mime Branch™ stent, with its ultra-thin 65 µm struts, hybrid design, and Flexi Connector Technology, offers an effective alternative by ensuring continuous SB access and facilitating optimal stent positioning.
A key advantage of the Bio mime Branch™ system is its Step-Up Balloon Technology, which allows for simultaneous deployment of both the main branch (MB) and SB segments, reducing the need for multiple recrossing attempts and minimizing procedural time. This feature is particularly relevant in complex anatomical scenarios, as it mitigates the risks of stent distortion, incomplete ostial coverage, and flow limitation in the SB. Additionally, the design of this stent facilitates the Culotte technique, a widely used approach for bifurcation PCI, by ensuring optimal SB access and deployment.
One particularly relevant aspect of this study is that a significant percentage of cases (21.3%) involved the left main (LM) artery. The LM is a critical vessel supplying a large myocardial territory, and interventions in this location require precise technique to avoid compromising either the left anterior descending (LAD) or the circumflex (Cx) arteries. The successful application of the Bio mime Branch™ stent in LM bifurcation lesions adds further value to this study, demonstrating its feasibility in high-risk, complex coronary anatomy. [20]
The high prevalence of radial access (82.5%) in this cohort also reflects a contemporary PCI approach aimed at enhancing patient safety and comfort. Importantly, this study highlights the role of meticulous lesion preparation, with pre-dilatation performed in nearly all cases (98.7%) and final kissing balloon inflation (FKBI) systematically applied. These steps are critical for optimizing stent expansion and preventing SB occlusion, ultimately contributing to the excellent procedural success observed.
Notably, the one case of procedural failure observed in this study occurred during the early phase of implementation, before the refinements to the implantation technique were fully developed. This underscores the importance of technical evolution in complex PCI procedures. A key modification that contributed to subsequent success was the adoption of a more aggressive plaque modification strategy, which proved essential in optimizing stent expansion and improving procedural outcomes. Nonetheless, the present study provides compelling evidence that this novel device represents an excellent option for the treatment of true bifurcation lesions, offering a technically refined solution that enhances procedural efficiency while ensuring optimal vessel patency.
This study demonstrates that the Bio mime Branch™ dedicated bifurcation stent is a feasible and safe option for the treatment of true bifurcation lesions. The high procedural success rate (98.7%) and the absence of major complications highlight its potential to simplify complex bifurcation PCI while ensuring optimal angiographic outcomes. The innovative design of the stent, particularly the Flexi Connector Technology and Step-Up Balloon System, plays a crucial role in facilitating precise and efficient stent deployment.
Although this study was conducted prospectively across two different centres, all procedures were performed by a single experienced operator. While this approach minimised variability and optimised the learning curve, it also introduces methodological bias, as the outcomes may be influenced by the individual operator's technique and expertise. This limits the generalisability of the results to the broader interventional cardiology community. Further studies involving multiple operators with varying levels of experience, as well as long-term follow-up, are warranted to better assess the durability and real-world applicability of this dedicated bifurcation stent system.
"Multicenter study evaluates the clinical outcomes of the Biomime Branch™ bifurcation stent. Promising results in coronary interventions. #BranchStent #BifurcationPCI #InnovativeStent
The authors would like to thank the clinical and research teams at all participating centers for their contributions. Additionally, we express our gratitude to the P-Investiga platform for its invaluable support in database management and statistical analysis.
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To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
