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Review Article | DOI: https://doi.org/10.31579/2690-4861/701
International Higher School of Medicine, Intergelpo Str, 1F, Bishkek, Kyrgyzstan.
*Corresponding Author: Abyt Ibraimov, International Higher School of Medicine, Intergelpo Str, 1F, Bishkek, Kyrgyzstan.
Citation: Abyt Ibraimov, (2025), On the Origin of Homeothermic Animals, International Journal of Clinical Case Reports and Reviews, 24(2); DOI:10.31579/2690-4861/701
Copyright: © 2025, Abyt Ibraimov. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 17 January 2025 | Accepted: 21 February 2025 | Published: 17 March 2025
Keywords: origin of homeothermic animals; chromosomal heterochromatin regions; condensed chromatin; cell thermoregulation; non-coding DNA
Temperature has a fundamental influence in all chemical and biochemical reactions and physiological processes. Maintaining the relative constancy of the internal temperature (temperature homeostasis) is a necessary condition for normal life. Mammals and birds as well as humans have been found to be able to maintain a temperature homeostasis in the body (homeothermic animals). However, it is unknown the origin of homeothermic animals. It is assumed that homeothermy is not the result of the evolution of the central organ-based physiological mechanisms of thermoregulation. Homeothermy is the result of the evolution of some part of non-coding DNAs in the genome of the higher eukaryotes that led to the emergence of chromosomal heterochromatin regions (HRs). Chromosomal HRs are capable to form the condensed chromatin around the nucleus, which underlie the material basis of cell thermoregulation and responsible for dissipating excess heat energy from the nucleus into the cytoplasm. Homeotherms are animals in whose cells chromosomal HRs are able to form the densest layer of condensed chromatin with high thermal conductivity capable efficiently removing excess heat from the nucleus to ensure the implementation of a very high level of cellular metabolism.
Some living beings maintain temperature homeostasis in the body due to external sources of energy (poikilothermy), others due to the energy of food consumption (homeothermy). Despite the fundamental similarity of the mechanisms of the central organ-based physiological thermoregulation, even among the higher vertebrates exists poikilothermic and homoeothermic animals.
Homeothermy (‘warm-bloodedness’) is the ability of an animal to maintain a relatively constant core temperature for an indefinitely long time, regardless of fluctuations in environmental temperature. Warm-bloodedness is maintained endothermically, i.e. by-product of metabolic heat. In poikilothermic animals, in contrast to homoeothermic animals, body temperature passively follows the change of the environment temperature.
It is known that homeothermy takes place when living beings has a high level of cellular metabolism to maintain the necessary body temperature by producing heat energy from the consumed food, i.e. it is based on a high and regulated level of metabolism. Thus, in contrast to poikilothermic organisms, homeothermic animals build their heat exchange based on their own heat production, which makes them independent of external temperature fluctuations. As a result, the temperature range of life activity of homeothermic animals practically coincides with the range of temperatures carried by living organisms.
Thus, heat generation is a basic property of endothermic homeotherms. However, the cause of this high metabolic rate remains a source of controversy. In particular, processes such as high ionic permeability of plasma and mitochondrial membranes and high fluidity of proteins and membranes have been suggested to underlie this phenomenon. It is also known the role of feathers and fur, as well as a layer of subcutaneous fat and high body mass, which significantly reduce resting heat loss to the environment. For example, the thermal conductivity of reptile coverings is so great that they cannot ensure the preservation of endogenous heat at rest at any body temperature. A reptile “dressed” in bird or mammalian coverings could retain heat at maximum aerobic muscular activity and body temperature as in homeothermic animals [1-3].
Thus, physical thermoregulation combines a complex of morphophysiological thermal insulating mechanisms that determine the overall level of heat dissipation at the level of the organism of homeothermic animals (feathers and hair). The significance of thermal insulation is that, by reducing heat loss, it contributes to the maintenance of homeothermy with less energy expenditure. This is particularly important when inhabiting persistently low temperatures. Adaptive changes in the heat-insulating function of the coverts are reduced to a reorganization of their structure, including the ratio of different types of hair or feathers, their length and dense arrangement. The pilomotor form of regulation of heat dissipation acts mainly at low temperature of the environment, requiring less energy expenditure. However, it should be remembered that insulating structures (feathers, hair) do not cause homeothermy, as is sometimes thought.
Origin of homeothermic animals
In the literature, we failed to find special theories or hypothesis about the origin of homeothermic organisms. Works devoted to this problem are limited to descriptions of chemical and physiological mechanisms of maintenance of relative constant temperature in a body with indication of pros and cons of homeothermy for organisms. Regarding the possible genetic mechanisms of homeothermy there is no information at all [4].
The existing hypotheses do not answer the questions: where, why and how did the phenomenon of homeothermy arise? The absence of transitional forms among modern species and the lack of paleontological evidence make understanding the origin of homeothermy difficult and ambiguous. If we assume that homeothermy occurred as part of the evolution of the central organ-based system of physiological thermoregulation in higher eukaryotes, then the question remains unanswered: why did it happen only in birds and mammals? Besides, higher vertebrates do not differ fundamentally in the organ-based system of physiological thermoregulation.
We suggest that homeothermy is not the result of the evolution of central organ-based physiological mechanisms of thermoregulation. Homeothermy is the result of the evolution of some part of non-coding DNAs in the genome of the higher eukaryotes that led to the emergence of chromosomal heterochromatin regions (HRs). Chromosomal HRs are capable to form the condensed chromatin around the nucleus, which underlie the material basis of cell thermoregulation and responsible for dissipating excess heat energy from the nucleus into the cytoplasm. Homeothermics are animals in whose cells chromosomal HRs are able to form the densest layer of condensed chromatin around the nucleus with high thermal conductivity capable efficiently removing excess heat from the nucleus to ensure the implementation of a very high level of cellular metabolism.
To better visualize this viewpoint, it is necessary to recall what chromosomal HRs, condensed chromatin and cell thermoregulation are. Briefly, chromosomal HRs are the highest form of organization of non-coding DNAs, consisting of short repetitive sequences of nucleotides, which constitute the bulk of DNA in the genome of higher eukaryotes and especially in birds and mammals. In humans, non-coding DNAs make up about 98% of their genome and 15%-20% of them form chromosomal HRs. In the interphase cell, chromosomal HRs form a layer of condensed chromatin around the nucleus, which is characterized by the highest density [5].
Based on study of distribution of chromosomal HRs in human populations living under different climate and geographic conditions, in norm and at some forms of pathology the hypothesis about thermoregulation existence at the cell level has been presented. The essence of hypothesis of cell thermoregulation (СТ) is elimination of the temperature difference between the nucleus and cytoplasm when the nucleus temperature becomes higher than in the cytoplasm. The higher eukaryotes use a dense layer of peripheral condensed chromatin (CC) as heat conductor for a more efficient elimination of the temperature difference between the nucleus and cytoplasm. The СС localized between a nucleus and cytoplasm is made of chromosomal HRs. The phenotypic manifestation of CT is the level of body heat conductivity of the individuals in the population with all the ensuing consequences for the organism [5-8].
The mechanism of cell thermoregulation is schematically represented as follows: if for one or another reason the temperature in the nucleus begins to exceed the temperature of the cytoplasm, the second law of thermodynamics comes into force. But it is not just the transfer of heat from the nucleus to the cytoplasm in general that is important here. What matters here is speed and safety. By the latter, we mean the integrity and functional safety of the nuclear envelope, which, like all cell membranes, is very sensitive to high temperature. Without going into details, let us only note that for safe removal of excessive heat energy, special temporary structures (nuclei, chromocentres and other nuclear bodies) are formed in the nucleus to localize and direct the ‘heat flow’ in an organized manner into the cytoplasm for the safety of the nuclear envelope. It is not difficult to imagine that excessive heat energy of the nucleus at uniform exposure of the nuclear envelope can affect its structural integrity and functional abilities (for details see [5-9].
The sources of temperature rise in the cell are more or less clear: all metabolic processes are associated with energy transformations, and they are invariably accompanied by heat release. However, it seems to us highly probable that the temperature rise in the cytoplasm and nucleus must have some peculiarities. In the cytoplasm, the generation of ATP through glycolysis or oxidative phosphorylation leads to an increase in its temperature, and it is removed into the intercellular space and further carried away by the circulation system. Complex processes also take place in the nucleus. Chromosomes have both internal (repair, recombination, rearrangement, modification, restriction) and external (replication, transcription, packaging, organized movement) molecular activities, which are accompanied, inter alia, by some heat output, which can lead to the appearance of excessive temperature. However, this temperature is carried out into the intercellular space not directly but through the cytoplasm, which is not so easy and may require the help of temporary heat dissipating structures in the nucleus (see above).
We believe that the temperature in the nucleus will be higher and rise faster than in the cytoplasm for the following reasons: a) the volume of the nucleus is not comparably smaller than that of the cytoplasm. Therefore, even at the same intensity of metabolism in all parts of the cell, the nucleus should overheat faster and more strongly than the cytoplasm; b) the heat-producing structures of the cytoplasm (mitochondria, ribosomes, etc.) are not gathered in one place as in the nucleus, but are scattered more or less evenly throughout the cytosol, which allows them to dissipate heat relatively easily by diffusion and conduction through the cytoskeleton and ER [5-9].
Thus, the nucleus can conduct heat only in the cytoplasm (in case the nucleus temperature, for this or that reason, exceeds the temperature in the cytoplasm). With this, the nucleus has two options for the dissipation of heat surplus: either by increasing its volume or increasing the heat conductivity of the nuclear envelope. As the first option is limited and the second one is difficult due to the vulnerability of cell membranes to temperature changes, apparently the higher eukaryotes took advantage of the opportunity of a dense layer of peripheral condensed chromatin as heat conductor for a more efficient elimination of the temperature difference between the nucleus and cytoplasm [4-8].
The role of the circulatory systems (CS) very important in maintaining temperature homeostasis on the organism level. However, the CS cannot influence directly to the temperature inside the cells (except for endothelial cells lining the intima of blood vessels), as they are linked with the CS indirectly - through the intercellular space. Thus, the CS influence on inner cellular temperature homeostasis is limited and its effect, in general, comes to transferring surplus heat from the intercellular space. That is why it seems that the problem of maintaining the inner cellular temperature homeostasis is solved by cells themselves, and we call it the cell thermoregulation [5,8].
Evidences for a possible role of cell thermoregulation in the origin of homeothermic animals
Over the years, several methods cell temperature measurements have been developed, each with its advantages and limitations. Broad categories include contact probes, offering direct but potentially invasive measurements; infrared thermography, which is non-contact and useful for surface temperature mapping; and fluorescence-based thermometry, providing high sensitivity and specificity (see review [10]). Thanks to these methods, it was found that heat is not evenly distributed in the cell. It turned out that there are areas in the cell that are characterized by high temperature: nucleus, mitochondria, ribosomes and ER. So, for example, Nakano et.al. [36] show differences of 2.9±0.3°C in the temperature across individual cells, between cytosol and nucleus areas. It is not yet known how heat is distributed in the nucleus. Having no direct experimental data yet, we still assume that heat in the nucleus, as well as in the cytoplasm, is distributed unevenly. Nuclei, chromocentres and other membrane less nuclear bodies should have the highest temperature.
Adaptation of a human to different climatic and geographical conditions has two principal features: a) only man managed to master the entire land of the Earth, while remaining a single, tropical biological species; b) in contrast to animals, human colonization of all climatic-geographical provinces, including the extreme ones (Far North and high-altitude), occurred in a very short period of time. It remains unclear how it all was managed by a human. Regarding genetic mechanisms, the main question is not clarified: did a human adapt only with the help of genes or did he use a means inherent only in H. sapiens? The data obtained when analyzing the genomes of populations living in different high-altitude provinces (Tibet, the Andes, and the Ethiopian Plateau) turned out to be extremely contradictory [11-19]. Without going into long discussions, we decided to limit ourselves here to the well-known remarks of E. Mayr [20], who rejected reductionism in evolutionary biology, arguing that ‘evolutionary pressures act on the whole organism, not on single genes, and that genes can have different effects depending on the other genes present’. He rejected the idea of a gene-centred view of evolution, insisting ‘a gene is never visible to natural selection and in the genotype’.
If not genes, then what? Our experience in the search for the genetic basis of human adaptation to some extreme natural conditions in Eurasia (the Extreme North of Eastern Siberia, the Pamir and Tien-Shan high-altitudes) shows that, apparently, chromosomal HRs is the sought genetic material. We believe that this is a highly probable response; in adapting to a climate different from that of East Africa, humans have used a non-genic part of their genome (chromosomal HRs), known for its high mobility and neo-conservatism in individual development and evolution (for details see [21-29]).
It is well known that only man is capable of endurance running and, in this sense, he has no equal among animals. There are different answers. Walking upright has allowed us to become some of the best distance runners, but at the expense of speed. It is also believed that to run long distances on the African savannah man needed to have an effective cooling system and it is believed that man has developed one.
We believe that there is another important factor unique to man, which ultimately allowed him to occupy the top of the food chain. This factor is the peculiarity of the heat-conducting ability of the human body. Man became a good long-distance runner because among animals he has the most highly heat-conducting body, which allowed him to effectively dissipate excess heat outside the body [30].
When running, especially for long distances, a person faces the main threat: overheating of the body. It is known that for this purpose a man uses two ways of heat dissipation: evaporation of moisture from the body surface and respiratory tract. However, we believe that humans must possess an additional, perhaps inherent only to the species H. sapiens means of combating overheating of the organism. By this, we mean its heat-conducting ability [31].
It has been experimentally shown that the effect of CT can be indirectly assessed by the level of the body heat conductivity (BHC). In particular chromosomal Q-HRs, which along with C-HRs are present in the human karyotype influence on the level of the human BHC [31]. We have shown in our time that the greatest number of chromosomal Q-HRs are contained in the genome of indigenous people of subequatorial Africa [24]. Since there is a close relationship between the level of human BHC and the quantitative content of chromosomal Q-HRs in its genome, there is nothing unexpected in the fact that athletes from subequatorial Africa (e.g. marathon runners from Kenya and Ethiopia) differ in sports that require, among other things, effective heat dissipation outside the body. Indeed, a sportsman with high heat conductivity cannot make much progress in mountaineering and water sports because their body cools rapidly. However, this sportsman can be more successful in sports, which require effective heat-loss [34].
Homeothermy is a pronounced aromorphosis - a progressive evolutionary change leading to an overall increase in the level of adaptation of an organism to changing environmental temperature conditions. Numerous studies have shown that birds and mammals use an order of magnitude more energy to maintain their vital activity and, consequently, consume more of it. It is known that the reptiles have survived to the present time mainly by lurking predators and only a small number of herbivorous forms, almost all of them living in ‘warm’ regions. At the same time, homeothermic animals have conquered practically the entire livable part of the biosphere, canalized new energy flows and displaced reptiles from the main niches.
Let us look at how homeothermic animals live in reality. We will try to illustrate of this issue by the example of two organisms, comparable in size, human and crocodile, typical homeothermic and poikilothermic organisms. Let us start with how they eat. As known, at one time crocodiles can eat up to 23% of their body weight. Crocodiles are well adapted for long-term fasting. Without food, adult crocodiles can live about one year. While the mammal predators of the same size as crocodiles daily require approximately 5–10 times more food. At the same time, about 90% of the calories obtained from food are spent on maintaining a constant core temperature in the body. It seems to us that the level of intracellular metabolism is not determined by the ability of animals comparable in mass to generate a lot of energy or its availability. The ability of cells to remove excess heat from the nucleus to the cytoplasm in a timely manner is extremely important in order to avoid undesirable consequences of high thermal energy for such vital genetic processes as repair, recombination, replication, transcription, rearrangement, packaging etc. of DNA. And this is possible only through CT using a dense layer of CC in interphase cells [4-6].
Nevertheless, this does not mean that CT is an effect exclusively of chromosomal HRs. As is known, in the chromosomes of higher eukaryotes except HRs there are G+ bands, which make up more than half of their length. It is believed that in the composition of chromosomal G+ bands can be heterochromatin materials, the so-called intercalary heterochromatin. Even if G+ bands do not contain HRs, the fact that they are tightly packed in the body of mitotic chromosomes convinces that they can also participate in CT as part of CC [7].
We believe that the CC should be the densest domain in bird and mammal interphase cells among higher vertebrates. This confidence is due to the fact that the clearest differentials staining (C-, G - and Q-bands) give the human mitotic chromosomes, then other higher primates, and then the rest of the mammals. Bad or not differential staining gives chromosomes of reptiles and amphibians. By the way, only C-bands can be obtained on plant chromosomes. Referring to the ability of chromosomes to give a differential staining, we have in mind the well-known fact that C+, G+ and Q+ bands represent the densest areas of mitotic chromosomes, enriched with heterochromatin and other types of non-coding high repetitive DNAs, which constitute the physical basis of CC. Our assumption about the highest density of CC in human cells among mammals is due to the fact that: a) the human genome has all known types of constitutive heterochromatin (C - and Q-HRs); (b) among the higher primates, the highest amount of chromosomal C-HRs is found only in the human karyotype [6,7,21-29].
We assume that the chromosome segments of the higher eukaryotes have undergone their own evolution in the direction: C-heterochromatin → G+ and Q+ bands → Q-heterochromatin as response of a cell nucleus for the demand of multicellular organisms in denser packaging of non-coding DNA for the increase of the heat-conducting effect of CC between the nucleus and cytoplasm [6,7]. For example, at a later stage of evolution of the mammals in Africa in the ancestors of three higher primates (Homo sapiens, Pan troglodytes and Gorilla gorilla) besides C-heterochromatin, a new type of constitutive heterochromatin, Q-heterochromatin, appeared [6]. Obviously, this is related to the increase of the metabolism intensity in their organism, and, accordingly, the further improvement of the cell thermoregulation. In this case the Q-heterochromatin is not only a new type of constitutive heterochromatin, but possibly an additional ‘center of compactization and attraction’ for more dense packaging of adjacent inactive chromatin, thus, increasing the heat conducting effect of CC in the interphase cell of three higher primates [4,7].
If our reasoning really has to do with real events in animal evolution, then for example, it is not difficult to explain why the crocodile did not become a homeothermic animal. It seems to us highly probable that the main cause of poikilothermy in a crocodile is the peculiarities of its karyotype; as in all reptiles’ crocodile chromosomes, give a bad differential staining. This means that in such cells the density of CC is low, which complicates the effective transition of excess metabolic heat from the nucleus to the cytoplasm. Perhaps a crocodile lies for so long after the reception of the next portion of food not because of problems associated with digestion (for example: lack or few of food processing enzymes), and because excessive physical activity may cause a risk of overheating of the body. Homeothermic animals solve this problem by efficient removal of excess metabolic heat from the interphase nucleus to the cytoplasm with a dense layer of CC, that is, they have a more perfect cell thermoregulation.
Of course, there will be opponents who believe that mechanisms of physiological thermoregulation, for example, in human are perfect; otherwise, he could not master almost all the land on Earth so rapidly and effectively. We suppose that during his evolution man, possibly owing to chromosomal Q-HRs, had an additional and very flexible tool to ensure more effective thermoregulation, allowing him to master almost all the oykumene [31,32]. In essence, all that was said comes to one simple thought: how does man as a homeothermic being differ from other mammals as concerns preservation of temperature homeostasis. As far as we know, H. sapiens is not only devoid of a more or less large anatomic structure, but also has no protein or enzyme that has no analogue in the animal world. The fundamental structural characteristic of man is the presence of chromosomal Q-HRs in its genome, which he has inherited together with the chimpanzee and the gorilla – from one common ancestor. In this context, the only difference of H. sapiens is the wide quantitative Q-HRs variability in his genome [5].
Every form of cell activity, like cell division, gene expression, enzyme reaction, metabolism and pathological states are marked by temperature changes. In fact, the heat energy released by individual cells as a by-product of their vital activity is very small. However, the approximately 37 trillion cells in the human body together have been shown to be capable of maintaining his core temperature at 37 ⁰C. This macroscopic outcome of the cell thermoregulation is the most important and only function of heat.
Birds and mammals have become homeothermic animals, perhaps not because they have the most developed systems of physiological thermoregulation. Their homeothermy is due to the evolution of non-coding DNAs, chromosomal HRs and chromosomal bands (G + and Q +), which have proven to form the densest layer of condensed chromatin around the nucleus among existing animal cells. Due to this, the removal of excess thermal energy from the nucleus has become more effective than that of poikilothermic animals with all the ensuing consequences. Essentially homeothermic organisms can be seen as energy conversion entities governed by the second law of thermodynamics [35].
Apparently, the physiological thermoregulation functions relatively independently from CT as evolutionally new adaptive system. From our point of view, CT can be the missing link, which should fill the "gap" between the thermoregulation systems, functioning at the molecular level and the whole organism (for details see [5,32,33]).
Acknowledgement
I apologize to those authors, whose works were not cited, or were cited only through reviews, owing to space limitations.
Conflicts of Interest: None.
Funding: Has not been received for the study.
Statement of Consent/Ethical Approval: Not required.
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Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
