AUCTORES
Globalize your Research
Research Article | DOI: https://doi.org/10.31579/2578-8965/111
1 Pediatric growth and development research center, Iran University of Medical Sciences, Tehran, Iran.
2 pediatric infectious diseases Department &Research center, Iran University of Medical Sciences. Tehran, Iran.
3 University of Medical Sciences, Tehran, Iran.
4 ENT and Head and Neck Research Center and Department, Hazrat Rasoul Akram Hospital, The Five Senses Health Institute, Iran University of Medical Sciences, Tehran.
*Corresponding Author: Samileh Noorbakhsh, pediatric infectious diseases Department &Research center, Iran University of Medical Sciences. Tehran, Iran.
Citation: Mohammad V.Shahi, Noorbakhsh S., Tahernia L., Ashouri S. (2022) Ocular Lesion Due To Congenital Infections with Cytomegalovirus, Toxoplasmosis: Diagnosis, Treatment And Follow-Up: A Prospective Study in Tehran, Iran. J. Obstetrics Gynecology and Reproductive Sciences; 6(3) DOI:10.31579/2578-8965/111
Copyright: © 2022, Samileh Noorbakhsh, This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 04 December 2021 | Accepted: 17 December 2021 | Published: 10 January 2022
Keywords: cytomegalovirus; ocular disorders; t. gondii; intrauterine infections; infants
Intrauterine infections lead to involvement of various organs in fetus, including the eye. The aim of this study was to determine the frequency and clinical response of ocular lesions to specific drugs in infants with congenital Toxoplasma and cytomegalovirus infections. This historical cohort study was performed in the pediatric and ophthalmology department of Rasoul Akram Hospital in Tehran from October 2011 to November 2017. Patients included 78 infants with ocular involvement due to proven intrauterine infection (cataracts, glaucoma, and retinitis). Infants who did not undergo additional and diagnostic tests, eye examinations, and follow-up and did not receive effective treatment were excluded from the study. Three patients expired during the study. Finally, 37 patients (including 25 patients with cytomegalovirus and 12 patients with toxoplasmosis) were included to assess and the clinical response to ocular lesions was evaluated for one year. Of 12 cases with toxoplasmosis, 5 patients received complete treatment. Four patients had appropriate clinical responses. Of 25 patients with CMV, 18 patients received complete treatment and 9 patients had appropriate clinical responses.
It concluded that successful treatment will be obtained in near 80% of ocular toxoplasmosis. So anti toxoplasma treatment is recommended in all confirmed congenital cases. About 50% of CMV infected cases (with hearing loss, ocular involvement) might respond well to antiviral therapy. We recommend anti CMV treatment in young congenital CMV (<2 years old) but it is not indicated in CMV infected cases with severe brain involvement.
Running title: Ocular lesion in congenital infection; Cytomegalovirus, Toxoplasmosis
Congenital or intrauterine infections are significantly important in all countries around the world in terms of prenatal control and postpartum diagnosis. Despite widespread use of vaccines to control common childhood infections, even in developed countries, infections such as cytomegalovirus, herpes, and other respiratory viruses or parasites such as toxoplasmosis cannot be prevented and may result in intrauterine infection syndrome in infants 1. The prevalence of cytomegalovirus in the world is between 40 and 100%. Toxoplasma is an important cause of intrauterine infection in neonates [ 2 , 3].
The prevalence of anti-toxoplasma antibodies varies in women of childbearing age in every country and even in different parts of a country [1-4]. The classic characteristics of congenital infections includes fever, hydrocephalus, microcephalus, hepatosplenomegaly, icter, seizure, chorioretinitis, cerebral calcification, and increased protein and mononuclear poleocytosis in cerebrospinal fluid 5. It seems that the probability of developing congenital toxoplasmosis is much higher in Iran compared to the United States, about more than 60 to 80 times [6,7].
According to the studies conducted in Iran similar to other countries, cytomegalovirus is one of the most common intrauterine infections. The previous studies in Rasoul Akram hospital with the aim of neonatal screening had shown that cytomegalovirus was more common but had milder symptoms compared to other causes of intrauterine infections [8]. In Iran, toxoplasmosis screening has not yet been performed, while the incidence of toxoplasmosis is so high to be screened. Prenatal screening can help identify mothers who are susceptible to infection. Screening for antibodies enables early prevention of toxoplasmosis infection in which dietary habits and hygiene practices are clearly identified as risk factors [9]. Recent studies have shown that frequency of immunoglobulin G and M against toxoplasmosis were 44.1% and 1% respectively which was less than frequency in mothers. In all cases, the polymerase chain reaction (PCR) of the cerebrospinal fluid was negative. The most common symptoms of congenital infection were ocular (50%) and cerebral (50%) symptoms [10].
The purpose of this study was to determine the frequency and rate of response to treatment in ocular lesions in children with various types of intrauterine infections.
The current historical cohort study was performed on all children aged up to 2 years referred to the clinic of ophthalmology department of the Rasoul akram Hospital in Tehran to diagnose and treat important ophthalmic problems from October 2011 to November 2017.
This study has adhered to the principles of Helsinki and has been approved by the ethics committee of the Infectious Diseases Research Center of Children affiliated with Iran University of Medical Sciences with code of 9321165001.Data from all individuals was also retained by the researchers. The all taken measures were after receiving informed consent from parents and all were completely necessary and very helpful for the diagnosis and treatment of referred patients.
Cases definition: Children with ocular lesions caused by intrauterine CMV and toxoplasmosis infections were included in this study.
All patients with eye lesions were followed regularly. Follow up sessions for at least a whole year were recorded in the file, and the results of ophthalmology examinations were recorded and finally evaluated. After this stage, all patients were referred to pediatrician in order to filling out the questionnaire, conducting additional evaluations according to the history and clinical examination, performing additional tests (if necessary) and finally study variables. The possible causes of ophthalmic lesions were identified. After diagnosing the site of involvement inside of the eye in each patient (retinitis, glaucoma, and cataract) for final diagnosis, determining the cause of ophthalmic lesions, examining other systemic problems in the child, all were referred to a pediatric clinic. Ultimately, in some patient’s intrauterine infection was diagnosed.
Exclusion criteria: Patients who did not reach the final diagnosis, despite the available examinations, did not undergo additional and diagnostic tests and were excluded did from our study. Those who acted contrary to the ophthalmologist prescribed instructions for treatment or follow-up were excluded as well from the study.
Statistic: the frequency for the qualitative variables was expressed based on the mean and standard deviation and for the qualitative variables as the percentage. Comparison between quantitative variables was performed by Student's t-test and comparisons between qualitative variables were also performed using Chi-square test or Fisher's exact test. SPSS software, version 18 (IBM SPSS, Armonk, NY, USA) was used to analyze the data statistics. Levels less than 0.05 were considered significant.
Totally, between 78 cases of patients with the diagnosis of Intra uterine infection, 37 of them had ophthalmic lesions. Of total cases, 25patients were infected with CMV and 12 were infected with toxoplasmosis. Three patients expired meanwhile. Other patients did not receive antiviral treatment due to parental dissatisfaction, the severity of brain involvement and parental frustration with complete recovery. Due to the mentioned causes, medical treatment was limited to supportive measures such as cerebral shunting, treatment of heart problems and cochlear implants.
Thirty-seven children were treated and examined for ophthalmic lesions resulted from intrauterine infection. Thirteen cases had specific treatment responses and 24 children did not respond to treatment. Of 12 children with ocular toxoplasmosis, only five patients continued their treatments, with four (80%) appropriate clinical response, but only one patient (20%) did not improve significantly despite treatment. Of 25 infants with cerebral involvement caused by congenital CMV infection, only 18 cases continued treatment. Totally 9 cases showed appropriate clinical responses and remaining 9 patients did not improve significantly despite antiviral therapy. One case did not follow examining sessions after treatment. The lack of response to CMV treatment was mainly observed in patients with severe brain lesions from birth. The best response to treatment was reported in patients with hearing loss, ocular involvement and no brain involvement. Comparison between patients' clinical response to antiviral drugs based on sex and other variables could not be concluded due to the small number of cases. The ophthalmic involvement was not different between two groups of with and without clinical response (P = 0.3). The mean age of patients who had a good clinical response did not differ significantly from the unresponsive group. (4±1.5 compared to 4.2± 2.5 months) (P =0.7).
In present study 25 patients with ocular lesion were infected with CMV and 12 were infected with toxoplasmosis. The ocular lesions responded well to specific treatment in 80% of toxoplasma cases and 50% of cytomegalovirus patients.
The unresponsive of CMV infection to antiviral therapy was generally observed in patients with severe brain damage at birth (due to severity and involvement in the early months of fetal period). The best response to treatment was detected in patients with hearing loss and ophthalmic lesions without cerebral involvement. The clinical response of CMV to specific drugs was not dependent on age of infants.
High CMV seroprevalance observed in Iranian pregnant women [9-11] On the other hand, congenital CMV infection has been one of the most common causes in infants suspected of having intrauterine infections not only in our center but also in other Iranian studies [12] .Karimina et al reported that from 1617 neonates born in Isfahan, only 8 cases at birth (49%) had a positive CMV-PCR (Polymerase chain reaction) in urine sample, that were mostly immature. In 3 patients, the clinical symptoms were temporary and resolved. In one case, a slight hearing loss was reported in the next follow-up [12].
In last decade results of studies for T Gondii infection determined the prevalence of T Gondii antibodies in Iranian population ranged between 24% to 57.7%. 13-15 Daryani et al. (2014) in a systematic review and meta-analysis studied the seroprevalence of T.Gondii in the Iranian general population in 35 studies 13. From of 35 reports, the overall seroprevalence rate of toxoplasmos among the general Iranian population was 39.3% (95% CI = 33.0%–45.7%). There was no significant difference in the seroprevalence rate between male and female patients. A significant linear trend of increasing overall prevalence by age was noted (P < 0>
Indeed we observed previous (+IgG) and recent (+IgM ) immunity to T Gondii in 34.7% and 7.1% of young pregnant women in in our centers , recent T Gondii infection ( +IgM) observed in 9.8% of infants(<2y>
So, congenital toxoplasmosis can be prevented by the treatment of Active T.Gondii infection in pregnantwomen [17].
Successful treatment will be obtained in near 80% of ocular toxoplasmosis, so anti toxoplasma treatment is recommended in all confirmed cases. About 50% of CMV infected cases (with hearing loss, ocular involvement) might respond well to antiviral therapy, we recommend anti CMV treatment in young cases (<2>
Ethics approval and consent to participate:
This study was accredited by Ethical Committee of Iran University of Medical Sciences. Helsinki Declaration was respected across the study and the informed consent form was signed by the parents.
Competing interests
The authors declare no conflict of interest in preparing this study.
Funding
This study received no specific grant from any funding agency in the public, institutions or not-for-profit sectors.
All authors confirm Consent for publication
All authors confirm Availability of data and materials
Acknowledgment
This paper is based on the result of a dissertation entitled "Determining the frequency and response rate of ophthalmic lesions in children with various types of intrauterine infections (cytomegalovirus and toxoplasmosis)" in 2017 and code of 3081 has been implemented with the support of the Infectious Diseases Research Center of Iran University of Medical Sciences.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
