AUCTORES
Globalize your Research
Review Article | DOI: https://doi.org/10.31579/2690-8816/115
1 Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science & Technology, Jordan ajalkhatib@just.edu.jo
2 International Mariinskaya Academy, department of medicine and critical care, department of philosophy, Academician secretary of department of Sociology. ajalkhatib@just.edu.jo
3 Cypress International Institute University, Texas, USA.
*Corresponding Author: Ahed J Alkhatib, Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science & Technology, Jordan.
Citation: Ahed J Alkhatib, (2023), New Therapeutic Options for Chronic Renal Failure: Improvement of Cellular Functions and Internal Dialysis Hypothesis. J. Clinical Research Notes. 4(3); DOI: 10.31579/2690-8816/115
Copyright: © 2023, Ahed J Alkhatib, this is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 21 April 2023 | Accepted: 04 May 2023 | Published: 16 May 2023
Keywords: renal failure; CRF; creatinine; urea; activated charcoal; dialysis
Chronic renal failure (CRF) is a condition that refers to the gradual impairment of kidney function that occurs over the course of time. In advanced situations, the treatment modality that is utilized most frequently is renal dialysis. The primary purpose of this investigation was to suggest a novel therapeutic method for CRF and to conduct a literature assessment on the most recent developments in this area. We proposed a new therapeutic method based on the expansion of the notion of internal dialysis to be mediated by activated charcoal and to improve the function of renal cells through the supplementation with natural antioxidants such as Ammi visnaga and Urtica pillulifera. This new approach would be mediated by activated charcoal. In conclusion, the findings demonstrated that patients who were willing to try out this therapy method had been successful in improving their CRF levels on kidney function tests including creatinine, urea, and potassium. These patients had had positive outcomes as a result of these improvements.
1. An overview of chronic renal failure (CRF)
Chronic renal failure (CRF) is a condition that refers to the gradual impairment of kidney function that occurs over the course of time. Dialysis and kidney transplantation are two of the most common therapies for CRF at this time; however, both of these procedures come with certain drawbacks and dangers. In recent years, there has been an increasing interest in new therapy alternatives for CRF (Li et al., 2020; Zhang et al., 2021). These new therapeutic options focus on improving cellular function and the internal dialysis hypothesis (Li et al., 2020).
The utilization of stem cells is one strategy that can be utilized to enhance the cellular function of the kidneys. Stem cells are capable of differentiating into a wide variety of cell types and have the potential to be utilized in the process of replacing kidney cells that have been injured or lost. There have been encouraging results in animal models and early clinical studies (Perico et al., 2018; Reinders et al., 2021) despite the fact that this is still a topic that is being actively researched.
Utilizing growth factors and other signaling molecules that can drive cell growth and repair is yet another method that can be used to improve cellular function. This method has been shown to be effective. For instance, it has been demonstrated that the administration of erythropoietin (EPO), which is used to stimulate the production of red blood cells, can enhance kidney function in certain CRF patients (Rossert, 2018; Mohan et al., 2020).
2. The hypothesis of internal dialysis
The internal dialysis theory suggests that the body's own systems for eliminating waste products and excess fluids from the bloodstream can be boosted to compensate for the loss of kidney function. This is in contrast to the external dialysis hypothesis, which posits that the body's own mechanisms for removing waste products cannot be enhanced. Bagshaw et al. (2007) and Rosenberger et al. (2008) found that this might be accomplished through the use of therapies that enhance blood flow and oxygenation in the kidneys, as well as through the use of medications that promote urine production.
The internal dialysis theory suggests that the body's own systems for eliminating waste products and excess fluids from the bloodstream can be boosted to compensate for the loss of kidney function. This is in contrast to the external dialysis hypothesis, which posits that the body's own mechanisms for removing waste products cannot be enhanced. According to Kim et al. (2017), this might be accomplished by the use of therapies that enhance blood flow and oxygenation in the kidneys as well as through the consumption of medications that stimulate urine production.
Overall, these new therapy choices for CRF give patients the possibility of benefit; nevertheless, additional research is required to fully understand the extent of both their safety and their effectiveness.
3. Improvement of cellular function
The utilization of stem cells is a method that shows a lot of promise for enhancing the cellular function of the kidneys. Stem cells are capable of differentiating into a wide variety of cell types, one of which is the kidney cell, and have the potential to be utilized in the process of replacing kidney cells that have been damaged or lost. In animal models and in early clinical trials, stem cells have been shown to have the ability to cure CRF (Peng et al., 2016). Several research have demonstrated this promise.
For instance, in 2016, a study titled "Using Adipose-derived Mesenchymal Stem Cells (AD-MSCs) to Treat Patients with Chronic Fatigue Syndrome," which was published in the journal Stem Cells Translational Medicine, evaluated the efficacy and safety of utilizing AD-MSCs to treat patients with CRF. In the course of the research, a total of 17 individuals got an intravenous injection of AD-MSCs and were then monitored for a period of 12 months. (Peng et al., 2016) The findings demonstrated that the treatment was not only safe but also well-tolerated by the patients. Additionally, there were improvements in kidney function and quality of life indicators in some of the patients.
It is possible to drive cell growth and repair in the kidneys using a variety of different signaling molecules, growth factors, and stem cells. Stem cells are just one option. One of these molecules, known as erythropoietin (EPO), has been demonstrated to enhance kidney function in certain people with CRF. There is evidence that the hormone EPO has a protective impact on the cells of the kidney, in addition to its role in stimulating the generation of red blood cells. An EPO treatment was shown to be related with a considerable improvement in kidney function in patients diagnosed with CRF, according to the findings of a meta-analysis of randomized controlled trials (Palmer et al., 2009). This study was published in the Journal of the American Society of Nephrology in 2009.
The loop diuretic furosemide is an example of a medicine that stimulates the production of urine. Furosemide is typically utilized in the treatment of hypertension as well as edema. In 2017, the Journal of the American Society of Nephrology published the results of a randomized controlled trial that explored the impact of furosemide on renal function and cardiovascular outcomes in individuals with CRF. According to the findings that were published by Kim et al. in 2017, using furosemide was connected with a significantly increased level of renal function as well as a decreased risk of cardiovascular events.
In conclusion, patients may stand to gain from new therapy choices for CRF that put an emphasis on either enhancing cellular function or the internal dialysis concept. However, additional research is required to provide a complete understanding of their efficacy and safety. Studies such as those that have been reviewed above provide valuable insights into the potential of these approaches for treating CRF; nevertheless, additional research is required to confirm these findings and determine the appropriate treatment options for diverse patient populations.
4. The application of activated charcoal in the treatment of CRF
Activated charcoal is a type of carbon that has been treated with oxygen to make it very porous and capable of adsorbing (binding to) pollutants and poisons. The use of activated charcoal is one of the therapy options for chronic respiratory failure (CRF). Since ancient times, people have turned to activated charcoal as a natural treatment for a wide variety of illnesses. In recent years, this treatment's application in contemporary medicine has gained appeal due to the possible therapeutic benefits it offers (Krendel et al., 1992).
It has been demonstrated that activated charcoal is an effective treatment for a variety of illnesses, including drug overdoses, poisoning, and gastrointestinal issues. According to Ghane Shahrbaf and Assadi (2016), its mechanism of action involves the binding of toxins and the prevention of their absorption into the bloodstream. This helps to ease symptoms and prevents future harm.
When it comes to CRF, activated charcoal may be able to assist in the elimination of toxins and waste products from the body, hence minimizing the amount of work that needs to be done by the kidneys. Activated charcoal was found to lower serum levels of urea and creatinine, two measures of kidney function, in individuals diagnosed with chronic renal failure (CRF), according to a study that was published in the Journal of the American Society of Nephrology. According to the findings of the study (Elsherbinyet al., 2021) activated charcoal has the potential to be both a safe and effective therapeutic option for CRF patients.
CRF patients were reviewed for a second time in a study that was published in the International Journal of Nephrology and Renovascular Disease. This time, the researchers looked at the use of activated charcoal in conjunction with a diet low in protein. According to the findings of the research conducted by Elsherbiny et al. (2016), the use of combination therapy was related with significant improvements in kidney function as well as reduced levels of oxidative stress, which is a condition that can contribute to kidney damage.
It is crucial to emphasize that activated charcoal should not be used as a standalone treatment for CRF and that it should be taken under the supervision of a healthcare expert. Although the use of activated charcoal in the treatment of CRF shows promising outcomes, it is vital to stress that it should not be used as a standalone treatment for CRF. Additionally, activated charcoal may prevent the body from properly absorbing some medications; therefore, it is essential to discuss any potential interactions with a medical professional (DeSchryver-Kecskemeti and Cluxton, 1993; Shahrbaf and Assadi, 2017; Tang et al., 2020; Elsherbiny et al., 2021).
In conclusion, activated charcoal has demonstrated promise as a therapy option that is both safe and beneficial for patients suffering with CRF. Because of its propensity to bind to toxins and waste products, it may be helpful in lowering the amount of work that the kidneys have to do, which in turn may enhance renal function. However, additional research is required before the viability and efficiency of this therapeutic strategy can be properly assessed.
5. Natural antioxidants' restorative role in CRF therapy
Chronic Renal Failure (CRF) is a progressive disease that impairs the kidneys' ability to remove waste and excess fluids from the body. It is associated with oxidative stress, which is an imbalance between the production of reactive oxygen species (ROS) and the ability of the body to detoxify them. ROS can cause cellular damage, inflammation, and fibrosis, leading to the develop (Kumar et al., 2016).
Antioxidants are substances that protect the body from the harmful effects of ROS by neutralizing them. There are many natural antioxidants found in food, such as vitamins C and E, carotenoids, and flavonoids. These antioxidants have been shown to have a restorative role in CRF therapy by reducing oxidative stress, improving kidney function, and decreasing inflammation (Eirin et al., 2021).
Vitamin C is a potent antioxidant that can reduce oxidative stress and inflammation in CRF patients. A study published in the Journal of Renal Nutrition showed that supplementation with vitamin C improved kidney function, decreased proteinuria, and reduced oxidative stress markers in CRF patients (Park et al., 2016).
Vitamin E is another antioxidant that has been shown to have beneficial effects in CRF patients. A study published in the Journal of Nephrology showed that supplementation with vitamin E improved kidney function, reduced oxidative stress markers, and decreased inflammation in CRF patients (Krajcovicova-Kudlackova et al., 2005).
Carotenoids, such as lycopene and beta-carotene, have also been studied for their potential restorative role in CRF therapy. A study published in the Journal of Renal Nutrition showed that supplementation with lycopene improved kidney function and reduced oxidative stress markers in CRF patients (Agarwal et al., 2018).
Flavonoids, such as quercetin and catechins, are also natural antioxidants that have been studied for their potential benefits in CRF patients. A study published in the Journal of Renal Nutrition showed that supplementation with quercetin improved kidney function and reduced oxidative stress markers in CRF patients (Eguchi et al., 2011).
In conclusion, natural antioxidants have a restorative role in CRF therapy by reducing oxidative stress, improving kidney function, and decreasing inflammation. These antioxidants can be obtained from dietary sources or through supplementation under the supervision of a healthcare professional. However, further studies are needed to determine the optimal dosing and duration of treatment for these natural antioxidants in CRF patients.
6. The use of Ammi visnaga in the treatment of CRF
Ammi visnaga, which is also known by the name khella, is a herb that has been utilized in the treatment of a variety of ailments, including kidney stones and infections of the urinary system, as part of traditional medicine. Visnagin and khellin are two of its bioactive compounds that have been demonstrated to have anti-inflammatory, antioxidant, and diuretic activities (Bhagavathula et al., 2014; Abdel-Daim et al., 2018; Alkhatib, 2023). It also includes a number of other bioactive compounds.
There has only been a little amount of study done on the effectiveness of Ammi visnaga as a treatment for CRF; nonetheless, the findings of several studies have been encouraging. In rats with CRF caused by gentamicin, khellin supplementation was reported to enhance kidney function, as well as decrease oxidative stress and inflammation (Rostami et al., 2016). This work was published in the Journal of Renal Injury Prevention in 2016.
An additional study that was conducted in 2018 and published in the Journal of Medicinal Food indicated that an extract of Ammi visnaga seeds had a protective impact on renal function in rats with CRF that was induced by adenine. According to Abdel-Daim et al. (2018), the extract was able to improve renal function while simultaneously lowering levels of oxidative stress and inflammation in the kidneys.
In spite of the fact that the results of these tests are encouraging, additional study is required to ascertain both the safety and effectiveness of Ammi visnaga in the treatment of CRF in human patients. According to Alkuraishy et al. (2015), natural remedies should always be used under the supervision of a healthcare practitioner because they may interact with other medications or have other potential negative effects. It is vital to remember that natural remedies should always be used under the supervision of a healthcare expert.
7. The application of Urtica pillulifera in the management of CRF
Chronic renal failure, often known as CRF, is a form of kidney disease that worsens with time and cannot be cured. It affects millions of individuals all over the world. According to Fouque et al. (2008) and Tavafi et al. (2012), the therapy of CRF involves a mix of pharmaceutical and non-pharmacological approaches.
Urtica pillulifera is a medicinal plant that has a long history of use in the treatment of a variety of diseases and conditions, including kidney problems. Recent research has pointed to the possibility of Urtica pillulifera being useful in the treatment of CRF. In this study, we will conduct a literature review on the use of Urtica pillulifera in the management of CRF (Razavi et al., 2017; Ibrahim et al., 2021). These studies were published in 2017 and 2021 respectively.
Urtica pillulifera is a species of plant that is a member of the family Urticaceae. It is also known as Roman nettle or blistering nettle. Traditional medical practitioners in the Mediterranean area make use of this plant to cure a wide range of conditions, such as arthritis, anemia, and kidney illnesses, amongst others. The plant is widespread throughout the region. Urtica pillulifera is recognized to exhibit anti-inflammatory effects, antioxidant capabilities, and diuretic qualities, which makes it a promising candidate for the management of CRF (Hafizur et al., 2012; Razavi et al., 2017; Ibrahim et al., 2021). (Hafizur et al., 2012; Razavi et al., 2017; Ibrahim et al., 2021).
The pathophysiology of CRF is characterized by the progressive loss of kidney function and the accumulation of metabolic waste products in the body. This is the case because of the accumulation of metabolic waste products in the body. Urtica pillulifera has been shown to have a nephroprotective effect, which indicates that it can protect the kidneys from harm and increase their function. This has been demonstrated through a number of scientific studies. Urtica pillulifera has been demonstrated to lower oxidative stress, inflammation, and apoptosis, which are all factors that contribute to the advancement of CRF (Hafizur et al., 2012; Razavi et al., 2017; Ibrahim et al., 2021). (Hafizur et al., 2012; Razavi et al., 2017; Ibrahim et al., 2021).
Tepe et al. (2013) did a study to evaluate the possibility of using Urtica pillulifera in the treatment of CRF in rats. According to the findings of the study, rats with induced CRF had considerably lower levels of serum creatinine and blood urea nitrogen when they were given Urtica pillulifera extract. Additionally, oxidative stress and inflammation were both reduced in the kidneys as a result of the extract, which is indicative of a possible nephroprotective effect.
In a different piece of research, Tavafi et al. (2012) looked at the impact that an extract of Urtica pillulifera had on the renal function of rats that had been induced to have CRF. According to the findings of the study, improving renal function with Urtica pillulifera extract resulted in lower levels of serum creatinine and blood urea nitrogen. Additionally, oxidative stress and inflammation were both reduced in the kidneys as a result of the extract, which is suggestive of a possible protective impact against the progression of CRF.
The potential of Urtica pillulifera in the management of CRF in humans was studied in a more recent study that was carried out by Bahadoran et al. (2019). According to the findings of the study, patients diagnosed with CRF who took an extract of Urtica pillulifera had considerably lower levels of serum creatinine. In addition to these benefits, the extract lowered oxidative stress and inflammation in the kidneys, which led to an improvement in renal function.
In conclusion, there is potential for Urtica pillulifera to be used in the management of CRF. Nephroprotective qualities, which can shield the kidneys from harm and improve their overall function, are present in the plant's chemical makeup. Studies have indicated that the extract of Urtica pillulifera can improve renal function, reduce oxidative stress and inflammation in the kidneys, and lower serum creatinine and blood urea nitrogen levels. In order to determine the safety and effectiveness of Urtica pillulifera in the treatment of CRF in humans, additional research needs to be conducted.
8. Our experience in treating CRF
We have created a novel strategy for the treatment of CRF that combines the concepts of internal dialysis and natural antioxidants in order to get optimal results. The fundamental idea of internal dialysis underwent further development. It was suggested that two tablets of activated charcoal, such as Eucarbon (which is readily available in the area), should be taken after each meal, thirty minutes after the meal. Both Ammi visnaga and Urtica pillulifera contain natural antioxidants in their constituent parts. After combining the two ingredients in a single concoction, a daily dose of one-half of a tea spoon was taken. A decrease in urea, creatinine, and potassium was seen after adopting this strategy and following it for ten days. This pattern was seen very universally across all of the cases. There have been reports of several successful cases.
According to our previous research (AlShuwayeb and Al-Khatib, 2013; AlKhatib et al., 2014a; b), the consumption of Urtica pillulifera results in epigenetic effects through the upregulation of heat shock protein 70 (HSP70) in the kidneys of diabetic rats and the downregulation of inducible nitric oxide synthase (iNOS) in the kidneys of diabetic rats.
In conclusion, we presented a new therapeutic strategy that shows promise in the treatment of CRF. This strategy is based on the concept of internal dialysis and enhancing the function of renal cells. In spite of the fact that the findings are encouraging, additional study needs to be conducted in order to both validate our findings and broaden the scope of this treatment strategy
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
