AUCTORES
Globalize your Research
Research Article | DOI: https://doi.org/10.31579/2834-5142/017
1 Departament of Urology. Hospital “Evita Pueblo”, Berazategui, Buenos Aires, Argentina.
2 Chair of Cytology, Histology and Embryology, Faculty of Medical Sciences, UNLP, Buenos Aires, Argentina.
*Corresponding Author: Pablo Francisco Colaci, Departament of Urology. Hospital “Evita Pueblo”, Berazategui, Buenos Aires, Argentina.
Citation: Pablo Colaci, Flavio Santinelli, Gustavo López, Fernando Mías, Marcela García, Claudio Baldarena (2022). Epidemiology and Prognostic Factors for Survival of Clear Cell Renal Carcinomas. International Journnal of Clinical Nephrology. 4(1); DOI:10.31579/2834-5142/017
Copyright: © 2022 Pablo Francisco Colaci. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 17 December 2021 | Accepted: 12 January 2022 | Published: 18 January 2022
Keywords: renal cell carcinoma; clear cell; survival; prognostic factors
Tumor size, histologic grade, and TNM classification characterize kidney tumors and provide a useful prognosis for predicting survival in research and medicine. Our objective was to determine the postoperative survival of operated patients with a diagnosis of clear cell renal carcinomas (CCRC) and to evaluate its relationship with other prognostic factors. Age, sex, clinical presentation, size, Fuhrman nuclear grade, tumor-nodule-metastasis (TNM) stage, and the presence of local invasion were retrospectively analyzed in 66 patients operated on for clear cell renal carcinomas. Clinical follow-up was performed for 5 years to determine postoperative survival.
During the follow-up period, 17 deaths occurred, with the cancer-specific survival rate being 77%. The presenting symptoms of the tumor that led to the diagnosis were not related to postoperative survival. The estimated survival for stages T2 was 100%, for T1 it was 93%, and for T3 it was 55%. No patients were found in stage T4. The lower Fuhrman grades (I and II) had an 85% survival rate, while the higher grades (III and IV) had a 53% survival rate. Survival rates also varied depending on the type of adjacent tissue that was affected. Specifically, survival decreased to 80% when infiltrating the renal capsule, 70% when infiltrating the perirenal tissues, and 28% when invading the renal vein. We can conclude that tumor size in CRCC is not a prognostic factor that allows determining postoperative survival independently, and for this reason, it should be considered as a variable that acquires importance when evaluated together with the presence of vascular invasion or adjacent tissues. We can confirm that the Fuhrman Histological Grade is useful as an independent parameter of survival when grouped into low and high grades.
Renal cell carcinoma represents the third most common genitourinary tumor, with prostate and bladder cancer being more prevalent. The clear cell renal carcinoma (CRCC) subclass represents between 84.5 and 90% of renal cell carcinomas, according to works published in North America and Mexico. In Argentina, however, the Institute of Oncology Ángel H. Roffo reported that clear cell tumors are responsible for 70 to 80% of total renal carcinomas [1-3]. Its incidence is higher in men than in women (1.5 / 1) and it affects black men more frequently. It presents an increased incidence in ages 54 through 70, with an average age of onset of 63 years, while these ages vary depending on the region studied [4]. In Latin America, the country with the highest incidence is Brazil [5]. In Argentina, renal cell carcinoma is the 9th leading cause of cancer death
in men and the 13th in women, with an incidence, according to the World Health Organization, of 6.1 cases per 100,000 inhabitants and a mortality rate per year of 3.4 cases per 100,000 inhabitants [1]. Various studies have shown that between 40 and 60% of CCRC are detected incidentally through imaging studies performed for other pathologies [3,6,7]. Only 6 to 10% of cancers present with one or more symptoms of the classic triad: hematuria, palpable flank mass, and low back pain or paraneoplastic syndromes [8]. Several prognostic factors for postoperative survival have shown their value in daily practice, such as tumor size, Fuhrman histological grade, and tumor-nodule-metastasis (TNM) staging. These prognostic factors are important pillars for both researchers and clinicians [9-11]. Our objectives are to evaluate the distribution of CCRC according to age, sex, and clinical presentation, and to determine overall postoperative and cancer-specific survival within our population.
With the approval of the teaching and research committee of the Hospital "Evita Pueblo", 66 patients with a diagnosis of CCRC during the period between January 2005 and December 2009 who had been operated in the aforementioned hospital were studied. Patients operated by all nephrectomy techniques (radical or partial, with open or laparoscopic technique) were included in the study. Fourteen cases were excluded for not having the necessary data for follow-up and 2 cases for presenting mixed tumors. The clinical characteristics studied were gender, age, and clinical presentation through the analysis of medical records, while the histopathological characteristics studied were tumor size, Fuhrman histological grade, and TNM staging. Preoperative files prepared before the patient's admission to the operating room, CT results, and ultrasound results were used to determine the age, gender of the patient, form of presentation, tumor size, and presence of metastases. The Fuhrman histological grades were re-evaluated by micrometric measurements, in the Chair of Histology "A" of the UNLP. The patients were followed up to assess survival, every six months for the first two years and then annually for up to 5 years. The SPSS Statistics 17.0 software was used to obtain descriptive data and the Kaplan Meier test to evaluate postoperative survival.
Of the total sample (n = 50), 12 were female and 38 were male, corresponding to 24% and 76% of the sample size, respectively. The mean age of detection of clear cell carcinoma was 60 years (range, 37-79 years). The mean tumor diameter was 6.38 cm (range, 2-15 cm). The right kidney was predominantly affected over the left, 58% and 42% respectively, and more frequently in the upper and mesorenal pole. In 58% of the cases, the tumors were diagnosed as an asymptomatic finding by ultrasound, computed tomography, or magnetic resonance imaging performed for other pathologies, while in 42% it was diagnosed by other signs and symptoms such as hematuria, flank pain, and urinary tract infection. The Fuhrman grades were distributed according to the following percentages: Fuhrman 1: 6%, Fuhrman 2: 68%, Fuhrman 3: 24% and Fuhrman 4: 2%. Regarding the infiltration of peripheral tissues, 40% of the tumors were not infiltrating, 20% infiltrated the renal capsule, 24% invaded perirenal tissues, and 16 affected the renal vein. No case infiltrated Gerota's fascia (Table I).
Stage T1 tumors were the most frequent (54%), followed in frequency by T3 (42%), and only 2 cases in stage T2 (4%). In our sample, we did not find tumors in T4 stage. There were 17 deaths during the 5-year follow-up, 12 of these due to metastases in the lung, bone, brain, or contralateral kidney; 1 due to postoperative hemorrhagic complication, and 4 due to other causes not related to the tumor. The overall survival rate was 70%, while the specific cancer survival rate was 77% (Table II. Figure 1 y 2).
Tumors smaller than or equal to 7 cm had a 3-year survival rate of 96%, and those greater than 7 cm, 67% (p <0>
The lower Fuhrman grades had a survival rate of 85%, while the higher grades had a survival rate of 53% (P.0.014) (Figure 3. Table V). Regarding survival depending on the type of peripheral tissues invaded by the tumor, when there was no infiltration, it was 100%, and successively lower when infiltrating the renal capsule (80%), perirenal tissues (70%) and renal vein (28%) (p 0.000) (Table VI).
The mean age of presentation (60 years) and the increased incidence of CRCC in males coincide with the main works published in several countries [4,6,7], although our incidence in men is even higher, possibly in relation to environmental factors, such as industrial pollution in the Buenos Aires suburbs and occupational exposure. The incidental finding is the most frequent form of diagnosis in the last decade, with predominant involvement of the right kidney [2,6,12-14]. The mean tumor size was similar to that found by other authors, while the predominant histological grade was Fuhrman grade II [6,12,14]. Regarding tumor stages, like another study in Madrid, we found a low percentage of T2, due to the fact that a large part of tumors larger than 7 cm present invasion of the perirenal tissues or involvement of the renal vein [15]. For this reason, there are insufficient cases in stage T2 to validate the statistics when calculating survival. Grouping stages T1 and T2 show significant differences in cancer-specific survival with respect to stage T3. Our cancer-specific survival rates are among those published in other countries such as Spain and China [16,17]. Unlike other authors, we have found statistically significant differences in postoperative survival in relation to tumor size [8,18,19]. In other words, in our study, patients with tumors smaller than or equal to 7 cm did not have a greater postoperative survival than those larger than that size; instead, invasion of the perirenal tissues and the presence of tumor venous infiltration were factors directly related to the risk of mortality from kidney cancer as in several published studies [20-27].
Based on the data obtained in our research, we can determine that tumor size in CRCC is not a prognostic factor that allows determining postoperative survival independently, and for this reason, it should be considered as a variable that acquires importance as it is evaluated together with the presence of vascular invasion or of the adjacent tissues. Likewise, we can confirm that the Fuhrman Histological Grade is useful as an independent parameter of survival when grouped into low (I and II) and high grades (III, IV). We believe that the high incidence in the male sample in our population could be attributed to work activity, since the hospital is located in a manufacturing area with high levels of environmental pollution, but more studies should be carried out that can corroborate our hypothesis.
The authors are especially grateful to María Laura Colaci, Camila Sarcone y Dora Pilz for their grammatical and technical assistance.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
