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Review Article | DOI: https://doi.org/10.31579/2640-1045/190
1Department of Clinical Pharmacy and Pharmacy Management, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University Awka, Anambra State, Nigeria.
2Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, David Umahi Federal University of Health Sciences, Uburu, Ebonyi State, Nigeria.
3Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, David Umahi Federal University of Health Sciences, Uburu, Ebonyi State, Nigeria.
*Corresponding Author: Ogbonna Brian O, Department of Clinical Pharmacy and Pharmacy Management, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria. Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, David Umahi Federal Univers
Citation: Enaike Evangeline N, Amagba Chinwendu J, Amagba Nneoma L, Eze Daniel C, Ogbonna Brian O, (2024), Dynamics of Psychoactive Substance Use among Pregnant Women in Nigeria, J. Endocrinology and Disorders, 8(5): DOI:10.31579/2640-1045/190
Copyright: © 2024, Ogbonna Brian O. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 30 June 2024 | Accepted: 18 July 2024 | Published: 28 August 2024
Keywords: psychoactive substances; pregnancy
Psychoactive substances could be used for medical and non-medical reasons, but need to be used with caution in pregnancy due to their negative effects on the fetus. Globally and in Nigeria, there are limited studies conducted on the use of, and effects of psychoactive substances by pregnant women probably due to the special population required despite the wide range of psychoactive substances readily available and easily accessible by pregnant women. This study examined the dynamics of psychoactive substance use in pregnancy in Nigeria, the effects on pregnancy and neonates, and critical methods of regulation, intervention, and prevention. The study utilized a narrative review to assess the dynamics in the prevalence, use, and effects of psychoactive substances by pregnant women. The study was synthesized from several research articles assessed through electronic means. Search terms were used either individually, in series, or using truncation where necessary. Studies considered were those conducted in Nigeria and published in the English Language from January 1970 to December 2023. All of the articles fell below the 3rd position on the 8points Oxford Center for Evidence-Based Medicine Scale (OCEMS). Overall, 11 articles were selected from a total of 1260 articles which gave rise to 0.87% selection eligibility criteria. The southwest had the highest distribution of studies on psychoactive substance use in pregnancy 6.0(54.5%), followed by south east 2.0(18.2%) and north central at 1.0(9.1%), and south at 1.0 (0.9%). Studies hierarchy fell in the fourth stage of the 6 points Scottish Intercollegiate Guideline Network Scale (SIGNS) for the hierarchy of study types. Psychoactive substance uses in pregnancy in Nigeria fell at the lower half of two standard benchmarks for study types. Most of the studies were predominantly carried out in the southern part of Nigeria. Systematic reviews and meta-analyses, Randomized Controlled Trials, Nonrandomized intervention studies, experiment studies, and Expert opinions on psychoactive substance use in pregnancy in Nigeria were still not available in the country.
The United Nations Office for Drugs and Crime (UNODC) has defined New Psychoactive Substances (NPS) as ‘substances of abuse, either in a pure form or a preparation, that are not controlled by the 1961 Single Convention on Narcotic Drugs or the 1971 Convention on Psychotropic Substances, but which may pose a public health threat’ [1]. Definitions of NPS can vary between countries, reflecting pharmacological and structural classifications, and differences in national legislation [2]. By 2018, a total of 892 individual NPS, reported by 119 countries, were being monitored by the UNODC early warning system, and by the end of 2018, over 730 NPS had been notified to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) [3, 4]. The rapid proliferation at which new NPS has emerged on the global drugs market is unparalleled, and it was estimated that at its peak in 2015, new NPS appeared at a rate of at least one new substance per week [5, 6].
Many studies have focused on the prevalence, knowledge, and attitudes associated with the use of psychoactive substances, and suggest that psychoactive substances are associated with harm in key populations such as adolescents, prisoners, and homeless people, but there are limited studies on the use and effects of psychoactive substances in pregnancy in Nigeria. This study intends to bridge the gap identified. It revealed what has been done, and the extent of research in this area, and provided direction for improvement on the nature and extent of studies. It addressed the statement of question concerning participants, interventions; comparisons, outcomes, and study design (PICOS Approach), and will serve as the audit trail required to broaden the scope of research in special populations. Without periodic reviews, it will be difficult to understand if progress is made and to proffer in-depth contributions to research done on the use and effects of psychoactive substances in pregnancy. This study examined the dynamics of psychoactive substance use in pregnancy in Nigeria, the effects on pregnancy and neonates, and critical methods of regulation, intervention, and prevention.
Methods
Study area
The study covered psychoactive substances studies originally carried out in Nigeria.
Review question
What is the extent of the use of psychoactive substances in pregnancy and its effects on the fetus?
Study population and types of studies included
All studies that passed the inclusion criteria and were published on Research Gate, PubMed, Academia.edu, and Google Scholar were utilized for the study. A manual search was also conducted for studies that met the inclusion criteria. This ensured the retrieval of relevant studies while focusing on the study objectives.
Eligibility criteria
Inclusion criteria
· Peer-reviewed studies published in English Language
· Studies conducted on the use of Psychoactive substances during pregnancy in Nigeria irrespective of the region between 1970 and 2023
· Studies with no conflict of interest stated
· Studies that provided other information that may help to understand the use and effects of psychoactive substances
· Studies with clearly stated and defined research methods and design
Exclusion criteria
· Studies conducted on the use of psychoactive substances during pregnancy in Nigeria irrespective of the region between 1970 and 2023 without clearly defined period, duration, sample size, and location were discarded
· Studies with methodological flaws
· Studies with incomplete data
Study design
The study was a narrative review of the dynamics of psychoactive substance use and its effects on pregnancy in Nigeria.
Risk of bias
The selected studies were assessed for subject, sample selection, and reporting bias.
Information source
Manual and secondary searches were conducted using PubMed, Research gate, and Google Scholar.
Condition and Domain studied
Studies conducted on psychoactive substances, and articles which described the use in pregnancy in Nigeria.
Prevalence, effects, traction study, and data extraction were done according to the standard reporting protocol for narrative reviews [7].
Data Items and Summary Measures
Data was sought for title of publication, study location, design, sample size, year of publication, inclusion criteria, exclusion criteria, study instrument, level of evidence, and hierarchy of studies. All the articles that met the inclusion criteria and fell within the years under review were selected.
Context
The study covered original studies and articles on psychoactive substances used in pregnancy carried out in Nigeria.
Articles search process
MEDLINE (PubMed), and Google Scholar were searched for studies and articles on the use of psychoactive substances in pregnancy in Nigeria between 1970 and 2023. The search strategy and terms were carried out as presented in Figure 1 as shown below. The primary concept and theme were used individually, in series/strings, and truncated where necessary during the search for articles. Additional words found appropriate and relevant to the title and objective were utilized. A total of 1260 articles were obtained, from 720 MEDLINE and 540 from Google Scholar (secondary search). These articles were assessed for eligibility based on inclusion criteria.
Study period and duration
The study lasted from May to June 2024 and covered peer-reviewed articles published from January 1970 to December 2023.
Ethical approval
Ethical approval is not applicable here as this is a narrative review article. However, only studies with ethical approval were included and utilized in the review process.
Data analysis
The data was summarized with descriptive statistics of frequency and percentages.
Study articles selection process
A total of 1260 articles were obtained, 720 from MEDLINE (PubMed) and 540 from Google Scholar (secondary search). These articles were assessed for eligibility based on inclusion criteria. Overall, 365 studies fell outside the scope of psychoactive substance use in pregnancy and were discarded, giving rise to 11 articles eligible for review.
Data extraction instrument, pilot testing, and data extraction process
The data extraction method was designed by examining the articles, writing out key data represented, and eliminating irrelevant ones based on the title and study objectives. The remaining data was harnessed into one extraction sheet and was pilot-tested for face and content validation using two articles that were not included in the study. The extracted data was arranged logically, and the sheet used to collate data was designed into an appropriate table format for ease of collation of results and analysis. The final instrument was given to an independent assessor to critique by using it on two independent studies before use for data collection.
Table 1: Characteristics distribution of selected studies (Evidence-Based Table)
Flow chart of the study process
| Reference | Title | Location | Design | Year of Publication | Sample Size | Inclusion | Exclusion | Study Instrument |
| [8] | Substance use and sexual cognitive orientation as predictors of academic performance among pregnant adolescents in Nigeria | North east | Cross-sectional study | 2023 | 400 | Pregnant Adolescents 15 to 19 years Students | Non pregnant adolescents Non students | Questionnaire |
| [9] | Use of substance and non-prescription drugs by pregnant Nigerian Women | South east | Cross -sectional study | 2003 | 1160 | Pregnant women registered in antenatal clinic | Non pregnant women | Questionnaire |
| [10] | Psychoactive substance use and psychiatric morbidity among pregnant women attending an ante-natal clinic in Benin City, Nigeria | South south | Cross-sectional Descriptive | 2018 | 395 | Psychiatric pregnant women 16 to 49 years | Participants who declined and cannot communicate in English Language | Questionnaire |
| [11] | Alcohol consumption and tobacco exposure among pregnant women in Ibadan, Nigeria
| South west | Prospective cohort study | 2022 | 1745 | Women ≤20 weeks’ gestation, aged ≥18 years, and women without severe medical complications | Pregnant women> 20 weeks gestation, with severe medical complications | Interviewer administered questionnaire |
| [12] | Psychosocial Correlates of Psychoactive Substance Use among Pregnant Women | South west | Descriptive Cross-sectional study | 2018 | 130 | Pregnant women who gave consent | Women who presented in labor or with hyperemesis gravidarum | Questionnaire |
| [13] | Psychoactive substance use in pregnancy: a cross-sectional study in Enugu Nigeria | South east | Cross sectional | 2020 | 205 | Consenting pregnant women attending antenatal clinic | Not stated | Questionnaire |
| [14] | Perception and Belief of Pregnant Women on the Effects of Psychoactive Substance use among Pregnant Women attending Antenatal Clinic in Ondo State | South west | Descriptive cross-sectional study | 2021 | 378 my | pregnant women attending antenatal clinic | Not stated | Structured questionnaire |
| [15] | Prevalence and consumption pattern of kola nut among pregnant women in Ibadan metropolis
| South west | Cross-sectional study | 2023 | 478 | Consenting pregnant women attending antenatal care | Women who were unable to communicate in any of the common languages, children under 15 years | Structured questionnaire |
| [16] | Self-Medication in Pregnancy and Associated Psychopathological Symptoms of Antenatal Nigerian Women | South west | cross-sectional hospital-based exploratory | 2020 | 277 | Pregnant women in good physical condition attending antenatal clinic, willing to spend about 8 minutes for the study | non-pregnant women, pregnant women experiencing ill health, and those who expressed a lack of time | Questionnaire |
| [17] | Medication and Substance Use among Pregnant Women in a Nigerian North Central Community, Kwara State, Nigeria | North central | Longitudinal cross-sectional study | 2017 | 200 | All pregnant women resident in the community | Pregnant women who could not give adequate response to the questions and did not consent to participate | Semi-structured questionnaire |
| [18] | Prevalence of Substance abuse by Pregnant women attending Traditional Birth Attendant (TBA) clinics in a Semi-urban region in South-West Nigeria | South west | Cross-sectional study | 2023 | 220 | Pregnant women attending Traditional Birth Attendant clinics | Non pregnant women | Questionnaire |
Table 2: Regional focus of psychoactive substance uses in pregnancy studies in Nigeria.
| s/n | Geopolitical zones | Number of studies n (%) | Study focus |
| 1 | North east | 1.0 (9.1) | Substance utilization and evaluation of effect |
| 2 | North west | 0.0 (0.0) | Nil |
| 3 | North central | 1.0 (9.1) | Substance |
| 4 | South east | 2.0 (18.2) | Prevalence and pattern of psychoactive substance utilization |
| 5 | South south | 1.0 (9.1) | Prevalence and pattern of psychoactive substance use |
| 6 | South west | 6.0 (54.5) | Prevalence, consumption pattern and effect |
| 7 | Mid west | 0.0 (0.0) | Nil |
| 8 | North | 0.0 (0.0) | Nil |
| Total | 11.0 (100) |
Table 3: Assessment of psychoactive substance use in pregnancy studies in Nigeria based on Oxford Center for Evidence-Based Medicine’s Levels of Evidence from Highest to Lowest [19]
| s/n | Level of evidence | Definition | n (%) |
| 1 | 1A | Systematic review of RCTs | 0.0 (0.0) |
| 2 | 1B | Individual RCT | 0.0 (0.0) |
| 3 | 2A | Systematic review of cohort studies | 0.0 (0.0) |
| 4 | 2B | Individual cohort studies, low-quality RCT | 6.0 (54.5) |
| 5 | 2C | Ecological studies | |
| 6 | 3A | Systematic review of case-control studies | 2.0 (18.2) |
| 7 | 3B | Individual case control studies | 3.0 (27.3) |
| 8 | 4 | Case series, poor quality cohort and case control studies | 0.0 (0.0) |
| Total | 11.0 (100.0) |
Table 4: Assessment of psychoactive substance use in pregnant women studies based on the Scottish Intercollegiate Guidelines Network for hierarchy of Study Type [20]
| s/n | Study types according to hierarchy | n (%) |
| 1 | Systematic review and Meta-analysis | 0.0 (0.0) |
| 2 | Randomized Controlled Trials | 0.0 (0.0) |
| 3 | Nonrandomized intervention studies | 0.0 (0.0) |
| 4 | Observational studies | 11.0 (100) |
| 5 | Non experimental studies | 0.0 (0.0) |
| 6 | Expert opinion | 0.0 (0.0) |
| Total | 11.0 (100.0) |
Table 5: Periodic distribution of psychoactive substance uses in pregnancy articles
| s/n | Period of publication of study | Number of articles published n (%) |
| 1 | < 2000> | 0.0 (0.0) |
| 2 | 2001 – 2010 | 1.0 (9.0) |
| 3 | 2011 – 2020 | 5.0 (45.5) |
| 4 | 2021 - 2023 | 5.0 (45.5) |
| Total | 11.0 (100.0) |
The distribution of the studies revealed a high incidence of observational studies in the country. All studies were carried out within the last three decades as shown in Tables 1 and 5. Although pregnant women have been using psychoactive substances such as alcohol, tobacco, cannabis, opioids, and cocaine, the extent and pattern of use have varied significantly over time and across different cultures. The study suggested a skewed distribution of cited articles to the southern part of the country as shown in Table 2. Studies have shown that there is a higher rate of psychoactive substance use in the south ant a higher attendance of antenatal clinics by pregnant women in the southern part of the country. This was followed closely by the north-central and northeast parts of Nigeria. Overall, studies on psychoactive substance use in pregnancy are very limited due to the special population required for the study (pregnant women), and the negative effects of psychoactive substances on both the mother and the fetus. Related studies indicated that substance use during pregnancy increases the chances of stillbirth and low birth weight in newborns [21,22]. Other studies indicated that about five percent of women use varying psychoactive substances during pregnancy [21,23,24]. The prevalence of above 40% was reported in northern Nigeria [25].
There has been no review article describing the use and effects of psychoactive substances in pregnancy in Nigeria. All studies on psychoactive substance use in pregnancy in Nigeria till January 2001 fell within the lower half of two standard benchmarks for the hierarchy of study types namely: Oxford and Scottish benchmarks for the hierarchy of clinical studies. Most of the studies on psychoactive substance use in pregnancy in Nigeria were carried out in the southern part of Nigeria. Despite the report of several studies on the use of psychoactive substances in pregnancy within Nigeria [26,27], review studies on the subject were lacking. This could be attributable to a lack of interest in this area, or poor documentation. This study described the dynamics of studies on the use of psychoactive substances in pregnancy in Nigeria provided an overview of the prevalence and effects of psychoactive substance use in pregnancy and on the fetus, and made comparisons with Oxford and Scottish benchmarks for the hierarchy of clinical studies to fill the gap, and documented information for intervention and policy formation.
The distribution of studies showed a high incidence of observational studies in the country. There has been a growing incidence of psychoactive substance use in pregnancy in hospitals within the last two to three decades. The evidence level of psychoactive substance use in pregnancy within the country remains limited. Most of the psychoactive substance use in pregnancy studies in the country was predominantly recorded in the southern part of the country, followed by the northern axis. The study fell short of the Oxford and Scottish benchmarks for the hierarchy of study, an indication of the limited studies conducted in this special population (pregnancy). No systematic review and meta-analysis of Randomized Clinical Trials, non-randomized intervention studies, Randomized Clinical Trials, and narrative reviews were recorded.
Limitations of the study
Some articles relevant to the study may have been left out due to search and search terms limitations. Some limitations associated with varying levels of bias may have existed in the primary studies which escaped elimination and may have affected the outcome of the study. There may be other better ways of presenting the tables. However, these formats were chosen for simplicity and clarity of purpose.
Conflict of Interest
The author has none to declare.
Grant/Sponsorship
None
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My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
