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Case Report | DOI: https://doi.org/10.31579/2690-4861/635
1OGBUZ "Bratsk Children's City Hospital", Irkutsk Region, Russia.
2Irkutsk State Medical University, Russia.
*Corresponding Author: M.F. Ermachenko, Ogbuz
Citation: M.F. Ermachenko., R.A. Ivanov., L.I. Sergeeva., R.M. Khakimov., O.S. Klimova, (2025), Postural Ventricular Tachycardia from Peripherally Inserted Central Catheter Line Placed Using a Tip Confirmation System, International Journal of Clinical Case Reports and Reviews, 23(2); DOI:10.31579/2690-4861/635
Copyright: © 2025, M.F. Ermachenko. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 02 January 2025 | Accepted: 31 January 2025 | Published: 14 February 2025
Keywords: sepsis; meningoencephalitis; trepanation
Control of bone hemostasis using bone wax is convincing. Around the prolapsed brain from the previous trepanation, a bone bridge was formed, which was also resected using Kerrison pliers. In the opened field, cyanotic, slightly protruding outward relative to the bone window, dura mater is visible, with traces of brain detritus, thrombotic masses and purulent film. The dura mater was opened for the purpose of subsequent sail plasty using the Xeno Dura implant, to provide a larger useful volume of the intracranial cavity for the purpose of subsequent prevention of wedging.
Purulent meningitis and purulent meningoencephalitis constitute a significant part (20-40%) in the structure of neuroinfections in children and the relevance of their study is due to the severity of the course, high frequency of disabling consequences and fatal outcomes (8-39%) [1,2,3,4,5,7,9,10]. According to statistics, bacterial meningitis is diagnosed in 3-10 people per 100 thousand population worldwide [1, 2, 6,9,10]. Bacterial purulent meningitis and meningoencephalitis are the most severe forms of infectious pathology of the central nervous system in children [3,4,6,8,15]. The leading role in their etiological factor is played by such pathogens as meningococcus, pneumococcus, streptococcus and Haemophilus influenzae [1,2,6,9,10]. These pathogens can affect not only the pia mater, but also the brain tissue. A high protein content is noted in the cerebrospinal fluid with the formation of fibrin capsules, in which the pathogen is preserved for a long time [1,6,7]. As a result, the disease takes on a severe course with frequent development of encephalitic syndromes, protracted and recurrent course, high frequency of residual effects [1, 2,6,8,9,10]. Children with purulent meningoencephalitis and intracranial empyema often have a severe, septic course of the disease, with a high frequency of disability and mortality [6,7,8,9,10]. Often such patients have to use combined treatment, combining conservative methods with surgical [1,3, 5,6,9,10].
The aim of the work is to analyze a rare case of combined treatment of sepsis against the background of purulent meningoencephalitis in an adolescent in the intensive care unit.
Material and methods. Under our observation in the intensive care unit of the Regional State Budgetary Healthcare Institution "Bratsk Children's City Hospital" there was a patient B., 14 years old, with sepsis that arose against the background of purulent meningoencephalitis, which required combined treatment (a combination of conservative and surgical tactics).
It is known from the anamnesis that she fell ill acutely, with a temperature rise to 39-40 0 C , headache, sore throat, rhinorrhea , and was ill for 6 days. The girl took antipyretics on her own. About 9 days ago, she fell during training, hitting her right parietal-temporal region. She did not lose consciousness. She is not registered with pediatric specialists. She has been vaccinated according to her age. Her allergy history is not complicated. On September 12, 2024, due to deterioration of her condition, impaired consciousness, increased headache, and the appearance of repeated vomiting, the ambulance team hospitalized her in the intensive care unit of the Bratsk Children's City Hospital with DS : Acute secondary purulent meningitis, severe, of unspecified etiology. The patient's condition on admission is severe. Conscious, very lethargic, hypodynamic. Consciousness level assessment according to the GCS is 14 points (stupefaction). Verbal contact is possible, answers questions correctly. Complains of weakness. Speech is inhibited. The face is symmetrical, the tongue is in the oral cavity along the midline. Pupils D > S , photoreactions are preserved. Meningeal symptoms (rigidity of the occipital muscles, Kernig's sign) are positive. Muscle tone is moderately diffusely reduced.
The skin is pale, gray in color, warm, dry. In the right temporoparietal region there is a subcutaneous hematoma about 3 cm in diameter. Acrocyanosis. Low skin turgor. Sunken eyes. Guedel's test 4 sec. The mucous membrane of the lips is dry, pale. The pharynx is hyperemic. The tongue is dry, coated with a white coating. The subcutaneous fat layer is poorly developed. Body temperature is 39.5 0 C. There is no shortness of breath. Percussion over the entire surface of the lungs - a clear pulmonary sound. In the lungs, breathing is harsh, conducted along all fields, there are no wheezing. Respiratory rate is 20 in min., SpO2 98%. Heart sounds are muffled, rhythmic. Pulse on a. radialis is of satisfactory quality. HR 129 beats. in min. BP 112/64 mm Hg.
The abdomen is sunken, painless on palpation. The liver and spleen are not enlarged.
09/13/2024 deterioration of condition to extreme severity. Consciousness Coma I - II. Transferred to the Newport ventilator in SIMV mode, FiO 2 30%, f 18 per min, PIP 22 mbar PEEP 5 mbar. The consultation made a diagnosis, taking into account the MSC examination: Basic: Severe sepsis of unspecified etiology.
Acute purulent meningoencephalitis, severe, of unspecified bacterial etiology.
Complication: Toxic exicosis of 1-2 degrees of severity. Infectious toxic shock of 1-2 degrees of severity.
Supplement. Diagnosis: Hygroma of the right parietal -temporal region? Empyema of the brain? Hematoma? (based on the results of MSCT of the brain).
A consultation with a neurosurgeon was held to decide on urgent surgical intervention.
On September 13, 2024, under combined endotracheal anesthesia, the following operation was performed: decompression trepanation of the skull of the right parietal-temporal region, opening of the subdural empyema.
When the dura mater was opened under pressure, liquid white pus was released. A bacterial culture was taken. The burr hole was widened to 4.0 x 4.0 cm. The dura mater was cut crosswise. Up to 150.0 ml of pus was evacuated. Two drains were installed in the subdural space for outflow through separate punctures of the skin. The subdural space was sanitized with a physiological solution until the waters were clear. Brain pulsation was preserved.
The condition after the surgery remained extremely serious. Artificial ventilation, drug-induced sleep, and intensive therapy were administered.
Control MSCT of the head on 09/16/2024 with clarification of the main DS : Bacterial sepsis, severe, unspecified etiology.
Acute purulent meningoencephalitis, severe, of unspecified bacterial etiology.
Infectious toxic shock grade 1-2.
Complication: Subdural empyema of the right parietal temporal region (surgery 09/13/2024)
Competing diagnosis: Child abuse syndrome? Closed craniocerebral injury? Subdural hematoma? Intracranial hematomas?
Complication: Suppuration of the subdural hematoma with transition to subdural empyema of the right parietal temporal region.
On September 18, 2024, under combined endotracheal anesthesia, a repeat surgical intervention was performed: Decompression infratemporal craniotomy on the right, dura mater plastic surgery.
The bone stage of trepanation was performed with subsequent intraoperative maximum accessible infratemporal decompression, as a result the bone window was about 12x10 cm. Control of bone hemostasis using bone wax is convincing. In the opened field, cyanotic, slightly protruding outward relative to the bone window, dura mater is visible, with traces of brain detritus, thrombotic masses and purulent film. The brain prolapse from the previous trepanation was revised , encephalotomy was partially performed , brain detritus, necrotic brain tissue were removed, surgical cellulose was laid out for hemostasis. A smear was taken from the brain area for bacteriological culture. The brain tissue itself began to slightly reflect the transmitted pulsation.
The department conducted an examination:
UAC dated September 12, 2024 ESR – 15 mm/h; Hb – 123 g/l; er – 4.3 X 10 12 ; Le – 14.0 X 10 9 ; n – 50; s – 44; l – 4; m – 2; e – 0; yu – 0; thrombus. – 178 X 10 9/l
OAC from 9/13/2024. SOE – 41 mm/h; Hb – 103 g/L; er – 3.6 X 10 The – 8.7 X 10 9 ; p – 46; s – 27; l – 6; m – 5; e – 0; y – 16; thrombus. – 93 X 10 9/l
OAC from 09/17/2024. SOE – 57 mm/h; Hb – 96 g/L; er – 3.3 X 10 The – 26.7 X 10 9 ; p – 6; s – 72; l – 13; m – 4; e – 0; y – 3; thrombus. – 161 X 10 9/l
UAC dated September 21, 2024 ESR – 70 mm/h; Hb – 92 g/l; er – 3.11 X 10 12 ; Le – 15.3 X 10 9 ; n – 9; s – 71; l – 12; m – 7; e – 1; yu – 0; thrombus. – 494 X 10 9/l
Biochemical blood test.
12.09.2024 AlT– 10.9 u / l ; AsT – 11.7u/ l ; total protein - 69.8 g/l; urea - 2.29 mm/l; creatinine 56 mm/l; c-Reactive Protein – 214; sugar - 8.8 mmol/l; bilirubin - 14 μm/l; LDL-C - 1.53 mmol/l; LPVP - 0.23 mmol/l;
17.09.2024 AlT u / l – 52.3; AsT – 58.9 u / l ; total protein - 69.6 g/l; urea - 6.3 mm/l; creatinine 47.4 mm/l; c-Reactive Protein - 68.8; sugar - 7.9 mmol/l; bilirubin - 13 μm/l;
21.09.2024 AlT u / l – 14.8; AsT – 46.3 u / l ; total protein - 67.7 g/l; urea - 7.8 mm/l; creatinine 45 mm/l; sugar - 7.2 mmol/l; bilirubin - 11 μm/l;
Contents of purulent discharge from the wound (craniotomy 09/13/2024) - streptococcus sp . sensitive to meropenem , vancomycin.
Blood for sterility from 09/13/2024. - negative .
Urine for sterility from 09/13/2024. - negative .
Bronchial lavage for microflora from 09/13/2024. - streptococcus viridans 10 x4 .
Figure 1: First trepanation of the skull. After opening the dura mater, the purulent discharge is cleaned.
Figure 2: Repeated craniotomy, the bone window was about 12x10 cm. A section of the prolapsed brain is visible. The brain prolapse from the previous trepanation has been revised, partially completed. encephalotomy, brain debris removed.
Figure 3: MSCT of the brain from 09/13/2024. Displacement of midline structures to the left. MSCT signs of subdural hygroma in the frontal-parietal-temporal region on the right. Suspected subarachnoid hemorrhage, with the presence of a hyperdense component in the frontal region on the right.
Figure 4: MSCT of the brain from 09/16/2024. Condition after surgery. Displacement of midline structures to the left (not distinct, weakly expressed positive dynamics). MSCT signs of subarachnoid hemorrhage. Additional hyperdense component in the cranial cavity in the frontal-parietal region on the right (subarachnoid hemorrhage? subdural hemorrhage?). MSCT signs of cerebral edema. MSCT picture of prolapse of the caudal contour of the cerebellar tonsils under the foramen magnum.
Figure 5: MSCT of the brain from 09/17/2024. In the parietal and occipital regions and in the frontal-parietal-temporal region on the right, an increase in the volume of superficial soft tissues is noted, due to the presence of an additional component of about 19H in their projection, in the frontal-parietal-temporal region on the right, also with the presence of a component of up to 76H.
In the parietal bone on the right, a postoperative defect of about 4.59 x 3.57 cm is noted. The median structures of the brain are shifted to the left by about 0.55 cm. Smoothing of the convex grooves is noted.
Figure 6: MSCT of the brain from 09/20/2024. Condition after surgery. Dynamics show expansion of the postoperative defect in the bones of the skull on the right. Displacement of the midline structures is not noted at the time of the study.
The patient was treated in the anesthesiology and intensive care unit of the Bratsk Children's City Hospital for 11 days. The development of sepsis and meningoencephalitis was facilitated by two factors: a head injury during training (hematoma in the right temporoparietal region) and bacterial nasopharyngitis with penetration of streptococcal infection under the dura mater. In addition to conservative treatment (transfer to Newport mechanical ventilation in SIMV mode , FiO 2 30%, f 18 per min, PIP 22 mbar PEEP 5 mbar 8 hours after admission; antibacterial therapy: meronem 120 mg/kg/day intravenously; vancomycin 40 mg/kg/day intravenously; immunocorrective therapy _ immunovenin 50 ml intravenously No. 5; infusion therapy (infusion of colloids and crystalloids, fresh frozen plasma, EMOLT); Hormonal therapy - dexamethasone 0.1 mg/kg/day intravenously - anti-edema therapy: mannitol 15% - 0.5 g/kg intravenously by drip + lasix 1% - 2.0 ml; for the purpose of synchronization with mechanical ventilation: sibazon, sodium oxybate 20P mg/kg/hour, fentanyl 0.005% 2 mcg/kg/hour via infusion pump; intravenous omeprazole 40 mg; intravenous etamsylate 12.5% - 2.0 ml; inotropic support with norepinephrine 0.12 mcg/kg/hour, metrogyl 7.5 mg/kg 3 times a day intravenously; fluconazole according to the regimen 1st day 6 mg/kg/day, 2nd day 3 mg/kg/day in connection with long-term antibacterial therapy, and surgical treatment was also performed twice:
Operation #1, September 13, 2024. Decompression trepanation of the skull in the right parietal-temporal region, opening of the subdural empyema.
Under combined endotracheal anesthesia, an arcuate incision was made in the right parietal-temporal region. A burr hole was made, when the dura mater was opened under pressure, liquid white pus was released. Bacterial culture. The burr hole was expanded to a size of 4.0 x 4.0 cm. The dura mater was dissected crosswise. Up to 150.0 ml of pus was evacuated. 2 drains were installed in the subdural space for outflow through separate punctures of the skin. Sanitation of the subdural space with saline until the waters were clear. Brain pulsation is preserved.
However, despite the conservative and surgical treatment, the patient's condition remained extremely serious, which required frequent medical consultations and constant monitoring with the resuscitation and advisory center of the Irkutsk State Children's Clinical Hospital in Irkutsk. (ISCHCH). Considering that the patient's condition remained extremely serious and the symptoms of brain compression persisted, the risk of transportation to the regional hospital (threat of brain wedging), a pediatric neurosurgeon was called to the Bratsk Children's Hospital and a second operation was performed.
Operation No. 2 from September 18, 2024. Decompression subtemporal craniotomy on the right, dura mater plastic surgery.
Under combined endotracheal anesthesia, using Luer pliers and Kerrison pistol pliers , the bone stage of trepanation was performed with subsequent intraoperatively maximally accessible infratemporal decompression, as a result, the bone window was about 12x10 cm. Control of bone hemostasis using bone wax is convincing. Around the prolapsed brain from the previous trepanation, a bone bridge was formed, which was also resected using Kerrison pliers. In the opened field, cyanotic, slightly protruding outward relative to the bone window, dura mater is visible, with traces of brain detritus, thrombotic masses and purulent film. The dura mater was opened for the purpose of subsequent sail plasty using the XenoDura implant, to provide a larger useful volume of the intracranial cavity for the purpose of subsequent prevention of wedging.
prolapse from the previous trepanation was revised, encephalotomy was partially performed, brain detritus and necrotic brain tissue were removed, surgical cellulose was laid out for hemostasis. A smear was taken from the area opened after the incision of the dura mater of the brain for bacteriological culture. The brain tissue itself began to slightly reflect the transmitted pulsation. Within the surgical field, a purulent film, blood clots and brain detritus were noted on the brain tissue. A template for subsequent plastic surgery with the material " XenoDura " was cut out using sterile material.
The dura mater plastic surgery was performed partially - the brain prolapse from the previous trepanation could not be eliminated completely. The next stage is the placement of a counter- perforate subgaleal catching drainage. The drainage is connected to a passive collection system.
After the combined treatment, the patient’s condition went from extremely serious to severe and transportable.
When analyzing the test results, it was revealed that the patient had postoperative anemia (a decrease in Hb from 123 g/l to 92 g/l), against the background of compensation for blood loss with a single-group EMOLT.
There was an increase in ALT to 52.3 u / l , AST to 58.9 u / l , a decrease in total protein to 67.7 g/l, an increase in C - reactive protein to 214, and urea, creatinine, and bilirubin levels within normal limits.
Changes in microelement and coagulogram parameters were also noted, which required infusion correction. In the general urine analysis, changes were also noted in the form of the appearance of protein up to 0.35 g/l and ketone bodies. The procalcitonin test was at the level of 0.5 – 2 ng /ml.
Streptococcus was isolated from a postoperative wound (cranial trepanation on 09/13/2024). sp . sensitive to meropenem, vancomycin. Bronchial lavage for microflora from 09/13/2024. - streptococcus viridans 10 x 4.
Ultrasound of internal organs, echocardiography, and ECG also showed changes caused by the acute stage of the purulent process and intoxication.
In Fig. 1 – craniotomy, sanitation of purulent discharge from under the dura mater. In Fig. 2 – repeated craniotomy, the bone window was about 12x10 cm. A section of the prolapsed brain is visible. The brain prolapse from the previous trepanation has been revised, partially performed encephalotomy, brain debris removed.
In the series of MSCT images Fig. 3, Fig. 4, Fig. 5, a shift of the midline structures of the brain to the left is visible, in Fig. 6, no shift of the midline structures of the brain is noted.
Thus, in the intensive care unit of the Bratsk City Children's Hospital, it was possible to stabilize the patient's condition.
At the time of transfer: the patient's condition is severe, with positive dynamics. The level of consciousness is coma 1. According to the PSSM 17 points, according to Glasgow 6, according to FOUR - 9 points. In response to loud speech, the patient tries to open his eyes slightly, nods his head. Tries to stick out his tongue, squeeze his hand (squeezes the right one better). When asked to move his legs, he bends the right leg better. He breathes into the ventilator. Reflexes with TBP, corneal and corneal reflexes are present. Both pupils react weakly to light, they are the same. Muscle tone is diffusely reduced. No seizures were noted. Infusion of 0.005
Despite the development of sepsis and purulent meningoencephalitis, with a high probability of a fatal outcome, the patient was brought from a state of extreme severity to a state of severe transportability with the help of the correct medical tactics (a combination of conservative and surgical treatment) and transferred for follow-up treatment to a 3rd level institution in the Irkutsk Regional Children's Hospital. The patient recovered, underwent a course of neurological rehabilitation and is awaiting surgery: plastic surgery of the trepanation hole.
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Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
