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Research Article | DOI: https://doi.org/10.31579/2693-4779/273
Department of Urology, North Manchester General Hospital, United Kingdom.
*Corresponding Author: Anthony Kodzo-Grey Venyo, Department of Urology, North Manchester General Hospital, United Kingdom.
Citation: Grey Venyo AK, (2025), Amyloidosis of the Seminal Vesicle, Ejaculatory Duct, vas Deferens and Epididymis an Update, Clinical Research and Clinical Trials, 13(1); DOI:10.31579/2693-4779/273
Copyright: © 2025, Anthony Kodzo-Grey Venyo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 17 May 2025 | Accepted: 30 May 2025 | Published: 14 July 2025
Keywords: amyloidosis of prostate gland; amyloidosis of seminal vesicles; amyloidosis of ejaculatory ducts; prostate biopsies;
It has been iterated that cases of primary amyloidosis of the prostate gland, seminal vesicles, vas deferens, epididymis as well as ejaculatory ducts are not common and in view of this pathologists, urologists, and oncologists should have high index of suspicion for the aforementioned four lesions Primary amyloidosis of the prostate gland, seminal vesicles, epididymis and ejaculatory ducts had tended to be diagnosed incidentally based upon microscopy histopathology examination of specimens of the prostate gland, seminal vesicle and ejaculatory duct and epididymis obtained pursuant to the undertaking or prostatectomy or during examination of specimens of the prostate gland that had been obtained from prostate biopsies taken during the assessment of the prostate gland to exclude prostate cancer related to raised levels of serum prostate specific antigen (PSA) or abnormal digital rectal examination findings of the prostate gland and or seminal vesicle or at times radiology imaging of the prostate gland and pelvis might demonstrate features of the prostate gland, seminal vesicle and ejaculatory duct or epididymis area that look abnormal or irregular which would necessitate the undertaking of radiology image-guided biopsies of the lesion. Majority of cases of primary amyloidosis of the prostate gland, seminal vesicle and ejaculatory duct and epididymis tend to be asymptomatic but some cases of primary amyloidosis of the seminal vesicle vas deferens, ejaculatory duct might manifest with blood within the semen of an individual. Some cases of amyloidosis of the prostate gland, seminal vesicles, vas deferens epididymis and ejaculatory ducts had been diagnosed contemporaneously in association with areas of adenocarcinoma of the prostate gland. Pathology examination of areas of the prostate gland, seminal vesicles, and ejaculatory ducts vas deferens and epididymis tends to depict or demonstrate amorphous, pale eosinophilic material which is often associated with cracks from processing of the biopsy or prostatectomy specimen Specimens of amyloid within the prostate gland, seminal vesicle, vas deferens, epididymis and ejaculatory duct exhibit immunohistochemical staining features with Congo Red by the demonstration of green birefringence upon polarised microscopy. Amyloidosis of the prostate gland, seminal vesicles, vas deferens epididymis and ejaculatory duct tends to simulate upon radiology imaging undertaken by magnetic resonance imaging (MRI) scan features of prostate cancer invading the seminal vesicle, vas deferens, epididymis or ejaculatory duct, carcinoma of the urinary bladder invading the seminal vesicle, vas deference, epididymis as well as ejaculatory duct, and adenocarcinoma of the rectum invading the seminal vesicle, epididymis, vas deference and ejaculatory duct as well as a rare case of primary adenocarcinoma of seminal vesicle. It has been iterated that therapy of primary amyloidosis of the prostate gland, seminal vesicles and ejaculatory does depend upon the underlying condition.
Amyloidosis of the seminal vesicle of Seminal vesicle (SV) amyloidosis is a well-documented histology examination entity; however, amyloidosis of the seminal vesicle is observed infrequently. It has been pointed out that the incidence of amyloidosis of seminal vesicle is rising which is perhaps related to the increasing undertaking of prostate biopsies to investigate patients with raised serum prostate-specific antigen levels. [1] Diagnostic prostate biopsies are commonly undertaken in men who are suspected of having prostate cancer and are typically prompted by raised serum prostate-specific antigen (PSA) levels. The protocol for trans-rectal ultrasonography (TRUS)-guided prostate biopsies has been well developed, and 10 to 12 cores are typically undertaken [1] [2] For patients who have initially negative biopsies, the ensuing options often tend to be considered: (i) a period of serum PSA monitoring; (ii) early repeat prostate biopsies (10 to 12 cores); (iii) saturation prostate biopsies under TRUS guidance; and (iv) trans-perineal (template) mapping of prostate biopsies. With an increasing trend for serum PSA testing in the asymptomatic male population over 50 years of age, urologists are undertaking prostate biopsies on an increasing number of patients, and an increasing number of needle cores are being collected at each setting, including that of the template approach for prostate biopsies. [1] [3] [4] [5]
Incidental pathology examination findings in the prostate and the seminal vesicles (SVs) are well described, including SV amyloidosis, a well-documented histological entity. [1] [6] SV amyloidosis is reported to be associated with haematospermia [7] and prostatitis, especially in ageing men. [6] [8]
It has been iterated that within anatomical regions of the male reproductive system which contribute to the transport, maturation and/or required fluid medium of spermatozoa, localized amyloidosis had been reported within the seminal vesicles, vasa deferentia and ejaculatory ducts [1] [6] [7] [8] [9] [10] [11] [12] [13] [14].
Diaz-Floez et al. [9] reported the first three cases of amyloidosis of the epididymis in 2017. Considering that amyloidosis of the seminal vesicles, vas deferens, ejaculatory duct and seminal vesicles are rare and they generally tend to simulate carcinoma of the prostate gland as well as carcinoma of the urinary bladder, it is important for every urologist to have a high index of suspicion for amyloidosis in order not to treat amyloidosis of the seminal vesicle, ejaculatory duct, vas deferens or epididymis under a mis-diagnosis of cancer. The ensuing article on amyloidosis of the seminal vesicle, ejaculatory duct, vas deferens or epididymis is divided into two parts: (A) Overview and (B) Miscellaneous narrations and discussions on case reports, case series, and studies related to amyloidosis of the seminal vesicle, ejaculatory duct, vas deferens amyloidosis and epididymis.
To provide an update on amyloidosis of seminal vesicle, vas deferens, ejaculatory duct and epididymis which tend to be diagnosed upon prostate biopsy and prostatectomy specimens.
[A] Overview
Definition / general statements [15]
Essential features
Epidemiology
Sites
Aetiology
Pathophysiology
The pathophysiology of amyloidosis has been summated as follows: [15]
Clinical features
The manifesting features of amyloidosis of the prostate gland, seminal vesicle, ejaculatory duct and epididymis had been summated as follows: [15]
Diagnosis
The diagnosis of amyloidosis has been summated as follows: [15]
Radiology description
Treatment
Gross description
The macroscopy pathology examination features of amyloidosis of the prostate gland, seminal vesicle, ejaculatory duct and epididymis had been summated as follows: [15]
Microscopic (histologic) description
The microscopy pathology examination features of amyloidosis of the prostate gland, seminal vesicle, ejaculatory duct and epididymis had been summated as follows: [15]
Positive stains
The staining features of amyloidosis specimens include the ensuing: [15]
Electron microscopy description
Electron microscopy examination features of amyloidosis specimens had been summated as follows: [15]
Differential diagnosis
[B] Miscellanous Narrations and Discussions from Some Case Reports, Case Series and Studies Related to Amyloidosis of The Seminal Vesicle Yang et al. [1] made the ensuing iterations:
Yang et al. [1] reported seven cases of incidental SV amyloidosis over a 3-year period and considered their relationship to the previously suggested aetiological factors. Based on their series, they concluded that incidental localized SV amyloidosis observed in diagnostic prostate biopsies does not warrant formal investigations for systemic amyloidosis.
Kee et al. [12] investigated the incidence of amyloidosis of seminal vesicles and ejaculatory system including ejaculatory ducts and vasa deferentia. Kee et al. [12] reviewed the whole mount sections of 447 radical prostatectomy specimens removed for prostatic cancer, including 273 cases from the United States of America and 174 cases from Korea. Kee et al. [12] summated the results as follows:
Kee et al. [12] made the ensuing conclusions:
Argon et al. [10] made the ensuing iterations:
Argon et al. [10] reported amyloid depositions in seminal vesicles of 207 radical prostatectomy materials of prostates had been removed due to localized prostate carcinoma. Amyloid depositions were confirmed with Congo red staining and polarization microscope. Argon et al. [10] summated the results as follows:
Argon et al. [10] made the ensuing conclusions:
Coyne and Kealy [8] reported the following:
Pitkänen et al. [6] reported the ensuing findings in their study:
Harvey and Têtu [16] stated localised seminal vesicle amyloidosis, is relatively infrequent. Harvey and Têtu [16] reported 9 additional cases. Harvey and Têtu [16] retrospectively retrieved the 9 cases from 803 radical prostatectomies which were undertaken between 1995 and 2000 for prostatic adenocarcinoma. In each case, the type of amyloidosis was characterised by immunohistochemistry staining features. Information regarding a possible concurrent disease or prior hormone therapy had been obtained. Harvey and Têtu [16] summated the results of their study as follows:
Harvey and Têtu [16] made the ensuing conclusions:
Linke et al. [17] made the ensuing iterations:
In order to address this issue, Linke et al. [17] used their microanalytic techniques to characterize the structure of the congophilic green birefringent protein extracted from 5 such amyloid-containing specimens. Linke et al. [17] summated the results as follows:
Linke et al. [17] concluded that:
Bjartell et al. [18] made the ensuing iterations:
In order to characterize the expression and tissue distribution of Sgl and Sgll in greater detail, Bjartell et al. [18] produced monoclonal immunoglobulin Gs (lgGs for immunocytochemistry (lCC) and specific [35S]-, digoxigenin-, or alkaline phosphatase-labeled 30-mer antisense probes to Sgl and Sgll for in situ hybridization (lSH). Bjartell et al. [18] summated the results as follows:
Bjartell et al. [18] made the ensuing conclusions:
Seidman et al. [13] reported localized amyloidosis of the seminal vesicles (ASV) as an incidental finding in surgical specimens from three elderly men. In two cases, the amyloid deposits were bilateral, subepithelial, and clinically inapparent, features similar to other cases in the literature. In one case, the diagnosis was made based upon a trans-rectal prostatic needle biopsy which included a small portion of seminal vesicle; and to their knowledge, this had not been previously reported. Electron microscopy in one case had shown non-branching fibrils characteristic of amyloid, and pretreatment of tissue sections using the permanganate method in two cases showed almost complete ablation of congophilia. Seidman et al. [13] concluded that:
Caballero Martínez et al. [19] undertook a clinical and pathological study of eight cases of localized amyloidosis of the seminal vesicles with a review of the literature. Caballero Martínez et al. [19] undertook an immunohistochemical and histochemical study in surgical specimens of the eight patients. Caballero Martínez et al. [19] summated the results as follows:
Caballero Martínez et al. [19] made the ensuing conclusions:
Singh et al. [20] made the ensuing iterations:
Singh et al. [20] reported an unusual case of amyloidosis involving multiple sites (prostatic stroma, trigone and lower ureters) in the lower urinary tract. MRI scan findings of bladder amyloid, which could be used to suspect this condition, were also described.
Jun et al. [21] reported localized amyloidosis involving seminal vesicles and vasa deferentia, which was found in two patients with prostatic adenocarcinoma. A 60-yr-old (Case 1) and a 59-yr-old (Case 2) man presented to their hospital with elevation of serum prostate-specific antigen (PSA) and biopsy proven carcinoma, respectively. MRI scan had demonstrated multiple irregular foci of low signal intensity within the prostates as well as within both seminal vesicles and vasa deferentia on T2-weighted imaging, indicating prostatic carcinoma with extension to both seminal vesicles and vasa deferentia in both cases. Under the clinical diagnosis of stage III prostatic adenocarcinoma, a radical prostatectomy was undertaken in both patients. Microscopy pathology examination of the specimens demonstrated Gleason score 7 adenocarcinoma in both patients. In addition, isolated amyloidosis of both seminal vesicles and vasa deferentia was found without carcinoma involvement. Jun et al. [21] made the ensuing discussions:
Lawrentschuk et al. [3] made the ensuing iterations:
Lawrentschuk et al. [3] reported their experience of two such cases of amyloidosis.
Maroun et al. [22] made the ensuing iterations:
Maroun et al. [22] stated that they therefore felt that knowledge of the entity is important and hence they had reported a typical case confirming the previous findings that amyloidosis of the seminal vesicles is a unique form of amyloidosis, a relatively common incidental finding and one that might be related to prostate cancer.
Rath-Wolfson et al. [23] made the ensuing iterations:
Diaz-Florez et al. [9] stated that after observing two cases (Cases 1 and 2) of pseudo-tumoral epididymal amyloidosis, epididymides (n: 120) were examined for the presence of pathological amyloid deposits and for amyloid detection. A new case (Case 3) of subclinical amyloidosis was obtained in their review. All patients were Caucasian, and the relevant findings of the cases had been illustrated in Table 1. Evidence of systemic amyloidosis, paraproteinemia, or underlying plasma cell dyscrasia was not identified. Finally, the amyloids tested in epididymal amyloidosis were also checked in seven normal epididymides. The study was undertaken in accordance with the code of ethics of the World Medical Association
| Case | Age (years) | Presentation and resulting diagnosis | Larger diameter (cm) | Contralateral epididymal exploration | Operation | Follow-up (months) | IHC Primary antibodies used |
|---|---|---|---|---|---|---|---|
| 1 | 77 | Nodule in the left epididymis Result: Epididymal amyloidosis | 1.4 | Thickened | Nodule removal | 48 (Free of disease) | Light chain λ Dako [D: 1:50] Light chain κ Dako [D: 1:50] Transthyretin Dako [D: 1:600] Amyloid P Abcam [D: 1:50] Amyloid A Dako [D: 1:50] CK AE1 AE3 Dako [D: 1:100] EMA Dako [D: 1:100] CD68 Dako [D: 1:100] CD34 Dako [D: 1:50] αSMA Dako [D: 1:50] |
| 2 | 72 | Nodule in the right epididymis Result: Epididymal amyloidosis | 1.6 | NED | Nodule removal | 9 (Free of disease) | |
| 3 | 67 | Left scrotal swelling for 4 years. Physical examination: a firm, non-reducible mass. Result: Para-testicular liposarcoma and Epididymal amyloidosis without tumour involvement | 0.7 (size refers only to epididymal amyloidosis) | NA | Radical Orchiectomy | NA |
Table 1: Characteristics of reported cases and antibodies used for immunohistochemistry
From: Localised amyloidosis of the epididymis: a previously unreported phenomenon
IHC Immunohistochemistry, NED No evidence of disease, NA Not available, CK Cytokeratin, EMA Epithelial membrane antigen
Reproduced from [9] under the Creative Commons Attribution License.
They summated the results as follows:
General characteristics of epididymal amyloidosis
In cases 1 and 2 of epididymal amyloidosis, the surgically removed nodules were noted to be firm, yellowish grey in colour, and 1.4 and 1.6 cm in size, respectively. Case 3 which was obtained pursuant to the microscopic review of 120 epididymides, demonstrated a larger diameter of 0.7 cm (see Table 1).
In H&E-stained sections, amorphous hyaline eosinophilic deposits were identified (see figure 1a). The deposits demonstrated Congo red positivity (see figure 1b), with yellow-green birefringence under polarized light (see figure 1c), and irregular PAS positivity. Immunohistochemical expression of transthyretin (see figure 2a), light chains kappa (see figure 2b) and lambda (see figure 2c), and amyloid P (see figure 2d) was identified. Pan cytokeratin (CK) AE1 AE3 also demonstrated irregular positivity in the amyloid deposits (see figure 2e). There was no immunoreactivity for amyloid A, and no amyloid deposits were identified within blood vessel walls. Spermatozoa were absent.
Figure 1
Amyloid deposits in the epididymes. a Eosinophilic amyloid deposits are observed in an H&E-stained section. Insert: a zone of deposits in the epididymal lumen. b Congo red positivity. c Yellow-green birefringence under polarized light. a corresponds to case 1, and b and c to case 2. a and b: ×10 (insert in A: ×20). c: ×120. Reproduced from [9] under the Creative Commons Attribution License.
Figure 2
Immunohistochemical expression and distribution of amyloid deposits (a, b, c, d, and e), and characteristics of free bodies and macrophages in other regions of the epididymal lumen (f to k). Expression in the amyloid deposits of transthyretin (a), light chain kappa (b) and lambda (c), amyloid P (d) and pan CK AE1 AE3 (e) is observed. Note the presence of epithelium-lined (arrows) (intraluminal) and non-epithelium-lined (interstitial) amyloid deposits. In C, the intraluminal and interstitial deposits are organized in a similar convoluted path to that of the epididymal tubule. In E, residual pan CK AE1 AE3+ epithelial cell bands persist in the periphery of the interstitial deposits. In other regions of the epididymal lumen, free amyloid bodies in the lumen associated with vesicles, particles and filaments are present (f to h). Note Congo red positivity (f) with yellow-green birefringence (g) and immunohistochemical expression of amyloid P (h). Intraluminal CD68 positive macrophages (i) showing PAS positive intracytoplasmic granules (j), which express amyloid P (k), are also observed. a, b, d and e correspond to case 2. c and f to k correspond to case 3. a, b, d and e: ×120, c: ×10, f, g, I and j: ×320, h and k: ×480. Reproduced from [9] under the Creative Commons Attribution License.
Distribution of amyloid deposits
Amyloid deposits were identified within the lumen of the convoluted epididymal tubule and in several lumps in the interstitium (see figures 1a and 2a to c, demonstrating similar immunohistochemical expression in both locations. On occasion, many separate aggregates of amyloid deposits were found to be organized in a similar convoluted path to that of the epididymis (see figure 2c).
The distribution and quantity of intratubular amyloid bodies had varied depending upon the section of the tubule. Hence, they were scarce and free within the lumen of some tubular sections of the epididymis, but many within others, where they were densely grouped, obliterating and distending the epididymal lumen (figures 1a and 2a to c). The free bodies within the lumen demonstrated Congo red positivity (see figures 2f), with immunofluorescence under polarized light (see figure 2g) and amyloid P [removed]see figure 2h), and were associated with other materials, including vesicles, particles, filaments and small dense bodies. Intraluminal CD68+ macrophages (see figure 2i) were also identified with intracytoplasmic PAS+ granules (see figure 2j), which expressed transthyretin and amyloid P (see figure 2k, corresponding to amyloid P). The interstitial amyloid deposits formed aggregates, ranging from small to large interstitial masses (see figures 1a, b and 2a to c).
Relationship between intratubular and interstitial amyloid deposits
Frequently, the luminal and interstitial deposits were noted to be in continuity and they were therefore partially lined by epithelium (see figure 3a), which demonstrated pan CK AE1 AE3 and epithelial membrane antigen (EMA) expression. Residual epithelial bands were even identified upon the surface of larger interstitial deposits (see figure 2e). The intratubular and interstitial zones in these confluent deposits were not only differentiated by the presence or absence of epithelial coating; but, also by the existence of other components within the deposits. A reticulin network, and CD34+ and/or αSMA+ stromal cells were identified in interstitial but not within luminal zones of the deposits (see figure 3b, corresponding to the reticulin network). Moreover, epithelial folds with degenerative phenomena surrounded occasionally portions of intraluminal amyloid deposits, which were partially incorporated in the interstitium (see figures 3c to e).
Figure 3
Relationship between intratubular and interstitial amyloid deposits (a to d), and detection of amyloids in normal epididymis (e to g). a: Epithelium-lined (arrow) (intraluminal) and non-epithelium-lined (interstitial) zones of an amyloid deposit are observed in continuity. b: A reticulin network in the interstitial zone but not in the luminal zone of the amyloid deposit is observed. c to e: Epithelial folds with degenerative phenomena are observed surrounding small portions of intraluminal amyloid deposits, which are partially incorporated in the interstitium. In normal epididymis, expression of transthyretin (f) and amyloid P (g) is observed in the apical surface of the epididymal epithelium. Strong expression of amyloid P is also shown in spermatozoa (g and h). a: transthyretin immunostaining. c and d: H&E staining. e: pan CK AE1 AE·immunostaining. a, b, e and f: ×120; c and d: ×320; g and h: ×340. Reproduced from [9] under the Creative Commons Attribution License.
Detection of amyloids (with tested expression in epididymal amyloidosis) in normal epididymides
Within the epididymides surgically obtained from neighbouring pathological processes, transthyretin (see figure 3f) and amyloid P (see figure 3g) were expressed in the apical surface of the epithelium. Amyloid P also demonstrated strong expression within spermatozoa (see figures 3g and h). Occasional macrophages with PAS and amyloid P positive bodies were demonstrated.
Diaz-Florez et al. [9] made the ensuing discussions and conclusion:
Nemov et al. [24] investigated if localized amyloidosis of the seminal tract (LAST) is associated with subsequent development of systemic amyloidosis. They stated that previous reports had recorded no systemic amyloidosis at the time of LAST diagnosis. Nevertheless, no follow-up studies exist to confirm that LAST is not a risk factor for subsequent development of systemic amyloidosis. Nemov et al. [24] reported their study cohort, which included patients whose prostate biopsy (PB) or radical prostatectomy (RP) specimen demonstrated LAST between 2014-2021. Clinical variables including age, race/ethnicity, prostate specific antigen (PSA), and prostate weight of they were analysed by Nemov et al. [24] Nemov et al. [26] assessed the patients for clinical and laboratory evidence of systemic amyloidosis and lymphoproliferative conditions during the follow-up period. Nemov et al. [24] summated the results as follows:
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Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
