AUCTORES
Globalize your Research
Review Article | DOI: https://doi.org/10.31579/2690-4861/742
*Corresponding Author: Abyt Ibraimov, International Higher School of Medicine, Intergelpo Str, 1F, Bishkek, Kyrgyzstan.
Citation: Abyt Ibraimov, (2025), Alimentary Obesity: Genes or Heterochromatin? International Journal of Clinical Case Reports and Reviews, 25(4); DOI:10.31579/2690-4861/742
Copyright: © 2025, Abyt Ibraimov. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 12 March 2025 | Accepted: 28 March 2025 | Published: 15 April 2025
Keywords: alimentary obesity; chromosomal Q-heterochromatin; cell thermoregulation; human body conductivity
Obesity is excessive fatty deposits in the subcutaneous tissue, organs and tissues. It is believed that the development of obesity contributes to: inactive lifestyle, genetic disorders, nutritional errors, endocrine pathologies, stress, etc. Obesity of different types have a similar general symptomatology; differences are observed in the presence or absence of endocrine or nervous system damage. In alimentary obesity, body weight increases gradually and there are no symptoms of endocrine gland involvement. The possible role of hereditary factors in the development of nutritional obesity is discussed here. This is usually understood as genes. We will consider the possible role of the non-genic part of the genome in the development of alimentary obesity.
Obesity is excessive fatty deposits in the subcutaneous tissue, organs and tissues. In adults, obesity corresponds to a body mass index greater than or equal to 30. A number of factors contribute to the development of obesity: inactive lifestyle; genetically determined disorders of enzymatic activity (increased activity of lipogenesis enzymes and decreased activity of enzymes that break down fat (lipolysis); brain injuries; errors in the nature and mode of nutrition (excessive consumption of carbohydrates, fats, salt, sweet and alcoholic beverages, eating at night, etc.); some endocrine pathologies; psychogenic overeating; physiological conditions (lactation, pregnancy, menopause); stress, lack of sleep, taking psychotropic and hormonal drugs (steroids, insulin, birth control pills), etc.
Obesity of different types has a similar general symptomatology; the differences are observed in the pattern of fat distribution and the presence or absence of signs of endocrine or nervous system damage. In alimentary obesity, body weight increases gradually, fat deposits are uniform, sometimes predominate in the thighs and abdomen. There are no symptoms of endocrine gland involvement.
Despite the fact that substantial advances have been made towards identifying the components of the systems that regulates body weight, we are still far from the full understanding of the pathogenesis of alimentary obesity. This is evidenced by: 1) during the last decades obesity has become on extremely wide spread occurrence with serious medico-social aftereffects. Besides the detriment to health, such as hypertension and heart disease, obese people are often stigmatized socially; 2) that the existing methods of treatment and other forms of control of obesity are insufficiently effective is indicated by the following fact: more than 90% of individuals who lose weight by dieting eventually return to their original weight [1].
The bulk of the ongoing research in this field focuses on the molecular mechanisms of appetite and satiety regulation, energy metabolism, nutrient partitioning, and adipose cell differentiation and enlargement. It is supposed that this is likely to provide geneticists with a whole new generation of candidate genes to explore for DNA sequence variation and relationships with body fat content and proneness to become obese with age.
The possible role of heredity in the development of alimentary obesity, i.e., in the absence of endocrine damage, is discussed here. The role of hereditary factors is usually understood to be genes. Indeed, progress has been made in this regard. Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity [2-8].
However, there are a number of circumstances that are directly or indirectly indicative of the scantiness of molecular approaches of studies, including the search for a hypothetical gene (or genes) involved in the development of obesity in man. Thus, for instance:
1) the results of numerous epidemiological studies carried out in many countries and regions have unequivocally shown that the frequency of obesity in females is two times higher than in males;
2) the global medico social problem of obesity only emerged in the last decades and we consider the functional derangements in the neuroendocrine and central nervous system in preserving energetic homeostasis in the contemporary man very doubtful just because of an improved diet and life conditions despite the fact that corresponding homeostatic systems act in nature have been acting for a long time. Moreover, our bodies are better adapted to combat weight loss than to combat weight gain, since for thousands of years our species evolved in circumstances where nutrients were in short supply and therefore, the increasing rates of obesity cannot be explained exclusively by changes in the gene pool;
3) The role of genes in evolution, heredity and development is now being seriously reconsidered. In connection of the aforementioned facts, we suppose that possibly exist other hereditary factors predisposing to obesity in man.
Without contesting the importance of these studies, we have chosen a somewhat different approach to the search for hereditary factors predisposing to the development of alimentary obesity. It is based on studying the phenomenon of wide quantitative variability of chromosomal Q-heterochromatin regions (Q-HRs) in the human genome in certain purely human pathologies [11,12]. The point is that quantitative chromosomal Q-HRs variability only exists in man, though this type of constitutive heterochromatin is present in the genome of two other higher primates: Pan troglodytes and Gorilla gorilla [9,10].
Facts.
Almost a decade ago, we were able to show for the first time that variability of the amount of chromosomal Q-heterochromatin regions (Q-HRs) is relevant to the development of so-called purely human forms of pathology, including alimentary obesity [10,11]. In particular, individuals with alimentary obesity in two ethnic groups living in Bishkek, Kyrgyzstan were studied. It was shown that obese individuals differ from controls in the extremely low number of Q-HRs in their genome.
Our sample included women of Kyrgyz and Russian nationality of reproductive age, whose weight exceeded 20% or more of the norm, and physicians diagnosed them as an alimentary form of obesity. Phenotypically healthy women of the same ethnic groups of reproductive age with normal weight were taken as controls. Inclusion of only female individuals in our sample was due to two reasons: 1) women lack the Y chromosome, which differs with the content of the largest block of Q-HRs in the human karyotype; 2) women, unlike men, including in our country, try to maintain a normal weight. Data on the distribution and mean number of chromosomal Q-HRs per individual in the samples studied are presented in Table.
Number of Q-HRs | Obese females | Controls | ||
Kyrgyz (n = 56) | Russians (n = 44) | Kyrgyz (n = 100) | Russians (n = 100 | |
| 1 | 2 | 3 | 4 | |
| 0 | 11 (19.6) | 5 (11.4) | 2 (2.0) | 4 (4.0) |
| 1 | 24 (42.9) | 18 (40.9) | 11 (11.0) | 7 (7.0) |
| 2 | 19 (33.9) | 19 (43.2) | 32 (32.0) | 24 (24.0) |
| 3 | 2 (3.6) | 2 (4.5) | 19 (19.0) | 33 (33.0) |
| 4 | 22 (22.0) | 31 (31.0) | ||
| 5 | 11 (11.0) | 1 (1.0) | ||
| 6 | 2 (2.0) | |||
| 7 | 1 (1.0) | |||
Total number of Q-HRs |
68 |
62 |
294 |
283 |
Mean number of Q-HRs |
1.21 ± 0.11 |
1.41 ± 0.11 |
2.94 ± 0.14 |
2.83 ± 0.11 |
| Statistics | t1,2 = 1.29 t1,3 = 9.72 t1,4 = 10.41 t2,3 = 8.59 t2,4 =9.13 t3,4 = 0.62 | |||
| df = 99 df = 156 df = 144 df = 140 df = 123 df = 189 | ||||
| P > 0.20 P < 0> 0.50 | ||||
Table : Distribution and mean number of chromosomal Q-HRs per individual in groups of obese females and in control samples.
As can be seen from this Table, females with obesity, regardless of their ethnic origin, are characterized by a consistently low value of the mean number and by narrow range of variability in the distribution of Q-HRs numbers in the samples as compared with controls.
Genes or heterochromatin?
Little progress has been made with respect to the genetic basis of human obesity. Let us mention at once that a number of mendelian disorders are known to exist in humans, but no specific genes have yet been identified for them [13,14]. Although several single gene defects are known that produce obesity in animals and all of these have been cloned for understanding obesity [15-19]. Nevertheless, the question still remains open: why then are some individuals obese and others not in the absence of neuroendocrine disorders? We searched for the answer by investigating the wide hereditary variability (polymorphism) of human chromosomal Q-heterochromatin regions (Q-HRs) in norm and pathology [10,11,20].
A remarkable feature of human chromosomal Q-HRs is their wide quantitative variability characterized by the fact that individuals in a population differ in the number, location, size and intensity of
fluorescence of these specific fluorescence areas. The existence of population Q-HRs variability in twelve polymorphic loci of seven autosomes and on the distal portion of the long arm of chromosome Y is
well-established fact [20,30-39]. By studying chromosomal C- and Q-HRs variability in the human populations permanently living in various climatic-and-geographic conditions of Eurasia and Africa, in norm and pathology we have obtained the data indicating possible participation of chromosomal Q-HRs as part of the condensed chromatin (CC) in cell thermoregulation (CT). We have checked this hypothesis on the level of human organism assuming that CT is the basis for heat conductivity of whole cell part of body [20,40,42].
To better visualize this viewpoint, it is necessary to recall what chromosomal HRs, condensed chromatin and cell thermoregulation are. Briefly, chromosomal HRs are the highest form of organization of non-coding DNAs, consisting of short repetitive sequences of nucleotides, which constitute the bulk of DNA in the genome of higher eukaryotes. In humans, non-coding DNAs make up about 98% of their genome and 15%-20% of them form chromosomal С- and Q-HRs. In the interphase cell, chromosomal HRs form a layer of CC around the nucleus, which is characterized by the highest density [20,40]. The essence of hypothesis of СТ is elimination of the temperature difference between the nucleus and cytoplasm when the nucleus temperature becomes higher than in the cytoplasm. The higher eukaryotes use a dense layer of peripheral CC as heat conductor for a more efficient elimination of the temperature difference between the nucleus and cytoplasm. The phenotypic manifestation of CT is the level of body heat conductivity (BHC) of the individuals in the population with all the ensuing consequences for the organism [20,40,42,43].
We believe that the pathogenesis of alimentary obesity (AO) is somehow related to the peculiarities of CT. Thus, in patients with AO and therefore with a low BHC (even assuming that they use the same number of calories as people with normal weight), we believe that a part of the calories accumulates in the body in the form of adipose deposits due to inadequate heat dissipation. The point is that excess heat energy is not effectively eliminated from the organism of individuals with low BHC, but accumulates in the form of fat deposits due to the low content of chromosomal Q-HRs in their genome. If we take into account the use of high-calorie, easily digestible foodstuffs, hypodynamia and, possibly, the use of energy-intensive drinks (alcohol), the accumulation of excess energy in the body of individuals with AO becomes obvious.
And finally the answer to the raised question: “Why are some individuals lean or some obese?” instead of the existing points of view that obesity is either the result of fundamental lack of discipline on the part of affected individuals or that the answer to this question will be found by the identification of genes that a responsible for human obesity, we would answer that obesity is not simply a personal failing or the result of abnormal functioning of some structural genes (here we mean only AO). We suppose that in a human population there is a very great variety in the functioning of the system of energy homeostasis involved in the regulation of food intake, fat stores and energy expenditure related to the number of Q-HRs in the genome. In individuals with a low BHC, even with a same consumption of food as in people with a normal weight, in comfortable conditions of life, more fat will be deposited than in individuals with a medium or high BHC, as their heat losses are lower due to a lesser BHC [20,43].
AO are individuals in whose cells chromosomal HRs are unable to form a sufficiently dense layer of CC around the nucleus to remove excess heat in a timely manner due to their small number of Q-HRs in the genome. This means that such individuals become unable to efficiently eliminate excess metabolic heat outside the body. There will always be excess energy in the body of such individuals, which over time can lead to the accumulation and deposition of fat cells with all the resulting harmful consequences for the host. It is this circumstance, as we believe, that is the decisive factor of heredity in the development of AO.
We tend to believe that the role of genes in vulnerability of individuals to AO, apparently, is not great. In addition to the lack of data directly pointing to a specific gene (or genes) in the development of AO, new theoretical ideas have emerged, prompting us to reconsider the established ideas about the role of genes in evolution, heredity, and development [44,45]. It is not our task to analyze their arguments in detail, and we will limit ourselves to quoting the main ideas of the supporters of the new movement in theoretical biology. It is noteworthy that their views became especially convincing after realization of the Human Genome Project and the failure of its promises of a revolutionary breakthrough in practical medicine.
One of the leaders of the new direction in theoretical biology D. Noble [45] writes: “The widely promised health benefits of genome sequencing have simply failed to materialise. We now need a careful rethink of priorities since it is clear that meeting the looming challenge of ageing populations manifesting diseases that are notoriously resistant to genetic explanations will require resources to be devoted to higher-level studies of the causes of health and disease. …Since the articles in this issue of the Journal were published, the case has been supported by the discovery that polygenic scores based on GWA fail to predict major diseases, including cardiovascular disease and cancer. Despite spending some US$8 billion by NIMH, no gene responsible for schizophrenia has been identified either”.
“I stand by the central claim that the primary functional element in the cell is not the gene/genotype but the cellular phenotype, represented by the process of gene product interaction, in today’s terminology, a gene product interactome. …I propose that the evidence dictates that the phenotype is the governor and regulator of the cell, which is the basic ‘building block’ of the organism. …genes are not responsible for common disease traits. …the failure of the candidate gene approach (based largely on classical genetics) ought to be a signal that something is very wrong: evidence has comprehensively rejected theory. …My argument is that the cellular phenotype, not the gene/genotype, plays the leading role in both inheritance and evolution [44].
Apparently, E. Mayr [46] was right when he wrote: ‘evolutionary pressures act on the whole organism, not on single genes, and that genes can have different effects depending on the other genes present’. He rejected the idea of a gene-centred view of evolution, insisting ‘a gene is never visible to natural selection and in the genotype’.
Thus, we concluded that, among the heredity factors, not genes but the number of chromosomal HRs play a decisive role in human susceptibility to AO. In particular, individuals with a low number of chromosomal Q-HRs in the genome, the phenotypic manifestation of which is a low level of heat conductivity of their bodies, are vulnerable to the development of AO, all other things being equal. Individuals due to low heat conductivity of their bodies are not able to effectively dissipate excess heat from the body and this circumstance may be accompanied by accumulation and deposition of fat cells, characteristic of alimentary obesity. In any event, the study factors implicated in weight gain and obesity is crucial for predictions about the future impact of the global epidemic of obesity, and provides a unique opportunity for the implementation of preventive actions.
Acknowledgement
We are grateful to all the women with obesity for their co-operation and understanding the importance of studying the problem of obesity.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
