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Research Article | DOI: https://doi.org/10.31579/2688-7517/232
1IMA Academy, applied Pharmacologist, Hospital Pharmacist Manager Italy.
2Hospital Pharmacist Pc area Italy.
3Medical pharmacologist, Hospital Pharmacist Manager Pc Area Italy.
4Medical Laboratory Turin, Citta Della salute -Italy.
5Libyan Authority for Scientific Research.
6Professor, Department of Medical & Health Sciences for Woman, Peoples University of Medical and Health Sciences for Women, Pakistan.
7Hematology Oncology, University of Aden.
8President of IMA Academy International.
*Corresponding Author: Luisetto M, IMA academy, applied pharmacologist, hospital pharmacist manager Italy.
Citation: Luisetto M, Ferraiuolo A, Fiazza C, Cabianca L, Edbey K, et al, (2025), AI Artificial Intelligence in Pharmaceutical Galenic Field: useful Instrument and Risk Consideration, J. Pharmaceutics and Pharmacology Research, 8(2); DOI:10.31579/2688-7517/232
Copyright: © 2025, Luisetto M. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 10 April 2025 | Accepted: 16 April 2025 | Published: 25 April 2025
Keywords: AI, artificial intelligence; chatbot; pharmaceutical galenic; risk management; toxicology; risks; benefits;
The integration of artificial intelligence (AI) technology into various fields, particularly healthcare, has shown significant promise in enhancing efficiency and accuracy. However, the potential risks associated with unprofessional or inappropriate use of AI cannot be overlooked. The current landscape of healthcare demonstrates a growing reliance on AI tools, which is expected to expand in the future. Existing literature highlights the effectiveness of various AI applications, including chatbots, in specific medical domains. This study aims to review relevant literature in the pharmaceutical and galenic fields while evaluating a prominent AI chatbot provider. Based on the findings, this article presents critical considerations for researchers and practitioners. A thorough assessment of the benefits and risks associated with AI technologies is essential as these tools become increasingly prevalent in pharmaceutical practices.
Artificial intelligence (AI) encompasses a range of technologies designed to enable systems to analyze data, learn from experiences, and make informed decisions, all guided by human input (ISO, 2023).
As articulated by Jakub Kufel et al. [1], AI includes subsets such as machine learning (ML), artificial neural networks (ANNs), and deep learning (DL), which have gained traction in recent years. These technologies are increasingly applied in the medical field to enhance the speed and efficacy of disease diagnosis and treatment.
The impact of AI on pharmaceutical laboratories is profound, as highlighted at the Pharmalabs Conference in November 2025. AI applications are revolutionizing analytical processes, regulatory compliance, and quality control, thereby improving automation, data interpretation, and compliance monitoring. Regulatory authorities are beginning to emphasize the importance of aligning AI innovations with Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) guidelines [Figure.1].
Figure 1: Adapted from Database Town.com How it work artificial intellience ?
According to the FIP International Pharmaceutical Federation, the FIP Development Goals launched in September 2020 aim to transform the pharmacy profession globally by 2030. These goals emphasize the significance of digital health, focusing on education, workforce development, practice, and science. [Figure.2]
Figure 2: Adapted from Applications of Artificial Intelligence (Al) in Healthcare Segment [2]
The wide-ranging applications of AI in drug discovery, dosage form design, process optimization, and pharmacokinetics/pharmacodynamics studies are further explored by Lalitkumar K. Vora et al [3]. AI technologies, including deep learning, natural language processing, and computer vision, are driving advancements in telemedicine, diagnosis, drug development, and personalized treatment. In contrast to other scientific fields, pharmaceutical sciences can cause delays in data codification and standardisation. Data accumulation and standardisation are essential for effectively training AI in the former [Figure. 3]
Figure 3: Applications of AI in the pharma sector adapted from Sultana A et al [4] While the benefits of AI in healthcare are substantial—such as time savings, improved diagnostic accuracy, and enhanced data management—significant risks also accompany these advancements.
As noted by the Royal Pharmaceutical Society and other experts, it is crucial for pharmacists to develop an understanding of AI technologies to navigate the associated benefits and risks effectively. This research aims to explore these dynamics within the pharmaceutical galenic field, assessing both the transformative potential of AI and the imperative for risk management in its deployment. [5-6]
The search for weaknesses or causes of errors is known as “root cause analysis.” The goal of such an analysis in practice is to:
Root cause analysis is a continuous task and a part of the continuous improvement process of a company, given the ever-increasing demands for quality and optimization [Figure. 4].errors in these large data sets.”
Figure 4: Adapted from AI-based root cause analysis of Hans-Ulrich Kobialka 2022 [
This study employed an observational approach to review scientific literature pertinent to the integration of artificial intelligence (AI) in the pharmaceutical and galenic fields. Relevant articles were identified and analyzed to understand the current landscape of AI applications and their implications for pharmacy practice. Figures 1 to 5 were included to visually represent key concepts and findings discussed in the literature.
Additionally, a practical component was incorporated into the study, wherein a series of queries—ranging from simple to complex—were submitted to a well-known AI chatbot. The chatbot’s responses were documented and evaluated for accuracy and relevance to pharmaceutical practice. This practical experience aimed to provide insights into the capabilities and limitations of AI technology in addressing specific pharmaceutical inquiries.
Following the literature review and practical experience, a comprehensive conclusion was drawn to summarize the findings and implications for researchers and practitioners in the field.
Literature Review Findings
1. Cognitive Limitations in Medicine: Aliasghar Karimi et al. noted that the human mind faces numerous obstacles in recalling and applying vast amounts of medical information. The proliferation of medical knowledge makes it impractical for clinicians to analyze extensive literature, leading to diagnostic errors primarily attributed to cognitive biases among healthcare workers. Medical errors remain a significant cause of mortality in the United States, often linked to human error [8].
2. AI in Pharmacy Practice: Sri Harsha Chalasani et al. highlighted AI as a transformative technology capable of enhancing medication management and patient care. By leveraging AI algorithms and machine learning, pharmacists can analyze extensive patient data, improving the identification of drug interactions and informing tailored recommendations (9).
3. Personalized Medicine: Lalitkumar K. Vora et al. emphasized that AI can facilitate personalized medicine through the analysis of real-world patient data, leading to improved treatment outcomes and adherence (10).
4. Streamlining Clinical Decisions: Kelsee Tignor et al. discussed how AI, referred to as pharmacointelligence, can assist clinical pharmacists in making evidence-based decisions by analyzing large volumes of patient data (11).
5. Enhancing Patient Safety: Rayn Oswalt noted that pharmacists are concerned about patient safety and that AI can help detect and prevent medication errors, thereby reducing adverse events and hospital readmissions (12).
6. Applications in Dosage Form Development: Praveen Halagali et al. reviewed AI’s applications in developing solid dosage forms, optimizing formulation processes, and assessing drug toxicity profiles, which streamline the path from pilot studies to market (13).
7. Excipient Compatibility: Ashutosh Kumar et al. pointed out that AI can significantly enhance the assessment of excipient compatibility, improving pharmaceutical development (14).
8. Predicting Drug Toxicity: Mahroza Kanwal Khan et al. highlighted the advantages of using AI to predict drug toxicity, which allows for a deeper understanding of drug interactions with biological systems (15).
9. Formulation Optimization: Negar Mottaghi et al. discussed how AI algorithms evaluate data to enhance the stability and compatibility of pharmaceutical ingredients, leading to improved formulations (16).
10. Pediatric Dosing: Andreea-Alexandra Mocrii et al. aimed to assist pediatricians in determining appropriate treatment doses for children based on various parameters (17).
11. Education on AI in Pharmacy: Muhammad Ahmer Raza et al. advocated for pharmacy education to incorporate AI and data science, emphasizing the need for pharmacists to develop skills that promote AI integration in practice (18).
12. Systematic Review of AI in Healthcare: Margaret Chustecki reported a systematic review yielding 8796 articles, which narrowed down to 44 studies. The review highlighted AI’s potential in healthcare, such as improving diagnoses and personalized treatment plans, while also addressing concerns about biases and data privacy (19).
13. Risk Prevention in Clinical Practice: Michela Ferrara et al. emphasized the usefulness of AI in risk prevention and incident reporting in clinical settings (20).
14. Advancing Toxicology: Nicole Kleinstreuer et al. noted that AI could advance toxicology into a more predictive discipline, safeguarding human and environmental wellbeing (21).
15. Risks Associated with AI: Mateusz LASKA et al. identified human error as a significant risk in AI applications, emphasizing the need for understanding and managing these technologies (22).
16. Ethical Considerations: Mitul Harishbhai Tilala et al. discussed the multifaceted ethical considerations surrounding AI in healthcare, including privacy, bias, and accountability (23).
17. 3D Printing in Pharmaceutical Development: Timothy Tracy et al. highlighted the versatility of 3D printing technology in creating customized dosage forms, which accelerates formulation development (24).
18. Prescription Monitoring: Cinzia Barberini et al. described a system that interconnects prescription-related aspects, enhancing stock monitoring and preparation checks (25).
19. AI System Failures: Sasanka Sekhar Chanda et al. identified potential failure points in AI systems, including input errors and processing deficiencies, which can lead to inappropriate outputs (26).
20. Risks of AI in Medicine: Karim Lekadir et al. outlined seven main risks of AI in healthcare, including patient harm, misuse of tools, and gaps in accountability (27).
21. Chatbot Accuracy in Healthcare: Stefanie Beck et al. evaluated the accuracy of ChatGPT versions 3.5 and 4 in healthcare contexts, revealing discrepancies in adherence to established guidelines (28).
22. Variability in Chatbot Responses: Meron W. Shiferaw et al. noted inconsistencies in ChatGPT’s responses, highlighting errors that could result in clinical harm (29).
23. Performance Comparison of ChatGPT Versions: Ronald Chow et al. reported varying performance levels between ChatGPT versions, emphasizing the need for further development to enhance reliability in medical training and decision-making (30).
These findings underscore the transformative potential of AI in pharmacy and healthcare while also highlighting the associated risks and ethical considerations that must be addressed to ensure safe and effective implementation.
Experimental Project:
In this section, a series of queries—ranging from simple to complex—were submitted to a widely recognized AI chatbot accessible for free on the web. The responses received are
documented below:
1. Is digoxin water-soluble? Response: It is poorly soluble in water and more soluble in alcohol.
2. What is the molecular weight of NaCl? Response: 58.44 g/mol.
3. Must collyria be sterile? Response: Yes, it is fundamental to avoid eye infections.
4. Is propranolol compatible with microcrystalline cellulose? Response: Yes.
5. Is omeprazole acid-sensitive? Response: Yes, it is inactivated in the acidic environment of the stomach.
6. What is the chemical structure of citric acid monohydrate? Response: (The chatbot did not provide a specific right structure).
7. Is lidocaine hydrochloride considered a poison by the Italian Pharmacopoeia No. 3? Response: Yes.
8. Is acetone flammable? Response: Yes.
9. What is the galenic use of NIPAGIN? Response: Preservative.
10. What is the water solubility of amoxicillin? Response: The water solubility is not extremely high, so specific formulations are needed to improve body absorption.
11. How can the solubility of water-insoluble active principles in galenic oral drops be increased?Response: Various strategies include using cosolvents like ethanol, glycerin, and propylene glycol; employing surfactants; utilizing cyclodextrin complexation; applying solubility enhancers (e.g., PEG); adjusting pH; and formulating suspensions.
12. How can the solubilization of a solute in a solution be increased?Response: Increase temperature, use a suitable solvent, apply agitation, increase the surface area of the solute, employ surfactants, adjust the pH, use co-solvents, apply pressure (for gases), and utilize complexants.
13. How many grams of KOH are needed to prepare a 100 ml solution at 30%? Response: Dissolve 30 grams in a total volume of 100 ml of solution.
14. How should medications be administered to children with difficulty swallowing? Response: Liquid suspensions, chewable tablets, dissolvable forms, powders, orally disintegrating tablets, other liquid forms, or suppositories.
15. What is the time needed to adequately mix APIs and excipients in the galenic field using a semi-automatic powder mixer to prepare capsules? Response: The chatbot provide answer as reported in the table figure. n 5
Figure 5: Responce from an AI Chat bot
The applications of AI in the galenic field are diverse, ranging from robotic systems in oncology laboratories to software for laboratory management, algorithms for verifying incompatibilities, and assessing posology or toxicity. As with other disciplines such as medicine and technology, AI tools are being introduced to assist healthcare professionals, including those in the pharmaceutical sector. By incorporating AI into clinical practice, health care professionals can augment their decision-making processes and provide patients with personalized care. AI allows for greater collaboration between different healthcare services provided to a single patient. [31-32]
In pharmaceuticals, adherence to regulatory and safety standards is paramount. Consequently, it is crucial to evaluate the results obtained from various AI instruments—be they robots, software, chatbots, or other technologies. The pharmaceutical industry demands certainty in drug production, while AI, by its nature, operates on probabilities and approximations. Despite the vast amounts of data and processing power available, AI models cannot guarantee exact outcomes, as they are trained on historical data and predict future behaviors based on identified patterns. [33-35]
Understanding the algorithms utilized and the potential error rates associated with this emerging technology is essential. Key concepts in the healthcare field include continuous updating, digital competencies, and innovation. According to the FIP, integrating AI in pharmacy requires pharmacists to grasp not only the capabilities of these new technologies but also their limitations, data quality, regulatory compliance, ethical considerations, and the infrastructural investments necessary for successful implementation.[36]
The responses generated by the AI in the experimental project were generally straight forward, differing from traditional search engines that yield multiple viewpoints from various sources. In this project, out of 15 scientific and technical questions posed, 14 responses were deemed acceptable, with one notable exception regarding the chemical structure of citric acid monohydrate, where the AI failed to provide the correct formula featuring three carboxylic acid groups. (37-38)
The limitations of AI include:
• Lack of transparency and explainability, making it difficult for users to understand AI and deep learning models.
• Potential biases in training data, which can lead to unequal treatment or misdiagnosis of certain demographic groups.
• New regulatory and legal challenges that complicate compliance with existing frameworks.
• Risks of manipulation through AI algorithms and increased control systems (e.g., facial recognition).
• Concerns regarding data privacy, particularly in the absence of explicit protective laws.
• Erosion of human influence in decision-making processes.
• Interoperability issues between existing healthcare systems and new data platforms.
• Accountability challenges in identifying responsibility for errors.
• Resistance from healthcare professionals towards adopting AI technologies.
• A general lack of trust in AI-generated recommendations.
• High costs associated with developing and implementing AI solutions.
• Absence of emotional intelligence and creativity in AI systems.
• Risks of diminishing critical thinking and judgment among healthcare professionals.
• Ethical dilemmas arising from AI decisions that may conflict with patient or family preferences.
• Data quality issues stemming from incomplete or inaccurate information.
• Potential cybersecurity threats, including ransomware, malware, data breaches, and privacy violations.
This study demonstrates that AI tools can be beneficial in guiding practices within the galenic field. However, the findings from the chatbot queries must be meticulously verified against established pharmaceutical standards. Of the 15 queries posed, 14 responses were found acceptable, resulting in a notable 6.7% rate of unacceptable responses. Given that the safety and efficacy of galenic products must adhere strictly to regulatory guidelines and prioritize patient health, human verification of chatbot-generated results is essential in the current landscape of pharmaceutical practice.
As AI continues to evolve and integrate into pharmaceutical applications, it is vital for professionals in the field to maintain a critical perspective, ensuring that the adoption of these technologies enhances rather than compromises patient safety and care.
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Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
