AUCTORES
Globalize your Research
Research Article | DOI: https://doi.org/10.31579/2768-2757/176
1Associate Professor, Professor of Department Hospital Surgery No. 2, Sechenov First Moscow State Medical University, Moscow, Russian Federation.
2Head of Department Hospital Surgery No. 2, Sechenov First Moscow State Medical University, Moscow, Russian Federation.
3Student, Faculty of Institute of Clinical Medicine, Sechenov First Moscow State Medical University, Moscow, Russian Federation.
4Medical sciences, Associate Professor of Department Hospital Surgery No. 2, Sechenov First Moscow State Medical University, Moscow, Russian Federation.
5Assistant of Department of Hospital Surgery No. 2, Sechenov First Moscow State Medical University, Moscow, Russian Federation.
6Intern researcher of Department Hospital Surgery No. 2, Sechenov First Moscow State Medical University, Moscow, Russian Federation.
*Corresponding Author: Sergey Yurievich Muraviev., Associate Professor, Professor of Department Hospital Surgery No. 2, Sechenov First Moscow State Medical University, Moscow, Russian Federation.
Citation: Muraviev S. Y., Tarabrin E. A., Sidorova V. A., Ebrahimnezhad M., Berikkhanov Z. G.-M. et al, (2025), Thyroid Dysfunction as A Hormonal Aspect of The Pathogenesis of Colorectal Cancer, Journal of Clinical Surgery and Research, 6(5); DOI:10.31579/2768-2757/176
Copyright: © 2025, Sergey Yurievich Muraviev. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 05 June 2025 | Accepted: 16 June 2025 | Published: 20 June 2025
Keywords: colorectal cancer; thyroid dysfunction; hyperthyroidism; hypothyroidism; thyroid hormones
Background
Studies show a link between thyroid hormones and cancer development, but their role remains unclear, and colorectal cancer (CRC) is an example.
Material & Methods
Our study's purpose was to examine the manifestations of thyroid dysfunction in patients with CRC. We have selected publications from popular databases for 2019-2024.
Results
The thyroid hormone (TH) levels studies show that, in addition to their biological significance in metabolism and growth, they can influence cancer outcome. Articles point to the cancer-stimulating effect of thyroid hormones. avß3-integrin is of particular importance in the progression of CRC and poor survival.
Conclusions
We concluded that cancer is sensitive to thyroid hormone changes. However, the complex relationships between TG and cancer do not yet allow us to draw unambiguous conclusions about TG as activators or suppressors of tumors. The thyroid dysfunction's influence on cancer requires further research, which may open up new horizons in cancer treatment.
AKT - protein kinase B
CRC – colorectal cancer
D1 - deiodinase type 1
D2 - deiodinase type 2
D3 - deiodinase type 3
ER - estrogen receptor
ERα - estrogen receptor alpha
ERβ - estrogen receptor beta
ERK1/2 - extracellular signal-regulated kinase 1/2
PI3K - phosphatidylinositol 3-kinase
TH – thyroid hormones
TRH - thyrotropin-releasing hormone
TRα - thyroid hormone receptors alpha
TRβ - thyroid hormone receptors beta
TSH - thyroid stimulating hormone
T4 – tetraiodothyronine
T3 - triiodothyronine
Modern oncological practice underestimates the role of endocrine glands in the process of carcinogenesis. In many ways, the unpopularity of the endocrine environment in the tactics of managing a cancer patient is associated with the prejudice that in the case of tumor growth and cancer intoxication, in addition to glucose and insulin, tumor growth, for example, adenocarcinoma, is of no importance. At the same time, tumor growth itself reformats metabolism with the shutdown or perversion of the hormonal activity of the endocrine glands. It is believed that antitumor drugs completely turn off the thyroid or gonads indirectly through hepato-depression, or directly on the excretory function of the glandular systems. But this underestimation pushes into the shadows information about the state of the endocrine glands in a patient with adenocarcinoma, for example, colorectal cancer. The emerging situation only "artificially" hides possible solutions in case of unsuccessful management tactics, and makes the solutions more mysterious in case of cancer recurrence. In this regard, we believe that in a patient with tumor activity it is necessary to take into account the role of the endocrine organs.
The aim of our study was to examine the manifestations of thyroid dysfunction in patients with CRC. Due to the fact that there is no consensus on its dysfunction and the course of pathology at different stages and types of cancer, although any phenomenon in the body develops according to the rules, we set the task of analyzing literature data based on the opinion of specialists and researchers to determine the role of the thyroid gland in carcinogenesis. To search for literature, we used the most reliable databases: PubMed/Medline, semanticscholar.org, scholar.google.com. The first filter applied for selecting studies was the publication period from 1990 to 2024. Subsequently, all articles obtained by searching, were transferred to the Rayyan platform. The Rayyan platform allowed us to significantly simplify the selection of the necessary publications and exclude duplicate studies. To search for literature sources, we used the following words and phrases: "cancer", "colorectal cancer", "hypothyroidism", "hyperthyroidism", "thyroid hormones", "biological mechanism".
Thyroid hormones are key regulators of fundamental cellular processes including proliferation, differentiation, apoptosis, and metabolism. Hypothalamic thyrotropin-releasing hormone (TRH) activates the pituitary gland to synthesize and secrete thyroid stimulating hormone (TSH), which in turn acts on the thyroid gland to stimulate the synthesis and secretion of thyroid hormones (TH). Tetraiodothyronine (T4), the main hormone synthesized in the thyroid gland, is catalyzed to triiodothyronine (T3) by specific iodothyronine deiodinases. T3 acts as a major metabolic agent through the formation of complexes between T3 and the nuclear thyroid hormone receptors alpha (TRα) and beta (TRβ). This T3-receptor complex within the cell nucleus binds to thyroid hormone response elements on specific genes, regulating their transcription. Diseases associated with excess TH (hyperthyroidism) and deficiency of TH (hypothyroidism) are widespread and manifest with distinct clinical symptoms [1]. In addition to the biological significance of TH in metabolism and growth, there is evidence that they may influence the clinical outcome of cancer as well as individual human lifespan [2]. The existence of a link between thyroid hormones and malignancy has been supported by numerous clinical studies showing that hypothyroidism suppresses tumor growth, whereas hyperthyroidism has the opposite effect [3, 4]. In recent decades, many studies have been conducted to determine how thyroid hormones exert their growth-promoting effects [1, 5]. Thyroid hormones mediate their effects on cancer cells through several nongenomic pathways, including activation of the membrane receptor for TH integrin αvβ3 [6, 7]. This receptor has been shown to contain two distinct hormone-binding sites, S1 and S2, each of which mediates unique signaling cascades. Only T3 at physiological concentrations can bind to S1, triggering phosphorylation and activation of the phosphatidylinositol 3-kinase (PI3K) pathway, which promotes cell proliferation and inhibits apoptosis; a second site, S2, binds T4 and has a lower affinity for T3, triggering oncogenic extracellular signal-regulated kinase 1/2 (ERK1/2), promoting a similar side effect while stimulating angiogenesis and the expression of fibroblast growth factor 2, components that are required for rapid tumorigenesis [1, 8, 16]. Binding of integrin αvβ3 promotes the proliferative effects of hormones on cancer cells as well as on blood vessel cells [1, 7, 9]. This ability may be important in various types of cancer, and because malignant cells express higher amounts of integrin αvβ3 compared to normal cells [10]. L ' Heureux A. , Wieland D. R. et al noted that TRβ1 may play a tumor suppressor role in the progression of malignancies. Conversely, overexpression of the thyroid hormone receptor TRα1 appears to be associated with accelerated tumor initiation and progression [11]. Numerous in vitro, in vivo and population studies have demonstrated the cancer-promoting effects of triiodothyronine and thyroxine. They have been shown to mediate tumor growth, proliferation and progression. In addition, hyperthyroidism is also associated with a worse prognosis for cancer development [12]. However, it is very important to take into account the fact that circulating TH levels do not necessarily reflect intracellular levels of these hormones due to the existence of many factors that control intracellular TH levels:
Thus, general hypo- /hyperthyroidism assessed based on circulating TH levels may provide information that does not correspond to the real intracellular situation [10].
The influence of hormone levels on the incidence of colorectal cancer
Du Q., Zheng Z. et al. found that genetically predicted hyperthyroidism, hypothyroidism, TSH, and T4 were not associated with the risk of CRC (all p>0.05). Stratified analysis showed that their basal metabolic level was significantly associated with colon cancer (OR=1.33, p=0.0074), but not with rectal cancer. Inverse analysis did not reveal an effect of CRC on thyroid function (all p>0.05) [13]. Therefore, the authors concluded that thyroid function changes in relation to CRC occur primarily (i.e., before tumor occurrence), and TH level does not affect the risk of CRC. However, Gagliardi F., Baldini E. et al. suggested that CRC may determine the onset of low T3 syndrome and that decreased peripheral deiodinase type 2 (D2) -mediated conversion of T4 to T3 (regulates local thyroid hormone levels) [14, 15, 16] may be a crucial event. The loss of muscle mass that occurs in cachexia and the subsequent decrease in deiodination (the removal of an iodine atom), as well as the liver injury caused by tumor spread with subsequent impairment of deiodination mediated by deiodinase type 1 (D1)-mediated deiodination (responsible for the salvage of iodine in TH synthesis) [17, 18, 19] may be considered as pathological mechanisms occurring in patients with metastatic CRC. Based on the correlation between altered peripheral deiodination and worse clinical outcome, the authors concluded that the prognostic value of the free T3/free T4 ratio can be taken into account in the assessment of prognostic indicators aimed at assessing life expectancy in patients with metastatic CRC. A correlation between low T3 syndrome and poor clinical outcome was found in patients with hematological, lung, and brain tumors. The authors also found that a state of intracellular hypothyroidism, caused by either decreased expression and/or function of specific nuclear receptors TRβ1 or decreased availability of T3, may contribute to the progression of CRC [21, 22]. Thus, the authors found a significantly higher prevalence of CRC in patients with subclinical hypothyroidism compared to patients with a euthyroid state [22]. As reported above, T4 binding to integrin αvβ3 induces the expression of genes involved in colorectal cancer cell proliferation [7, 9]. T4 activates integrin αvβ3 at physiological concentrations of free hormone, whereas supraphysiological serum levels of the hormone are required to trigger integrin-dependent cell proliferation under the influence of T3 [7]. Estrogens also influence cellular functions by binding to two nuclear estrogen receptors (ER): estrogen receptors alpha (ERα) and beta (ERβ). Like TH, estrogens can influence cellular functions by binding to receptors located either on the cell plasma membrane or on the nuclear membrane. Two ERs have been reported to exert opposing effects on CRC cells: ERα stimulates the ERK/MAPK and PI3K/AKT pathways, resulting in increased colon cancer cell proliferation, and ERβ induces apoptosis of malignant colon cells via the p38/MAPK pathway and caspase 3 activation. Although ERβ is the predominant estrogen receptor in normal colonic epithelium, its expression is often downregulated or abolished during CRC progression, suggesting that estrogen signaling may play a role in disease development. THs have been shown to increase ER expression, and T4, via the integrin receptor αvβ3, can activate MAPK-mediated phosphorylation of nuclear ERα; this phosphorylation influences the ability of ER to interact with chromatin, recruit coregulators, and modulate gene expression even in the absence of estrogen [22]. Asbaghi O., Shimi G. et al. did not find a significant association between hypothyroidism and the risk of developing CRC. Also, in their review, no significant association was found between hyperthyroidism and the risk of developing CRC. In addition, significant associations were found between hypothyroidism and the risk of developing CRC in studies in the Far East, between hyperthyroidism and the risk of CRC in the Middle East, and in studies with a small sample size [23], therefore, it can be assumed that climatic and ethnic factors play a role in the association between hypothyroidism and the risk of developing CRC. Gómez-Izquierdo J., Filion K. B. et al. concluded that subclinical hypothyroidism is associated with an increased risk of cancer incidence, especially colorectal cancer and thyroid cancer, and cancer-related mortality [24]. In colorectal cancer, two additional nuclear receptors with antagonistic effects are involved: TRα1 and TRβ1. Thyroid hormones act on TRα1 to stimulate β-catenin, which induces cell proliferation in the colon. Conversely, TRβ1 blocks cell proliferation when activated by thyroid hormones. Thus, lack of TRβ1 expression is associated with malignant transformation of colon cancer [24]. Furthermore, it has been shown that TH contribute to the depletion of CRC stem cells. The study, presented in L' Heureux A. et al. provide a potential mechanism for the feedback observed in hyperthyroid patients; in their xenografts and in models In vitro, T3-treated CRC stem cells had significantly reduced self-renewal capacity; decreased nuclear β-catenin accumulation; and increased sensitivity to treatment, particularly when deiodinase type 3 (D3) was inhibited [11]. Intracellular T3 may have antitumor properties because it induces differentiation of CRC stem cells [11]. As for T4, its nongenomic action through binding to integrin αVβ3 promotes nuclear β-catenin accumulation and T4 dose-dependently promotes cell viability in CRC cell lines. Therefore, there may be a potential mechanism by which low free T4 levels in primary hypothyroidism may protect against CRC by reducing integrin interaction [11]. Schiera G., Di Liegro C. M. et al. suggest that hypothyroidism correlates with an increased risk of CRC and hepatocellular carcinoma. In particular, THs may control the balance between proliferation and differentiation of CRC stem cells, inducing differentiation and reducing growth, thus acting as an anticancer agent [10].
Thyroid function in oncology is today considered an ambiguous phenomenon. There is no consensus on its dysfunction and the course of pathology at different stages and types of cancer, although any phenomenon in the body develops naturally. By avoiding the assessment of endocrine disorders, their observation and analysis, we may be slowing down the development of oncology and supporting existing scientific results. It has long been generally accepted that thyroid hormones are key regulators of basic processes in cells, including cell proliferation, differentiation, apoptosis, and metabolism. However, the question of a similar effect of TH on cancer remains. At the same time, there is already data on the effect of thyroid hormones on the clinical outcome of cancer. However, the mechanisms of influence are different [6]. On the one hand, thyroid hormones mediate their effect on cancer cells through several non-genomic pathways, including activation of the membrane receptor for TH integrin αvβ3. Binding of the latter promotes proliferation of cancer cells [1]. At the same time, malignant cells express a higher amount of integrin αvβ3 compared to normal cells [4]. Most importantly, a chain of interactions is formed that is realized in various types of cancer. The relationship between thyroid function and the risk of developing CRC is also indicated by the binding of T4 to integrin αvβ3, which induces the expression of genes involved in the proliferation of CRC cells. Speaking of T4, there may be a potential mechanism by which low levels of free T4 in primary hypothyroidism can protect against CRC by reducing interaction with integrin [3]. Schiera G., Di Liegro C.M et al. suggested that hypothyroidism correlates with an increased risk of CRC and hepatocellular carcinoma. In particular, TH may control the balance between proliferation and differentiation of CRC stem cells, inducing differentiation and reducing growth, thus acting as an anticancer agent [10]. On the other hand, genetically predicted hyperthyroidism, hypothyroidism, TSH, and FT4 were found to be unrelated to CRC risk, and inverse analysis, no effect of CRC on thyroid function was found [13].
However, the reduction in peripheral T4 to T3 conversion by D2 [12, 15] may be a critical event, and CRC may determine the onset of low T3 syndrome. Subsequent reduction in D1-mediated deiodination [8, 18, 19] is still considered as a pathological mechanism occurring in patients with metastatic CRC. Further supporting the debate about the state of intracellular hypothyroidism, decreased expression and/or function of specific nuclear receptors THRβ1, or decreased availability of T3, which may contribute to the progression of CRC, confirms the significantly higher prevalence of CRC in patients with subclinical hypothyroidism compared to patients with a euthyroid state [22]. Interestingly, in the absence of data on a significant association between hyperthyroidism and the risk of developing CRC, the authors (Gómez-Izquierdo J., Filion KB et al.) conclude that subclinical hypothyroidism is associated with an increased risk of cancer incidence, especially CRC and thyroid cancer, as well as cancer-related mortality [24]. And they prove that in CRC, the absence of TRβ1 expression is associated with malignant transformation of colon cancer [24]. In view of this, it is possible that changes in thyroid function in relation to CRC occur primarily (i.e., before the tumor develops), and the TH level does not affect the risk of CRC. TSH, TH, integrin αvβ3, and deiodinases are involved in cancer proliferation. CRC has high levels of integrin αvβ3-expressing tumor vasculature and is associated with significantly lower disease-free and overall survival compared with patients with low levels of integrin αvβ3 in tumor vasculature [20]. Based on these observations, Liu Y. C., Yeh C. T., et al. suggest that thyroid hormones not only modulate CRC progression through cell surface integrin αvβ3, but also that integrin αvβ3 acts as a prognostic indicator for colon carcinoma. D3 is also involved in CRC progression and has been reported to promote the development of human colon adenoma and adenocarcinoma compared with healthy surrounding mucosa. The β-catenin/T-cell factor complex activated in CRC stimulates D3 expression and T3-induced CRC cell proliferation [20].
Currently available clinical and experimental data provide conflicting results regarding the ability of TH to influence CRC progression. Although some studies have shown that cancer is sensitive to changes in thyroid hormone levels, both when it occurs after the tumor has developed and before. However, the complex and multidirectional links between TH and cancer do not yet allow us to draw firm conclusions about TH as activators or suppressors of cancerous tumors. We assume that the contradictory data are related to complex interactions of thyroid hormones and their receptors in normal and neoplastic colorectal tissues. However, most researchers are inclined to believe that hypothyroidism contributes to the progression of CRC. However, the mechanisms of the influence of hypothyroidism on the progression of CRC are also still unclear and require further research. We aim to decipher and study the underlying cause of the pathogenetic interaction between CRC and thyroid dysfunction. We believe that clarifying this issue and including reasonable correction of thyroid hormone levels in patients with CRC may improve the quality of early cancer diagnosis and treatment outcomes by increasing life expectancy.
The authors are fully responsible for the content of the manuscript. The concept, design and supervision of the study was carried out by SYM. EAT was a scientific consultant and developed a research project. ZGMB and ANN carried out an independent examination and selection of publications. VASid performed the analysis of the material and the writing of the text. -.
The statistical processing was done by IAM and VSR. Search and collection of material implemented by VASav, MYI. Editing was perfomed by – ME.
The authors declare that they have no financial or non-financial competing interests.
The authors state that they received no funding for the study.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
