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case report | DOI: https://doi.org/10.31579/2693-2156/130
Aim: To report a case of right ventricular myxoma prolapsing through the tricuspid valve with an attachment of vegetation in a 3-year-old male child.
Introduction: Right-sided endocarditis commonly involves the tricuspid valve. Low pressure and low oxygen saturation in the right sided cardiac chambers protect the tricuspid and pulmonary valves from being subjected to excessive strained and damage occurs from injected particulate matter, contaminated venous lines and drug solutions causing endocarditis. RV (right ventricular) myxoma harboured the infection due to trauma as a result of friction movement across the tricuspid valve. Case Report: A 3-year-old male child having the spikes of fever for 2 weeks, presented with tumor “plop” and 3/6 systolic murmur in lower left sternal border and echocardiography revealed a tumor-mimicking vegetation visible as a mass lesion across the tricuspid valve, which is attached to the interventricular septum by a pedicle suggesting a RV myxoma. The vegetation was found to be attached with the tumor and it disappeared with antibiotics and aspirin therapy and the child was advised surgical removal of the tumor. Conclusion: A diagnosis of infective endocarditis can be made in tricuspid valve dysfunction with a floating mass and fever. The tricuspid vegetations are often large and in rare instances, it may reach the size in excess of 20 mm [1]. The cardiac myxoma with attached vegetation masquerading as vegetation mass in this case on transthoracic echocardiography and the vast majority of patients in right-sided endocarditis respond to antimicrobial therapy and do not require surgery [2].
*Corresponding Author: Ramachandran Muthiah, President of all Nations Morning Star Hospital, Enayam Thoppu, Kanykumari District, India
Citation: Ramachandran Muthiah, (2025), Right-Sided Infective Endocarditis, Journal of Thoracic Disease and Cardiothoracic Surgery; 6(3):DOI: 10.31579/2693-2156/130
Copyright: © 2025 Ramachandran Muthiah, this is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 06 May 2025 | Accepted: 23 May 2025 | Published: 19 June 2025
Keywords: RV myxoma; Vegetation; Tricuspid regurgitation; Aspirin therapy; AngioVac
Infective endocarditis (IE) is a microbial infection of the endocardial (endothelial) surface of the heart. It accounts for about 0.75 admissions per 1000 per year in large community hospitals [3] and a population-based incidence of 4-10 per 100,000 per year, with a slightly higher rate in men [4],[5]. Children with underlying cardiovascular disease may develop endocarditis at any age. It is most frequent on the left side of the heart [6]. Right-sided infective endocarditis is relatively rare, occurring in 5-10% of cases [7]. It involves the tricuspid valve in 90%, pulmonary valve in < 10>
Tricuspid valve infective endocarditis accounts for 2.5-3.1% of IE cases [11]. The right-sided infective endocarditis involving the right ventricular myxoma, prolapsing through tricuspid valve is uncommon and so this case had been reported.
A 3-year-old male child with 2 weeks fever was referred for echocardiographic evaluation. His pulse rate was 112 bpm with a temperature elevation up to 101₀ F. Blood chemistry revealed leukocytosis with an elevation of total count up to 42700 cells/cubic mm of blood (normal- 4000 to 11000 cells/ cubic mm of blood) (Polymorphs -80% (normal-45 to 75%), Lymphocytes-17% (normal-25 to 40%), Eosinpphils-3% (normal-2 to 6%), Platelets-2.27 lakhs/cubic mm of blood. The child was mildly anemic- normochromic, normocytic red blood cell indices (Hb-7.7 gm % (normal-13.5 to 17 gm/dl). ESR (erythrocyte sedimentation rate) was elevated-48 mm/hour (normal-0 to 20 mm/hr). Serum rheumatoid factor (RA factor) was negative (which may be detected in 50% of cases). Blood widal, Dengue antibody test, smear for malarial parasites and blood cultures were negative. Urinalysis revealed no microscopic hematuria. He had no other features of infective endocarditis such as Osler’s nodes, Janeway lesions, Roth spots, splinter hemorrhages which are relatively rare in children and no spotty skin pigmentation, a characteristic feature of myxoma in Carney complex. Abdominal examination revealed no splenomegaly (which occurs only in 10 to 15% of cases). ECG and X-ray chest PA (postero-anterior) were normal as shown in Figures 1 and 2. Physical examination revealed a grade 3/6 systolic murmur which increases with inspiration (Carvallo’s sign) and an early diastolic tumor “plop” due to abrupt diastolic seating of a mass in the right atrioventricular orifice [12] in the lower left sternal border on auscultation. 2 D echocardiography revealed a large, mobile homogeneous mass in the tricuspid orifice, visible as a ‘tumor-mimicking vegetation’ as shown in Figures 3 to 9.
Figure 1. ECG revealed a heart rate of 112 bpm due to fever.
Figure 2. X-ray chest PA (postero-anterior) view revealed normal.
Figure 3. Showing the vegetation prolapsing through the tricuspid valve in a 3-year-old male child
Figure 4. Short axis view showing the vegetation prolapsing through the tricuspid valve in a 3-year-old male child.
Figure 5. showing the tumor-mimicking vegetation in a 3-year-old male child
Figure 6. Showing the tumor-mimicking vegetation in a 3-year-old male child
Figure 7. Showing the tumor-mimicking vegetation in a 3-year-old male child
Figure 8. Subcostal view showing the tumor-mimicking vegetation in a 3-year-old male child
Figure 9. Short axis view showing the tumor-mimicking vegetation in a 3-year-old male child [13]
An irregular homogeneous hypodense mass suggesting a vegetation was attached to the mass, which is globular shape and a heterogeneous or mottled appearance throughout, with echolucent areas representing hemorrhage or necrosis suggesting a myxoma [14] as shown in Figures 10, 11 and 12.
Figure 10. Showing a vegetation attached to the myxoma in a 3-year-old male child.
Figure 11. Showing the myxoma with vegetation in a 3-year-old male child.
Figure 12. Showing the myxoma with vegetation in a 3-year-old male child.
The mass was attached to the interventricular septum by a pedicle (stalk), protruding through the tricuspid valve and appear as “cluster of grapes” [15] as shown in Figures 13 and 14, suggesting a RV (right ventricular) myxoma.
Figure 13. Showing the RV (right ventricular myxoma) attached to the interventricular septum by a pedicle and appears as “cluster of grapes” with filamentous fronts in a 3-year-old male child.
Figure 14. Showing the RV (right ventricular myxoma) attached to the interventricular septum by a pedicle.
The mass, producing a traumatic regurgitation across the tricuspid valve due to friction movement as shown in Figures 15, 16 and 17.
Figure 15 Showing the severe tricuspid regurgitation with a mass lesion in a 3-year-old male child
Figure 16. Showing the moderate tricuspid regurgitation with a mass lesion in a 3-year-old male child
Figure 17. Spectral Doppler showing the ‘tiger-stripe’ appearance of the tricuspid regurgitant jet due to the oscillating mass across the valve
The child was treated with a course of intravenous ceftriaxone combined with gentamycin along with aspirin therapy for a period of 10 days, the tricuspid regurgitation decreases as in Figure 18 and the vegetation was found to be disappeared as shown in Figures 19. The child was advised periodic echocardiographic evaluation with a continuation of medications up to 4 weeks period and advised early surgical removal of the tumor.
Figure 18. Showing the mild tricuspid regurgitation with a mass lesion in a 3-year-old male child.
Figure 19. Showing the clearance of vegetation from the myxoma due to antibiotics and aspirin therapy.
Review of literature
Lewis and Grant were the first to describe the infective endocarditis [16]. Gould, et al [17] found that bacteria most frequently responsible for endocarditis (e.g., viridans streptococci) displayed a propensity for adherence to human valves. There are only few reports of large tricuspid valve vegetations in the literature. Song, et al [18] reported a vegetation on tricuspid valve in a 33-year-old male, presented with right-sided heart failure and Furui, et al [19] reported a 1.5 cm vegetation on tricuspid valve in a 71-year-old male who developed ventricular septal perforation caused by right-sided infective endocarditis.
Etiopathogenesis
The endothelial lining of the heart and its valve is normally resistant to infection with bacteria and fungi. When there is a pressure gradient with resultant turbulence of blood flow, which against either the mural endocardium or vascular endothelium results in tissue damage due to high velocity jet (‘jet lesions’). Endocarditis begins as endothelial damage, followed by focal adherence of platelets and fibrin. The initial sterile platelet-fibrin nidus, first recognized by Angrist [20] and called as ‘nonbacterial thrombi, then becomes infected by microorganisms circulating in the blood stream. Platelet-fibrin nidus involves a complex interaction of the components of microbial cell wall such as dextran in the cell wall of gram-positive organisms and valvular endothelium [21], intrinsic binding affinity to fibronectin [22] and glucosyl transferases which may act as “modulins” to express various cytokines (interleukin-6) or adhesions that in turn further recruit leukocytes into the vegetation [23]. The other factors which mediate adherence include fibrinogen, laminin, type 4 collagen which are the components found in the damaged endothelium or platelet-fibrin aggregate. Following colonization of platelet-fibrin aggregate [24], microbial growth results in the secondary accumulation of platelets and fibrin to form a vegetation. It consists of bacteria encashed in a meshwork of platelets and fibrin, serves as a barrier to host defences and it is not vascularized.
The propensity for vegetation to form at specific sites may also relate to a decrease in lateral pressure downstream from the regurgitant flow, which causes a decrease in the perfusion of intimal lining at these sites [25]. Tricuspid vegetations are large due to the low pressure in right heart chambers, allowing them to grow and may be in excess of 2 cm [26]. Vegetation often prevent proper valvular leaflet or cusp coaptation, thereby causing valvular incompetence resulting in congestive heart failure [27] or leaflet perforation secondary to vegetation growth [28] with recruitment of matrix metalloproteinases (MMPs) and eventually destroy the collagen. Pneumonia or septic pulmonary embolism resulting from dislodgement of vegetative material are common. Recurrent pulmonary events, anemia and microscopic hematuria, the so called “tricuspid syndrome” is a feature of right-sided tricuspid valve endocarditis [29].
Tricuspid valve endocarditis may occur in community –acquired or hospital acquired infection and the organisms responsible for both are shown in Table 1.
Organism
| Community acquired endocarditis (IV drug users) | Hospital acquirefd endocarditis (intravascular devices) |
Staphylococcus aureus
Α-hemolytic streptococci (viridians)
Enterococcus
Culture negative
Fungi
Staphylococcus epidermidis (coagulase negative)
Others (Escherichia coli, Klebsiella, Corynebacterium) | 30-50 % (MRSA-minority)
10-35 %
5-10 %
5-30 %
< 5>
< 5>
< 5> | 60-80 % (MRSA-majority)
< 5>
5 %
5 %
10 %
< 5>
5-10 % |
Table 1 showing the organisms responsible for infective endocarditis. MRSA - methicillin resistant staphylococcus aureus.
Cardiac myxomas are seen initially with protean manifestations that mimic many disease processes. About 5% of myxomas are found in the ventricles, usually solitary and attached to the interventricular serptum by a pedicle [30]. Small myxomas are silent and manifest if they become infected or embolize. The systemic manifestations consist of fever, weight loss, malaise, with leukocytosis, thrombocytopenia, elevated ESR (erythrocyte sedimentation rate), increase in gamma globulins, polycythemia and Raynaud’s phenomenon [31] may occur in 90% of myxomas.
Echocardiographic features
The most common and direct evidence of infective endocarditis is the vegetation and it must be at least 3 to 6 mm in size to be reliably seen. Transthoracic echocardiography (TTE) can, at best, detect vegetation to a minimum size of 2 mm and it is usually the more sensitive technique, with sensitivities in children up to 80% [32]. The characteristic echo appearance of a vegetation is of an echogenic mass, irregular in shape, attached to the ‘upstream’ side of a valve leaflet, i.e, atrial side of atrioventricular valves, most commonly at the coaptation line and prolapsed through the tricuspid valve as shown in Figures 3 and 4. The vegetation vary in size, sometimes reaching 2-3 cm in diameter and can be so big that they are mistaken for a cardiac tumor as shown in Figures 5 to 9.
The gold standard for diagnosis of infective endocarditis is the modified Duke criteria [33] and it emphasized the essential relationship between clinical and echocardiographic findings. Duke’s criteria have been predominantly applied for left-sided endocarditis and have not been studied specifically in tricuspid valve endocarditis [34] and it may be difficult to determine [35] in its diagnosis.
Echocardiography remains the most safe and simple noninvasive method to diagnose the presence of an intracavitary myxoma [36]. Myxomas are typically non-homogeneos in texture with lucent centers or areas of calcification. They may be smooth surfaced but are more often irregularly shaped with filamentous fronts or have the appearance of “cluster of grapes” as shown in Figures 13 and 14. They are either sessile or pedunculated with a distinct stalk (pedicle), variably friable and originates from subendocardial nests of primitive mesenchymal cells. The tumor arising from the ventricular cavity was attached by a stalk to the interventricular septum as shown in Figures 10 to 14.
Vegetation can occur on any surface [37]. Endocarditis usually begins as a mechanical traumatic event during the protrusion of myxoma through the tricuspid valve and the vegetations are attached to its surface as shown in Figures 10 to 12. The tumor mass is seen to oscillate into the right atrium through the tricuspid valve and producing regurgitation as shown in Figures 15 and 16 and the oscillations visible as ‘tiger-stripe’ appearance in the Spectral Doppler imaging as shown in Figure 17.
Management
Medical therapy
Fever, multiple pulmonary emboli and sustained bacteremia by staphylococcus aureus are the signs of clinical alert for right-sided endocarditis [38]. After the diagnosis of tricuspid valve endocarditis, medical treatment with antibiotics is indicated and should be continued for 4 to 6 weeks until the signs of infection disappear. Prolonged therapy is necessary since very high densities of bacteria approaching 109 to 1010 organisms per gram of tissue, become metabolically dormant and are difficult to eradicate since the organisms are relatively protected within the vegetation from phagocytic and other host defence mechanisms. Bactericidal antibiotics or antibiotic combination rather than bacteriostatic agents with high serum concentration may reach the central area of avascular vegetation by passive diffusion [39]. In small children, intravenous antibiotics with the use of heparin lock devices are preferred and home intravenous therapy is generally not recommended.
Uncomplicated tricuspid valve endocarditis is successfully treated medically in 80% of cases. Given the low likelihood of adherence to 4–6-week therapy, shorter courses of therapy with a combination of β-lactam with or without an aminoglycoside (for 2 weeks) have become an accepted standard in methicillin-sensitive staphylococcus aureus native valve endocarditis. Experience with 2 weeks regimen in children is limited, but it appears promising [40]. Short course therapy should not be used for patients infected with a relatively penicillin – resistant organisms, nutritionally deficient streptococcus and a presence of vegetation visible by echocardiography.
Unless the clinical or epidemiologic clues suggest an etiological diagnosis, the recommended treatment for culture-negative native valve endocarditis is ampicillin plus gentamycin. Ceftriaxone can be used in this regimen instead of ampicillin. Isolated native non-rheumatic fungal tricuspid valve endocarditis with a large and more friable vegetation is the most severe form of endocarditis. Aspergillus species (mostly Aspergillus fumigatus) are the second most common fungi isolated from cardiac vegetation (25%), whilst Candida accounts for 53% and Histoplasma for 6% of cases of fungal endocarditis. Amphotericin B has been the ‘gold standard’ treatment for Aspergillus endocarditis, despite its known poor penetration into vegetation [41]. The role of new echinocandins such as caspofungin has been recently approved and a combination of voriconazole with caspofungin is an alternative approach with promising results in refractory Aspergillus infection [42].
Aspirin therapy Bacteria-platelet interaction appears to be important in both the induction of a vegetation and its enlargement after colonization. Acetylsalicylic acid was shown to have an effect on both platelets and organisms in a rabbit model of staphylococcus aureus endocarditis. Animals treated with aspirin had reduction in the weight of valvular vegetation, its growth, density of bacteria and a decrease in embolic events compared to controls [43].
Surgical therapy
Although tricuspid valve endocarditis is successfully treated medically in about 75% of patients, conservative treatment is not always effective, and surgical treatment is required in approximately the remaining 25% [44],[45]. The indications of surgery in right-sided infective endocarditis are not well defined, but it should be considered in the following circumstances as shown in Table 2 [46].
| Indications of surgery in right-sided infective endocarditis |
TV (tricuspid valve) vegetation > 20 mm and recurrent septic pulmonary embolism with or without concomitant right heart failure
IE (infective endocarditis) caused by microorganisms that are difficult to eradicate (e.g. fungi) or bacteremia for at least 7 days (e.g., Staphylococcus aureus, Pseudomonas aeruginosa) despite adequate antimicrobial therapy
Right heart failure secondary to severe tricuspid regurgitation with poor response to diuretic therapy.
|
Table 2. Indications of surgery in right-sided infective endocarditis)
Timing of surgery in right-sided infective endocarditis is less clear. The optimum timing for the surgery was also stated previously [47]. The ESC (European Society of Cardiology) guidelines classified surgical indications in infective endocarditis as emergent (within 24 hours), urgent (within a few days), and elective (after 1 to 2 weeks of antibiotic therapy). The AHA/ACC guidelines defines early surgery as occurring during the initial hospitalization and before completion of a full therapeutic course of antibiotics. Early surgery of tricuspid valve infective endocarditis is considered if there is infected indwelling catheters or pacing leads and a dehiscence of prosthetic valve due to perivalvular infection (unstable prostheses) [48]. Vegetation size is a questionable indication for surgery and a study by Lutas, et al [49] showed that the size of vegetation is not an indication for surgery by itself. According to the current guidelines, patients with large vegetation (> 15 mm) should be operated [50],[51] on urgently (within days) and those with fungal infection that are resistant to medical treatment should be operated during the hospitalization period.
Tricuspid valve infective endocarditis can be especially perilous because the proliferation of growth called vegetation, may cause the valve to regurgitate. After the infection causes structural damage to the valve, antibiotics alone cannot cure and require surgery to stem the “snowball effect” the leaking valve [52]. The principles of surgery include radical debridement of vegetation/infected tissue and valve repair using a variety of techniques [53],[54] such as autologous pericardial patch augmentation of the destroyed leaflets, implantation of an annuloplasty ring and expanded polytetrafluoroethylene neochord whenever possible. If the damage is too severe, the valve should be excised and replaced with a bovine pericardial valve, a bioprothesis preferably since there is a high risk of thrombosis due to low velocity of blood flow in right-sided chambers. The complete excision of the tricuspid valve was first described by Arbulu, et al [55] and valvectomy accounts for 7.2% of operations performed for tricuspid valve endocarditis in North America [56]. TV (tricuspid valve) excision should be limited to extreme cases only when the pulmonary artery pressure and vascular resistance are not elevated. Subsequent valve replacement should be considered once the infection is resolved. Fungal endocarditis remains a ‘stand-alone’ indication for surgical replacement of an infected valve. Tricuspid valve replacement resulted heart block in 16% of cases and epicardial lead placement should be considered since the placement of permanent endocardial leads across a bioprosthesis may cause regurgitation and reduces the prosthesis durability due to leaflet fibrosis and retraction.
Prompt surgical removal of the intracardiac tumor is mandatory as systemic emboli or valvular obstruction can occur unexpectedly. The first surgical excision of a myxoma was performed in 1954 [57]. The myxoma is removed en bloc with its attachment to the interventricular septum [58] and every effort should be made to avoid fragmentation and embolization. Laser photocoagulation of a 1-cm area around the stalk attachment site has also been suggested as a way of eradicating pretumorous cells [59].
Interventional therapy
Surgical management of acute infective endocarditis is a major challenge. AngioVac [60], a suction thrombectomy device approved for removal of undesirable intravascular material, such as clots, tumors, or any foreign material in the vascular system. It can be an option in the management of right-sided infective endocarditis in critically ill patients with high surgical risk. Debulking the infection site and achieving lower bacterial load can increase antibiotic efficacy. Percutaneous vegetation removal has been used as a bridge to surgery in acute tricuspid valve endocarditis [61],[62].
Outcome
The long-term prognosis of patients with negative blood culture infective endocarditis has been found to be similar to that of patients with positive blood culture infective endocarditis across all age groups [63]. Tricuspid valve infective endocarditis has a benign prognosis and an in-hospital mortality of < 10>15 mm [68] and, > 20 mm and fungal etiology [69] are the predictors of increase in mortality rate. Right-sided heart failure is also a predictor of poor outcome in right-sided endocarditis [70],[71].
Numerous reports documented complete cure of myxoma with follow-up period of 10 to 15 years [72],[73] and the surgical results are excellent with resolution of associated symptoms [74]. In about 1 to 5 % of cases, a recurrence or secondary cardiac myxoma has been reported after resection of the initial tumor [75],[76].
Case Analysis
A 3-year-old febrile male child despite antibiotic treatment for 2 weeks with an auscultatory findings of a right –sided regurgitant lesion as evidenced by grade 3/6 systolic murmur and a mass lesion as evidenced by tumor “plop” in lower left sternal border, suggesting a right-sided infective endocarditis of acute onset clinically. The non-drug users are generally present with symptoms of > 2 weeks duration [77] and if tricuspid valve is involved, heart murmurs are found with variable frequency in 35 to 72% of cases [78]. The source of infection is from in-situ intravenous canulas and the blood cultures are negative due to prior antibiotic therapy. Elevated total leukocyte counts up to 42,700 cells/cubic mm of blood is due to leukemoid reaction as the result of infection. The mass lesion can be confused as valvular vegetation by echocardiography as shown in Figures 5 to 9. The vegetation is adherent to the mass, which is attached to the interventricular septum by a pedicle suggesting the RV (right ventricular) myxoma as in Figures 10 to 14 and it is masquerading as tricuspid valve vegetation in figures 5 to 9. The infective process and trauma due to mass lesion results in significant valve damage and producing moderate to severe tricuspid regurgitation as shown in Figures 15 to 17.
Right-sided endocarditis, often allows time for medical treatment to take effect because the regurgitant lesion is well tolerated. Hence, it is recommended to treat medically with antibiotics initially before sending the patient for surgery. With effective treatment, regurgitant lesion decreased as in Figure 18, the vegetation gradually shrinks and disappeared as shown in Figure 19 even though disappearance of a vegetation should raise a suspicion that the vegetation has broken free and embolized elsewhere, but there were no signs of septic pulmonary emboli since the X-ray chest PA view revealed normal as in Figure 2. Because there is a high risk of relapse after short-term antibiotic therapy, prolonged therapy is recommended for a minimum period of 4 weeks [79] with an advice of surgical removal of tumor in this child.
Screening of population
Calcification is present approximately in 10 to 20% of cardiac myxomas and right atrial myxomas appear to calcify more readily than left atrial myxoma [80] as shown in Figure 20 and it is associated with rheumatic AV valve (mitral and tricuspid) regurgitation as in Figure 21 in a 28-year-old male. A left atrial myxoma, attached to fossa ovalis, is associated with rheumatic AV valve stenosis (mitral and tricuspid) and tricuspid regurgitation as shown in Figures 22, 23 and 24 (Note: Thrombus typically produce a ‘layered appearance’ and is generally situated in the posterior portion of the atrium)
Figure 20. Showing the calcified right atrial myxoma in a 28-year-old male.
Figure 21. Showing the rheumatic AV valve (mitral and tricuspid) regurgitation associated with calcified right atrial myxoma in a 28-year-old male.
Figure 22. Showing the left atrial myxoma arising from the fossa ovalis of the interatrial septum in a 53 –year old male
Figure 23. Showing the left atrial myxoma associated with rheumatic AV valve stenosis (mitral and tricuspid) in a 53 –year old male.
Figure 24. Showing the left atrial myxoma associated with rheumatic tricuspid regurgitation in a 53-year-old male.
Right-sided endocarditis is generally considered to have a better prognosis and the initial approach to the treatment is conservative with antibiotics according to ESC (European Society of Cardiology) guidelines. The medical treatment yielded very good results in this case as the disappearance of vegetation mass as shown in Figure 19. Even though optimum management of tricuspid valve infective endocarditis has not yet been defined, it is a serious and potentially lethal condition in an infant or child [81] and so early surgical intervention to remove the large obstructive vegetation is indicated. The surgical treatment can be performed with low risk and good early, mid and long-term results [82].
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I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
