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Research Article | DOI: https://doi.org/10.31579/2690-4861/853
*Corresponding Author: Obioma Raluchukwu, Department of Haematology, College of Medicine, Federal University of Technology Owerri, Imo State.
Citation: Emeka-Obi, Obioma Raluchukwu, Jane Ugochi CM, Ugwuibe O. Goziem, Okpara L. Tobechukwu, (2025), Red Cell and Platelet Indices in Women with Preeclampsia in Federal Medical Centre, Owerri, International Journal of Clinical Case Reports and Reviews, 27(3); DOI:10.31579/2690-4861/853
Copyright: © 2025, Obioma Raluchukwu. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 24 May 2025 | Accepted: 17 June 2025 | Published: 14 July 2025
Keywords: pregnancy; preeclampsia; haemoglobin; red cell indices; platelet indices
Preeclampsia is a serious and life-threatening pregnancy complication. It is universally defined as hypertension and significant proteinuria developed at or after 20 weeks of pregnancy in an otherwise normotensive woman. The aim of this study was to determine the levels of haematological parameters in pregnant women with preeclampsia in Federal Medical Centre Owerri. A total of 120 pregnant women aged 18-45 years at 28-40 weeks of pregnancy were recruited; 60 were women with preeclampsia while 60 were pregnant women with normal blood pressure. Haematological parameters were analyzed using haematology auto-analyser by Sysmex® KX-21N. The median value of RBC (3.20 x1012/l), Hb (9.60 g/dl), PCV (29.00 %) and MCV (86.00 fl) were significantly lower (p<0.05) in women with preeclampsia compared with normotensive pregnant women RBC (3.66 x1012/l), Hb (10.60 g/dl), PCV (33.70 %) and MCV (91.30 fl) while the median value of MCH (30.00 pg) and MCHC (34.00 g/dl) were significantly higher (p<0.05) in women with preeclampsia compared with normotensive pregnant women MCH (29.45 pg) and MCHC (32.85 g/dl) . The median value of platelet (136x x1012/l), MPV (9.20 fl) and PCT (0.14 %) of women with preeclampsia decreased significantly (p<0.05) when compared to Normotensive pregnant women platelet (199x x1012/l), MPV (9.40 fl) and PCT (0.16 %) while the median value of PDW (15.70 %) and PLCR (21.00 %) of women with preeclampsia increased significantly (p<0.05) compared to normotensive pregnant women PDW (14.75 %) and PLCR (18.75 %). In this study, red cell and platelet indices were altered in preeclampsia. Thrombocytopenia was observed in most of our study population. Therefore, assessing these markers may be useful in the diagnosis and management of preeclampsia.
Preeclampsia is universally defined as hypertension and significant proteinuria developed at or after 20weeks of pregnancy in an otherwise normotensive woman [1]. Gestational hypertension is the presence of new hypertension (usually systolic BP > 140 mmHg and/or diastolic BP > 90 mmHg) occurring in the second half of pregnancy, while preeclampsia is the combination of gestational hypertension in the new proteinuria [2]. In the absence of proteinuria, hypertension together with evidence of systemic disease such as thrombocytopenia or elevated levels of liver transaminase is required for diagnosis [3]
Recently, the definition of preeclampsia has been broadened. Now the internationally agreed definition of preeclampsia is the one proposed by the International Society for the Study of Hypertension in Pregnancy (ISSHP). According to the ISSHP, preeclampsia is defined as systolic blood pressure at ≥140 mm Hg and/or diastolic blood pressure at ≥90 mm Hg on at least two occasions measured 4 hours apart in previously normotensive women and is accompanied by one or more of the following new-onset conditions at or after 20 weeks of gestation: Proteinuria (i.e. ≥30 mg/mol protein: creatinine ratio; ≥300 mg/24 hour; or ≥2 + dipstick); Evidence of other maternal organ dysfunction, including: acute kidney injury (creatinine ≥90 μmol/L; 1 mg/dL); liver involvement (elevated transaminases, e.g. alanine aminotransferase or aspartate aminotransferase >40 IU/L) with or without right upper quadrant or epigastric abdominal pain; neurological complications (e.g. eclampsia, altered mental status, blindness, stroke, clonus, severe headaches, and persistent visual scotomata); or hematological complications (thrombocytopenia–platelet count <150>
Preeclampsia is a multisystem disorder unique to human pregnancy. It is a common complication of pregnancy associated with high maternal morbidity, mortality and uterine fetal growth restriction [5]
Worldwide, preeclampsia affects estimated 2-10% pregn1ant women [6]. More than 4 million women across the world develop this disorder every year and an estimated 50,000 - 76,000 women and 500,000 infants die of this condition every year [7]. In Nigeria, it is estimated that 3-10% are complicated by Hypertensive Disorder in Pregnancy (HDP) [8]
Risk factors for preeclampsia include nulliparity, multifetal gestations, previous history of preeclampsia, obesity, diabetes mellitus, vascular and connective tissue disorders like systemic lupus erythematosus and antiphospholipid antibodies, age >35 years at first pregnancy, smoking, and African American race [9]. The symptoms of preeclampsia may include edema of the hands and face/eyes and weight gain. Severe preeclampsia may present headache, abdominal pain, agitation, decreased urine output, nausea, vomiting and vision changes.
The pathogenesis of preeclampsia is unknown. Most theories on the etiology of preeclampsia suggest that the disease is a cascade triggered by combination of endothelial cell activation/damage, defective placental vascular remodeling in pregnancy (presumably secondary to impaired trophoblast invasion), reduced uteroplacental perfusion, immune intolerance (rejection of the placenta by the maternal immune system), and exaggeration of inflammatory response [10].
During pregnancy, changes occur in the haematological indices such as red blood cell count, haemoglobin concentration, platelet count, and white blood cell count [11]. Preeclampsia also results in a variety of haematological aberrations [12]. Thrombocytopenia is the most common haematological abnormality found in pre-eclampsia. It is a strong indicator of severity of the disease [13]. The pathogenesis of thrombocytopenia in preeclampsia is not clear. Although it is suggested that low platelet count in the disease are associated with abnormal activation of coagulation system and accelerated platelet consumption. Haemoconcentration manifested with increased haematocrit due to increased endothelial permeability has also been reported in preeclampsia [14]. On the contrary, in a study by [15], observed a significant decrease in the haemoglobin level in preeclampsia with increase in severity of the disease when compared to normotensive pregnant women.
However, most of these studies were done in countries outside of Africa. There were limited published reports on the generalization of these findings to women in Nigeria. Therefore, this study will be done to provide data on the level of haematological indices, in pregnant women with preeclampsia in Owerri, Imo State Nigeria.
Study Area:
This study was carried out in Federal Medical Centre Owerri in Imo State, Nigeria. Imo state is one of the 36 states of Nigeria.
Study Design:
Cross-sectional study design was used in the study. A total of 120 subjects all preganant women aged from 18-45 years in their third trimester (28-40 weeks) were recruited for the study. The subjects were group into two. The first group consists of 60 pregnant women clinically diagnosed as having preeclampsia (test group) while the second group consists of 60 gestational age-matched normotensive pregnant women which served as control subjects. An oral consent was gotten from the patients after; a structured questionnaire was administered to all respondents who were also part of clinical study.
Sample Size Determination
The sample size was obtained using the formula by Naing et al., (2006). Prevalence rate of preeclampsia is 3.4% (Onoh et al., 2019).
n = z2 × P (1-P)/d2
Were
n = Sample size
p = prevalence rate 3.4%
z = confidence interval 95% - 1.96
d = Degree of accuracy- 0.05
N = 1.962 x 0.034(1-0.034)/0.052 = 50
Therefore, the minimum sample size was 50. Considering 10% attrition, a sample size of 60 was used for the study.
Sampling Technique
Purposive sampling technique was employed in selecting the participants based on the inclusion criteria.
Sample Collection
After obtaining informed consent, 8mls of venous blood was collected from the fore arm of each subject using a disposable syringe; 2.5mls was dispensed into a sterile EDTA vacutainer for determination of haematological parameter. The collected samples were analysed immediately for haematological tests
Ethical Approval:
Ethical approval was sought and obtained from the Ethics committee of Federal Medical Centre Owerri before the commencement of this study (Reference: FMC/OW/ETHICAL/VOL.1/9316)
Inclusion Criteria
Participants included in this study were pregnant women who were diagnosed of preeclampsia aged 18-45 years in their third trimester attending antenatal care at Federal medical Centre Owerri and normotensive pregnant women who gave their consent.
Exclusion Criteria
Those pregnant women who have evidence of chronic infection like HIV, chronic renal disease, tuberculosis and subjects who are using any kind of anticoagulant drugs were excluded from the study with those less than 18 years and above 45 years. Pregnant women in-active labour, in need of emergency care or having an at-risk pregnancy such as gestational diabetes; gestational hypertension was also excluded from the study.
Laboratory Diagnosis
Hematological Parameter Estimation
The EDTA blood was measured on a fully automated haematological analyser, a five-part auto analyser able to test 19 parameters per sample using the Sysmex® KX-21N autohaematological analyser. Standardization, calibration of the instrument and processing of the sample was done according to the manufacture’s instruction.
Principle of Test
The Kx-21N employs three detector blocks and two kinds of reagents for blood analysis. The WBC count is measured by the WBC detector block using the DC 38 detection method. The RBC count and platelets are taken by the RBC detector block, also using the DC detection method. The HGB detector block measures the haemoglobin concentration, using the non-cyanide haemoglobin method. Blood is aspirated from the sample probe into the sample rotor valve. Six microlitres (6μl) of blood measured by the sample rotor valve is transferred to the WBC transducer chamber along with 1.994 ml of diluents. At the same time, 1.0 ml of WBC/HGB lyse fluid is added to prepared 1: 500 dilution sample. When the solution is made to react for approximately 10 seconds, the RBC is haemolyzed and platelets shrink, with WBC membrane maintained as they are. At the same time, haemoglobin is oxidized to methaemoglobin (Sysmex Corporation, 2006). Of the diluted/haemolyzed sample in the WBC transducer chamber, approximately 1.0 ml is transferred to the HGB flow cell. Then, 500μl of sample in the WBC transducer is aspirated through the aperture. The pulses of the blood cells when passing through the aperture are counted by the DC detection system. In the HGB flow cell, 555 nm wavelength beam irradiated from the light emitting diode (LED) is directed to the sample in the HGB flow cell. Concentration of the sample is measured as absorbance. The absorbance is compared with that of the diluents alone that was measured before addition of the sample, thereby quantifying HGB (haemoglobin value) (Sysmex Corporation, 2006).
Procedure
An EDTA anticoagulated blood was well mixed, and inserted into the probe. The button was pressed and 0.02ml of blood was aspirated. After a period of 1 minute the haematological result was displayed in the screen and printed with the aid of the printer.
Table 4.1 showed the comparison of the levels of some haematological variables in the test and control group. From the result obtained, the median values of WBC and basophil did not differ significantly in test group when compared with control group (p>0.05). The median value of neutrophil, monocyte and eosinophil were significantly higher in test group when compared with the control group (p<0>
Table 4.2 shows the comparison of the levels of red cell indices in the test group and control group. From the result of the findings, the median value of MCH and MCHC were significantly higher in test group when compared with the control group (p<0>0.05).
Table 4.3 showed the comparison of the levels of platelet indices of test and control group. The median value of platelet, MPV and PCT of test group were significantly decreased (p<0>
| Parameters | Preeclampsia | Control | Mann-Whitney U | p-value |
| WBC (x109/l) | 7.20 | 6.65 | 1484.500 | 0.980ns |
| Lymphocyte (%) | 25.00 | 32.00 | 993.500 | <0> |
| Neutrophil (%) | 72.50 | 65.00 | 1021.500 | <0> |
| Eosinophil (%) | 1.00 | 1.00 | 878.00 | <0> |
| Basophil (%) | 0.0 | 0.00 | 1760.000 | 0.750ns |
| Monocyte (%) | 1.00 | 0.00 | 1165.500 | <0> |
Significant level- *P<0>0.05)
Table 4.1: Levels of some Haematological Variables (WBC and Differentials) in Test and Control Groups (Median Values)
| Parameters | Preeclampsia | Control Group | Mann-Whitney U | p-value |
| RBC (x1012/l) | 3.20 | 3.66 | 792.000 | <0> |
| HB (g/dl) | 9.60 | 10.60 | 1066.000 | <0> |
| PCV (%) | 29.00 | 33.70 | 883.500 | <0> |
| MCV (fl) | 86.00 | 91.30 | 777.500 | <0> |
| MCH (pg) | 30.00 | 29.45 | 1372.500 | 0.024* |
| MCHC (g/dl) | 34.00 | 32.85 | 833.000 | <0> |
| RDWC (%) | 15.50 | 15.10 | 1432.500 | 0.054ns |
| RDWS (µm3) | 51.00 | 52.15 | 1529.500 | 0.155ns |
Significant level- *P<0>0.05)
Table 4.2: Levels of some Haematological Variables (Red Cell Indices) in Test and Control Groups (Median Values)
| Parameters | Preeclampsia | Control group | Mann-Whitney U | p-value |
| Platelet (x109/l) | 136.00 | 199.00 | 568.000 | <0> |
| MPV (fl) | 9.20 | 9.40 | 1643.000 | 0.409ns |
| PCT (%) | 0.14 | 0.16 | 1127.000 | <0> |
| PDW (%) | 15.70 | 14.75 | 1018.000 | <0> |
| PLCR (%) | 21.00 | 18.75 | 1310.000 | 0.010* |
Significant level- *P<0>0.05)
Table 4.3: Levels of some Haematological Variables (Platelet Indices) in Test and Control Groups (Median Values)
Physiological changes occur in pregnancy to nurture the developing foetus and prepare the mother for labour and delivery. Some of these changes influence normal biochemical values while others may mimic symptoms of medical disease. During pregnancy, changes occur in the haematological indices such as red blood cell count, haemoglobin concentration, platelet count, and white blood cell count [16]. Preeclampsia also results in a variety of haematological aberrations. In this study, there was a significant lower level of red blood cell and haemoglobin value in preeclampsia compared to normotensive pregnant women. This finding is in agreement with studies done by [17]. They observed a significant lower haemoglobin level in preeclamptic women with increase in severity of the disease when compared to normotensive pregnant women. The anemia is most frequently associated with HELLP syndrome and it is due to microangiopathic intravascular haemolysis – physical destruction of erythrocytes in the microcirculation affected by disseminated microthrombosis. Haemoconcentration manifested with increased haematocrit due to increased endothelial permeability has also been reported in preeclampsia [18]. According to the World Health Organisation, anaemia is defined as haemoglobin values of <12>
In our study, the values of the red cell indices, MCH, MCHC and RDWC were higher while MCV was lower though within normal level in preeclampsia than the control group. The finding is in accordance with the work done by [18], who found an increase in RDW, MCH, and MCHC with a decrease in MCV. It was discovered an increase in MCV, MCH and RDW but no significant change in MCHC. Despite the differences in MCV, MCH, and MCHC values in preeclampsia versus normotensive pregnant women, an increase in RDW in preeclampsia was found in all the studies. Increased RDW values had been linked to inflammation in hypertensive non-pregnant women; inflammatory theory has also been blamed for increased RDW values in preeclampsia. In a study by [19], a positive correlation between high-sensitivity C-reactive protein and increased RDW levels was determined in preeclampsia. In the present study, the normal values of MCV, MCH and MCHC in preeclampsia might be due to satisfactory taking of iron replacement therapy given to pregnant women on ante-natal visit. From the questionnaire, most participants indicated an adequate attendance of ante-natal care in the pregnancy. In addition, the study population was living in the southern part of Nigeria and the research was conducted during the period of rainy season in which vegetable nutrition is common. Nutritional status (e.g., iron, folate, and vitamin B12 deficiency) and eating habits may affect red blood cell indices [10]
White blood cell count is increased in pregnancy with the lower limit of the reference range being typically 6.0 X109/l. Leucocytosis, occurring during pregnancy is due to the physiologic stress induced by the pregnant state [12]. In this study, there was non-significant increase in total white cell count in preeclampsia compared with normal pregnant controls. Differential analyses further demonstrated that the increased neutrophil, not monocyte or lymphocyte numbers account for the total leukocyte increase in preeclampsia. The data obtained in this study is consistent with the study by [20] in which an increase in neutrophil count in preeclamsia was found. There is an absolute monocytosis during pregnancy, especially in the first trimester, but decreases as gestation advances. Monocytes help in preventing fetal allograft rejection by infiltrating the decidual tissue (7th–20th week of gestation) possibly, through PGE2 mediated immunosuppression [13]. In this study, the data obtained showed that monocyte was significantly higher in preeclamptic patients when compared to the control, while lymphocyte and basophil numbers were significantly lower when compared with normotensive pregnant women. This finding is in accordance with the work done by [11] Lymphocyte count decreases during pregnancy through the first and second trimesters and increases during the third trimester [18]
Leukocytosis is considered to be evidence of an increased inflammatory response during normal pregnancy and in preeclampsia. It was also found the total leukocyte count was even higher in preeclampsia with hemolytic anemia, elevated liver enzymes, and low platelet count (HELLP syndrome) than those without HELLP syndrome, suggesting an association between increased leukocytes and worsening thrombocytopenia in those patients [19].
In this study, platelet count was significantly lower in pregnant women with preeclampsia compared with normotensive pregnant women. This is in agreement with the study done by various researchers [20]. Preeclampsia results to reduced platelet production and lifespan, and reduced antithrombin, leading to activation of the clotting cascade and the fibrinolytic system, which leads to low platelet counts, fibrin deposition and increased fibrin degradation products. As the disease progresses, small fibrin strands cause microangiopathic haemolytic anaemia. Thrombocytopenia is the most common haematological abnormality found in preeclampsia. It is a strong indicator of severity of the disease. The pathogenesis of thrombocytopenia in preeclampsia is not clear. Although it is suggested that low platelet count in the disease are associated with abnormal activation of coagulation system and accelerated platelet consumption [21]. Increased plasma levels of platelet activation markers (β-thromboglobulin and platelet factor-4) and increased expression of activation markers on the surface of platelets in preeclampsia confirm platelet activation in this disease. Besides, an impaired endothelial synthesis of prostacyclin and nitric oxide has been related in preeclampsia [22]
Platelet indices made available as part of the data obtained from full blood count in this study was statistically analyzed. They include mean platelet volume (MPV), which reflects the marrow bone function, platelet distribution width (PDW), which corresponds to size distribution of platelets; plateletcrit (PCT), which corresponds to the volume that platelets have in 100 mL of total blood; and platelet large cell ratio (PLCR), which reflects the percentage of platelets larger than 12 fL . The statistical analysis of these platelet indices in this study showed lower values of MPV and PCT in preeclampsia. MPV showed no significant difference while PCT was significantly lower in preeclampsia when compared to the normotensive pregnant women. In preeclampsia, PDW and PLCR were significantly higher than that of normotensive pregnant women. The result obtained in this study was in keeping with the work of [23]. Some studies have evaluated the applicability of platelet indices, particularly MPV for the clinical and pathophysiological understanding of vascular diseases, including preeclampsia, but their value is not established yet . It has long been known that platelet volume is a direct indicator of increased platelet synthesis [24]
The results obtained from this study also showed alterations in the levels of parameters in preeclamptic women. Anaemia and severe thrombocytopenia were found in these women.
Moreso, the demographic data obtained in this study showed that nulliparity, advanced maternal age and family history of high blood pressure were the most dominant risk factor of preeclampsia.
A keen observation and monitoring of the haematological parameters in preeclamptic women is vital. Therefore, assessing these parameters can be a reliable and competent marker to diagnose and manage preeclampsia thereby improving pregnancy outcome in this disorder.
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Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
