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Review Article | DOI: https://doi.org/10.31579/ 2642-1690/014
*Corresponding Author: Johan L Heemskerk, Department of Neurological Surgery, Mayo Clinic, Jacksonville, USA
Citation: Heemskerk JL, Akinduro OO, Clifton W, Hinojosa AQ, Iyamah KOA (2019) Long-Term Clinical Outcome of Minimally Invasive Versus Open Single-Level Transforaminal Lumbar Interbody Fusion for Degenerative Lumbar Diseases with a Minimum Follow-Up of 2 Years: A Meta-Analysis Protocol. J Spinal Dis Res 2(1): Doi: 10.31579/ 2642-1690/014
Copyright: © 2019 Heemskerk JL. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 05 July 2019 | Accepted: 12 July 2019 | Published: 17 July 2019
Keywords: Meta-analysis, degenerative spine disease, transforaminal lumbar interbody fusion, TLIF, MIS-TLIF, minimally invasive surgical transforaminal lumbar interbody fusion, O-TLIF, open transforaminal interbody fusion, long-term, clinical outcome
Minimally invasive surgical transforaminal lumbar interbody fusion (MIS-TLIF) is a relatively new approach for fusion of the lumbar spine. It was developed in addition to traditional open transforaminal interbody fusion (O- TLIF) to minimize iatrogenic soft tissue damage and prevent denervation and atrophy of the paraspinal trunk musculature. Potential disadvantages of MIS-TLIF are inadequate neural element decompression and higher risk of cage migration, resulting in persistent symptoms and a need for reoperation. Other disadvantages include inadequate visualization of bony landmarks for instrumentation, and less robust postero-lateral arthrodesis than open approaches, which may affect fusion rates. Several studies have reviewed the differences between both treatments for degenerative lumbar disease, but they mainly focused on the peri- operative and short-term post-operative outcomes. Since the potential disadvantages of MIS may be expected after a longer follow-up, we performed a meta-analysis comparing MIS-TLIF with O-TLIF for long-term outcomes.
Questions/purposes
In this systematic review, we compared clinical outcome of MIS and open single level TLIF for degenerative lumbar disease with a minimum follow-up of 2 years, with regard to (1) clinical outcomes (VAS pain scores and Oswestry Disability Index [ODI], (2) adverse events (reoperation, revision, readmission, implant failure rate, infection, cage migration, cage extrusions), and (3) Fusion rate.
Conclusion
This meta-analysis will provide a detailed summary of the long-term clinical outcome of minimally invasive versus open single-level transforaminal lumbar interbody fusion for degenerative lumbar diseases. Previous meta-analyses have been published, but all focused on the peri-operative or short-term outcomes. This meta- analysis is the first in including only studies with a minimum follow-up of 2 years.
Degenerative spinal diseases are one of the most common comorbidities in elderly patients, potentially leading to back pain, radiculopathy and spinal instability. In case of clinical deterioration of neurologic deficits or failed conservative management, surgery should be considered. This may occur in the form of decompression, stabilization, or both. In transforaminal lumbar interbody fusion (TLIF), decompression and cage placement are generally performed through a unilateral approach, which provides exposure of the disc space while reducing potentially harmful retraction of the thecal sac and nerve root when compared with a posterior lumbar interbody fusion (PLIF) approach.(1) The first described TLIF was an open procedure (O-TLIF). This results in an extensive muscle dissection of the back with possible denervation and atrophy of the paraspinal trunk musculature. This has been suggested as the major cause for persistent or recurrent postoperative pain.
Because of the multi-segmental anatomy of the stabilizing posterior paravertebral muscles, chronic damage to these muscles might also influence the development or progression of adjacent segment degeneration or sagittal imbalance. (2) More recently, the minimally invasive surgery TLIF (MIS-TLIF) was developed, to minimize iatrogenic soft tissue damage and decrease the risk on atrophy of the multifidus or longissimus muscle.(3) This procedure has become more popular in recent years, since it may have some potential advantages. It aims to achieve the same clinical results as the O-TLIF, however with smaller wounds, fewer soft tissue damage, reduced blood loss, reduced postoperative pain, faster recovery time and shorter hospital stay.(4) The main drawback of MIS-TLIF is the potentially longer operating times, a steeper learning curve, higher intraoperative radiation exposure due to reliance on bi-planar fluoroscopy to compensate for diminished surgical exposure and visualization, a potentially higher risk for cage and pedicle screw misplacements and potentially higher risk for cage migrations.(5) There are also persisting concerns regarding inadequate neural decompression, resulting in persistent symptoms and a need for reoperation, because an open approach may be associated with improved deformity reduction.(6) Although numerous studies on the differences between MIS-TLIF and O-TLIF have been performed, most of these studies have focused on peri- operative and short post-operative outcomes. Differences in mid- to long-term outcomes in MIS-TLIF vs O-TLIF are still inconclusive and, therefore, require more research.(7) The aim of this meta-analysis is to compare the long-term clinical outcomes between the MIS-TLIF and O-TLIF in single-level degenerative lumbar diseases with a minimum follow-up of 2 years in terms of (1) clinical outcomes (VAS back/ leg pain scores or Oswestry Disability Index [ODI], (2) Fusion rate and (3) adverse events (revision, readmission, adjacent segment disease, implant failure rate, pseudoarthrosis, cage migration, cage extrusions)
To evaluate the clinical outcome, measured by VAS back/leg pain or ODI, of patients with degenerative lumbar diseases treated with single-level TLIF (open vs MIS) with a minimum follow-up of 2 years.
The systematic review will conducted following the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions (version 5.1.0 from 2011) to insure quality (8) We accessed the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) Network to find the right guideline for accurate reporting of our systematic review (http://www.equator-network.org/) and the correct checklists for accessing the quality of the included studies. (9) To strengthen the methodological quality of our systematic review we used the PRISMA-P guideline for protocols.(10) The protocol will be registered in the international register of systematic reviews to strengthen the transparency and reliability (http://www.crd.york.ac.uk/PROSPERO).(11) The systematic review will be performed in accordance with the PRISMA guideline ‘Preferred Reporting Items for Systematic reviews and Meta-Analyses’ to secure proper reporting and improve methodological quality of our review.
Review Inclusion Criteria
Types of studies: RCT, prospective and retrospective observational studies.
Randomized controlled trials RCTs prospective and retrospective observational studies will be included. Case- control designs and studies without original data will be excluded.
Types of participants: Patients with degenerative lumbar disease.
Studies will be included if they include patients with degenerative lumbar disease, for which they received a single level TLIF. Degenerative lumbar disease encompasses conditions such as spondylosis, degenerative spondylolisthesis, degenerative disc degeneration and lumbar spinal stenosis. Studies describing a population treated with TLIF because of traumatic or congenital disorders will be excluded.
Type of intervention: Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF).
Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is a surgical technique first described by Schwender et al. in 2005 (3). The MIS-TLIF procedure was developed to achieve neural decompression and interbody arthrodesis, while offering the advantages of reducing soft tissue trauma and reducing recovery time when compared to the open techniques. However, MIS TLIF is a technically challenging procedure and the main drawback has been increased intra-operative radiation exposure due to reliance on bi-planar fluoroscopy that is required to compensate for diminished surgical exposure and visualization. There are also persisting concerns regarding inadequate neural decompression and higher risk for cage migrations, resulting in persistent symptoms and a need for reoperation.
Type of comparison: Open transforaminal lumbar interbody fusion (O-TLIF).
The O-TLIF technique was introduced to reduce the risks associated with a PLIF procedure. For an O-TLIF, a unilateral transforaminal route to the intervertebral space is used, with a unilateral facetectomy and insertion of one cage which reduces potentially harmful retraction of neural structures. The advantage of an O-TLIF when compared with MIS-TLIF is the extensive surgical exposure allowing visualization of key landmarks for facetectomy and screw placement. The main drawback of the O-TLIF technique is that it still requires extensive soft tissue preparation, which may result in denervation and atrophy of the paraspinal trunk musculature, more intraoperative blood loss and more postoperative pain.(5)
Types of outcome measures:
Primary outcomes
Clincal outcome, as measured by:
Visual Analogue Scale (VAS), Oswestry Disability Index (ODI)
Secondary outcomes
Fusion rate
Pseudoarthrosis
Lower extremity pain relief
Back pain
Neurological deficits
Revision
Readmission
Implant failure rate
Cage migration
Cage extrusions
Literature Search Strategy
With help of a clinical librarian (Lisa Marks), a search strategy will be developed. For our literature search strategy, we will combine the terms: ‘‘minimally invasive’’, ‘‘open’’, ‘‘transforaminal lumbar interbody fusion’’, ‘‘TLIF’’, “treatment outcome” and “complication”, as either key words or MeSH terms. Details about the search strategy are presented in Appendix 1.
Electronic Searches
An electronic search of the literature will be conducted in the following databases from from their dates-of- inception to 7-1-2019:
Pubmed
MEDLINE
CENTRAL (Cochrane Register of Controlled Trials)
Ovid EMBASE
Scopus
Web of Science
ClinicalTrials.gov
Searching Other Resources
The following strategies will also be used to ensure a comprehensive search:
Reference lists will also be hand searched for further relevant studies.
Searching of the main electronic sources of ongoing trials (National Research Register, meta-Register of Controlled Trials; Clinical Trials)
Study Screening and Selection
All retrieved articles will be uploaded in the online program Rayyan (http://rayyan.qcri.org) after deletion of the duplicates. (12) Title and abstract of all articles will be screened against predetermined selection criteria and potential eligible studies will be independently selected b by two authors (JH and OA.) After this initial assessment, we will obtain full-text copies of all studies considered to be potentially relevant. Two review authors (JH and OA) independently will check the full papers for eligibility. Disagreements will be resolved by discussion. A third review author (KA) will be contacted if disagreements persist. We will record all reasons for exclusion of studies. We will complete a PRISMA flowchart to summaries this process. For final inclusion, all eligibility criteria had to be fulfilled.
We will not have a restriction on language.
Abstracts, case reports, conference presentations, editorials, reviews and expert opinions will be excluded.
Table 1: Inclusion and exclusion criteria
Inclusion criteria | Adult patients diagnosed with degenerative lumbar disease |
Treated with one level MIS-TLIF or one level open TLIF | |
Outcomes in terms of back and leg pain measured with VAS or ODI | |
With a minimal follow-up of 2 years | |
Exclusion criteria | TLIF for other reasons than degenerative lumbar disease |
Reviews | |
Case-control studies | |
Abstracts | |
Case reports | |
Conference presentation | |
Editorials | |
Expert opinions | |
Overlapping cohort | |
Studies with insufficient data |
Adult patients diagnosed with degenerative lumbar disease
Treated with one level MIS-TLIF or one level open TLIF
Outcomes in terms of back and leg pain measured with VAS or ODI
With a minimal follow-up of 2 years
TLIF for other reasons than degenerative lumbar disease
Conference presentation
Studies with insufficient data
Table 1: Inclusion and exclusion criteria
Data Extraction and Management
All outcomes will be extracted from full-length article texts, tables, or figures. A standardized data extraction form will be prepared in Excel and will be used to extract data from the included papers. Two review authors (JH & OA) will be independently extract the data. Discrepancies between the two reviewers (JH & OA) will be resolved by discussion and consensus. A third review author (KA) will be consulted if disagreements persist. If studies will be found with overlapping cohorts from individual institutions, only the complete report will be included.
The following data will be extracted:
Critical Appraisal and Assessing of Bias
The risk of bias for each RCT study will be assessed using the revised tool to access risk of bias in randomized trials (RoB 2 tool).(13) It included the following domains: (1) random sequence generation, (2) allocation concealment, (3) blinding of participant and personnel, (4) blinding of outcome assessment, (5) incomplete outcome data, (6) selective reporting, and (7) other bias. Each domain will be measured as low bias, unclear bias, or high bias. The risk of bias of observational studies will be assessed using the ROBINS-I tool (Risk of Bias
In Non-randomized Studies - of Interventions).(14) It accesses bias in the following domains: (1) Bias due to confounding, (2) Bias in selection of participants into the study, (3) Bias in classification of interventions, (4) Bias due to deviations from intended interventions, (5) Bias due to missing data, (6) Bias in measurement of outcomes and (7) Bias in selection of the reported result. The response options for each domain-level are low risk of bias, moderate risk of bias, serious risk of bias, critical risk of bias and no information on which to base a judgement. Risk of bias will be assigned to each article independently by 2 reviewers (JH & OA). Disagreements among any of the above data points will be resolved through discussion among the authors. A third review author (KA) will be consulted if disagreements persisted.
Strategy for Statistical Analysis
Data will be analyzed using Review Manager, version 5.3 or Rstudio (2016).(15, 16) Clinical outcomes will be assessed using the relative risk (RR) for dichotomous variables or weighted mean difference (WMD) and their 95% confidence interval (CI) for continuous variables. Pooled results will be assessed for heterogeneity using the Cochrane Q test and I2 tests. Cochrane Q test will be used to test heterogeneity between studies.
Heterogeneity will be considered as statistically significant when the P value derived from Cochrane Q is <0.1. I2 statistic will be used to quantify the percentage of total variation across studies, owing to heterogeneity rather than chance.(17) Heterogeneity will be defined as absent when I2 is between 0 and 25%; low, between 25.1 and 50%; moderate, between 50.1 and 75%; or high, between 75.1 and 100%. Fixed-effects meta-analysis will be performed when P ≥ 0.1 and I2 ≤ 50%; otherwise, random-effects meta-analysis will be performed.
Statistical tests will be two-sided; significance will be defined using the alpha threshold of 0.05, unless otherwise specified.
We will access the overall quality of the evidence for each primary outcome. To accomplish this, we will use the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) approach .(18) The quality ofthe evidence on a specific outcome is based on the performance against six factors: study design, risk of bias,consistency and directness of results, precision of the data and non-biased reporting of the results across allstudies that measured that particular outcome. The quality of evidence for each outcome will be assessed independently by two reviewers (JH and OA) Cases of discrepancy will be resolved through discussion. Each outcome will be rated as either high, moderate, low, or very low based on the studies on which the outcome is based and will be entered into the risk of bias table.
Publication Bias Assessment
Publication bias will be graphically assessed using the funnel plot and will be tested using the Egger’s linear regression test and Begg’s correlation tests. (19, 20) If the effect size will be symmetrical and P value drawn from Begg’s test will be more than 0.05 indicated that there is no publication bias. Publication bias will be assessed using the procedure of ‘‘Metabias’’ on Rstudio.(16)
This meta-analysis will provide a detailed summary of the long-term clinical outcome of minimally invasive versus open single-level transforaminal lumbar interbody fusion for degenerative lumbar diseases. Previous meta-analyses have been published, but all focused on the peri-operative or short-term outcomes. This meta- analysis is the first in including only studies with a minimum follow-up of 2 years.
We thank Lisa Marks, medical librarian in Mayo Clinic, for her assistance with the search strategy for this manuscript.
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I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
