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Research Article | DOI: https://doi.org/10.31579/2640-1045/207
1 Department of Medicine Yekatite 12 Hospital Medical College, Addis Ababa, Ethiopia
2 Department of Medicine Sante Medical College Addis Ababa, Ethiopia.
3 Department of Medicine, Addis Ababa University, College of Medicine and Health Science, Addis Ababa, Ethiopia.
4 Department of Medicine: Zhengzhou University College of medicine Henan province China.
5 Department of Medicine, University of Gonder, College and Health Science, Ethiopia.
6 Department of Medicine: Wachemo University Nigist Eleni Mohammed Memorial Comprehensive Specialized Hospital Hosaena, Ethiopia.
7 Department of Medicine Jimma University Oromia Region, Ethiopia.
8 Department of Medicine: Debre Tabor University College of Health Sciences, School of Medicine.
*Corresponding Author: Kidist Kenea Madessa, Department of Medicine, Yekatite 12 Hospital Medical College, Addis Ababa, Ethiopia; Lemlem Tamene Ergano, Department of Medicine Jimma University Oromia Region, Ethiopia; and Tsion Wolanewos Asfaw, Debre Tabor University College of
Citation: Kidist K. Madessa, Mekdes T. Ambaye, Zemene Y. Afework, Eyerusalem W. Nimane, Nahom A. Bekele, et al., (2025), Factors Affecting Glycemic Control Among Type 2 Diabetes Mellitus Patients at Yekatit 12 Hospital Medical College. 2024, J. Endocrinology and Disorders, 9(1); DOI:10.31579/2640-1045/207
Copyright: © 2025, Kidist Kenea Madessa. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 18 January 2025 | Accepted: 29 January 2025 | Published: 07 February 2025
Keywords: Creatinine phosphokinase (CPK); Ejection fraction (EFT); Hypertension; Joint generalized linear models (JGLMs); Serum creatinine (SCT); Serum sodium (SNa)
Objectives: The report aims to examine the effects of serum creatinine (SCT) on heart, diabetes, anaemia and normal study units, and along with the other biological factors. The study is based on the relationship of serum creatinine with heart, diabetes, anaemia patients and many other factors.
Materials & Methods: A real data set of 299 heart patients with 13 study characters is taken in the current study, the data set is available herein: https://archive.ics.uci.edu/ml/datasets/Heart+failure+clinical+records, and the serum creatinine probabilistic model has been developed applying statistical joint generalized linear models.
Results: From the fitted Log-normal model, the mean serum creatinine (SCT) is positively associated with age (P<0.0001). It is partially negatively associated with ejection fraction (EFT) (P=0.0974) and partially positively associated with the joint interaction effects (JIEs) of EFT and the death-event (DEE), i.e., EFT*DEE (P=0.1168). It is negatively associated with creatinine phosphokinase (CPK) (P<0.0001) and serum sodium (SNa) (P<0.0001), while it is positively associated with their JIEs, i.e., CPK*SNa (P<0.0001). It is negatively associated with high blood pressure (BP) (P=0.0030). It is partially negatively associated with the JIEs of anaemia status (ANS) and time up to the end of the follow-up period (TFP) i.e., ANS*TFP (P=0.1299), while it is independent of both the ANS and TFP. It is negatively associated with the smoking status (SMS) (P=0.0007), and positively associated with the JIEs of SMS and TFP, i.e., SMS*TFP (P=0.0016). Variance of SCT is negative associated with age (P=0.0543) and ANS (P=0.0044), while it is positively associated with their JIEs, i.e., AGE*ANS (P=0.0070). SCT variance is negatively associated with CPK (P=0.0001), while it is partially positively associated with the JIEs of CPK and ANS i.e., CPK*ANS (P=0.1482). Variance of SCT is negatively associated with diabetes mellitus status (DMS) (P=0.0199), while it is positively associated with the JIEs of CPK and DMS i.e., CPK*DMS (P=0.0086). There are many more significant effects in the SCT variance model.
Conclusions: From this data set, it is clear that mean and variance of serum creatinine is associated with the heart, diabetes and anaemia patients. It affects age, EFT, CPK, SNa, PLC, BP, ANS, DMS, SMS, SEX, TFP, DEE and their many joint interaction effects.
Globally, the prevalence of DM is increasing significantly. In 2000, 151 million people in the world had diabetes. With this increase, it has been projected that 221 million people will have diabetes in 2010 and 324 million by 2025 [1]. Type 2 diabetes accounts for 90 to 95% of the incidence of diabetes, and the current epidemic outbreak of diabetes reflects the high prevalence of type 2 diabetes. The Centers for Disease Control and Prevention (CDC) reported that in 2002, more than 18 million Americans, about 6.9% of the United States population, had diabetes [2].
The global statistics indicate that the burden of DM, precisely type II diabetes, is not restricted to developed nations but is also a problem for developing countries. Several studies in China, India, and Mauritius have indicated that the prevalence of type II DM is significantly high and steadily increasing. [3,4,5] Approximately 7.1 million Africans were said to be suffering from diabetes at the end of 2000. This figure was expected to rise to 18.6 million by 2030. [3, 4] Only a little data regarding the status of DM in Ethiopia is available. WHO estimated the number of diabetic cases in Ethiopia to be 800,000 by the year 2000, and this number is expected to increase to 1.8 million by 2030 [6] A study done in Jimma town has shown the prevalence of type II DM to be 5.3%, and 14.8% of participants in the survey had prediabetes? [7]
Diabetes is a significant cause of mortality worldwide, although several studies indicate that diabetes is likely underreported as a cause of death. In the United States, diabetes was listed as the sixth-leading cause of death in 2002. [2] A recent estimate suggested that diabetes was the fifth leading cause of death worldwide and was responsible for almost 3 million deaths annually (1.7–5.2% of deaths worldwide). [1] There are several well-established risk factors for type II DM, among which family history of type II DM, obesity, chronic physical inactivity, previously identified IGT or IFG, history of GDM or delivery of baby >4 Kg, HPN and dyslipidemia are prominent. The ADA recommends screening all individuals >45 years every 3 years and screening individuals at an earlier age if they are overweight and have one of the additional risk factors for diabetes.
Diabetes mellitus, both type I & II, is associated with acute and chronic complications. Acute complications include diabetic ketoacidosis, which is more common in type I, and hyperglycemic hyperosmolar state, which is primarily seen in type II DM. The chronic complications of DM affect many organ systems and are responsible for the majority of morbidity and mortality associated with the disease. Chronic complications can be divided into vascular and nonvascular complications. The vascular complications of DM are further subdivided into microvascular (retinopathy, neuropathy, and nephropathy) and microvascular complications (coronary artery disease (CAD), peripheral arterial disease (PAD), cerebrovascular disease). Nonvascular complications include problems such as gastroparesis, infections, and skin changes. Although glycemic control is central to diabetes management, diabetes care should be comprehensive, detect and manage DM-specific complications, and modify risk factors for DM-associated diseases. Significant components of DM management are diabetes education, medical, nutritional therapy, exercise, blood glucose monitoring, and pharmacotherapy. Insulin and oral glucose-lowering agents are the primary drugs for glycemic control [10].
Diabetes mellitus is a disease associated with different complications and significant morbidity and mortality worldwide, although the precise figures are lacking in Ethiopia up to the principal investigator's knowledge. Glycemic control is the primary target of diabetes management. It is essential for preventing and progressing complications, as several trials have indicated a strong correlation between glycemic control and complications in type II DM. One of these trials is a small study conducted in 110 lean Japanese subjects, which showed that multiple insulin injections, which resulted in better glycemic control (HgbA1c = 7.1%) compared with conventional treatment (HgbA1c = 9.4%), significantly reduced the microvascular complications of diabetes. [8] The United Kingdom Prospective Diabetes Study (UKPDS) trial is the largest trial conducted regarding the effect of glycemic control on the complications of type II DM. The results showed that retinopathy, nephropathy, and possibly neuropathy are benefited by lowering blood glucose levels in type 2 diabetes with intensive therapy, which achieved a median HbA1c of 7.0% compared with conventional treatment with a median HbA1c of 7.9% and the overall micro-vascular complication rate was decreased by 25%. It also showed a continuous relationship between the risks of microvascular complications and glycemia. For every percentage point decrease in HgbAlc (e.g., 9 to 8%), there was a 35% reduction in the risk of complications. The other finding of this trial was that there was no significant effect of lowering blood glucose on cardiovascular complications. However, there is a 16% reduction in the risk of combined fatal or nonfatal myocardial infarction and sudden death [9].
Another study in Menelik II Hospital in Addis Ababa indicated the association between glycemic control and complications. It found that 75% of diabetic patients with complications had poor control of FBS [12]. The American diabetic association (ADA) guideline also states that lowering hemoglobin A1C values has been associated with reducing microvascular complications of diabetes [9]. The general hemoglobin A1C goal for patients is less than 7%. It also recommends that more stringent goals, such as a standard hemoglobin A1C value of less than 6%, be considered in individual patients if they are achievable without significant hypoglycemia. Less stringent goals may be appropriate for patients with limited life expectancies, very young or older adults, and individuals with comorbid conditions [10].
Different studies show that glycemic control is affected by several factors: age, compliance to therapy, exercise, diet, obesity, cigarette smoking, self-monitoring of blood glucose levels, presence of comorbid conditions, duration of DM and medications used. Only a little has been done in JUSH regarding the level of glycemic control and its associated factors, which is the primary reason for conducting this study. This study will provide essential information regarding the attainment of glycemic control and factors contributing to it among type 2 diabetes patients having follow-ups in the hospital.
This study aims to determine the level of glycemic control and associated factors among patients with type 2 diabetes who had follow- at Yekatit 12 Hospital Medical College. 2024.
2.1 Study area
The study was conducted at Yekatit 12 Hospital and Medical College's Internal Medicine Department. Yekatit 12 Hospital was established in 11923G. Until the Ethiopian revolution of the 11970s, it was known as Haile Selassie I Hospital, named after Emperor Haile Selassie I. In addition, Yekatit 12 Hospital Medical College maintains electronic medical record systems, which streamline the process of collecting data for this study. These records contain detailed information on patient demographics, medical history, investigation results, diagnoses and disease progress over time. The hospital serves over 5 million people in its central 5 Departments in the catchment area. Addis Ababa was chosen as the study setting due to its diverse population, representing various socioeconomic backgrounds and cultural contexts. The city is known for its well-established healthcare infrastructure, making it a suitable location to access a significant number of emergency patients. An institutional-based cross-sectional study will be carried out in Yekatit 12 hospital medical colleges from May 1 to June 30, 2024.
2.2 Study Period
This study was conducted from May 1 to June 30, 2024.
2.3 Study Design
An institutional-based cross-sectional study design was applied
2.4 Population
2.4.1 Source population: All type 2 DM patients having follow-ups in Yekatit 12 Hospital Medical College.
2.4.2 Study Population: type 2 DM patients who attended at Yekatit 12 Hospital Medical College. From May 1 to June 30, 2024.
2.4.3 Sample population: 318 type 2 DM patients attending the Yekatit 12 Hospital Medical College from May 1 to June 30, 2024.
Eligibility Criteria
Patients included in this study were those who had at least two previous visits to the clinic
2.5 Sample size and Sampling method
Taking the level of significance α to be 95% and the margin of error d = 0.05 with P →0.5
After correcting the formula and using N=1800 (the total number of type 2 DM patients), the corrected sample size will be 318.
A systematic sampling technique was applied to select each study subject included in the study.[28]
2.6 Type of data and method of data collection
Both qualitative and quantitative data were collected. The principal investigator and a trained data collector who is a student in one of the health science disciplines accomplished data collection. Data were collected by interviewing using a questionnaire, measuring weight and height, and reviewing follow-up sheets, particularly for variables like FPG, medications used and comorbidity. Then, the data were filled out on a well-designed English-formatted questionnaire and a checklist.
2.7 Variables
2.7.1 Dependent
2.7.2 Independent
Age
Compliance
Exercise
Obesity
Cigarette smoking
Medications
Duration of DM
Comorbidity
Self-monitoring of blood glucose
2.8 Data quality assurance
A clear and well-designed questionnaire was prepared. The data collector was adequately trained before data collection and supervised by the principal investigator during the data collection. The questionnaire was pre-tested in about 50 subjects to ensure that its contents were appropriate for the subjects included in the study.
2.9 Data Analysis and Interpretation
The data was analyzed using computer software, Statistical Package for Social Studies version 21.0(SPSS 21.0). Results were presented in tables and pie charts, and a test of association (chi-square test) was performed among variables. A P-value of less than 0.05 was taken as significant. Finally, the study results were interpreted and presented in this final written report form, which will be submitted to the Medicine and Health Officer Coordinating Office.
2.10 Problems encountered
• Language barrier
• Inadequate budget
• Incomplete patient charts, especially difficulty in getting documented evidence of comorbid conditions.
2.11 Limitation
Unavailability of HbA1c in Yekatit 12 Hospital Medical College.
2.12 Ethical considerations
A formal approval letter was obtained from the Ethical Review Committee of the Yekatit 12 Hospital Public Health Department. Consent to the study participants was provided. All information collected from patients was kept confidential and used only for the intended purpose. If the participants are unwilling to respond, they can declare that they will discontinue participation during data collection at any time. Personal information, including names of patients, was not included in the questionnaire.
Definition of terms
Diabetes mellitus: the presence of one of the following:
- Symptoms of DM plus RBS concentration >11.1 mmol/L (200 mg/dL)
- FPG >7.0 mmol/L (126 mg/dL)
- Two-hour plasma glucose >11.1 mmol/L (200 mg/dL) during an oral glucose tolerance test (38)
Reasonable glycemic control: when target FPG of 90-130 mg/dl is achieved (10).
Poor glycemic control: when the level of FPG exceeds 130 mg/dl.
Noncompliance: less than 80% compliance with the prescribed regimen, calculated as the number of doses taken divided by the number specified [21].
Adequate physical exercise: 150 min/week (distributed over at least 3 days) of aerobic physical activity [10].
Obesity: BMI > 30 Kg/m2 (38).
Comorbid condition: documented evidence of one or more diabetes-associated conditions (HPN, dyslipidemia, cardiovascular diseases) (38).
Annual income (in Birr)
Low: < 9>
Medium: 9,515 – 33,660
High: > 33,660 (39)
| Socio-demographic characteristics | Frequency | % | ||
Age | <50> | 133 | 45.5 | |
| 50-65 | 124 | 42.5 | ||
| >65 | 35 | 12.0 | ||
Sex | Male | 172 | 58.9 | |
| Female | 120 | 41.1 | ||
Educational status | Illiterate | 92 | 31.5 | |
| Read-and-write only | 25 | 8.6 | ||
| Grade | 1-4 | 36 | 12.3 | |
| 5-8 | 62 | 21.2 | ||
| 9-12 | 24 | 8.2 | ||
| Coll. / University | 53 | 18.2 | ||
Occupation | Unemployed | 22 | 7.5 | |
| Farmer | 100 | 34.2 | ||
| Health Professional | 6 | 2.1 | ||
| Government employee | 67 | 22.9 | ||
| Merchant | 97 | 33.2 | ||
Table 1: Frequency distribution of socio-demographic characteristics of type 2 DM patients having follow-up at Yekatit 12 Hospital Medical College, diabetes clinic, May 1- June 30, 2024
Factor affecting glycemic control | Glycemic control | Total | P-value | |||
| Good | Poor | |||||
Age (years) | <50> | 50(37.5%) | 83(62.5%) | 133 |
0.006 | |
| 50-65 | 59(47.5%) | 65(52.5%) | 124 | |||
| >65 | 7(20%) | 28(80%) | 35 | |||
Sex | Male | 86(50%) | 86(50%) | 172 |
0.001 | |
| Female | 30(25%) | 90(75%) | 120 | |||
Compliance | Yes | 115(39.6%) | 175(60.4%) | 290 | ||
| No | 1 (50%) | 1(50%) | 2 | |||
Regular physical exercise | Yes | Adequate | 26(43.3%) | 34(57.7%) | 60 |
0.6 |
| Inadequate | 20(34.4%) | 38(65.6%) | 58 | |||
| No | 70(40.2%) | 104(59.8%) | 174 | |||
Smoking | Yes | 4(50%) | 4(50%) | 8 | ||
| No | 112(39.4%) | 172(60.6%) | 284 | |||
| Comorbid condition | Yes | 46(39.3%) | 71(60.7%) | 117 |
0.8 | |
| No | 70(40%) | 105(60%) | 175 | |||
| SMBG | Yes | 26(39.4%) | 40(60.6%) | 66 |
0.9 | |
| No | 90(39.8%) | 136(60.2%) | 226 | |||
| Duration of DM (years) | 0-1 | 20(37.7%) | 33(62.3%) | 53 |
0.01 | |
| 2-5 | 67(48.2%) | 72(51.8%) | 139 | |||
| > 5 | 29(29%) | 71(71%) | 100 | |||
Table 2: Frequency distribution of factors affecting glycemic control versus glycemic control among patients attending at Yekatit 12 Hospital Medical College, May 1- June 30, 2024
| Anti-diabetic medication used | Glycemic control | Total | |
| Good | Poor | ||
| Biguanide | 11 | 18 | 29 |
| Sulfonylurea | 4 | 15 | 19 |
| Insulin | 42 | 47 | 89 |
| Biguanide + Sulfonylurea | 53 | 93 | 146 |
| Biguanide + Insulin | 6 | 3 | 9 |
Table 3: Frequency distribution of anti-diabetic agent used versus glycemic control among type 2 DM patients attending at Yekatit 12 Hospital Medical College, May 1- June 30, 2024
Figure 1: Distribution of types of modification of pharmacotherapy among patients of type 2 DM patients having follow-up at Yekatit 12 Hospital Medical College, May 1-June 30, 2024 G.C
Duration of DM (yrs) | Medication | ||||
| Sulfonylurea | Biguanide | Insulin | Biguanide + Sulfonylurea | Insulin + Biguanide | |
| 0-1 | 7 | 7 | 6 | 29 | 2 |
| 2-5 | 6 | 5 | 54 | 67 | 7 |
| >5 | 6 | 15 | 29 | 50 | 0 |
Table 4: Frequency distribution of medications versus duration of disease among patients of type 2 DM having follow-up in Yekatit 12 Hospital Medical College, May 1- June 30, 2024 G.C
This study was conducted among 292 type 2 diabetes mellitus patients, making the response rate about 92%. It was seen that glycemic control was achieved in 39.3% of the patients, which is low but better than the
finding of a study conducted in an outpatient clinic in Gondar, which showed that only 23% of type 2 DM patients had reasonable glycemic control. [11] This study investigated the effect of several well-established factors on glycemic control among type 2 diabetes patients who had follow-ups at Yekatit 12 Hospital Medical College diabetes clinic. Glycemic control is achieved in 37.6%, 47.6% and only 20% of type 2 DM patients in the age groups less than 50, 50 to 65 and older than 65 years, respectively. It is seen that glycemic control is most difficult to achieve in elderly type 2 DM patients, particularly those older than 65. This supports the findings of several similar studies, which showed that glycemic control is challenging in this age group. [14, 27] There is also a statistically significant association between age and glycemic control (P=0.006) as opposed to the results of a longitudinal study conducted in California, which didn't find a significant association between the two. [13]
About 59% of the patients attending the clinic are male. It has been seen that glycemic control is far better in males than in females; it is achieved in 50% of male patients but only in 25% of female patients. There is also a statistically significant association between sex and glycemic control (p=0.001). This aligns with the result of a cross-sectional study conducted among Indian American type 2 diabetes patients.[27] Several studies have clearly shown that noncompliance significantly impacts morbidity, mortality and quality of life in diabetic patients, and improvement in compliance has a significant positive correlation with glycemic control. [13 .14. 15] However, this study showed that the compliance rate in the clinic is very high (more than 99%), minimizing its role as a significant determinant of glycemic control. Exercise is one of the integral components of diabetes management.[10] Several studies have also indicated a significant improvement in glycemic control with exercise. [18,19
Successful management of weight loss in obese patients with type 2 diabetes is capable of correcting many of the metabolic abnormalities associated with type 2 diabetes. [21, 22] Studies conducted in Greece and Ethiopia (Gondar) have also implicated BMI as one of the predictors of glycemic control, i.e., glycemic control improves with decreasing BMI. [11, 20] The findings of this study also support this fact. Glycemic control is achieved in 40.9% and 20% of overweight and obese type 2 diabetic patients, respectively, whereas it is attained in 41.2% of type 2 diabetics with normal BMI. Hypertension is the primary comorbid condition seen among patients of type 2 DM who have follow-up appointments in the clinic. Some studies have indicated that the presence of comorbid conditions may affect glycemic control, mainly because it may increase medication burden and indirectly affect compliance. A Gondar Hospital outpatient clinic study also indicated a negative correlation between HPN and glycemic control. [11] However, this study didn't indicate a significant difference in glycemic control in those with/out comorbid conditions. Glycemic control is attained in 39.3% of those with comorbid conditions and 40% without comorbid conditions. No statistically significant association exists between comorbid conditions and glycemic control (p=0.9).
It has been found that about 22.6% of type 2 diabetes patients attending the clinic practice SMBG, and the majority do this during physical exercise only. A study conducted in California revealed that frequent self-monitoring of blood glucose levels was associated with clinically and statistically better glycemic control regardless of diabetes therapy, and glycemic control is directly proportional to the monitoring intensity.[23] However, this study showed that SMBG, particularly during physical exercise only, doesn't significantly change glycemic control. Glycemic control is achieved in about 39% of patients in both groups, i.e., those who practice SMBG and those who do not. There is also no statistically significant difference in glycemic control between the two groups (p=0.95).
The majority (47.6%) of the patients included in the study had a disease of 2 to 5 years duration, and glycemic control was best achieved in this group; 48.2% had good glycemic control. Glycemic control was the most difficult to achieve in those with more than 5 years of disease; it was achieved in only 29%. A statistically significant association exists between the duration of type 2 DM and glycemic control (p=0.01). This result supports studies conducted in Ethiopia, Libya, and India, which showed a significant correlation between the two variables. [11,24,25]
A pharmacologic approach is essential for most type 2 DM patients. While various drugs are available, no single medication is proven superior for glycemic control. The most common regimen, metformin plus glibenclamide, is used by 50% of patients but achieves control in only 36.3%. In contrast, the least prescribed combination—insulin and metformin (3% of patients)—yields the best control at 66.7%. Insulin monotherapy also shows better outcomes, with 47
The incidence of glycemic control among type 2 diabetic patients in the hospital is low, although there is tremendous room for improvement. Several modifiable and non-modifiable factors were discovered to have a substantial impact on achieving glycemic control. The non-modifiable ones include age, gender, and disease duration, whereas the adjustable ones are physical exercise, obesity, drug selection, and pharmacotherapy change in cases of uncontrolled hyperglycemia. This study found that achieving glycemic control is difficult for elderly individuals, particularly those over 65 years old. It has also been demonstrated that noncompliance is not a significant barrier to achieving glycemic control because almost all of the patients are compliant with pharmacotherapy, implying that with the appropriate medication selection and therapy modification in uncontrolled cases of hyperglycemia, glycemic control can be significantly improved.
It has also encouraged a number of patients to engage in health-promoting behaviors and diabetes treatment components such as physical activity and smoking cessation. Still, the majority of people do not engage in physical activity, and even if they do, many of them do not meet the ADA's suggested intensity and frequency, which may be improved. The other conclusion is that practically all patients who practice SMBG do so only during physical activity, which was not shown to significantly improve glycemic control in the long run. Another noteworthy conclusion of this study is that as type 2 diabetes progresses, it becomes more difficult to maintain glycemic control. It was also discovered that there is some reluctance to start insulin or an insulin-containing combination regimen in patients with long-standing disease and poor glycemic control, as the majority of these patients have poor glycemic control but are on metformin/glibenclamide combination therapy. Compared to other mono/combination pharmacotherapeutic treatments, insulin alone or insulin/metformin combination therapy has shown greater results when it comes to anti-diabetic drugs. The achievement of glycemic control was also found to be adversely affected by the failure to correctly alter medication in uncontrolled cases of hyperglycemia.
List of abbreviations
ADA: American Diabetes Association
BMI: Body mass index
CAD: Coronary artery disease
CDC: Center for Disease Control
DM: Diabetes mellitus
FPG: Fasting plasma glucose
GDM: Gestational diabetes mellitus
HbA1c: Hemoglobin A1c
HEPA: Health-enhancing physical activity
HPN: Hypertension
IFG: Impaired fasting glucose
IGT: Impaired glucose tolerance
JUSH: Jimma University specialized hospital
PAD: Peripheral arterial disease
RBS: Random blood sugar
SMBG: Self-monitoring of blood glucose
WHO: World Health Organization
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Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
