Review Article | DOI: https://doi.org/10.31579/2693-4779/287

Effect of Contraceptives on Fertility

  • Rouzin Abdulkader Al Amou 1*
  • Aml Marei Alkatherei 2
  • Mohamed Eltayieb Elawad 3
  • Abrar Bakry Malik 3

1Resident doctor, obstetrics and gynecology department, Ostfold Hospital Kalnes, Norway.

2Senior resident, family medicine, Bergen Kommune sykehjemedisin. Teatergaten, BERGEN, Norway.

3Research and administration committee, Elmalik Academy of Medical Research. 

*Corresponding Author: Rouzin Abdulkader Al Amou, Resident doctor, obstetrics and gynecology department, Ostfold Hospital Kalnes, Norway.

Citation: Rouzin Abdulkader Al Amou, Aml M. Alkatherei, Mohamed E. Elawad, Abrar B. Malik, (2025), Effect of Contraceptives on Fertility, Clinical Research and Clinical Trials, 13(3); DOI:10.31579/2693-4779/287

Copyright: © 2025, Rouzin Abdulkader Al Amou. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: 12 August 2025 | Accepted: 28 August 2025 | Published: 08 September 2025

Keywords: contraceptives; fertility; pregnancy

Abstract

Pregnancy and childbirth carry risks of morbidity and mortality. Although the contraceptives that couples use to avoid pregnancy have their own health risks, they also have substantial noncontraceptive health benefits. Information about these risks and benefits is necessary for informed decision making. Oral contraceptives, for example, not only prevent pregnancy, but they also reduce the risk of endometrial and ovarian cancer and protect against acute pelvic inflammatory disease and ectopic pregnancies. However, oral contraceptives increase the risk of cardiovascular disease. IUDs provide effective contraception but increase the potential for infection in certain high-risk groups. Barrier methods of contraception provide less effective contraception, but they protect against sexually transmitted infections including human immunodeficiency virus (HIV). The importance of the noncontraceptive benefits and risks of contraceptives varies among societies because of variations in the prevalence of the diseases involved.

In this review we will discuss evidence on the effectiveness and health consequences of specific contraceptive methods on fertility.

Introduction

Depending on their circumstances, women have different reproductive goals and contraception habits. Many women are now free to decide to become pregnant voluntarily rather than by accident thanks to the availability of extremely efficient reversible contraception. Any reversible method of contraception must not negatively impact future fertility, which is frequently a major worry for women [1]. Particularly in young women [2], whose general mistrust of effective contraceptive methods is exacerbated by misconceptions and a lack of information [2], [3], any fertility delay or impairment after stopping a particular method of contraception may be linked to decreased use and low user satisfaction.

Initial reports from the 1960s indicated that some women who had previously experienced regular menstruation might experience anovulation and infertility after stopping oral contraceptives [4], [5], [6], and [7]. Clinicians were concerned that using oral contraceptives to suppress ovulation for an extended period of time could result in a protracted ovulatory suppression state, delaying the return to regular menstruation and leaving some women amenorrheic for over a year. Since then, this so-called postpill amenorrhea syndrome has been disproved [8]. However, some doctors remain concerned about the impact of long-term oral contraceptive usage on fertility and reproductive function, especially as it may impact teenage maturation and reproductive development [3].

Fertility is a complicated topic that is influenced by a variety of elements (both male and female), such as environmental influences, behavioral/lifestyle factors, and underlying reproductive capacity. It is widely acknowledged that fecundity and age are negatively correlated [9], [10], and that this correlation is linked to decreased coital frequency [11], [12], decreased fertility [10], [13], and a higher prevalence of underlying gynecological disease [14]. Smoking has also been linked to decreased fertility in women [15], [16], [17], obesity [18], and exposure to various environmental pollutants (such as pesticides, solvents, and chlorinated hydrocarbons) [19], [20], and [21]. Therefore, a variety of underlying characteristics unique to the community being studied may have an impact on studies evaluating pregnancy rates or time to pregnancy after stopping the use of contraceptives.

This article's objective was to do a thorough analysis of the literature that compares the rates of pregnancy among women who wish to conceive after stopping different forms of contraception. The majority of reversible methods of contraception have not been well reviewed, despite recent evaluations concentrating on this feature for specific methods such oral contraceptives [22] and copper intrauterine devices (IUDs) [23]. When advising individuals or couples regarding the effect of using contraceptives on their future fertility, this information will be helpful, particularly for those who have not yet had children.

Contraceptive Methods

Generally, reversible contraceptive techniques can be classified as either hormonal (like progestin-only pills or estrogen-progestin patches) or nonhormonal (like diaphragms and condoms), as well as long-acting (like IUDs) or short-acting (like pills). The efficiency of reversible contraceptive methods in preventing pregnancy can also be categorized. In the United States, contraceptive techniques are only available with a prescription, with the exception of condoms, spermicide, and behavioral methods.

Hormonal Contraceptives

Pharmacology of Steroidal Hormone Components

Estrogen and progesterone are lipid or steroid hormones. Progestin, either alone or in combination with estrogen, is a component of hormonal contraception. The majority of progestins used in contraceptives, including levonorgestrel and norethindrone, are produced from testosterone; progesterone is the only progestin that occurs naturally. In order to inhibit ovulation, progestins suppress the hypothalamus's gonadotropin-releasing hormone, which in turn reduces the pituitary's luteinizing hormone. [24,,25] Furthermore, progestins directly impair the permeability of cervical mucus. Progestins decrease sperm survival and transit to the fallopian tube as well as endometrial receptivity. [26,27] By inhibiting gonadotropins and follicle-stimulating hormone, estrogens increase the effectiveness of contraceptives by halting the growth of a dominant follicle. However, reducing irregular bleeding is the main way that estrogens contribute to progestin-based contraceptives. Ethinylestradiol is the estrogen component found in the majority of combined hormonal contraceptives.

Progestin-Only Contraception

There are numerous progestin-only contraceptive options available. The progestin's dosage, strength, and half-life, as well as user-dependent elements like following the prescribed regimen, all affect how effective they are. [28,29] 
The efficacy of progestin-only pills to inhibit ovulation varies depending on whether they include drospirenone or norethindrone. Unlike a regular combination contraceptive pill, which contains 1000 µg of norethindrone, norethindrone pills only contain 300 µg. Because norethindrone pills contain less progestin, there is a greater chance of breakthrough bleeding and less regular ovulation suppression. Other progestin-mediated effects sustain the effectiveness of the contraceptive. Drospirenone-only pills help suppress ovulation because they contain a little more progestin than a hormonal contraceptive that combines progestin and estrogen. Ovulation suppression was maintained in one trial where participants postponed taking a drospirenone-containing pill by 24 hours, simulating a missing dose. Only one participant out of 127 showed signs of ovulation. [30] Progestin-only contraceptive pills have the following advantages: minimal impact on hemostatic parameters, safety profile, simplicity of beginning and withdrawal, and fertility return within one cycle. [31] Depot medroxyprogesterone acetate (DMPA) is an injectable progestin that is given at 12- to 14-week intervals. It comes in intramuscular (150 mg) and subcutaneous (104 mg) formulations. Even though DMPA is linked to irregular uterine bleeding, this pattern gets better the longer the drug is used. 46% of DMPA users experienced amenorrhea in the ninety days after their fourth dose, according to a systematic evaluation of DMPA-related bleeding patterns (13 studies involving 1610 participants). [32] The only type of contraception that can postpone a return to fertility is DMPA. Due to its ability to block the hypothalamic-pituitary-ovarian (HPO) axis and its persistence in adipose tissue, the contraceptive effect and irregular cycle may extend for up to 12 months following the last dose. DMPA may be most appropriate for people who benefit from amenorrhea (such as patients with bleeding disorders or developmental difficulties), but not for people who wish to become pregnant right away after stopping the medication. DMPA and progestin-only contraceptive tablets typically result in 4–7 births per 100 women annually. [29,33]

Similar to permanent techniques like tubal ligation or vasectomy, progestin-only long-acting options like the levonorgestrel (LNG) IUD and the subdermal implant often have efficacy rates of less than one pregnancy per 100 women year. [29,33] These techniques are also linked to a restoration to fertility within one cycle following cessation. With amenorrhea rates as high as 20% at 12 months and 40% at 24 months, the LNG IUD is effective for at least 7 years. [34] However, initiation necessitates a face-to-face meeting with an IUD placement-trained doctor. The etonogestrel subdermal implant is simple to insert and remove, and it can last up to five years [35]. In-person visits are also necessary for initiation and cessation. Because of the unpredictable nature of the implant's bleeding profile, up to 11% of patients remove it within the first year. [36] The bleeding pattern during the first three months (such as protracted, frequent, or irregular episodes) is associated with subsequent bleeding patterns, according to an analysis of 11 research (923 participants) from Europe, Asia, South America, and the US. [36] Those who experience prolonged or frequent bleeding during the first three months, however, have a 50% chance of improving within the next three months. [36]

Combined Hormonal Contraception

The weekly transdermal patch, monthly vaginal ring, and daily oral pill are examples of combined hormonal therapies that contain both progestin and estrogen. The success of these procedures, when fully adhered to, is two pregnancies per 100 users annually. However, the effectiveness varies depending on the user's adherence, with an average of 4 to 7 pregnancies per 100 women year. [29,33] A recent cohort study of almost 10,000 people in the US showed how important patient adherence to hormonal contraception is. Short-acting reversible techniques (pills, patches, and rings) had a pregnancy rate of 4.55 per 100 participant-years, while long-acting reversible methods (IUD, implant) had a pregnancy rate of 0.27. 13. The risk of pregnancy was higher for women under 21 who used short-acting techniques than for those who were 21 or older (adjusted hazard ratio, 1.9 [95% CI, 1.2-2.8]). [30] There were no age-related risk differences for the long-acting reversible IUD or implant techniques. Age-stratum absolute rates were not provided. 
The processes by which progestin-only approaches and combined hormonal contraceptives prevent conception are identical. Their capacity to create a steady, predictable bleeding pattern is their biggest benefit over progestin-only techniques. About 90% of users of combined hormonal contraception pills (n = 1003) over a 90-day standard reference period reported regular scheduled withdrawal bleeds, while no one experienced amenorrhea, according to a study that compared the bleeding diaries of 5257 women using nine different methods of contraception (nonhormonal, combined hormonal contraception, and progestin-only). [37] Sometimes, throughout the week of the placebo, people do not experience a withdrawal bleed. If the patient or physician is worried that pregnancy might be the cause of the lack of bleeding, a pregnancy test may be conducted. Patients can be confident that the absence of withdrawal bleeding does not signify a medical condition or decreased fertility if pregnancy is ruled out. This is because the HPO axis is suppressed.

Nonhormonal Contraceptives

Behavioral Methods

Fertility awareness-based techniques and penile retraction prior to ejaculation are examples of behavioral contraceptive treatments. Patients may refer to these techniques using euphemistic terminology like the rhythm method, natural family planning, or other imprecise terms. Patient education, cycle regularity, the patient's dedication to daily symptom assessment (first morning temperature, cervical mucus consistency), and the patient's capacity to refrain from sexual activity or ejaculation during the period of maximum fertility are all necessary for the effectiveness of withdrawal and fertility awareness. Pregnancy rate data are often of low quality and heavily influenced by the design of the study. [38] Fertility awareness strategies failed to prevent 22 pregnancies per 100 woman-years, according to a meta-analysis of higher-quality prospective studies of women at risk for unwanted pregnancy. [39]

Condoms and Diaphragms (Barrier Methods)

Other nonhormonal techniques include physical barriers (condoms and diaphragms) or substances that kill sperm or reduce their motility (pH modulators and spermicides) to stop sperm from entering the upper reproductive canal. These procedures typically have a first-year success rate of 13 pregnancies per 100 women annually. [29,33]

Copper-Bearing IUD

One extremely successful nonhormonal reversible technique is the copper-bearing IUD. 12,18 The average annual use pregnancy rate is 1%. [29,33] The user's HPO axis remains unaffected, therefore menstrual cyclicity and ovulation continue. Through the direct actions of copper salts and endometrial inflammatory alterations, the main mode of action is spermicidal. [38] The main drawback of the copper IUD is that, primarily in the first three to six months of use, it might make menstruation more frequent, uncomfortable, and prolonged. 36 The risk of tubal infertility later on is not increased by IUD use. [40] Testing for sexually transmitted infections (STIs) can be done in conjunction with IUD installation if necessary. [41-43] The risk of pelvic inflammatory illness is not increased by the accelerated STI testing procedure during IUD implantation. Those who already have gonorrhea or a chlamydial infection (0%–5%) or do not (0%–2%) have a low absolute risk of developing pelvic inflammatory illness following IUD installation. [44]

Emergency Contraception

When taken after unprotected sexual activity, emergency contraception (EC) lowers the risk of pregnancy. When put within five days of unprotected sexual activity, a copper IUD, the most effective form of EC, lowers the probability of conception to 0.1%. [45] Another benefit of a copper IUD is that it gives users continuous contraception. EC had not previously thought about LNG IUDs as a viable alternative. But in a recent randomized noninferiority trial, women who requested EC and had at least one unprotected sexual encounter in the previous five days were randomly assigned to either a 52-mg LNG IUD (n = 355) or a copper IUD (n = 356). With a between-group absolute difference of 0.3% [95% CI, −0.9% to 1.8%], [46] LNG IUD was not inferior than copper IUD. However, it was not disclosed what percentage of study participants engaged in unprotected sexual activity throughout their menstrual cycle, putting them at risk for pregnancy. Given the scant and ambiguous evidence supporting the use of a 52-mg LNG IUD alone for EC, it makes sense to insert the IUD and administer an oral EC right away if the patient needs EC. 

One dose of either an antiprogestin (ulipristal acetate, 30 mg) or a progestin (LNG, 1.5 mg) makes up oral EC. These two substances function by preventing or postponing ovulation. Abortifacient neither. While ulipristal acetate requires a prescription, LNG EC can be purchased over-the-counter. For optimal effectiveness, the drug should be taken as soon as possible after unprotected sexual activity; however, ulipristal acetate can be administered up to five days later. [47-49] After three days, the effectiveness of LNG is reduced. When taken within the first 72 hours of sexual activity, the two agents seem to be equally effective (ulipristal acetate EC: 15 pregnancies of 844, LNG EC: 22 pregnancies of 852); the estimate of the reduction in pregnancy without EC use is 90% lower. However, pharmacodynamic and clinical studies showed that the ulipristal acetate treatment effect lasts for up to 120 hours without any pregnancies (0/97). 46 Pregnancy prevention rates were lower than anticipated in actual EC use studies including 3893 participants; this appears to be connected to several acts of unprotected intercourse before and after EC use. [50,51] EC must be taken again if additional unprotected sexual activity takes place 24 hours after EC use and a regular method of contraception has not been initiated. [52] There are no significant side effects from repeated usage of LNG EC, and there is no particular research on repeated dosing for ulipristal acetate EC. [53] Before beginning a user-controlled technique, like condoms, clinicians should go over the EC alternatives with each patient. Oral EC may be prescribed to these patients to be used right away at home if necessary.

Restoring Fertility After Contraception

This review found that within the first 12 months after stopping contraceptive, 83.1% (95% CI = 78.2-88%) of women were pregnant. There was no discernible difference in the first-year fertility return between IUD and hormonal treatments. Likewise, the type of progesterone used in contraception and the length of time using oral contraceptives had no discernible effects on the return of fertility after stopping contraception. However, there was conflicting evidence on the impact of parity on the restart of pregnancy after stopping contraception.

This review's fertility return rate was similar to earlier studies and publications that evaluated particular forms of contraception [54–57]. Pregnancy rates among LNG-IUS ex-users, copper IUDs, and oral contraceptives also overlapped and were similar to earlier findings. The results, however, were marginally less than the 85.2–94% reported by women who stopped using barrier methods or who did not use any form of contraception [58,59]. This discrepancy could be because hormonal contraceptives frequently take months to leave the body, which causes a brief postponement of the start of pregnancy for months [56,57].

The one-year pregnancy rate after stopping an implant ranges from 37.5% to 90%, which is similarly consistent across studies [54,55]. According to Affandi et al. [54], there are studies that show a remarkably low risk of conception within a year after stopping contraceptive, with reports of 37.5 and 48.8% for Norplant and Implanon ex-users, respectively. However, the rate of fertility return is comparable to other techniques when the study with the low rate of conception following the withdrawal of contraception is eliminated. Furthermore, no discernible variations between the various implant types were noted. The fact that implants are impregnated with the same hormone, which makes no difference, could help to explain this.

Resumption ranged from 71 to 96%, with an average of 84.75%, and fertility returned after IUD termination was not hampered in any way. Furthermore, pregnancy is unaffected by the kind of IUD, how long it is used, or whether hormones are added to the device [54–58]. According to Mansour et al. [54], the pregnancy rate after IUD termination ranges from 86.1 to 92.3%, which is similar for both natural method users and non-users. This research also shows that fertility quickly resumes following IUD termination. According to other research, the kind and length of IUD use had little bearing on the rate of pregnancy following cessation [55,56].

Despite the widespread belief that oral contraceptive may hinder conception, this review found that 87% of women were able to conceive. Other researchers found that fertility returned similarly after stopping oral contraception, which is consistent with this conclusion [54–57]. Nonetheless, this review and meta-analysis acknowledges that there may be a small lag in fertility recovery following the withdrawal of hormonal contraception until the hormone's blood bioavailability is fully eliminated. Additionally, it has been seen that using hormonal contraception for three months prevents pregnancy, but this impact is negligible for users who are 12 months along and nonexistent for those who are 24 months [54–59]. Currently, there is no longer a concern about decreased fertility that was linked to early use of high-dose oral contraceptive pills. This is because low-dose contraceptive regimens are available for usage [57–59]. 

Our analysis also demonstrates that the restoration of fertility was not substantially impacted by the length of time spent using contraception. It is consistent with the findings of several other studies [54–59] and the several papers that were part of the review [54–62]. However, there is evidence that suggests women who used oral contraceptives for a longer period of time may have had a slightly lower pregnancy rate than women who used them for a shorter period of time [54]. This could be due to the effect of aging, as fertility declines with age.

The potential association between prolonged use of hormonal contraception and the rate of restart of pregnancy, however, might not be revealed through acceptable and trustworthy conclusions because none of the research were randomized control trials and the majority of the studies had small sample sizes. 

Likewise, our analysis revealed that the kind of progestin had no discernible impact on the short- or long-term pregnancy rate. This is due to the fact that dose is more important than duration. But at the moment, only formulations with minimal dosages are being used. As a result, reproductive delays after stopping the usage of contraception may not be prevalent. Furthermore, women who stop long-term or continuous OC regimens experience a similar return in fertility as those who stop cyclic OCs [54–58]. Previous investigations evaluating the restoration of fertility after stopping oral contraception also reported same outcome [54–60]. 

There was conflicting evidence on parity's impact on fertility rates. This review's conclusion indicates that parity may or may not increase fertility. The review's studies specifically contrasted nulliparous and multiparous women without taking into account the infertility rate [54]. Therefore, it is assumed that multiparous women who have been shown to be fertile will have a greater pregnancy rate. In all situations, the fertility rates of women who want to get pregnant after stopping a form of birth control may be impacted by the baseline incidence of infertility.

Conclusion

usage of contraception, type of contraception, duration of usage, and type of progesterone did not influence the resumption of fertility after stopping contraception. Nevertheless, there was conflicting evidence about the impact of parity on the restart of pregnancy after stopping contraception. In order to provide women the freedom to choose and use contraception for as long as they choose, it is crucial to inform them that using it in the past, regardless of its type or length, does not have a detrimental effect on their ability to conceive in the future.

References

Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.

img

Virginia E. Koenig

Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.

img

Delcio G Silva Junior

Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.

img

Ziemlé Clément Méda

Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.

img

Mina Sherif Soliman Georgy

We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.

img

Layla Shojaie

The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.

img

Sing-yung Wu

Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.

img

Orlando Villarreal

Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.

img

Katarzyna Byczkowska

Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.

img

Anthony Kodzo-Grey Venyo

Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.

img

Pedro Marques Gomes

Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.

img

Bernard Terkimbi Utoo

This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.

img

Prof Sherif W Mansour

Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.

img

Hao Jiang

As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.

img

Dr Shiming Tang

Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.

img

Raed Mualem

International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.

img

Andreas Filippaios

Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.

img

Dr Suramya Dhamija

Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.

img

Bruno Chauffert

I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!

img

Baheci Selen

"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".

img

Jesus Simal-Gandara

I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.

img

Douglas Miyazaki

We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.

img

Dr Griffith

I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.

img

Dr Tong Ming Liu

I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.

img

Husain Taha Radhi

I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.

img

S Munshi

Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.

img

Tania Munoz

“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.

img

George Varvatsoulias

Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.

img

Rui Tao

Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.

img

Khurram Arshad

Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.

img

Gomez Barriga Maria Dolores

The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.

img

Lin Shaw Chin

Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.

img

Maria Dolores Gomez Barriga

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.

img

Dr Maria Dolores Gomez Barriga

Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.

img

Dr Maria Regina Penchyna Nieto

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.

img

Dr Marcelo Flavio Gomes Jardim Filho

Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”

img

Zsuzsanna Bene

Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner

img

Dr Susan Weiner

My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.

img

Lin-Show Chin

My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.

img

Sonila Qirko

My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.

img

Luiz Sellmann

I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.

img

Zhao Jia

Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."

img

Thomas Urban

I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.

img

Cristina Berriozabal

To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.

img

Dr Tewodros Kassahun Tarekegn

"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".

img

Dr Shweta Tiwari

I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.

img

Dr Farooq Wandroo

Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.

img

Dr Anyuta Ivanova

We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.

img

Dr David Vinyes

My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.

img

Gertraud Teuchert-Noodt

To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina

img

Dr Elvira Farina

Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.

img

Dr Oleg Golyanovski

Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.

img

Dr Susan Anne Smith

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.

img

Dr Farahnaz Fallahian

Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.

img

Dr Victor Olagundoye

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.

img

Dr Susan Anne Smith

Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD

img

Dr Eric S Nussbaum

Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.

img

Hala Al Shaikh

Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.

img

Dr Rakhi Mishra

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.

img

Dr Walter F Riesen

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.

img

Dr Jelle Lettinga

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora

img

Dariusz Ziora

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.

img

Dr Ravi Shrivastava

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.

img

Dr Aline Tollet

Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.

img

Dr Chiara Giuseppina Beccaluva

Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti

img

Dr Claudio Ligresti

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.

img

Dr Matteo Bonori