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Case Report | DOI: https://doi.org/10.31579/2693-2156/144
1Department of anaesthesiology and critical care, SGT Medical college, Budhera, Gurugram, Haryana, India.
2Department of CTVS, Tender palm, super specialty hospital, Lucknow.
*Corresponding Author: Vishnu Datt, Professor & HOD, Department of Anesthesiology and critical care, SGT Medical College, Bhudera, Gurugram, Haryana, India.
Citation: Vishnu Datt, Priyanka, Divya, Vijay Agarwal, Parth Gangwar, et al, (2025), Central Venous Pressure Catheter induced Superior Vena Cava Syndrome in a 2.7 kg Neonate after Patent Ductus Arteriosus (PDA) Ligation: Report of a Rare Case, J Thoracic Disease and Cardiothoracic Surgery, 6(4); DOI:10.31579/2693-2156/144
Copyright: Copyright: © 2025, Vishnu Datt. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 30 June 2025 | Accepted: 07 July 2025 | Published: 14 July 2025
Keywords: CVP catheter; GA; left thoracotomy; PDA Ligation; SVC syndrome; swelling of chest; face; head; and neck
Superior vena cava syndrome (SVCS) is an uncommon but severe complication following neonatal cardiac surgery. It is caused by severe obstruction or occlusion of the SVC. In neonates, SVCS is known to cause swellings of the face, head, neck, or upper chest; prominent vessels around the chest wall and neck; or even a significant airway obstruction and respiratory distress, cerebral edema, and significant morbidity and mortality. Recently, the growing use of SVC catheterization makes catheter-related thrombosis a potential cause of serious complications. Approximately 47 % of the SVCS occur in cardiac cases associated with congenital heart diseases. Following PDA ligation surgery, the SVCS can occur due to surgical trauma or direct injury to the SVC or surrounding veins during ligation under cardiopulmonary bypass (CPB) or CVP catheter or PICCs leading to the genesis of thrombus or stenosis. Prompt recognition and appropriate management are vital for improving outcomes in the affected neonates.
We report A 9-day-old, 2.7 kg neonate diagnosed with a PDA with left-to-right shunt and persistent respiratory distress, who underwent its emergency surgical ligation. Despite an initially unremarkable postoperative course, a progressive swelling of the neck, face (including the periorbital area and head), and upper chest, with engorged veins on the chest wall, was noticed. The baby slowly and progressively became lethargic and unresponsive to the stimulus and dusky in color and developed respiratory difficulty and arterial oxygen desaturation (87%), requiring high-flow nasal cannula (HFNC) oxygen therapy. Such a complication immediately following PDA ligation is uncommonly expected. The diagnosis of SVC syndrome in neonates can be challenging due to the subtle initial symptoms and the rarity of the condition. On the exclusion criteria, clinical picture and ultrasonography parameters, and the diagnosis of the SVC line (4.5Fg), induced SVCS was reached, and it was decided to remove it. There was spontaneous regression of the swelling and improvement in the mental status and respiratory efforts and the baby again became active within 2-3 hours of CVP catheter removal. The SPO2 was maintained at 97-99% with 2L oxygen flow through nasal cannula. The rest of the course was uneventful, and the baby was sent back to the referral hospital on the second postoperative day. We are of the opinion that cardiac-related SVCS has a faster onset and more symptoms, and so delay in diagnosis of acute complications would result in an increased rate of the primary outcome. To the best of our knowledge, SVC syndrome after PDA ligation caused by the obstruction due to a CVP line without thrombosis or injury has not been reported in the literature to date. Early diagnosis of SVC syndrome in neonates after cardiac surgery and prompt action is crucial in preventing the major complications and significant morbidity and mortality.
Superior Vena Cava syndrome (SVCS) in neonates after cardiac surgery is a rare but potentially serious complication. It occurs due to obstruction of blood flow through the SVC, leading to swelling of the face, head, neck, and upper chest with venous engorgement particularly on the upper extremities and chest, or even significant morbidity and mortality due to increased cerebral venous pressure resulting in hydrocephalus or respiratory distress or low cardiac output. [1,2,3]
SVCS can be caused by thrombosis, external compression, or iatrogenic caused by improper placement of catheters or cannula during cardiac surgery or by direct injury to SVC. it can occur even after some heart procedure like Glenn or Senning cardiac repair.
Early diagnosis and treatment are crucial to prevent progression and potential morbidity and mortality. We describe a rare case of acute SVC syndrome in a 2.7 kg- female -neonate after successful PDA ligation, due to obstruction of the SVC by triple lumen CVP catheter inserted via right internal jugular vein (RIJV). Removal of the CVP catheter resulted in rapid recovery from the respiratory distress and lethargy within few hours.
To report on a rare case of acute superior vena cava syndrome (SVCS) developed in cardiac ICU immediately after the cardiac surgery in neonates. The nearly complete blood flow obstruction due to mismatch of the size of SVC cannula and the IJV or SVC should be suspected the cause of SVCS after ductus ligation, and its removal causes a swift recovery from the signs and symptoms of SVCS not only the edema but respiratory distress and consciousness level.
A 9-days- 2.7 kg Female, born at 37 weeks as normal delivery in a general hospital, presented with shortness of breath since 3rd day of life. The baby required oxygen therapy and diuretics round the clock. On examination, she was conscious, respiratory rate was 45 cycles /min, HR 144bpm. Chest auscultation revealed generalized bilateral basal crepitations. CVS examination revealed normal S1 and S2 sounds and a machinery murmur on left parasternal and sub clavicular region suggestive of a PDA. The attempt of ductus pharmacological closure with intravenous indomethacin (0.1-0.2 mg/kg) slowly over a minimum of 30 minutes and even 3 doses were unsuccessful. Therefore, she was referred to CTVS department of the super speciality tertiary care centre for the surgical PDA ligation. Echocardiography revealed situs solitus, levocardia, a PFO of 3mm with L-R shunt, PDA of 6mm with L-R shunt and PG of 38 mmHg, no PAH, good biventricular functions and no other congenital anomalies. Chest X-Ray (AP) view showed cardiomegaly with lung plethora suggestive of increased lung blood flow. Her HB was 16.8 gm%, TLC- 8800/cmm, platelets -1.64 lacs/cmm, total bilirubin of 14.9mg/dl with direct 2.58mg/dl and indirect of 12.32 mg/dl, total bilirubin decreased to 10.2 on the day of surgery. CRP value was in decreasing order from 15mg/l to 7.02mg/l suggestive of decreasing the body infection, PT of 13.7sec, INR of 1.06 and PTT of 32 sec. A detailed informed consent was obtained from the parents, and the baby was posted for emergency surgical PDA ligation.
In OR, a standard ASA monitoring including ECG, SPO2, ETCO2, were attached, The SPO2 revealed a baseline arterial oxygen saturation of 93%. General anaesthesia was induced with sevoflurane 8% in oxygen in air with a FIO2 of 60% until venous access with 24 G cannula was achieved and then its concentration was reduced to 1% and anaesthesia was further supplemented with fentanyl (5 mcg), midazolam (0.25 mg) and atracurium bromide 2mg was used as a muscle relaxant to facilitate the endotracheal intubation with 3mm cuffed tube, fixed at 9cm. A 22G leader Cath was inserted in the left femoral artery for continuous BP monitoring and serial arterial blood gas analysis. 4.5 Fg triple lumen catheter was inserted via the right internal jugular vein (RIGV) for CVP monitoring and administration of anaesthetic drugs, fluids, and inotropes as well as vasodilators.
The patient positioned for left lateral thoracotomy and the ductus was approached through the left 4th intercostal space. The aortic arch vessels, descending aorta, pulmonary artery and PDA were dissected. The PDA was confirmed by temporary clamping resulting in increase in diastolic pressure from 29 mm hg to 43 mmHg without any drop in the arterial saturation. Following appropriate hemodynamic assessment, the BP was reduced to MAP of 40 mmHg with administration of NTG (1mcg/kg/min) and sevoflurane 5-8% to facilitate the smooth ligation of the ductus and to avoid its rupture, a catastrophic complication. After ligation, Milrinone (0.3mcg/kg/min) was started to counter the systolic dysfunction following ductus ligation. The haemostasis was secured, and chest incision was closed in layers as usual fashion, and intercostal chest tube was also inserted. Incision and chest tube sites were infiltrated with bupivacaine (0.125%, 3ml) for post operative pain relief. Patient was extubated successfully in the OR and showed full recovery with good cry and saturation of 99-100% with oxygen support at 2L/min by nasal prongs. However, the slow and progressive swelling on the face around eyes, upper extremity, neck and upper chest and engorged veins on the chest and respiratory distress with decrease in arterial oxygen saturation to 87% was noticed.
Figure 1: the postoperative photograph of the baby showing the swelling of head, neck, chest along with bluish discoloration of the face and chest, the features suggestive of the SVCS. In addition, a right sided triple lumen catheter and the HFNC oxygen therapy for respiratory distress and arterial O2 desaturation canalso be noticed.
The baby, became lethargic and developed and bluish discoloration of the lips and tongue and therefore, she was put on HFNC with a 4L oxygen flow and fluid was restricted and furosemide (1mg) was given, however, there was no relief occurred and swelling kept on increasing over the next 12 hrs., but hemodynamic were still maintained, BP systolic/ diastolic70-80/45-55 mmHg, CVP of 2mmHg, HR 150bpm. Postoperative, Chest X-ray (AP) view revealed only cardiomegaly with normal lung fields, without any gross widening of the mediastinum or any mass looking(thrombus) opacity on the right side of the chest, a right sided CVP line was confirmed, reaching almost to the RV so withdrawn 2-3 cm. (Figure-2)
Figure-2. Chest X-ray (AP) view show - cardiomegaly with normal lung fields, without any gross widening of the mediastinum or any mass looking(thrombus) opacity on the right side of the chest, a right sided CVP line is seen reaching almost to the RV. So primarily excludes SVC thrombus with dilatation or compression by any mass
The ultrasound revealed noncompressible and nondistended IJV and SVC, with catheter in situ, there was a scanty blood flow, and the S, D, AR and VR waves could not be appreciated suggestive of severe SVCS. Finally, on the bases of clinical picture and USG parameters, the diagnosis of SVC syndrome was established and CVP catheter was the culprit for it, and so, it was decided to remove it. Following that the swelling started regressing and a gross improvement was observed over the next 2hr, and a complete recovery with recovery of alertness, normal colour of the face and saturation of 97% even without any oxygen support (Figure 3, &4).
Figure 3: The postoperative photograph of the neonate shows regression of the swelling of the body. Normal colour of the skin and completely weaned off the oxygen after removal of the CVP catheter. Now there is no CVP line on the right side of the neck as it was noticed in the figure 1a.
Figure 4: The monitor screen shows BP of 80/56mmHg, CVP of 2, SPO2 of 97% and HR of 150bpm without oxygen and milrinone therapy. At this point, the arterial line and PICC lines were also removed.
The femoral arterial cannula and chest tube were also removed before the neonate was transferred back to the referral hospital on the 2nd postoperative day and the rest of the course was uneventful as informed by the treating physicians.
SVC syndrome affects a small proportion of neonates, but its effects can be devastating. It has been reported after congenital cardiac surgical procedures, but not because of direct impact of PDA ligation. This single case report suggests that acute SVCS can develop in cardiac ICU immediately after the cardiac surgery in neonates. The mismatch of the size of SVC cannula and the IJV or SVC should be suspected the cause of SVCS after ductus ligation, and its removal causes a swift recovery from the signs and symptoms of SVCS not only the edema but respiratory distress and consciousness level also. We are of the opinion that cardiac related SVCS, have faster onset, more symptoms, and so delay in diagnosis of acute complications would result in an increased rate of the primary outcome. Use of anticoagulation therapy is not the first choice in such cases due to risk of fresh bleeding.
Funding sources: Nil
Conflict of interest: declare no conflict of interest
Ethical approval: Not required
Authors declaration: all authors have contributed equally for the writing, reviewing, editing, and approval of the manuscript
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Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.