AUCTORES
Globalize your Research
Research Article | DOI: https://doi.org/10.31579/2690-8816/173
1Faculty of medical laboratory science, Federal university Otuoke, Bayelsa State.
2Department of Medical Laboratory Science Imo State University Owerri.
*Corresponding Author: Chinedu-Madu Jane Ugochi, Faculty of medical laboratory science, Federal university Otuoke, Bayelsa State.
Citation: Chinedu-Madu J.U., Nnodim Johnkennedy, (2025), Cardiomyopathic Parameters in Sickle Cell Anaemia, J Clinical Research Notes, 6(4); DOI:10.31579/2690-8816/173
Copyright: © 2025, Chinedu-Madu Jane Ugochi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 04 April 2025 | Accepted: 11 April 2025 | Published: 21 April 2025
Keywords: crp; troponin t; ck-mb; ldh; sickle cell anaemia
Serum levels of creatine kinase (CK-MB), lactate dehydrogenase (LDH), troponin T., and C-reactive protein (CRP) were assessed in sickle cell patients who were attending General Hospital Owerri, Nigeria. One hundred confirmed sickle cell patients (HbSS) between the ages of five and thirty were chosen. As a control, 100 healthy individuals (HbAA) between the ages of 5 and 30 were used. In sickle cell anemia, the levels of CRP, Troponin T., CK-MB, and LDH were considerably higher (p<0.05) than in the control group (HbAA). However, sickle cell disease had far greater levels of CRP, Troponin T, CK-MB, and LDH than HbAA. According to the findings, sickle cell anemia is associated with elevated levels of CRP, Troponin T, CK-MB, and LDH, all of which may raise the risk of cardiovascular disease. In sickle cell anemia, measurements of soluble CRP, Troponin T, CK-MB, and LDH may be useful indicators of an imminent coronary artery insult.
Sickle hemoglobin (HbS), an aberrant hemoglobin that polymerizes upon deoxygenation, is the cause of sickle cell disease (SCD), a collection of hereditary blood diseases. The majority of SCD children born in wealthy nations survive until adulthood with neonatal screening and extensive care, albeit with a markedly reduced life expectancy. The leading cause of death for adults with sickle cell disease is cardiopulmonary problems [1]. Elevated pulmonary artery pressures (PAPs), diastolic dysfunction, and heart chamber dilatation are often observed symptoms in sickle cell disease (SCD), although no single pathophysiologic cause has been identified. Diastolic dysfunction, left atrial dilatation, and left ventricular (LV) enlargement are the hallmarks of cardiomyopathy in sickle cell anemia (SCD). Often, systolic function is good, but myocardial fibrosis and poor perfusion reserve may also be present. A genetic disorder of red blood cell synthesis, sickle cell disease can impact the skeletal system by causing bone infarction and rapid hematopoiesis [2]. High levels of sickle cell hemoglobin are present in people with sickle cell anemia. The sickle cell disease red blood cells produce sickle cell hemoglobin (Hbs), an aberrant hemoglobin [3]. At least as good as cholesterol levels, CRP appears to indicate the likelihood of heart issues. According to one study, having high levels of C-reactive protein increases the chance of having a heart attack by three times. Skeletal and cardiac muscle contain the protein subunit troponin T, which is a component of the troponin complex. Its release into the bloodstream may be a sign of heart attack or injury. Proteins called troponin T (TnT), troponin I (TnI), and troponin C (TnC) combine to create the troponin complex, which is essential for heart and skeletal muscle contraction. The findings of a troponin test can verify that a cardiac attack has damaged the heart muscle. Troponin is released into the blood in greater amounts when the heart is damaged. Therefore, determining the blood's troponin level can also aid in estimating the extent of heart injury. A marker for heart injury, creatine kinase-MB is an isoenzyme of creatine kinase (CK), which is mostly found in heart muscle. It is especially useful for diagnosing or tracking myocardial infarction (heart attack) [4]. One type of enzyme that is mostly present in heart muscle cells is creatine kinase-MB (CK-MB). This test quantifies blood levels of CK-MB. The enzyme creatine kinase (CK) has three different forms, or isoenzymes, including CK-MB. Among these isoenzymes are CK-MM, which is present in the heart and skeletal muscles. Typically, a lactate dehydrogenase (LDH) test quantifies the amount of LDH present in a blood sample. LDH levels are occasionally assessed in bodily fluid samples. This involves testing the peritoneal fluid from the abdomen, the pleural fluid from the chest, and the cerebrospinal fluid from the spine [5].
Lactic acid dehydrogenase is another name for LDH. It's an enzyme. A protein called an enzyme quickens specific chemical reactions in your body. Your cells need LDH to produce energy. Almost every tissue in your body contains it. Your red blood cells, liver, kidneys, and muscles have the highest concentrations of LDH. Adults with SCD die primarily from cardiopulmonary problems, such as heart failure and arrhythmias [7]. According to reports, 25–30% of SCD patients die suddenly for no apparent reason; these deaths are most likely the result of cardiopulmonary events [8]. A worldwide understanding of the cardiac dysfunction in SCD is still inadequate, despite the fact that numerous research over the past 20 years have looked at the cardiac pathology and cardiac mortality in SCD and have identified risk factors for early mortality in SCD. The most reliable indicators of early mortality in people with sickle cell disease (SCD) are diastolic dysfunction, pulmonary hypertension (PH), and elevation of the tricuspid regurgitant jet velocity (TRV) as determined by echocardiography [9].
It is unclear what pathophysiology and mechanisms underlie inexplicable consequences such arrhythmias and sudden death and connect these risk factors to the cardiac phenotype of SCD. This disease has a significant impact on society [6]. Even though sickle cell disease may be killing a lot of people, Nigeria hasn't done much research to improve knowledge, diagnosis, and treatment. This study was conducted to assess the status of CRP, Troponin T., CK-MB, and LDH in sickle cell anemia in light of the aforementioned information. This study was conducted with the intention of improving our understanding of sickle cell anemia by the knowledge gathered from the research.
One hundred HbSS diagnosed by haemoglobin electrophoresis, aged 5 - 30 years were selected for the study. One hundred HbAA normal subjects were used as control. Both male and female were equal.
Blood sample: In all subjects, 5ml of venous blood was collected into a non - anticoagulated tubes. The sample were spun in a Wisterfuge (model 684), centrifuge at 1000g for 10 minutes and the serum collected into a clean dry bijou bottle. The Serum CRP, Troponin T., CK-MB, LDH were measured by enzyme linked immunoabsorbent assay (ELIZA) using standard commercial kits (Bachem UK). Informed consent of the participants was obtained and was conducted in line with the ethical approval of the hospital.
The results were expressed as mean ± standard deviation. The statistical evaluation of data was performed by using students t- test. The level of significance was calculated at P<0>
| Parameters | HbSS | HbAA |
| CRP (mg/L) | 87.10 ±12.43* | 31.11 ±14.15 |
| Troponin T (ng/L) | 89.83 ±14.50* | 36.22 ±15.23 |
| CK-MB (ng/mL) | 48.13 ±11.3* | 27.16 ±10.41 |
| LDH (U/L) | 289.21 ±23.51* | 211.53 ±21.35 |
* Significantly increased when compared with the control at p<0>
Table 1. CRP, Troponin T., CK-MB, LDH levels in sickle cell anaemia and control
A rare but serious side effect of sickle cell disease (SCD) is hypercoagulability, which is a hereditary trait that increases the risk of thromboembolic events [10]. In this study, sickle cell anemia was found to have higher levels of CRP, Troponin T, CK-MB, and LDH than the control group. The stimulation of the vascular endothelium in sickle cell anemia may be the cause of this rise. It is becoming more widely acknowledged that endothelial dysfunction is one of the early signs of vascular disease. Since endothelium damage is the primary cause of sickle cell anemia's onset and progression, endothelial abnormality indicators are implicated [11]. In sickle cell anemia, inflammation may be connected to the rise in CRP. Although it cannot identify the exact origin or location, a rise in C-reactive protein (CRP) suggests inflammation in the body, possibly brought on by an infection, trauma, or chronic illness. Similarly, compared to the control, sickle cell anemia showed a markedly elevated Troponin T level. This might most likely be the result of inflammatory events. Muscle fibers are bound to troponin proteins via troponin T [12].
After an injury, like a heart attack, the heart releases troponin I and troponin T into the circulation. Generally speaking, elevated troponin levels indicate a recent heart attack. Myocardial infarction is the medical term for this attack. Significantly elevated troponin levels are a clear sign of a heart damage, especially if they increase and decrease over several hours. Extremely elevated troponin levels usually signify a heart attack, which can happen when the blood flow to a portion of the heart muscle is abruptly cut off. Lower but still increased troponin levels could indicate a different diagnosis [13]. According to this study, sickle cell anemia patients had higher levels of CK-MB than the control group. One type of enzyme that is mostly present in heart muscle cells is creatine kinase-MB (CK-MB). Every time there is muscular damage, CK is released from the muscle cells and can be found in the blood. CK-MM makes up the majority of the tiny amount of CK that is typically present in the blood. CK-MB is usually only seen in considerable quantities when the heart is injured, whereas CK-BB hardly ever enters the blood. A CK test does not differentiate between the three isoenzymes; instead, it assesses the total level. The CK-MB test can be used to identify whether an elevated level of CK in the blood is caused by heart damage or is more likely to be attributable to skeletal muscle injury. To ascertain whether an elevated creatine kinase (CK) is the result of skeletal muscle injury or cardiac damage, a creatine kinase-MB (CK-MB) test may be performed as a follow-up test. If a person feels chest pain or if their diagnosis is unclear—for example, if they have nonspecific symptoms like nausea, dizziness, shortness of breath, or excessive fatigue—the test is most likely to be ordered [14].
The troponin test, which is more specific for cardiac injury, has largely supplanted the CK and CK-MB tests that were originally the main assays ordered to identify and track heart attacks [15]. When a troponin test is unavailable and a heart attack is suspected, the CK test may occasionally be utilized. A CK-MB test may be performed as a follow-up test in this situation to ascertain whether the high CK is the result of skeletal muscle or cardiac injury [15]. Additionally, compared to the control, sickle cell anemia patients had higher levels of LDH. Nearly every bodily tissue has the enzyme lactate dehydrogenase (LDH), which is essential for the synthesis of energy and whose levels can reveal illness or tissue damage. The enzyme lactate dehydrogenase is found in practically every bodily tissue. Liver illness, anemia, heart attacks, bone fractures, muscular damage, malignancies, and infections including HIV, encephalitis, and meningitis can all result in elevated LDH levels in the blood. Another non-specific indicator of tissue turnover, a typical metabolic process, is LDH. Increases in LDH levels or one of its isozymes are common in several malignancies [16]. As a result, it might not be a distinct tumor marker that can be used to determine the type of cancer. Since routine isozyme testing is typically not available in clinical laboratories and LDH is non-specific.
That sickle cell anemia is linked with increased CRP, Troponin T., CK-MB, LDH level which could lead to increased risk of cardiovascular risk in Sickle cell anaemia. Measurement of soluble CRP, Troponin T., CK-MB, LDH may be helpful marker of impending coronary artery insult in sickle cell anaemia
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
