AUCTORES
Globalize your Research
Review Article | DOI: https://doi.org/10.31579/2640-1053/248
Interdisciplinary researcher of the International Academy of Education, Technological Platform MEDICINE OF THE FUTUR, Russia, Novosibirsk.
*Corresponding Author: Evgeniy Bryndin, Interdisciplinary researcher of the International Academy of Education, Technological Platform MEDICINE OF THE FUTUR, Russia, Novosibirsk.
Citation: Evgeniy Bryndin, (2025), Elimination of Cancerous Tumors of Different Organs by Intelligent Cell Therapy and Spontaneous Regression, J. Cancer Research and Cellular Therapeutics. 9(5); DOI:10.31579/2640-1053/248
Copyright: © 2025, Evgeniy Bryndin. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 11 July 2025 | Accepted: 22 July 2025 | Published: 04 August 2025
Keywords: elimination of cancerous tumors; intelligent cell therapy; spontaneous regression
Preparing the body's systems for spontaneous regression of cancer tumors with intelligent cell therapy is a modern and promising approach in oncology based on the use of specially modified cells of the immune system to recognize and destroy cancer cells. CAR-T cell therapy is a technology in which T lymphocytes are taken from a patient, genetically modified to express special receptors capable of recognizing antigens on the surface of tumor cells, and then returned to the body to fight cancer. TIL therapy uses lymphocytes extracted directly from the tumor, which are then activated and scaled in vitro and reintroduced into the patient to fight cancer cells. Dendritic cell vaccines stimulate the immune response against cancer.The advantages of intelligent cell therapy include high specificity and the ability to adapt to various tumor types.Elimination of cancer tumors using spontaneous regression provides a key to understanding the natural mechanisms of resistance to cancer cells and potential methods for their natural destruction. Spontaneous regression activates the immune system, which recognizes, modifies and destroys cancer cells. Hormonal changes inside tumor cells cause their spontaneous disappearance.Technological combination of intelligent cell therapy and spontaneous regression is a promising approach in the field of oncology and regenerative medicine. Firstly, the use of cognitive and artificial intelligence systems for diagnostics, monitoring and optimization of cell therapy, secondly, the implementation of machine learning algorithms and big data analysis to identify factors predisposing to spontaneous regression, thirdly, the development of individual therapy protocols based on predictive models, which increases the effectiveness and safety of treatment. Technological combination of intelligent cell therapy and spontaneous regression mechanisms opens new horizons for personalized treatment, increasing effectiveness and minimizing side effects. Increases the effectiveness of therapy by integrating natural regression processes, predicts spontaneous regression, stimulates immune mechanisms using motivated artificial intelligence. In the future, such approaches can become the basis for innovative methods of combating oncological and other serious diseases.
Malignant tumors of various organs differ in morphological, clinical and molecular features.Let's consider the main differences for some organs:
1. Lungs: squamous cell carcinoma or small cell carcinoma.Metastases to the lymph nodes, brain, bones.
2. Breast: invasive or non-invasive carcinoma. Characterized by hormonal sensitivity (estrogen or progesterone receptors).Metastases to bone tissue, liver, lungs.
3. Liver: hepatocellular carcinoma. Associated with cirrhosis, viral hepatitis. Metastases are usually few, primary cancer dominates.
4. Stomach: adenocarcinoma. Associated with Helicobacter pylori. Metastases to the lymph nodes, liver.
5. Intestines: adenocarcinoma of the colon. Can develop against the background of polyps. Liver metastases, lymph nodes.
6. Prostate: Malignant tumors - adenocarcinomas. Metastases - to bones.
7. Brain: gliomas, metastases from other organs. Metastases from the lungs, mammary gland are the most common.They progress rapidly, causing neurological symptoms.
General differences include cell type, growth rate, tendency to metastasize and response to treatment.Each tumor has unique characteristics, which are important to consider when diagnosing and choosing a therapy.
Activation of body systems with the help of intelligent cell therapy for spontaneous regression of cancer tumors is a modern and promising approach in oncology, based on the use of specially modified cells of the immune system to recognize and destroy cancer cells [1-8].
Spontaneous regression processes in malignant tumors are a phenomenon in which the tumor shrinks or completely disappears without specific treatment [9-17]. These processes may manifest themselves differently in different organs. This is due to the peculiarities of tumor biology, immunological mechanisms, and the microenvironment of the organs. The main differences in spontaneous regression in different organs are listed below:
1. Lungs: spontaneous regression is associated with hypersensitivity or an immune reaction caused by an infection, such as tuberculosis. In some cases, regression is associated with inflammatory processes or antibodies.
2. Breast: spontaneous disappearance of some invasive carcinomas, especially with hormonal dependence. Associated with changes in hormonal levels and immune response. The mechanism often involves apoptosis of tumor cells.
3. Liver: spontaneous regression of hepatocellular carcinoma is observed. May be accompanied by inflammation or necrosis caused by immune mechanisms or viral infection.
4. Stomach and intestines: spontaneous regression is associated with inflammatory processes, infections or immune attack.
5. Prostate: hyperplasia or tumors decrease with immune reactions.
6. Brain: a decrease in metastases is observed due to immune processes or therapy that coincide with natural changes.
7. General features of spontaneous regression processes: associated with activation of the immune system, including cytokines, T-lymphocytes, NK cells. In some cases, they are caused by infections that stimulate an immune response against the tumor. May be accompanied by necrosis, inflammation and changes in the tumor microenvironment. Spontaneous regression is more often observed in tumors with high immunogenic activity, such as melanoma, renal cell carcinoma.
The mechanisms of spontaneous regression remain poorly understood, and this phenomenon is still difficult to predict and use in therapy.
Conditions for triggering spontaneous regression of a malignant tumor are a complex and multifactorial process that includes the interaction of the immune system, tumor cell characteristics, and the microenvironment. The main conditions and factors that contribute to this phenomenon are as follows:
1. Activation of the immune system:
- Inflammatory reactions that attract T-lymphocytes, NK cells, and macrophages to tumor tissue. - Release of cytokines (e.g., interferons, interleukins) that stimulate the immune response.
2. Infections and inflammations:
- Some infections, such as tuberculosis or viral diseases, can stimulate the immune system and promote tumor cell recognition.
- Inflammatory processes can lead to tumor tissue necrosis and activation of immune mechanisms.
3. Immunological reaction against the tumor:
- Detection of tumor antigens and their presentation to lymphocytes.
- Formation of antibodies and cytotoxic cells that attack the tumor.
4. Modification of the tumor microenvironment:
- Reduction in the level of immune regulatory factors that suppress immunity.
- Changes in the vascular system that increase the penetration of immune cells.
5. Genetic and molecular features of tumor cells:
- Mutations that increase their immunogenicity.
- Low expression of factors that suppress the immune response.
6. Triggers of external or internal stimulation:
- Medical procedures or accidental injuries that cause inflammation.
- Temporary decrease in immune tolerance.
7. Hormonal or metabolic changes:
- Disturbances that affect the growth and immune response of tumor cells.
In general, spontaneous regression is triggered when the immune system recognizes the tumor as a foreign object and responds to it effectively, overcoming the immune suppression mechanisms that develop in the tumor environment.
The physiologic process of spontaneous regression of various malignant tumors is a well-documented phenomenon in which the tumor shrinks or completely disappears without targeted treatment.This process is associated with complex immunological, genetic and microbiological mechanisms.Below is an overview of the key aspects of the physiology of spontaneous tumor regression.
1. Immunological mechanisms
- Involvement of the immune system: activation of immune cells such as cytotoxic T lymphocytes (CD8+), fasting NK cells and macrophages leads to recognition and destruction of cancer cells.
- Inflammatory reactions: local inflammation can stimulate the immune response, contributing to the suppression of tumor growth.
- Immunological memory: sometimes regression is associated with the development of long-term immunological memory, which prevents relapse.
2. Genetic and molecular factors
- Genetic mutations: Some tumors may have genetic changes that make them more vulnerable to the immune response or induce apoptosis.
- Release of antiviral and antimicrobial cytokines: interferons, for example, help suppress tumor growth.
3. Intracellular and cellular mechanisms
- Apoptosis: programmed cell death of tumor cells triggered by internal or external signals.
- Decreased angiogenesis: decreased formation of new blood vessels needed to feed the tumor.
- Microenvironmental effect: changes in the tumor microenvironment, including suppression of vascular growth and changes in immune cells.
4. Microbiota and environmental effects
- Some evidence suggests that the gut microbiota and external factors may influence the immune response and promote regression.
5. Hormonal mechanisms
- In some cases, changes in hormonal status (e.g., decreased levels of hormones that stimulate tumor growth) can promote regression.
6. Other factors
- Genetic and epigenetic changes that make the tumor vulnerable.
- The influence of stress or infectious agents that activate immune responses.
Spontaneous regression of malignant tumors is a complex interdisciplinary process that includes activation of the immune system, molecular changes, and the tumor microenvironment. This process stimulates the body's own mechanisms to suppress tumor growth.
Recording and monitoring of spontaneous regression of malignant tumors are important steps in the study of this rare phenomenon, allowing to understand its mechanisms and to ensure the accuracy of data. The main directions and methods include:
1. Documentation of clinical cases
- Detailed description of the anamnesis, time frame of regression, symptoms and factors preceding the event.
- Photographic recording of changes in the appearance of the tumor (e.g., reduction in size, disappearance of nodes).
2. Medical imaging
- Use of imaging methods: ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET).
- Regular monitoring of changes in tumor size and structure over time.
3. Histological and molecular recording
- Tumor biopsy before and during regression for morphological analysis.
- Use of fixatives (e.g., formalin), preservation of samples for further examination, including immunohistochemical methods.
4. Monitoring of immunological parameters
- Blood and tissue analysis for the presence of immune cells, cytokines, markers of immune system activation.
- Evaluation of changes in the immune environment in the peripheral blood and inside the tumor. 5. Regular observation and recording
- Continuous clinical observation of the patient with recording of any changes, symptoms or signs of regression.
- Maintenance of detailed protocols and databases for analysis of regression patterns and possible factors influencing the process.
6. Etiological and factorial analysis
- Evaluation of possible triggers, such as infectious agents, immunological reactions, treatment, stressful situations.
Effective fixation and observation allow not only to document cases of spontaneous regression, but also to reveal the mechanisms of this phenomenon, which is important for application.
Directions of clinical trials of spontaneous regression of malignant tumors include several key areas:
1. Study of immunological mechanisms
- Analysis of the role of the immune system in spontaneous regression, including the participation of T-lymphocytes, macrophages and cytokines.
- Identification of biomarkers associated with the activity of the immune response during regression.
2. Genetic and molecular studies
- Study of genetic changes and mutations in regressing tumors.
- Analysis of the expression of genes associated with apoptosis, proliferation and immune regulation.
3. Clinical observations and retrospective studies
- Collection of data on cases of spontaneous regression, their characteristics, age, tumor type and conditions.
- Analysis of factors preceding regression and possible triggers.
4. Experimental models and preclinical studies
- Development of animal models that reproduce spontaneous regression.
- Testing hypotheses about the mechanisms of regression, including the role of immune cells and molecules.
5. Research into therapeutic approaches that mimic regression
- Development and evaluation of immunotherapies that stimulate similar processes.
- Studying methods for activating the immune response to achieve tumor regression.
These areas of clinical trials help to understand the mechanisms of spontaneous regression and may contribute to the development of new treatments for malignant tumors based on stimulating their own regression processes.
Medical indicators that determine the body's readiness for spontaneous regression of a malignant tumor include a number of immunological and biochemical characteristics indicating the activation of the body's defense mechanisms. These indicators help to understand how well the immune system is able to fight the tumor and whether its natural regression is possible [18-19].The main ones are:
1. High activity of immune system cells:
- Increased number of cytotoxic T-lymphocytes (CD8+ T-cells) and natural killers (NK-cells) in the bloodstream and in tumor tissue.
- Increased activity of macrophages capable of destroying cancer cells.
2. Changes in the cytokine profile:
- Increased levels of interferons (for example, IFN-γ), which stimulate antitumor immunity.
- Increased levels of interleukins (e.g., IL-2) that promote proliferation of T cells and NK cells.
3. Presence of antibodies to tumor antigens:
- Presence of specific antibodies in the blood indicating an active immune response against the tumor.
4. Presence of tumor antigens and immune complexes:
- Detection of tumor-specific antigens in the blood or tissue indicating an immune system response to the tumor site.
5. Intracellular and interstitial parameters:
- High proliferative activity of lymphocytes in tumor tissue.
- Presence of apoptotic cells within the tumor indicating an active process of cancer cell destruction.
6. Genetic and molecular markers:
- Genetic predisposition to an enhanced immune response (e.g., certain HLA alleles).
- High expression of genes associated with immune activation.
7. General body parameters:
- No severe concomitant diseases or immunodeficiency.
- Good functional status of the body (e.g., ECOG or Karnofsky scale).
These parameters together help to assess the body's potential ability to spontaneous tumor regression.Research in this area is ongoing, with the aim of determining the precise predictors and mechanisms of this phenomenon.
Preparation of body systems for spontaneous regression of malignant tumors using intelligent cell therapy includes a set of measures aimed at strengthening and modulating the immune system to increase the likelihood of natural destruction of tumor cells.This approach involves not only the use of cellular preparations, but also the integration of modern technologies and methods to optimize the immune response. The main stages and areas of preparation include:
1. Diagnostic assessment of the body's immune status:
- Analysis of the immune cell profile (T-lymphocytes, NK cells, macrophages).
Determination of the levels of cytokines, antibodies and tumor antigens.
- Genetic and molecular characterization of the immune system to identify the potential for regression.
2. Modulation of the immune system:
- Use of immunomodulators (e.g., interferons, interleukins) to increase the activity of T- and NK-cells.
- Administration of immunostimulants that stimulate the development and activation of immune effectors.
- Correction of the imbalance between regulatory and active T cells.
3. Personalization of cell therapy:
- Isolation, modification, and expansion of autologous immune cells (e.g., T lymphocytes, dendritic cells) to enhance their antitumor activity.
- Use of genetic modification technologies (e.g., CAR-T or TCR therapy) to increase the specificity and effectiveness of cells.
4. Providing a microenvironment favorable for regression:
- Monitoring the condition of surrounding tissues and reducing inflammatory processes or immune suppression.
- Use of drugs that reduce tumor immune tolerance (e.g., checkpoint inhibitors). 5. Maintaining general health and eliminating concomitant factors:
- Improving nutrition, correcting metabolism, eliminating chronic infections and inflammation.
- Adequate therapy of concomitant diseases to increase overall resistance.
6. Monitoring and correction of therapy:
- Constant monitoring of immune parameters and tumor condition.
- Adaptation of protocols depending on the dynamics of the body's response.
7. The intelligent aspect of cell therapy involves the use of modern information technologies, such as artificial intelligence systems, bioinformatics and personalized models, to predict the body's response, optimize protocols and timely activation [20].
The goal of intelligent cell therapy is to create conditions inside the body that maximally promote the activation of immune mechanisms and the destruction of tumor cells, which can lead to spontaneous regression without the need for aggressive drug intervention. However, it is important to emphasize that such approaches require an individual approach, interdisciplinary research and clinical confirmation.
Using a motivated adaptive reflexive erudite AI assistant with a multimodal ontology to identify the body's readiness for spontaneous regression of a specific malignant tumor based on medical indicators is an advanced technology that combines modern achievements in the field of artificial intelligence, ontologies and medical diagnostics [21].Below is an analysis of the key components and possible approaches to the implementation of such a system.
1. Motivated adaptive AI assistant
- Motivation: the system must have built-in goals and motivation to search for and analyze data related to tumor regression.
- Adaptability: the ability to learn and adjust its models based on new data, individual patient characteristics and the dynamics of the condition.
- Reflexivity: the ability to evaluate one's own decisions and conclusions, as well as adjust them. 2. Erudite AI assistant
- Has an extensive knowledge base in the field of medicine, oncology, biology and statistics.
- Uses expert knowledge to interpret data and form hypotheses.
3. Multimodal ontology
- Integration of various types of data: medical images (MRI, CT, ultrasound), laboratory parameters, genetic data, clinical observations.
- Structuring knowledge using ontologies to ensure interrelation and semantic consistency.
4. Identifying the body's readiness for spontaneous regression
- Analysis of medical indicators: marker levels, genetic mutations, immunological indicators, features of the tumor histotype.
- Monitoring the dynamics of these indicators over time.
- Using machine learning and statistical analysis methods to determine signs preceding spontaneous regression.
5. System architecture:
- Collection and integration of multimodal data using interfaces and sensors.
- Processing and preliminary analysis of data using multimodal neural networks.
- Using ontological models for semantic data unification.
- Using adaptive machine learning models trained on individual patient data.
- Internal reflexive system for assessing the accuracy of predictions and adjusting the model.
- Visualization of results and recommendations for doctors.
- Creating a knowledge base and ontologies in the medical field.
- Developing modules for processing multimodal data.
- Implementation of machine learning methods (e.g., deep neural networks, random forests) for pattern analysis.
- Building a feedback system for continuous learning and improvement of the model.
Using such a system will improve the accuracy of prediction and identification of patients who have the potential for spontaneous tumor regression, which can significantly affect the choice of treatment and monitoring tactics. An important aspect is ensuring the reliability and interpretability of AI solutions, as well as compliance with ethical and legal standards in medical practice.
The future of intelligent regression of malignant tumors is a promising direction in oncology based on the integration of modern technologies and fundamental research.
1. Personalized medicine and forecasting
- Using artificial intelligence (AI) to analyze genomic, proteomic and clinical data of the patient. - Creating models that predict the likelihood of spontaneous regression or the success of therapeutic interventions.
- Individual treatment protocols optimized for the characteristics of a particular patient.
2. Mechanisms of spontaneous regression and their stimulation
- In-depth study of immunological and molecular factors that contribute to regression.
- Development of methods for pharmacological or genetic stimulation of natural regression processes.
- Implementation of gene therapy technologies and immunomodulators to activate tumor self-regulation mechanisms.
3. Integration of artificial intelligence and big data
- Using machine learning to identify patterns preceding regression.
- Constantly updating knowledge bases and algorithms based on new clinical data.
- Development of decision support systems for doctors and patients.
4. Biomarkers and diagnostics
- Identification of biomarkers predicting the tendency to regression.
- Creation of non-invasive methods for monitoring the tumor condition and the effectiveness of therapy.
- Use of liquid biopsy and nanotechnology to track the dynamics of the process.
5. Ethical and clinical aspects
- Development of standards and protocols for the safe use of regression stimulation technologies. - Conducting clinical trials to evaluate the effectiveness and safety of new methods.
- Ensuring patient awareness and consent.
In general, the future of intelligent regression of malignant tumors involves the creation of complex, dynamically adaptive systems that can not only predict and stimulate natural regression processes, but also integrate them into individual treatment regimens. Such a strategy has the potential to radically change approaches to oncological therapy, increase its effectiveness and reduce side effects.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
